Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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Episodes1269

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Jul 8, 2020 · 28 min
Serpins and the Neutrophil Extracellular Traps in Respiratory Distress and the Coronavirus. 08 July 2020
Dr Guerra recaps protease mechanisms and zymogen activation ultimately linking serpin mediation of neutrophil elastase during coronavirus infection. Published 08 July 2020
Jul 3, 2020 · 28 min
Dr Guerra examines proteases and protease inhibitors in ovarian and hepatocellular cancers and their pathobiochemical mechanisms. 03 July 2020.
Dr Guerra presents how a protease inhibitor protects a serine protease that is linked to ovarian cancer progression plus how protease inhibitor polymerization overloads the Endoplasmic Reticulum Associated Degradation pathway and Unfolded Protein Response to induce autophagy-linked Hepatocellular Carcinoma. Finally, a mechanistic step-wise summary of the serine protease catalytic triad is presented. Published 03 July 2020.
Jun 30, 2020 · 28 min
The Role of Alpha anti-trypsin in the IL-1 pro-inflammatory cascade. 30 June 2020
Far from becoming monomeric and unimodal in effect, the anti-trypsin protease inhibitor functions to modulate the transcriptome and proteome of induced pro-inflammatory responses in both systemic and tumor microenvironments. Dr Dan Guerra 30 June 2020
Jun 29, 2020 · 28 min
SERPINs and the Acute Phase Response in the Pathophysiological State. Dr Dan Guerra, 29 June 2020
Dr Guerra targets his lecture on protease inhibitors as positive acute phase proteins serving a modality of repression against proteolytic degradation processes as induced by the pro-inflammatory cytokine mediated hyper-immune response. Published 29 June 2020.
Jun 25, 2020 · 28 min
Dr Guerra Presents: Serine Protease Inhibitor Biochemistry in Human Health and Disease I. 25 June 2020
In this session Dr Guerra discusses the physiological and pathophysiological roles of serine protease inhibitors (SERPINS). For example, the physiological role of plasminogen activator inhibitor 1 (PAI-1) involves control over fibrinolysis which is an essential hemostatic mechanism for regulating the dissolution of fibrin clots associated with airway passage remodeling systemic wound repair, and the inflammatory response as linked to cytokine mediated immune responses and circulating t-PA mediated cardiovascular function. Dr Guerra also mentioned that he has established a PATREON site: https://www.patreon.com/user?u=37615512&fan_landing=true&fbclid=IwAR0L8ADIhtIgZM_WtkJejz_x-3hAdzr39mrvoZxdAu6glm9zkAG5L4NnhCo Lease strongly consider recombining with the Patreon link as a means to provide monetary donations to the Authentic Biochemistry Podcast and YouTube lecture series plus the VerEvMed Facebook postings that include Authentic Biochemistry "Minutes" and some original (North)Western philosophy, courtesy of Dr Guerra and his existentialist individualism.
Jun 19, 2020 · 28 min
Dialectical Event Ontological Analysis of the Scientific Method as Prolegomena to a Recap of PEDF in Hepatocellular Carcinoma
In this Lecture I define and then implement a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra
Jun 12, 2020 · 28 min
Dr. Guerra presents: Contrarion opposition of PEDF in Tumor progression explained via dyslipidaemia and corruption of AMPK mediated control. 12 June 2020.
Dr. Dan Guerra apprehends several research publications going back to 2012 and proceeding through 2019 in a synthesis of oppostional logic and the published scientific evidence to explain the mediation of metabolic zonation, transcriptional control, and bioenergetcs using PEDF to mitigate cancer progression.
May 31, 2020 · 28 min
Dr Guerra's second lecture on T2D and its link to Obesity plus a bonus Clinical Misdiagnosis Study Question Review. 31 May 2020
A brief concluding lecture on the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring.
May 31, 2020 · 28 min
Dr Guerra discusses Obesity-linked Type 2 Diabetes and clinical manifestation of the disease
Dr Guerra lays out the prodromal manifestations of metabolic syndrome and insulin resitance that can lead to Type 2 diabetes in the obese sedentary aging population.
May 26, 2020 · 29 min
Nutritional biochemistry and the obesogenic induction of insulin resistance and type-2 diabetes. Dr Daniel J. Guerra. 25 May 2020
Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b.
May 25, 2020 · 28 min
Obesity and pathophysiological Implications including hyper-Immunity, increased susceptibility to serious infection and high-mortality disease.
Dr Guerra reminds his audience that obesity is the global health pandemic of a generation and that it leads to multiple high mortality diseases associated with a corruption in lipid metabolism, both innate and acquired immunity and associated cancer and cardiovascular disorders. Because obesity sets as a precondition and continued distress to human health and well-being, the predisposition to a constellation of diseases both infectious and non-infectious is obtained. Recorded and produced on 25 May 2020 by Dr Daniel J. Guerra
May 14, 2020 · 28 min
Basic Endocrine Hormone Nomenclature and physiological biochemistry. Authentic Biochemistry 14 May 2020.
Dr Guerra provides the basic detail necessary to prepare one for our future examination of the current peer-reviewed literature involving hormonal control over health , infection and inflammation via the immune system.
May 5, 2020 · 28 min
General Hormone Lectures II. The Hypothalamic Pituitary Axis. Dr Daniel Guerra. 05 May 2020.
Dr Guerra discusses hormonal ontology via receptor -binding mechanisms plus the cascade of the hypothalamic-pituitary axis.
May 4, 2020 · 27 min
General Human Hormone Physiology and Biochemistry Lecture I. Published by Dr Daniel J. Guerra. 04 May 2020
Dr Guerra gives a fast paced knowledge-laden series of lectures on the medical physiological and biochemical features of human hormonal signaling. Lecture I Introduction and Classification. Published on line 04 May 2020
Apr 28, 2020 · 29 min
From Hypothalamic POMC to Palmitate and back again: Lipid Metabolism needs to Be Authenticated. Dr Dan Guerra. 28 April 2020.
Dr Guerra opens up the refereed published scientific literature to provide verified evidence associated with the arcuate nucleus of the hypothalamic arc leading to hormonal control over nutrition and the immune system. Published 28 April 2020
Apr 27, 2020 · 29 min
Chapter V Immuno Endocrinology of Disease Dr Dan Guerra Authentic Biochemistry Podcast 27 April 2020
Patho-Biochemical Pathways in CNS-Endocrine Organs with a special emphasis on sphingomyelin phosphodiesterases in the HPA axis of the CNS and Beta hemolysins as virulence factors from the human bacterial pathogen, Staphylococcus aureus. Dr Daniel J Guerra published on 27 April 2020.
Apr 23, 2020 · 6 min
Request to check out my video lectures and subscribe to my podcast and YouTube Channel; This will add tremendous excitement and freedom to your day!
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Apr 12, 2020 · 28 min
ASM-generated Ceramide Lipid Rafts and the Fatty Acid Transport Protein in the Hyperimmune Disease Response.
Dr Guerra delivers his third informed discussion of Membrane lipid raft biology and the role of Sphingolipids in mediating an immune response that results in massive tissue damage and poor disease outcome. Published 11 April 2020
Apr 11, 2020 · 29 min
How do Sphingolipids associate with SSRI's to offer advice to Pharmacologists working on Coronavirus?
In this audio lecture presentation, Dr Guerra gives an aggregated explanation for the association of subcellular biochemical metabolism of sphingolipids via the target of Cationic Amphipathic Drugs such as SSRI's in altering cell fate from programmed cell death to tissue preserving autophagy. Published 11 April 2020.
Mar 23, 2020 · 28 min
Dr. Guerra uses Logical and Scientific Principles to Perform a Dialectic On the Validity of COVID 19 Corona virus Pandemic. 23 March 2020.
Dr Guerra uses the Dialectical Method via the Logical Square of Opposition combined with an analysis of the current biomedical evidence associated with the COVID 19 corona virus to obtain validated conclusions. 23 March 2020.