Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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Sep 14, 2020 · 28 min
Dr Guerra presents: The Agency of the Immune System Treg Lymphocytes in Senescence and Human Aging. Authentic Biochemistry Podcast.14 September 2020
Cellular senescence is a physiological process with genetic determinants and external modififiersincluding stress, nutrition and cell fate reprogramming including autophagy and apoptosis. Human aging is a lifelong teleological process that includes the specifics of cellular senescence plus an underdefined terminus that tracks chronological longevity and occurs in all systems including musculature, solid organs, the PNS and the CNS Aging is at the organismal level and is inevitable with increasing morbidity with or without definable etiological agency and the end is always death. This is in contrast to senescence, which is variable , tissue specific and both plastic and elastic relative to short but stochastic progress that presents with intervals of remission and progression without a necessary uniformity of morbidity or coordinated coincidental death. PLEASE CONTRIBUTE TO my PODCAST TODAY!
Sep 9, 2020 · 28 min
Glucocorticoid Associated Naive Treg Differentiation and the Role of T Memory and Treg Sub-populations in Aging and End Stage Renal Disease
Dr Guerra discusses the Glucocorticoid-induced tumour necrosis factor receptor-related protein (GITR) and its role in stabilizing T Regulatory cell populations relative to T memory cells and T effector Cells in healthy and End-Stage Renal Disease patients of differing chronological age. This plank is laid down to form the final structural foundations that allow us to examine dialectically, the role(s) of the Immune system on aging and the chronic and auto-immune diseases of the elderly. Published 08 September 2020 by DJGPhD. Please subscribe to Authentic Biochemistry and give us a % star review and please donate directly to the podcast or join our Patreon page https://anchor.fm/dr-daniel-j-guerra
Sep 1, 2020 · 25 min
Innate Like Lymphocyte and T Regulatory Cell Modulation against a backdrop of Immunostimulatory Effectors 01 September 2020.
Dr Guerra builds the foundation for transcription factor and epigenetic regulation of Treg cell differentiation in counterbalance to ILC's and T effector lymphocyte populations. Published 01 September 2020.
Aug 24, 2020 · 27 min
T lymphocyte and MVA pathway cross-talk in Breast Cancer, Lymphomas, Leukemias, CVD and aging. 24 August 2020
Dr. Daniel Guerra recombines the discussions of pharmacotherapeutic inhibition of prenylation in T cell activation and the failure of the NF-Kappa B pathway in estrogen receptor associated breast cancer and the lymphoproliferative lymphomas and leukemias with aging and neurodegeneration. PUblished 24 August 2020. Please join our Patreon and contribute to Authentic Biochemistry today!
Aug 19, 2020 · 28 min
The Sterol Response Element Binding Protein expression, cellular translocation and transcription factor pathways in T cell activation. 18 August 2020. by Dr Dan Guerra
Dr Guerra discusses the induction of transcription factor SREBP in activated T lymphocytes and the regulation of cellular translocation from the ER to the Golgi to the nucleus for the induction of prenyl and acyl lipogenesis, Published 18 August 2020 by Dr Daniel J. Guerra. Review of: Front. Pharmacol., 17 March 2020. https://doi.org/10.3389/fphar.2020.00265
Aug 7, 2020 · 28 min
Dr Guerra lectures about Chronic Genomic Instability as a means to an end called senescence. Published 06 August 2020.
In this segment I discuss the phenomenon of DNA and genomic instability and the DNA repair systems implemented as mechanisms to drive cellular longevity . 06 August 2020 .
Aug 5, 2020 · 29 min
Dr Guerra discusses canonical Programmed Cell Death. Published 05 August 2020
Programmed Cell Death is a classical cell fate that occurs during embryonic development, tissue repair and both leucocyte and lymphocyte turnover. Various subforms of apoptosis ( classical, necroptosis and ferroptosis) are also involved during infection, genotoxicity, oncogenesis and aging. Published By Dr Guerra 05 August 2020. Subscribe to the podcast! Contribute on Patreon!
Aug 4, 2020 · 29 min
The Aging biochemical landscape as associated with chromatin organization and the alteration of cell cycle dynamics leading to the Senescence Associated Secretory Phenotype
Dr Guerra discusses the cancer marker gene mKI67 and its turnover linked to predisposition to euchromatin formation and the progression toward a senescent phenotype. Published 04 August 2020.
Aug 2, 2020 · 27 min
Dr Guerra discusses how Isoprenoid metabolism is linked to T cell activation via glycolysis and glutaminolysis. 02 August 2020
The mevalonic acid biosynthetic pathway maintains canonical cell activation triggers that link intermediary metabolism to T lymphocyte differentiation. 02 August 2020
Aug 1, 2020 · 29 min
Dr Guerra discusses the mTORC -AMPK axis and the control of the rate of aging as central to the slow growth hypothesis to longevity. 01 August 2020
The master regulator of protein translation, mTORC, is itself regulated by the stress-induced AMPK pathway. Rapamycin and semi-selective drugs regulating AMPK may reduce glioblastoma progression and this observation helps to advance a theory for healthy longevity that requires a reduction in anabolism. By Dr Daniel J. Guerra. Published 01 August 2020
Jul 30, 2020 · 29 min
Dr Guerra discusses aging associated oxidative phosphorylation, gluconeogenesis, NAD+ sirtuin activity and telomerase. 30 July 2020
In this lecture I gather some of the notable molecular components of age-related decline and the contrarion opposition imposed by cell proliferation. Published 30 July 2020. DJGPhD.
Jul 28, 2020 · 29 min
The Categorical Logic of Aging Systems as Influenced by Nutrition and the Introduction of Pharmacotherapeutics that Target Disease. Lecture VI. Published 27 July 2020.
Dr Dan Guerra examines nutritional restriction and exercise in combination with anti-diabetic drugs to impact the aging process. Published 27 July 2020.
Jul 26, 2020 · 29 min
The triad of biological auto-oxidation and the progress of aging as sine qua non to pathology. Published 26 July 2020.
Dr Guerra explains chain initiation, propagation and termination during lipid oxidation and the REDOX reactions of the electron transport chain as a lead in to enzymatic oxidations and the plasticity of immune linked senescence. 26 July 2020.
Jul 25, 2020 · 29 min
Reactive oxygen is generated in biological systems leading to a physiological transit to senescence. Published 24 July 2020
Dr Guerra lays out the reduction of molecular oxygen to water and the accumulation of intermediate free radical oxygen species that are reduced via enzymatic activity and anti=oxidants. Aging is related to the auto-oxidation of nucleic acids, protein and significantly, membrane unsaturated molecular species of lipids. 24 July 2020
Jul 24, 2020 · 29 min
The oncogenic intermediary metabolic corruption as contrarion ontology to aging. Published 24 July 2020.
Dr Guerra explains how mutations in the glycolytic enzyme, pyruvate kinase, may lead to histone phosphorylation and the florid production of pro-oncogenic events. 24 July 2020.
Jul 21, 2020 · 29 min
Biochemical/Physiological Paradigms of Aging and Tumor Metabolism: the classical Warburg Aerobic Glycolysis and Krebs Cycle Corruption. 21 July 2020.
Dr. Guerra delivers lecture 2 on human aging with a walk on the other side of cell fate:-pathobiochemical immortalization during oncogenesis. Published 21 July 2020
Jul 19, 2020 · 29 min
Dr Guerra starts a series on the biochemistry and physiology of human aging and the ontology of sequential phenomenon in living systems. 19 July 2020.
Today I start this robust examination of human aging from the fundamentals of life span and the molecular events that mediate the rate of senescence. This is Part One. Also please consider contributing to Authentic Biochemistry by becoming a patron on Patreon. I need your support! https://podbay.fm/podcast/1454408625
Jul 12, 2020 · 28 min
Neutrophil Elastase and the extracellular trap mediated hyperinflammatory response leading to pulmonary edema, Na+ hyperabsorption: linkage to coronavirus .
The synthesis of protease-mediated hyper inflammation in pre-morbid respiratory distress pathobiochemical states linked to coronavirus transmission . How COPD and ARDS in association with cardiovascular disease, diabetes and lung dysfunction pre-dispose to viral infection and illness. Published 11 July 2020.
Jul 10, 2020 · 28 min
Neutrophil elastase-mediated pulmonary disease including Cystic Fibrosis, RDS, COPD and viral pneumonia 10 July 2020
Airway passage disease has been well characterized in cystic fibrosis and this research which involves both clinical and animal model systems can inform general respiratory distress syndrome and viral pneumonia as that ascribed to the coronavirus 19. Published 10 July 2020
Jul 9, 2020 · 27 min
A Narrative on the Nature of Belief as Universal within Knowledge yet Regularly Discounted in the Scientific World View. 09 July 2020
Dr Guerra presents his existential view on the purposive avoidance in science to admit the significance of belief in the knowledge paradigm. 09 July 2020.