Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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Episodes1269

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Mar 20, 2020 · 28 min
Dr Guerra's Epistemology and Metaphysics informing a Scientific World View III. Recorded 20 March 2020.
In this third segment on the grounding of Natural Science and the world View it advances, Dr Dan Guerra introduces the endojective perspective for space-time and the foundation of knowledge toward the representation of phenomena as pattern recognition from a possibilistic metaphysical landscape via freely chosen inductive reasoning in an ultimately uncertain universe. Published 20 March 2020.
Mar 16, 2020 · 27 min
Dr. Guerra's Epistemology and Metaphysics of a Scientific World View. Part II. 15 March 2020.
In this second philosophical segment, Dr. Guerra introduces space-time as a physical manifestation of the synthetic a priori of Phenomenological Metaphysics as he draws inferences from pre-Socratic concepts of vortices and co-mingles these ideas with Clerk Maxwell's explanation of the electromagnetic theory and quantifiable resolution for the velocity of light. Published on the IDES of March 2020.
Mar 12, 2020 · 29 min
Dr. Guerra Introduces his epistemology and metaphysics that ground his scientific world view. 11 March 2020
In this first segment of a three part series, Dr Guerra sets out to ground his scientific principles with an a priori epistemological reasoning that leads to the transcendental method for instantiating metaphysics to perform biochemical, genetic and physiological research. Recorded 11 March 2020.
Mar 4, 2020 · 28 min
Dr. Dan Guerra further discusses Ceramide and Sphingosine Mediated cell fate in Pathobiochemistry IV. March 04, 2020.
Dr Guerra explains how there is a cumulative balance between S1P and Ceramide will influence apoptosis and change the regulation of autophagy by the complex interplay between mTOR, beclin, and Bcl-2 where S1P-dependent autophagy is thought to be a homeostatic, pro-survival response involved in the clearance of intra-cellular debris.Describing these systems within the context of inflammation and pathobiochemistry will be obtained.
Mar 3, 2020 · 28 min
Dr Guerra presents today's podcast: Lipid –Associated Pathobiochemistry III. March 3 2020
Today's podcast establishes the significance of sphingolipids in maintaining normal biochemical and physiological homeostasis by detailing membrane organization of pathways and linkage to cell fate and the potential for pathobiology in human disease. Published 03 March 2020 by Daniel J. Guerra, PhD
Mar 1, 2020 · 28 min
Dr.Guerra authenticates evidence in lung Inflammation and associated resident macrophages in disease. 01 March 2020
Dr. Dan Guerra discusses a new publication reviewing the process of resident pulmonary macrophages and innate lymphoid cells in disease with attention to pathogen activation and hyperinflammation as potentiated by co-morbidities leading to poor clinical outcome. 01 March 2020
Feb 28, 2020 · 28 min
Sphingolipid linked Coronavirus, Neurodegenerative, Neuropsychiatric and Inflammatory disease.
Dr Dan Guerra recombines Coronavirus with Ceramide linked Neurological Disease and the Pro-Inflammatory Response. 28 February 2020.
Feb 20, 2020 · 27 min
Dr Guerra examines Sphingolipids as mediators of Inflammasome Formation and Potency in Coronavirus
In this Authentic Biochemistry Podcast, Dr. Dan Guerra explains the roles of acid sphingomyelinases and associated ceramide production on the NLRP3 inflammasome activation as linked to coronavirus pathogen molecular patterns and the production of proinflammatory cytokines 19 February 2020.
Feb 3, 2020 · 27 min
Authentic Biochemistry examines the epidemiology of the Novel Coronavirus Infectious Pneumonia of 2020. Episode II.
Dr. Guerra discusses a published NEJM paper from late January (2020) that details the initial epidemiology of the novel Coronavirus from China and gives an insight on how sphingolipid metabolism may be a potential pharmacotherapeutic target. Podcast Published 03 February 2020.
Jan 31, 2020 · 28 min
Dr Guerra presents the molecular organization, pathology, and transmission of the Novel Coronavirus Infective Pneumonia (NCIP). I.
Dr Guerra of Authentic Biochemistry starts his lecture series on the current disease-causing Coronavirus from China. This first segment gives detail on the basics of molecular arrangement, replication, intracellular trafficking through the ER-Golgi and ultimate virion transmission with some medical-historical references to the more common animal Nidovirales/Coronavirales and the previous human outbreaks of related SARS and MERS CoV. Please visit https://www.facebook.com/danguerra00 and contribute to our Authentic Biochemistry Fundraiser! Also, subscribe to the Podcast!
Jan 28, 2020 · 27 min
Lupus Autoimmune Disease involves a specialized set of plasma and T cell lineages: From Dr. Dan Guerra 28 January 2020.
Professor Guerra arrives at the functionality of autophagy and bioenergetic coupling via chemokine and cytokine signalling through antigen presenting cell population mediated germ center secondary lymphoid organ resident B cell somatic hypermutation via T follicular-helper cell activation thus evincing the autoimmune paradigmatic disease system lupus erythematosus. 28 January 2020.
Jan 22, 2020 · 27 min
Dr Guerra explains how folic acid, homocysteine, and ceramide apprehend the pro-inflammatory neurodegenerative paradigm
Authentic Biochemistry's Dr Dan Guerra gathers published biomedical literature to offer mechanisms and means for sphingolipids and amino acids to make a pathobiochemical donation to immunoepigenomic neurodegenerative disease. 21 January 2020.
Jan 20, 2020 · 27 min
Part III. Autoimmune Disease : essential background and cellular dynamics. Dr Dan Guerra
19 January 2020. This is a podcast delivering Part 3 in my new arc describing the significance of biochemical and epigenetic reprogramming of T lymphocytes in human autoimmune disease. Parts 1&2 of this series are found as video lectures at https://www.youtube.com/playlist?list=UUcEoA2N9WSlNvDk1BtuznfQ. Dr Daniel J. Guerra of VerEvMed and Authentic Biochemistry.
Jan 1, 2020 · 28 min
Dr Guerra brings the autoimmune disease discussion into view. 31 December 2019
Dr Guerra investigates T and B cell mediated autoimmune induction in this critical podcast lecture before the full analysis of these destructive human diseases are authentically examined in the peer-reviewed biomedical literature.
Dec 19, 2019 · 25 min
T lymphocyte mediated autoimmune diseases as arising from immunological networking Dr. Guerra . 18 December 2019
As it turns out, autoimmune bacterial epitope mimicry can play a crucial role in autoimmune primary biliary cholangitis and may correlate to major human disorders such as lupus . Prof. Guerra examines a series of papers from the primary literature to focus attenuation on T cell sub-population differentiating dynamics production.related to Plasma cell IgG
Dec 17, 2019 · 29 min
T lymphocyte mediated auto inflammation from Dr. Guerra's Authentic BIOCHEMISTRY
T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains
Nov 2, 2019 · 27 min
Episode 2 of Authentic Biochemistry Foray into Epigenetics. Dr Dan Guerra. 01 November 2019
The epigenetic control over gene expression via transcriptional and post-transcriptional molecular interactions through time including interfering RNA and covalent modification of chromatin results in enivonmental, nutritional and age-related phenotypes . In this episode of Authentic Biochemistry, Dr. Guerra starts investigating the molecular mechanisms employed.
Oct 30, 2019 · 28 min
Lecture 1 on General Epigenetics from Dr Guerra of Authentic Biochemistry on 29 October 2019
Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.
Oct 16, 2019 · 15 min
Dr Dan Guerra provides a Leptin Coda
Prof Guerra gives a brief examination of Leptin -associated cancers. 15 October 2019
Oct 10, 2019 · 22 min
The Adipokine Leptin in Lupus, Osteoporosis and Glioma
Dr Guerra discusses the intricate roles of Leptin and its receptor in various human diseases. 10 October. 2019