Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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Episodes1269

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Oct 2, 2019 · 28 min
The Homeostatic Roles of Leptin in Obesity and Disease: the adaptive biochemical evolution and dysfunction of lipid homeostasis
Dr Guerra of Authentic Biochemistry provides his third discussion of adipokine-mediated control over obesity and associated disease from animal models to clinical disease. 02 October 2019.
Sep 23, 2019 · 27 min
Leptin Molecular Endocrinology #2 Dr Guerra further explores the adipokine-mediated CNS.
Dr Dan Guerra pursues how Leptin and POMC regulate neuroendocrine and neuro-appetitive behaviours that link obesity and associated metabolic and life-style disease with the dysregulation of energy homeostasis
Sep 22, 2019 · 28 min
Leptin's critical role in the HPA hormonal axis: a saturating overview 22 Sept 2019 DJGPhD
Dr. Guerra of Authentic Biochemistry and the VerEvMed YouTube channel provides critical in-depth neuro-anatomical and HPA axial complicity in Leptin Signaling from the Adipose to the stress- and basal regulation of human physiological responsiveness. 22 September 2019
Sep 9, 2019 · 27 min
Primer on Omega 6 and Omega 3 Long chain polyunsaturated fatty acid metabolism in humans with Clinical Event Ontology
In this Authentic Biochemistry Podcast Episode Prof. Guerra describes the specific metabolism of very long chain polyunsaturated fatty acids from essential dietary precursors of both the Omega 6 and Omega 3 series and associates these pathways with a recent 2019 publication that provides evidence for Omega 3 fatty acid inhibition of adipose stem cell associated IL17a proinflammatory cytokine transcription thus inhibiting obese adipose inflammation. 08 September 2019.
Sep 4, 2019 · 27 min
Dr Guerra provides an in-depth interrogation of lipid metabolism of omega three fatty acids and their complex roles in controlling inflammation.
Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid. 04 Sept 2019.
Sep 3, 2019 · 27 min
Do Omega three fatty acids ameliorate obese adipose derived inflammation via a T cell response?
Dr. Guerra of Authentic Biochemistry discusses a current published paper that shows how DHA and EPA derived from dietary alpha linolenic acid (18:3 cis d 9,12,15) correlates with a decrease in the production of the pro-inflammatory cytokine, IL17-A in a model system composed of obese adipose stem cell populations.
Aug 18, 2019 · 27 min
Dr. Guerra finishes the Treg lectures by drawing upon on a transcription factor molecular thread of Ariadne to deliver T cell lineage architechtonics.
This is volume VI of the Tregs lecture narrative in which Dr. Guerra provides an introduction to a Diaeventontological process for navigating the labyrinth of T cell biochemistry. Published 17 August 2019. Authentic Biochemistry Podcast.
Aug 17, 2019 · 28 min
Dr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcription while activating Th1 and Th2
Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression.DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-β signaling pathway led to increased Nfil3 expression which blocked Foxp3 transcription via SMAD3. This is an important contribution to the T lymphocyte literature as it points to the proximal and distal modulation of T cell lineage differentiation, thus focusing attention to potential pharmacotherapeutic and immunoepigenetic mechanisms to control inflammation in diseases such as IBD while simultaneously suggesting strategies to reorganize the T cell profile to destroy tumors. Dr Daniel J Guerra, Authentic Biochemistry. 17 August 2019.
Aug 15, 2019 · 28 min
Dr Guerra moves onward through the T cell lineages to an event ontology for Treg Stimulation/Activation and Stabilization IV.
Prof. Guerra provides a narrative focusing on evolutionary perspectives and the resultant lymphocyte differentiating foundations for the adaptive immune response as a means to apprehend the event-ontological diverse transcriptional mediation ultimately landing on the Treg FOXp3 promoter . Part IV
Aug 13, 2019 · 28 min
T-regulatory Transcription Factor modulation directs lineage adaptation and potency in a pro-inflammatory environment
In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response
Aug 4, 2019 · 28 min
Innate lymphoid cells and the frank T lymphocyte family as controlled by cytokinogenesis, co-stimulation, and Tregs. Part I.Dr Dan Guerra
Dr Dan Guerra presents "T regulatory Cells in Human Biology and Disease. An update on transcriptional control". Vol.I. This first segment introduces the elaborate nature of innate and acquired lymphoid cells and the transcription factors that drive lineage differentiation.
Aug 4, 2019 · 7 min
Prolegomena to T regulatory cell transcriptional control mechanisms and a request to subscribe from Dr. Guerra
This is a brief introduction to what will be a multi-segmented sequence of podcasts on the complexity of T cell mediated immunity and its native regulation via Treg activation.
Jul 13, 2019 · 28 min
The fate of the mammalian CNS is a matter of lipid sponsored program cell death
In this podcast, Authentic Biochemistry's own Dr. Dan Guerra ties the actuated Moebius strip of anti-apoptosis rendered neuronal differentiation amidst a tempest of ceramide synthetic possibility.
Jul 3, 2019 · 28 min
Dr. Guerra provides a clinical discussion of HCC pathogenesis and treatment including the role of HCV. 03 July 2019
Dr Guerra of Authentic Biochemistry navigates through the protease inhibitor literature and starts a journey into hepatitis C virus (HCV)-mediated HCC induction and some of the pharmacotherapies impacting this axis.
Jun 30, 2019 · 28 min
SERPIN mediates transcriptional control over pro-tumorigenic pathways including a phosphatidyl inositol 1,3 kinase delta mediated mechanism.
Dr. Guerra focuses on emerging signaling and immunoepigenetic variations around the theme of protease inhibitor mediation of various stages and forms of solid organ and metastatic tumorigenesis in this June 29,2019 installment of Authentic Biochemistry.
Jun 29, 2019 · 29 min
Dr Guerra admits Serpin mediated cancer ablation is multivalent and pharmaceutically treacherous
Dr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeutic anisotropy.
Jun 26, 2019 · 29 min
Introduction to Proteases and Protease Inhibitors as Prolegomena to Specific HCC pathophysiology
Dr.Guerra of Authentic Biochemistry provides a primer on polypeptide proteases and their mode of action as well as their control via processing and inhibition in clinical medicine
Jun 8, 2019 · 28 min
HCC Episode VII. Dr Guerra tackles the pathogenecity of the serine proteinase inhibitor paradigm . 08 JUne 2019
Serine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease potentiation leading to subcellular protein aggregation, enhanced inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient conditions in HCC.
May 28, 2019 · 28 min
Hepatocellular Carcinoma Pathobiochemistry Chapter/Lecture V from Dr. Daniel J. Guerra. Authentic Biochemistry.28 May 2019.
In this segment I provide more discussion of the published evidence linking glycolytic pathway enzymes to HCC progression. The expression of certain interfering RNA's that differentially regulate gene expression and promoter habilitation can lead to cyclin dependent kinase mediated chromatin remodeling enhancing cell -specific expression of enzyme isoforms that promote rather than defeat disease progression.
May 26, 2019 · 28 min
Dr Guerra Characterizes How Glycolytic Enzymes Proxy Oncogenically in Prodromal Hepatocellular Carcinoma. 26 May 2019
Dr. Guerra of Authentic Biochemistry continues with the 4th in a series of HCC lectures from the primary research literature by explaining the interacting roles of pyruvate kinase M2 and phosphofructokinase 2 promote aerobic glycolysis-enhancing cancer progression.