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Dr. John Campbell

Campbellteaching

Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider

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  • October 5 · 21 min

    More vaccinated fatalities than unvaccinated fatalities from covid (US)

    58% of covid US deaths now in the vaccinated Kaiser Family Foundation vice president Cynthia Cox https://www.cdc.gov/vaccines/covid-19/effectiveness-research/protocols.html https://covid.cdc.gov/covid-data-tracker/#rates-by-vaccine-status https://www.cdc.gov/coronavirus/2019-ncov/vaccines/effectiveness/monitoring.html https://data.cdc.gov/Public-Health-Surveillance/Rates-of-COVID-19-Cases-or-Deaths-by-Age-Group-and/d6p8-wqjm https://www.washingtonpost.com/politics/2022/11/23/vaccinated-people-now-make-up-majority-covid-deaths/ 58% of coronavirus deaths in August were people who were vaccinated or boosted (people who had completed at least their primary series of vaccines) Therefore 42% coronavirus deaths in August were people who were unvaccinated First time there were more deaths covid deaths in the vaccinated versus the unvaccinated https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-people-booster-percent-pop5 In September 2021 Vaccinated people, 23% of coronavirus fatalities In January and February 2022 Vaccinated people, 42% of coronavirus fatalities We can no longer say this is a pandemic of the unvaccinated (who conducted the analysis on behalf of the Post) https://www.cdc.gov/mmwr/volumes/71/wr/mm7144a3.htm?s_cid=mm7144a3_w Safety Monitoring of Bivalent COVID-19 mRNA Vaccine Booster Doses Among Persons Aged ≥12 Years — United States, August 31–October 23, 2022 On August 31, 2022 FDA authorized bivalent, Pfizer-BioNTech and Moderna mRNA encoding the spike protein from original strain of SARS-CoV-2, and from Omicron BA.4 and BA.5 Advisory Committee on Immunization Practices (ACIP) recommended, all persons ≥12 years receive an age-appropriate bivalent mRNA booster dose v-safe a voluntary smartphone-based U.S. safety surveillance system, established by CDC to monitor adverse events after COVID-19 vaccination As of 3rd October, 10 million users https://icandecide.org/press-release/breaking-news-ican-obtains-cdc-v-safe-data/ Vaccine Adverse Event Reporting System (VAERS) Total data, August 31–October 23, 2022 14.4 million received a bivalent Pfizer-BioNTech 8.2 million adults (≥18 years) a bivalent Moderna booster dose v-safe, among the 211,959 registrants (aged ≥12 years) August 31–October 23, 2022 Reported in the week after vaccination Injection site reactions, 60.8% Systemic reactions, 54.8% Fewer than 1% of v-safe registrants reported receiving medical care Vaccine Adverse Event Reporting System (VAERS) 5,542 reports of adverse events after bivalent booster vaccination (≥12 years) 95.5% of reports were nonserious 4.5% were serious events Health care providers and patients can be reassured that adverse events reported after a bivalent booster dose are consistent with those reported after monovalent doses. Relative risk Absolute risk not given Health impacts after COVID-19 vaccination are less frequent and less severe than those associated with COVID-19 illness (2). Relative risk Absolute risk not given This is their Reference 2 Block JP, Boehmer TK, Forrest CB, et al. Cardiac complications after SARS-CoV-2 infection and mRNA COVID-19 vaccination—PCORnet, United States, January 2021–January 2022. MMWR Morb Mortal Wkly Rep 2022;71:517–23. https://doi.org/10.15585/mmwr.mm7114e1 PMID:35389977 myocarditis; myocarditis or pericarditis; and myocarditis, pericarditis, or MIS, within 7-day or 21-day risk windows after the index date Comparisons between after vaccine and after infection Relative risk Absolute risk not given Review of v-safe Data During August 31–October 23, 2022 211,959 v-safe registrants had a bivalent booster 1,464 (0.7%) were aged 12–17 years 68,592 (32.4%) were aged 18–49 years 59,209 (27.9%) were aged 50–64 years 82.694 (39.0%) were aged ≥65 years Fourth dose 96,241; 45.4% Fifth dose 106,423; 50.2% In the week after receipt of the biva Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 20 min

    Increases

    Professor Angus Dalgleish, (Fellow of the Royal College of Physicians, Fellow of the Royal College of Pathologists, Fellow of Medical Science.) Professor Dalgleish is a highly experienced doctor, physician, medical teacher, medical author and researcher with over 500 primary research publications. He was also a pioneering researcher into HIV/AIDS. Here we discuss the recently observed changes in cancer presentations and deaths. Some of the discussion considers this research paper noting excess cancer deaths in Japan. Increased Age-Adjusted Cancer Mortality After the Third mRNA-Lipid Nanoparticle Vaccine Dose During the COVID-19 Pandemic in Japan https://www.cureus.com/articles/196275-increased-age-adjusted-cancer-mortality-after-the-third-mrna-lipid-nanoparticle-vaccine-dose-during-the-covid-19-pandemic-in-japan#!/ Gibo M, Kojima S, Fujisawa A, et al. (April 08, 2024) Increased Age-Adjusted Cancer Mortality After the Third mRNA-Lipid Nanoparticle Vaccine Dose During the COVID-19 Pandemic in Japan. Cureus 16(4): e57860. DOI 10.7759/cureus.57860 Conclusions Statistically significant increases in age-adjusted mortality rates of all cancer and some specific types of cancer, namely, ovarian cancer, leukemia, prostate, lip/oral/pharyngeal, pancreatic, and breast cancers, were observed in 2022 after two-thirds of the Japanese population had received the third or later dose of SARS-CoV-2 mRNA-LNP vaccine. These particularly marked increases in mortality rates of these ERα-sensitive cancers may be attributable to several mechanisms of the mRNA-LNP vaccination, rather than COVID-19 infection itself or reduced cancer care due to the lockdown. Researchers have reported that the SARS-CoV-2 mRNA-LNP vaccine may pose the risk of development and progression of cancer. Several case reports have described cancer developing or worsening after vaccination and discussed possible causal links between cancer and mRNA-LNP vaccination. Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 21 min

    Covid, vaccines, malaria

    I have worked directly with Wefwafwa in rural Uganda, he is the real deal. If you buy him a coffee, he will not spend it on coffee. Buy me a coffee https://www.buymeacoffee.com/awmedicalvideos Patreon https://www.patreon.com/awmedicalvideos To contact Wefwafwa directly, wefandrew@gmail.com or WhatsApp+256756320736 YouTube channel, https://www.youtube.com/c/WefwafwaAndrew Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 26 min

    Increased deaths in the US

    Idaho, activates “crisis standards of care” https://www.washingtonpost.com/nation/2021/09/07/covid-delta-variant-live-updates/ Activated “crisis standards of care” 10 hospitals because of a severe shortage of staffing and available beds massive increase in patients with COVID-19 who require hospitalization Less than 40% fully vaccinated May have to wait for beds Get treated in hallways etc Delayed operations Basic equipment may not be available Governor Brad Little More Idahoans need to choose to receive the vaccine so we can minimize the spread of the disease and reduce the number of COVID-19 hospitalizations, many of which involve younger Idahoans and are preventable with safe and effective vaccines United States data https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases https://covid.cdc.gov/covid-data-tracker/#vaccination-trends https://covid.cdc.gov/covid-data-tracker/#hospitalizations UK data https://coronavirus.data.gov.uk Australian data https://www.health.gov.au/news/health-alerts/novel-coronavirus-2019-ncov-health-alert/coronavirus-covid-19-case-numbers-and-statistics Cuba https://www.washingtonpost.com/world/2021/09/06/brazil-coronavirus-vaccine-vaccination-rollout-sinovac/ Vaccinating from 2 years Own vaccine, Soberana 02 Cuba’s Finlay Vaccine Institute https://www.cecmed.cu/noticias/aprueba-cecmed-autorizacion-uso-emergencia-vacuna-cubana-soberanar-02-poblacion-pediatrica 3 to 18 years similar trial efficacy as 19 to 29 The safety profile evidenced was similar between the groups compared Adults in Cuba Abdala vaccine, (efficacy, 92%) since July Neither vaccines recognized by WHO (Chile’s health authority, approved Sinovac 6 year olds) Afghanistan About 90% of 2,300 medical facilities at risk of closure International humanitarian donors struggle to operate The Leading Causes of Death in the US for 2020 https://jamanetwork.com/journals/jama/fullarticle/2778234 National Center for Health Statistics (NCHS) National Vital Statistics System (NVSS) https://www.cdc.gov/nchs/nvss/manuals/2a-2021.htm Data from 50 states and the District of Columbia Increase number of deaths between 2019 and 2020, 15.9 to 17.7% https://www.cdc.gov/mmwr/volumes/70/wr/mm7014e1.htm?s_cid=mm7014e1_w Increases in many leading causes of death Code, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision https://icd.who.int/browse10/Content/statichtml/ICD10Volume2_en_2010.pdf Based on the underlying cause of death The disease or condition responsible for initiating the chain of events leading to death Total deaths, 2,712,630 Heart disease, 633,842 Cancer, 595,930 Covid-19, 345,232 (647,461 now) Unintentional injuries, (ODs) 192,176 Stroke, 159,050 COPD, 151,637 Alzheimer’s, 133,382 Diabetes, 101,106 Influenza and pneumonia, 53,495 Kidney disease, 52,260 Suicide, 44,834 Direct and indirect effects of the pandemic Most increase in deaths, directly attributed to COVID-19 Underreporting of COVID-19 Increases heart disease, Alzheimer, diabetes Disruptions in early detection and disease management Increases in unintentional injury largely driven by drug overdose Life expectancy at birth, largest decline since 1943 Do you support vaccine mandates? Please vote here, https://www.youtube.com/c/Campbellteaching/community Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 28 min

    Paxlovid, evidence base?

    Paxlovid, it this an evidence based intervention in May 2022? Paper FDA EMU was based on https://www.nejm.org/doi/full/10.1056/NEJMoa2118542 EPIC-HR (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients) 1120 patients received nirmatrelvir plus ritonavir 1126 received placebo Relative risk reduction Risk of progression to severe Covid-19, 89% lower than the risk with placebo Absolute risk reduction https://www.precisionvaccinations.com/what-paxlovids-absolute-and-relative-covid-19-risk-reduction 7% down to 1% symptomatic, unvaccinated, non hospitalized adults at high risk for progression to severe coronavirus disease 2019 July 16 and December 9, 2021 If vaccinated people and previously infected people are partly protected More people would need to be treated to prevent one adverse event Pfizer press release (5th November 2021) https://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate our oral antiviral candidate, … has the potential to save patients’ lives, reduce the severity of COVID-19 infections, and eliminate up to nine out of ten hospitalizations Pfizer Shares In Vitro Efficacy of Novel COVID-19 Oral Treatment Against Omicron Variant https://www.pfizer.com/news/press-release/press-release-detail/pfizer-shares-vitro-efficacy-novel-covid-19-oral-treatment https://www.yalemedicine.org/news/12-things-to-know-paxlovid-covid-19 https://www.fda.gov/media/155051/download The results showed in all cases that nirmatrelvir was a potent inhibitor of its target. PAXLOVID™ for Post-Exposure Prophylactic Use https://www.pfizer.com/news/press-release/press-release-detail/pfizer-shares-top-line-results-phase-23-epic-pep-study Evaluated data from 2,957 adults Pfizer observed risk reductions of 32% (5 day course) 37% reduction (10 day course) These results, however, were not statistically significant and, as such, the primary endpoint of reducing the risk of confirmed and symptomatic COVID-19 infection in adults who had been exposed to the virus through a household contact was not met. FACT SHEET FOR PATIENTS, PARENTS, AND CAREGIVERS EMERGENCY USE AUTHORIZATION (EUA) OF PAXLOVID FOR CORONAVIRUS DISEASE 2019 (COVID-19) https://www.fda.gov/media/155051/download PAXLOVID is not an FDA-approved medicine in the United States. PAXLOVID is an investigational medicine Some medicines may interact with PAXLOVID and may cause serious side effects. If you take too much PAXLOVID, call your healthcare provider or go to the nearest hospital emergency room right away. Possible side effects of PAXLOVID are: Allergic Reactions trouble swallowing or breathing, swelling of the mouth, lips, or face, throat tightness, hoarseness, skin rash Liver Problems. Tell your healthcare provider right away, loss of appetite, yellowing of your skin and the whites of eyes (jaundice), dark-colored urine, pale colored stools and itchy skin, stomach area (abdominal) pain. Other possible side effects include: altered sense of taste, diarrhea, high blood pressure, muscle aches Dr. Ashish K. Jha, White House, Covid-19 coordinator The new White House Covid czar says avoiding all virus infections isn’t the goal of U.S. pandemic policy. Paxlovid, push to reach the vulnerable Doctors are too hesitant to prescribe the drug https://en.wikipedia.org/wiki/Ashish_Jha Senior Advisor at Albright Stonebridge Group https://www.politico.com/newsletters/transition-playbook/2021/03/23/the-blob-abides-492214 The firm advises clients on international policy and global markets Patrick Vallance From 2012 to 2018, he was President of Research and Development at global pharmaceutical company, GlaxoSmithKline (GSK) https://www.telegraph.co.uk/news/2020/09/23/revealed-sir-patrick-vallance-has-600000-shareholding-firm-contracted/ Cashed £5,000,000 GSK share Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 20 min

    Chinese vaccine contrasts

    Chinese and Western vaccines compared https://www.bbc.co.uk/news/world-asia-china-63855508 Big changes, all of a sudden Live with the virus Vice-premier, Sun Chunlan China entering a new situation Virus ability to cause disease weakening Lifting most severe Covid policies End of quarantine camps People can isolate at home No more family separations Close contacts not taken to camps Strict ban on blocking fire exits No need to show tests for venues Less rules on internal travel Lateral flow tests to replace PCR tests in most areas Lockdowns continue in smaller more targeted areas Foreign travel soon Cases, 30,000 + Now Everyone will be exposed Will the medical system will be overwhelmed? National Health Commission All localities, focus on improving the vaccination rate of people aged 60-79, accelerating the vaccination rate of people aged 80 and above, and making special arrangements Prof Ivan Hung, Hong Kong University The main way for China to exit Covid with the least damage is via vaccination and three doses of vaccination is a must Hopefully before Chinese New Year (January 22) Rabbit Sinopharm Strategic Advisory Group of Experts on Immunization (SAGE) https://www.who.int/news-room/feature-stories/detail/the-sinopharm-covid-19-vaccine-what-you-need-to-know The vaccine is safe and effective for all individuals aged 18 and above. Individuals may choose to delay vaccination for 3 months following the infection. An inactivated vaccine with adjuvant (that is routinely used in many other vaccines) with a documented good safety profile, including in pregnant women. Symptomatic SARS-CoV-2 infection and efficacy against hospitalization 79% Does it prevent infection and transmission? No substantive data Does it work against new variants of SARS- CoV-2 virus? SAGE currently recommends using this vaccine Not yet been evaluated in the context of circulation of widespread variants of concern. How does this vaccine compare to other vaccines already in use? We cannot compare the vaccines head-to-head, (different approaches taken in designing the respective studies) but overall, all of the vaccines that have achieved WHO Emergency Use Listing, are highly effective in preventing severe disease and hospitalization due to COVID-19. Comparison with Western vaccines Pfizer original paper https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 https://www.nejm.org/doi/suppl/10.1056/NEJMoa2034577/suppl_file/nejmoa2034577_appendix.pdf BNT162b2 was 95% effective in preventing Covid-19 Later analysis from Efficacy and effectiveness of covid-19 vaccine - absolute vs. relative risk reduction https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115787/ AAR, Pfizer, during the trial period, 0.84% AAR https://patient.info/news-and-features/calculating-absolute-risk-and-relative-risk Absolute risk of a disease is your risk of developing the disease over a time period. Five to six-months update, AAR BNT162b2 3.7% mRNA1273 (Moderna-NIH) 4.9% Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 1 hr 29 min

    Expired with Dr. Clare Craig

    COVID, the untold story. So much more makes sense after this book and my first illuminating discussion with Dr. Craig. Get your copy in the UK here: https://www.amazon.co.uk/Expired-untold-Dr-Clare-Craig/dp/1739344707 For friends in the US get your copy here, https://www.amazon.com/Expired-untold-Dr-Clare-Craig/dp/1739344707 Have you ever felt the covid story did not entirely add up? Expired contains multiple eye-opening revelations about covid with compelling evidence that provides a coherent, sober and clear explanation that better fits the data we have so far. Meticulous research by pathologist Dr Clare Craig sheds light on the largely overlooked evidence of airborne virus transmission, examining twelve related beliefs on spread, lockdowns, asymptomatic infections, and masks. In addition, Expired champions the importance of Western ethical principles, damaged by pandemic actions and calls for their restoration. The covid debate has proved incredibly polarising. One side believed every intervention was saving lives, while the other emphasised the harms caused. Biased modelling based on a worst-case scenario led to fearful assumptions presented as fact. By dint of sheer repetition these ‘facts’ became unquestionable. Those scientists who dared to question were proclaimed dangerous. Welcome to Cloud-Covid-Land. Let’s bring back nuance. It’s time to return to reality." Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 13 min

    mRNA and pregnant women

    Advice is not based on clinical trial data A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19 https://ctv.veeva.com/study/a-study-of-mrna-1283222-injection-compared-with-mrna-1273222-injection-in-participants-12-years-o Key Inclusion Criteria: For female participants of childbearing potential: negative pregnancy test, adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to the first injection, and agreement to continue adequate contraception or abstinence through 90 days following the vaccine administration. In other words Pregnant or potentially pregnant women are excluded Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 This report does not address the prevention of Covid-19 in other populations, such as younger adolescents, children, and pregnant women. https://www.nhs.uk/pregnancy/keeping-well/pregnancy-and-covid-19/ It's strongly recommended that you get vaccinated against COVID-19 to protect you and your baby. https://www.rcog.org.uk/guidance/coronavirus-covid-19-pregnancy-and-women-s-health/vaccination/covid-19-vaccines-pregnancy-and-breastfeeding-faqs/ (updated on 20 October 2023) COVID-19 vaccines are strongly recommended in pregnancy. Vaccination is the best way to protect against the known risks of COVID-19 in pregnancy for both women and babies https://vaccineknowledge.ox.ac.uk/covid19-vaccines-in-pregnancy#Are-COVID-19-vaccines-recommended-for-pregnant-people COVID-19 vaccines are recommended during pregnancy due to an increased risk of serious illness and complications from COVID-19 in pregnant people, https://www.rcog.org.uk/media/0qune0d3/covid-19-infection-in-pregnancy-v161-final.pdf Vaccination in pregnancy against COVID-19 is strongly recommended 2025 https://www.gov.uk/government/publications/covid-19-vaccination-in-2025-and-spring-2026-jcvi-advice/jcvi-statement-on-covid-19-vaccination-in-2025-and-spring-2026 Pregnancy, neonates and young infants Recent data indicates that the risk of hospitalisation and/or mortality in pregnant individuals has significantly reduced in the Omicron period. Notably, there were no deaths in people who were pregnant in the last 18 months …. JCVI advised that it was highly unlikely that vaccination in pregnancy would be cost-effective. Exclusion of pregnant and lactating women from COVID-19 vaccine trials: a missed opportunity https://pmc.ncbi.nlm.nih.gov/articles/PMC7989536/?utm_source=chatgpt.com The exclusion of pregnant and lactating women from COVID-19 vaccine trials reflects a historic pattern of ‘protection by exclusion’, representing an instance in which the estimated effect of a therapy on mother and child will rely on anecdotal and delayed reports from healthcare settings rather than the monitored setting of a clinical trial. This exclusion is not justified. Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 18 min

    Good news at Easter

    Omicron wage generates large scale immunity https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---12-april-2022 Omicron 379, 278 sequences, 99.2% were Omicron less than 0.1% were Delta Omicron VOC Several descendent lineages under the Omicron VOC BA.1, BA.2, BA.3, BA.4, BA.5 (Botswana and South Africa) Belgium, Denmark, Germany, United Kingdom BA.1/BA.2 recombinant forms, such as XE https://cov-lineages.org/lineage_list.html Highest new weekly deaths https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---12-april-2022 United States of America (3 682 new deaths; -9%) Republic of Korea (2 186 new deaths; -6%) Russian Federation (2 008 new deaths; -15%) Germany (1 686 new deaths; +6%) Brazil (1 120 new deaths; -22%). Africa (WHO) Cases, lowest since the pandemic began From a peak of more than 308,000 weekly cases, to fewer than 20,000 last week Cases down, 29% Deaths down, 37% (239 deaths for the week) No country in the region is currently seeing an increase of COVID-19 cases. Southern Hemisphere winter there is a high risk of another wave of new infections Dr. Matshidiso Moeti, WHO Africa director With the virus still circulating, the risk of new and potentially more deadly variants emerging remains, and the pandemic control measures are pivotal to effective response to a surge in infections Dr. Tedros Adhanom Ghebreysus Repeated warnings that the coronavirus would devastate Africa Most African infections, asymptomatic Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 36 min

    Childhood viral hepatitis – Vulnerabilities and the Chickenpox (Varicella) Vaccine

    Thank you Rachel and Tom Barker for sharing your daughters recent illness and treatment, together with the need for chicken pox vaccinations. We all wish Clara and yourselvs the best possible outcomes. Summary of the USA status on Chickenpox (Varicella) and the benefits of the vaccine - Centers for Disease Control and Prevention (CDC) – Chickenpox (Varicella) in the United States - https://www.cdc.gov/chickenpox/about/index.html Summary of the need for representative Chickenpox (Varicella) modelling in the UK- https://www.ox.ac.uk/research/everything-you-need-know-about-chickenpox-and-why-more-countries-don%E2%80%99t-use-vaccine Planning for new Chickenpox (Varicella) Vaccine modelling - The Joint Committee on Vaccination and Immunisation (JCVI) Minutes - https://www.gov.uk/government/groups/joint-committee-on-vaccination-and-immunisation#minutes Chickenpox (Varicella) key facts - Oxford University - Chickenpox (Varicella) Vaccine - https://vk.ovg.ox.ac.uk/vk/chickenpox-varicella-vaccine Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 13 min

    Genetic vaccine inadequacies

    With Professor Robert Clancy. This is part 1, still editing the next parts.... Link to but the book, https://covidthroughoureyes.com.au/products/covid-through-our-eyes-an-australian-story-of-mistakes-mistreatment-and-misinformation First part of this excellent talk with Professor Robert Clancy, doctor, immunologist, consultant physician, professor of pathology and professor of medicine, highly published medical researcher, author, teacher, doctor of science, doctor of philosophy, holder of the Australia Medal. Letters from Australia is Alison Bevege's Substack, https://lettersfromaustralia.substack.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 14 min

    Difficult watch from Uganda

    The flood footage on this video has been verified as recorded locally in and around Mbale in Uganda on Sunday 31st July 2022. Other recordings were made on Monday 1st August 2022 in the same area. Link to video on Wefwafa’s channel, https://www.youtube.com/watch?v=1-DIfidWThU&t=34s To contact Wefwafwa directly, wefandrew@gmail.com or WhatsApp+256756320736 To donate to this community health project, (Just now our admin percentage is zero) Buy me a coffee https://www.buymeacoffee.com/awmedicalvideos Patreon https://www.patreon.com/awmedicalvideos Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 25 min

    Covid autoimmunity

    Covid toe, caused by the immune response to the virus, not the virus itself https://covidskinsigns.com https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.20707 Objectives To study skin and blood endothelial and immune system activation In chilblain-like lesions (CLL), CLL in comparison with healthy controls and seasonal chilblains (SC) (cold-induced sporadic chilblains occurring during 2015 and 2019) Methods Observational study Saint-Louis Hospital, Paris, France N = 50 Cytokine assays Assessment of interferon-stimulated gene expression in whole blood Soluble markers of endothelial activation and/or angiogenesis Histological examinations Lateral flow spike assay Circulating endothelial cell counting Statistical analysis Results Histological patterns were similar in CLL and SC groups Transcriptomic signatures overlapped in both the CLL and SC groups Type I interferon Cytotoxic–natural killer gene signature CLL were characterized by higher IgA tissue deposition More complement and angiogenesis factors in CLL compared with SC Autoimmune vasculitis Confirmed endothelial dysfunction in CLL Microangiopathy leading to clinical chilblains Disrupt the thrombo-protective state of endothelial cells Likely contributing to microvascular thrombosis Systemic endothelial activation? The PT ratio and aPTT were normal in all patients Only three patients (6%) had a moderate increase in D-dimer levels Conclusions Inflammation in the skin in CLL Associated with endothelial alteration Immune infiltration of cytotoxic and type I IFN-leading to clinical manifestations https://www.bbc.co.uk/news/health-58801462 UK podiatrist Dr Ivan Bristow like the regular chilblains typically seen during cold spells and in people who have problems with circulation - the lesions usually go away on their own. But some may need treatment with creams and other drugs. The confirmation of the cause will help to develop new treatments to manage it more effectively Dr Veronique Bataille, consultant dermatologist, British Skin Foundation Covid toe was seen very frequently during the early phase of the pandemic, but has been less common in the current Delta variant wave. That might be down to more people being vaccinated or having some protection against Covid from past infections. Presentations after vaccination are much rarer Delayed presentation my mean link is missed Free download my two comprehensive but free educational text books (over 50,000 downloads so far) or make a donation to the campbellteaching project using this link: http://159.69.48.3 Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 25 min

    Omicron positive news

    Omicron, Guess work so far More transmissibility Some vaccine escape Some natural infection escape Causing reinfections in SA in people that had had infection and vaccination Mostly mild symptoms in the vaccinated Effecting younger people Sinovac recipients may do well Global within the week Lateral flow tests still work Every vaccinated and unvaccinated person will encounter this variant Tiredness, headache, body aches, scratchy throat, dry cough Netherlands https://www.dw.com/en/omicron-present-in-netherlands-earlier-than-thought-say-health-authorities/a-59977047 Omicron present at least a week Before 13 (out of 61) passengers from South Africa found to be omicron positive National Institute for Public Health (RIVM) https://www.rivm.nl/en November 19th and 23rd Omicron variant in two test samples (South Africa announced they had identified omicron November 26th) (First Belgium case, 24th November) (Botswana on November 11th) It is not yet clear whether the people concerned (in the earlier cases) had also been to southern Africa Tracking down some 5,000 passengers from South Africa, Botswana, Eswatini, Lesotho, Mozambique, Namibia, Zimbabwe Michael Hoelscher, Department for Infectious Diseases and Tropical Medicine, Munich University Hospital We're finding an increasing number of variant cases all around Europe, and in fact we believe that the introduction of those variants has been ongoing for a few weeks already What we are also seeing is that there are now first cases of community transmission, so it's within Europe, and the travel bans will probably delay the spread of the disease a little bit but will not be able to hold it up US President Biden Cause for concern not a cause for panic Get boosted No new US lockdown Sequencing 80,000 samples per week Moderna No tweaked vaccine until 2022 Endemic with yearly vaccines UK 13 England, 9 Scotland omicron cases All 5 English cases linked to southern Africa Scotland Nine omicron cases so far Scotland Chief Medical Officer Gregor Smith Not aware of anyone dying of the omicron variant as of yet Boosting boosters https://www.dailymail.co.uk/home/index.html Prime Minister, throw everything at it Next Thursday Finished by end of Jan, next 2 months Sites all over the place Boosters to all over 18 Gap between 2nd dose and boosters, cut to three months From December 1, doctors, £15 per jab £20 for Sunday and Bank Holiday 400 soldiers will help The best thing to happen? https://www.dailymail.co.uk/news/article-10253611/Could-Omicron-GOOD-news-Variant-speed-end-pandemic-causes-mild-illness.html Professor Karl Lauterbach, clinical epidemiologist (Germany's next health minister) Could mean omicron it is optimised to infect, in line with how most respiratory viruses evolve Professor Paul Hunter The theory may prove to be true ? levels of protection from previous infection in SA High levels of previous infection and vaccination, offering protection Franco Locatelli, president of Italy's Higher Health Council Not overly concerned by the new variant May be more contagious but it is not more dangerous than other strains The time it took to become predominant was much less compared to other variants But we don't have any evidence to suggest it can provoke more serious illness or evade the protective effect of vaccines in a major way Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 29 min

    Pandemic changing age profiles

    Burden and characteristics of COVID-19 in the United States during 2020 Columbia University and NIH, Director Francis S. Collins, Nature https://pubmed.ncbi.nlm.nih.gov/34438440/#affiliation-3 United States, 2020, highest numbers of reported cases and deaths In the light of later antibody studies March 11.3% December, 24.5% Population susceptibility at year's end was 69.0% So, 31% of population had been exposed (100 million people) Prevalence rates rose above 0.8% by end of 2020 As high as 2.4% in some major metropolitan areas Infection fatality rate fell to 0.3% by end of 2020 https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/ As of September 2 5,049,465 children have tested positive 252,000 cases were added the past week Largest number of child cases in a week ever Since the pandemic began, children, 15.1% of total cumulated cases Week ending September 2nd, 26.8% of reported weekly COVID-19 cases 2,400 children were hospitalized nationwide (highest in pandemic) Hospitalizations (24 states and NYC reported) Children ranged from 1.6%-4.1% of total cumulated hospitalizations 0.1%-1.9% of all their child COVID-19 cases resulted in hospitalization Mortality (45 states) Children were 0.00%-0.27% of all COVID-19 deaths (7 states reported zero child deaths) 0.00%-0.03% of all child COVID-19 cases resulted in death Vaccination in children Half of children ages 12 to 15 have received at least one vaccine dose 58 percent for 16- and 17-year-olds Anthony Fauci, National Institute of Allergy and Infectious Diseases We’ve got to get the school system masked, in addition to surrounding the children with vaccinated people That’s the solution Los Angeles mandates today Soon mandate vaccination for school attendance 600,000 would have to get their first shot by Oct. 3 Second shot by the end of October (LA counts since last month) Direct link to vote, https://www.youtube.com/c/Campbellteaching/community Pascal Soriot, AstraZeneca chief executive on Booster doses https://www.telegraph.co.uk/business/2021/09/07/covid-booster-jab-campaign-may-not-needed-says-astra-boss/ UK is still "a few weeks away" from being able to decide Moving too quickly to boost across the entire adult population will deprive us of these insights, leaving this important decision to rest on limited data NHS resource implications Nadhim Zahawi NHS is ‘ready to go’ Philip Dormitzer, Pfizer’s chief scientific officer Encouraged booster shots Dismissed criticism that his company should have produced a more potent vaccine Professor Sarah Gilbert https://inews.co.uk/news/politics/creator-oxford-vaccine-sarah-gilbert-warns-vulnerable-will-have-shield-covid-19-cases-rise-1096315 UK, 3.8 million people classed as clinically extremely vulnerable In people who have been vaccinated and have had the two doses, they will be well protected against disease that is severe enough to put them in hospital and against death And there are unfortunately some people with particular health conditions that mean they just don’t respond to a vaccine and they are going to have to make sure that they are protected, probably by shielding again, if there is a lot of spread of the virus https://www.gov.uk/government/publications/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19 we are advising clinically extremely vulnerable people, as a minimum, to follow the same guidance as everyone else you may wish to think particularly carefully about additional precautions you might wish to continue to take Sweden Removing all remaining restrictions by the end of this month Vietnam Health Ministry, offering Pfizer-BioNTech as a second-dose after Moderna (l Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 33 min

    Ivermectin fulfills Bradford Hill

    With Professor Colleen Aldous Critical appraisal of multidrug therapy in the ambulatory management of patients with COVID-19 and hypoxemia Part II: Causal inference using the Bradford Hill criteria https://www.jstage.jst.go.jp/article/antibiotics/78/1/78_35/_pdf/-char/en We continue the critical appraisal of three published case series of 119 COVID-19 patients with hypoxemia, treated in the United States, Zimbabwe, and Nigeria with similar ivermectin-based multidrug treatments, to assess the available evidence supporting a causal relationship between treatment and reduction in hospitalizations and mortality. A narrative review was conducted to assess the Bradford Hill criteria for a causal association. We used a previously proposed refinement of the Bradford Hill criteria that reorganized them into three categories of direct, mechanistic, and parallel evidence. The efficacy of the two most aggressive ivermectin-based multidrug protocols is supported by the Bradford Hill criteria for temporality, strength of association, biological gradient, biological plausibility, coherence, consistency, and analogy. The causal relation between the treatment of hypoxemic COVID-19 patients using these protocols and the reduction in hospitalizations and mortality is supported as an inference to the best explanation. Critical appraisal of multidrug therapy in the ambulatory management of patients with COVID-19 and hypoxemia Part I. Evidence supporting the strength of association https://faculty.utrgv.edu/eleftherios.gkioulekas/papers/032-c19-ivm-oxygen.pdf On March 11, 2020, Coronavirus Disease 2019 (COVID-19), the disease caused by the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), was declared a pandemic by the World Health Organization (WHO) [1]. Worldwide, 768,187,096 confirmed cases of COVID-19 and 6,945,714 deaths have been reported to the WHO as of June 21 2023, amounting to an average Case Fatality Rate (CFR) of 0.9% [2]. During 2020, while several governments and public health agencies were focused on contagion control and in-hospital patient care, several medical doctors from all around the world innovated and discovered early outpatient multidrug treatments using several repurposed medications in combination [3–15]. In the United States, several independent efforts coalesced into the formulation of a sequenced multidrug protocol [10, Fig. 3] (hereafter, McCullough protocol), which is based on the pathophysiological understanding of COVID-19 as a triphasic illness with three overlapping phases: (1) viral proliferation; (2) hyperinflammatory cytokine storm (COVID-19 pneumonia); and (3) thrombosis. McCullough’s protocol proposed a combination antiviral therapy for treating the viral proliferation phase, immunomodulators for treating the cytokine storm, and antiplatelet agents and antithrombotics for handling the thrombotic stage, based on risk stratification and how the disease presents in each individual patient. Thus, the McCullough protocol is an algorithmic treatment using sequenced multiple drugs in combination and customized to the individual patient and their response to treatment; no single drug is necessary nor sufficient to achieve treatment efficacy towards reducing hospitalizations and deaths. A recently published update of the McCullough protocol [16, Fig. 3] introduced some adjustments including virucidal nasal washes and oral gargles [17–24]. A large case series of 869 high-risk patients [25, 26], who were treated using an early version of the McCullough protocol, has been compared against population-level and historical controls [27], showing the existence of efficacy with respect to the reduction of mortality and hospitalizations, which is also resilient with respect to random selection bias, provided that patients are treated early enough within the first 3 to 5 days from the onset of illness. Indeed, an earli Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 5 · 1 hr 10 min

    Pericarditis after vaccine

    Kyle's statement before US Senate expert panel on federal vaccine mandates and vaccine injuries Kyle starts at 53 minutes https://www.youtube.com/watch?v=lepqvdXoA2E Our previous video with Kyle https://www.youtube.com/watch?v=H7inaTiDKaU Dr Patterson video https://www.facebook.com/watch/live/?ref=watch_permalink&v=486953922413886 Kyle's YouTube channel https://www.youtube.com/c/KyleAprilRideMtb Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 4 · 20 min

    mRNA vaccines

    Sorry, had to reupload the last video Presentation to the European Parliament October 15, 2025, launch of the MEHA initiative. Dr. Panagis Polykretis Make Europe Healthy Again site https://gomeha.com Dr. Polykretis warns the scientific community Systemic distribution to brain, heart. Triggers the immune system. European Medicines Agency (Feb. 2021) https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf?r=artikellink Page 47, (Feb. 2021) Over 48 hours, distribution was mainly observed to liver, adrenal glands, spleen and ovaries, with maximum concentrations observed at 8-48 hours post-dose. Role of the antigen presentation process in the immunization mechanism of the genetic vaccines against COVID-19 and the need for biodistribution evaluations (2022) https://pubmed.ncbi.nlm.nih.gov/35298029/ The ‘traditional’ vaccines generally do not induce human cells to produce viral proteins, and thus, human cells do not expose viral antigens deriving from their proteosynthetic activity. On the contrary, the genetic vaccines against COVID‐19 induce human cells to produce the spike protein, relying intrinsically to an autoimmune reaction, extended to all the cells that intake the genetic material. https://panagispolykretis.substack.com/p/the-launch-of-the-make-europe-healthy https://x.com/newstart_2024/status/1981375686251069797?t=NnbtQBvA_EbgMJgCzZWThA&s=19 Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 4 · 1 hr 2 min

    DNA scientist discusses contamination

    With eminent DNA scientist and virologist, Dr. David J. Speicher. Quantification of residual plasmid DNA and SV40 promoter-enhancer sequences in Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada https://pubmed.ncbi.nlm.nih.gov/40913499/ 32 vials representing 16 unique vaccine lots. These data demonstrate the presence of billions to hundreds of billions of DNA molecules per dose in the modRNA COVID-19 products tested. All products tested exceeded the guidelines for residual DNA set by the FDA and WHO of 10ng/dose by 36–627-fold. Total DNA in all vials tested Exceeded the regulatory limit for residual DNA set by the US Food & Drug Administration (FDA) and the World Health Authorization (WHO) by: Pfizer: 36-153-fold Moderna: 112-627-fold 3 Pfizer vials exceeded the regulatory limit for the SV40 promoter-enhancer-ori (p53) The PCR results for the most recent XBB.1.5 Moderna and Pfizer vaccines suggest that DNA residues have not been reduced from previous vaccine versions. Pfizer, Total DNA ranged 371-1,548 ng/dose Moderna, 1,130-6,280 ng/dose Specific DNA of multiple plasmid DNA targets Pfizer ranged 0.22-7.28 ng/dose Moderna 0.01-0.78 ng/dose for Moderna. The SV40 promoter-enhancer-ori(0.25-23.72 ng/dose) was only detected in Pfizer vials. Sequencing of one vial Mean DNA length, 214 bp Maximum length, 3.5 kb Presence of 1.23 × 108 to 1.60 × 1011 plasmid DNA fragments per dose encapsulated in lipid nanoparticles. Our findings extend existing concerns about vaccine safety and call into question the relevance of guidelines conceived before the introduction of efficient transfection using LNPs. This work highlights the need for regulators and industry to adhere to the precautionary principle and provide sufficient and transparent evidence that products are safe and effective, and disclose the details of their composition and method of manufacture. For some of the COVID-19 vaccines, the drug substances released to market were manufactured differently than those used in clinical trials. Rationale for study Manufacturing nucleoside-modified mRNA for commercial COVID-19 vaccines relies on RNA polymerase transcription of a plasmid DNA template. Previous studies identified high levels of plasmid DNA in vials of mRNA vaccines, suggesting that the removal of residual DNA template is problematic. Therefore, we quantified the DNA load in a limited number of Pfizer-BioNTech and Moderna COVID-19 modRNA vaccine vials using two independent methods. This study emphasizes the importance of methodological considerations when quantifying residual plasmid DNA in modRNA products, considering increased LNP transfection efficiency, and cumulative dosing presents significant and unquantified risks to human health. Learn more about your ad choices. Visit megaphone.fm/adchoices

  • October 4 · 25 min

    Young children deaths from Group A Strep

    Group A strep bacterium causes scarlet fever, which has caused nine UK child deaths this season. Most likely Respiratory viral infections Group A streptococcus Invasive Group A streptococcus https://what0-18.nhs.uk Currently high rates in the UK https://www.gov.uk/government/news/ukhsa-update-on-scarlet-fever-and-invasive-group-a-strep Higher than normal for the time of year UK, Notifiable diseases https://www.gov.uk/guidance/notifiable-diseases-and-causative-organisms-how-to-report#list-of-notifiable-diseases Week 46, (W/E 19th November) 851 reported cases (Average is 186 cases) Close contact, droplets, hands, food Incubation, 2 to 5 days Most common, 2 years to 8 years 90% under 10 years Typically lasts for 7 – 10 days Rash disappearing in 7 to 10 days Should ne immune for decades or life Invasive Group A strep (iGAS) Rare occasions, bacteria get into the bloodstream More cases of iGAS, particularly in children under 10 Scarlet fever Caused by the bacteria Group A streptococcus Usually a mild illness Highly infectious At increased risk Elderly Immunocompromised Clinical features Sore throat/tonsillitis Headache Fever (temperature of 38°C (100.4°F) or above Painful, swollen glands in the neck A red tongue (strawberry tongue) Rash of scarlet fever Starts 12 to 48 hours after symptoms Often begins with small spots on the body, then spread to the neck, arms and legs over the next 1-2 days. Fine, pinkish or red body rash It is often 'sand-paper' like to touch (but not itchy) Darker skin, rash more difficult to see Sandpapery feel Diagnosis of scarlet fever / Group A strep less likely Child who also has a runny nose with their tonsillitis Antibiotics Reduce the chance of infection becoming more severe Stop spread of infection Penicillin V Amoxicillin (Plenty in the UK) 10 days Finish the course Home until at least 24 hours after the starting Possible complications Occasionally, Group A streptococcus can spread to other areas of the body, Tonsillar abscesses Neck lymph node abscesses Chest infections (pneumonia) Bone and joint infections (spetic arthritis) Sepsis Red warning signs Pale, mottled and feels abnormally cold to touch Difficulty breathing, grunting noises, indrawing Cyanosis, skin, tongue, lips Has a fit/seizure Is extremely agitated Non blanching rash Child is floppy and will not wake up or stay awake Amber signs Rapid breathing Unable to swallow saliva Features suggestive of scarlet fever Seems dehydrated, dry nappy Drowsy or irritable Shivering or complains of muscle pain Painful, swollen gland in the neck Baby is under 3 months and has a temperature of 38°C / 100.4 °F Baby feels hotter than usual or feels sweaty Is 3-6 months temperature of 39°C / 102.2°F or above Continues to have a fever of 38°C or above, more than 5 days Child has recently had scarlet fever Puffy face/eyelids (renal involvement) Tea 'coca-cola' coloured urine Swollen, painful joint(s) Is getting worse or if parents are worried In the week or two after recovering from scarlet fever Post streptococcal glomerulonephritis Post-streptococcal arthritis Later Rheumatic heart disease Is this a new strain? High amounts of circulating bacteria Social indoor mixing Is this a post lockdown effect? Learn more about your ad choices. Visit megaphone.fm/adchoices

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