Covid autoimmunity

Covid toe, caused by the immune response to the virus, not the virus itself Uploaded 08-10-21 https://covidskinsigns.com https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.20707 Objectives To study skin and blood endothelial and immune system activation In chilblain-like lesions (CLL), CLL in comparison with healthy controls and seasonal chilblains (SC) (cold-induced sporadic chilblains occurring during 2015 and 2019) Methods Observational study Saint-Louis Hospital, Paris, France N = 50 Cytokine assays Assessment of interferon-stimulated gene expression in whole blood Soluble markers of endothelial activation and/or angiogenesis Histological examinations Lateral flow spike assay Circulating endothelial cell counting Statistical analysis Results Histological patterns were similar in CLL and SC groups Transcriptomic signatures overlapped in both the CLL and SC groups Type I interferon Cytotoxic–natural killer gene signature CLL were characterized by higher IgA tissue deposition More complement and angiogenesis factors in CLL compared with SC Autoimmune vasculitis Confirmed endothelial dysfunction in CLL Microangiopathy leading to clinical chilblains Disrupt the thrombo-protective state of endothelial cells Likely contributing to microvascular thrombosis Systemic endothelial activation? The PT ratio and aPTT were normal in all patients Only three patients (6%) had a moderate increase in D-dimer levels Conclusions Inflammation in the skin in CLL Associated with endothelial alteration Immune infiltration of cytotoxic and type I IFN-leading to clinical manifestations https://www.bbc.co.uk/news/health-58801462 UK podiatrist Dr Ivan Bristow like the regular chilblains typically seen during cold spells and in people who have problems with circulation - the lesions usually go away on their own. But some may need treatment with creams and other drugs. The confirmation of the cause will help to develop new treatments to manage it more effectively Dr Veronique Bataille, consultant dermatologist, British Skin Foundation Covid toe was seen very frequently during the early phase of the pandemic, but has been less common in the current Delta variant wave. That might be down to more people being vaccinated or having some protection against Covid from past infections. Presentations after vaccination are much rarer Delayed presentation my mean link is missed Free download my two comprehensive but free educational text books (over 50,000 downloads so far) or make a donation to the campbellteaching project using this link: http://159.69.48.3 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices