The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

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357 episodes
Updated July 21

Episodes357

Newest first

Mar 9, 2021 · 1 hr 14 min
Ep. 188: “Discovery and Translation at CIRM” Featuring Dr. Kelly Shepard
Guest: Dr. Kelly Shepard is the Associate Director of Discovery and Translation at the California Institute for Regenerative Medicine (CIRM). CIRM was created by the voters of California in 2004. The agency funds stem cell research at institutions and companies throughout California with the goal of accelerating treatments to patients with unmet medical needs. Featured Products and Resources: Contest: Subscribe to Organoid News for a Chance to Win a Personalized Lab Coat Try mTeSR™ Plus The Stem Cell Science Round Up Intestinal Organoids for Regeneration – Researchers have generated a functional small intestinalized colon using ileum-derived organoids, offering a possible strategy for short bowel syndrome treatment. Gene Disrupts Lipid Homeostasis in Glia – Scientists have shown that APOE4 has widespread effects on the brain’s ability to metabolize lipids and respond to stress, offering an explanation for why the gene enhances Alzheimer’s risk. Maturation of Year-Old Brain Organoids – 3D cultures of human brain cells kept alive for nearly a year have been shown to undergo transitions in gene activity that resemble those seen in newborns. Brain Cell Grafts Reverse Parkinson’s Symptoms – Grafting neurons grown from a monkey’s own cells into their brain relieved the debilitating movement and depression symptoms associated with Parkinson’s disease. Photo Reference: Courtesy of Dr. Kelly Shepard Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Feb 23, 2021 · 1 hr 9 min
Ep.187: “Stem Cell Education” Featuring Dr. Willy Lensch
Guest: Dr. Willy Lensch is Strategic Advisor to the Dean at Harvard Medical School. Previously Executive Director of the Harvard Department of Stem Cell and Regenerative Biology, his experience in research, education, administration, science policy, intellectual property, science consulting, and outreach have combined to support and advance stem cell science and discovery at Harvard. Featured Products and Resources: Contest: Subscribe to Organoid News for a Chance to Win a Personalized Lab Coat STEMCELL Technologies Survey Report: Where Is Pluripotent Stem Cell Research Now? The Stem Cell Science Round Up Human Heart-Forming Organoids – For the first time, researchers have reproduced early human heart development in a culture dish using human pluripotent stem cells. Bile Duct Organoids Used to Repair Human Livers – A new study has found that when transplanted into damaged mouse or human livers, cholangiocyte organoids functioned normally and repaired bile ducts. Reversing Severe Muscle Wasting in Disease, Aging, and Trauma – Scientists have discovered a novel protein that triggers muscle stem cells to regenerate, leading to complete muscle replacement and movement in mouse models. Deletion of Tumor Suppressor Gene Enhances HSC Self-Renewal – Deletions of the Kmt2c gene selectively protect cycling hematopoietic stem cells (HSCs) from differentiation without inducing HSC proliferation themselves. Photo Reference: Courtesy of Dr. Willy Lensch Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Feb 9, 2021 · 1 hr 17 min
Ep.186: “Human Congenital Heart Disease” Featuring Dr. Sean Wu
Guest: Dr. Sean Wu is an Associate Professor of Medicine at the Stanford School of Medicine. The Wu lab seeks to identify mechanisms responsible for human congenital heart disease, and uses mouse models and stem cells to study cardiovascular developmental biology, and to engineer cardiac tissue. Featured Products and Resources: Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability Try MyoCult™ Myogenic Progenitor Culture Media and Supplements The Stem Cell Science Round Up hESC-Derived Dopamine Progenitors for Parkinson’s Treatment– Researchers have generated midbrain dopamine neurons from hESCs, and manufactured large-scale cryopreserved dopamine progenitors for clinical use in the treatment of Parkinson’s disease. Reactivating Neural Crest Pluripotency – A new study suggests that cranial neural crest cells expand their developmental potential through a transient reacquisition of molecular signatures of pluripotency. Engaging Eosinophils against Liver Injury – Scientists have discovered a mechanism of eosinophil-mediated liver protection that could serve as a therapeutic target to improve outcomes of patients undergoing liver transplantation. Disrupting the Identity of Heart Muscle Cells – Mutations in the LMNA gene severely disrupt chromatin organization in cardiomyocytes, but not hepatocytes or adipocytes, leading to abnormal activation of non-heart muscle genes. Photo Reference: Courtesy of Dr. Sean Wu Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jan 26, 2021 · 1 hr 16 min
Ep. 185: “Cerebral Organoids” Featuring Dr. Jürgen Knoblich
Guest: Dr. Jürgen Knoblich is Scientific Director of the Institute of Molecular Biotechnology at the Austrian Academy of Sciences. The Knoblich lab is known for the development of an organoid model of early brain development, and is currently using iPSCs and cerebral organoids to investigate inter-brain region interactions, neurodevelopmental disorders, and neuronal connections and functions. Featured Products and Resources: Webinar: Challenges in Translating iPSC Technology Try the STEMdiff™ Cerebral Organoid Kit The Stem Cell Science Round Up Study Reveals Immune Driver of Brain Aging – Researchers have identified a key factor in mental aging, and suggested that it might be prevented or reversed by reprogramming myeloid glucose metabolism. A Tonsil Organoid System for Studying Adaptive Immunity – Scientists have developed a tonsil organoid system, and used it to evaluate immune responses to rabies and SARS-CoV-2 vaccines. Antisense Oligonucleotide Targets IRF4 Gene to Treat Multiple Myeloma – Researchers have shown that silencing IRF4 with an antisense oligonucleotide impairs myeloma cell survival and promotes sensitivity to clinical drugs. Illuminating the Path to Cervical Cancers – By creating novel organoid models, scientists have established a new approach to studying the biology of the cervix, and have identified key turning points in cancer development. Photo Reference: Courtesy of Dr. Jürgen Knoblich Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jan 12, 2021 · 1 hr 12 min
Ep. 184: “Engineering Intestinal Grafts” Featuring Dr. Vivian Li
Guest: Dr. Vivian Li is Group Leader of the Stem Cell and Cancer Biology Laboratory at the Francis Crick Institute. The Li lab investigates how Wnt signaling controls stem cells in the healthy gut and during colorectal cancer development. The lab also aims to engineer functional intestinal constructs using patient-derived intestinal organoids. Featured Products and Resources: Protocol: CRISPR-Cas9 Genome Editing of Human Intestinal Organoids Try IntestiCult™ Organoid Growth Medium The Stem Cell Science Round Up Machine Learning and iPSC Approach for Drug Discovery – A machine learning approach has been developed to conduct network-based screens in iPSC-derived cells. The method identified a potential drug candidate for heart valve disease. Mapping the Developing Intestine – Using single-cell RNA sequencing and spatial transcriptomics, scientists have mapped the development of the human intestine over time. Sensory Neurons Promote HSC Mobilization – Scientists have shown that nociceptive nerves in the bone marrow, which are activated by external stimuli like ingestion of spicy foods, are required for hematopoietic stem cell mobilization. Understanding Intestinal Stem Cell Self-Renewal and Differentiation – Scientists have identified a specific intestinal stem cell niche signaling pathway, the Wnt/planar cell polarity pathway, that regulates intestinal stem cell self-renewal and lineage decisions. Photo Reference: Courtesy of Dr. Vivian Li Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Dec 15, 2020 · 1 hr 18 min
Ep. 183: “Glomerulus-on-a-Chip” Featuring Dr. Samira Musah
Guest: Dr. Samira Musah is an Assistant Professor in the Department of Biomedical Engineering and Associate Professor in Medicine at Duke University. The Musah lab applies stem cell biology to engineer functional models of the human kidney and brain, with the goal of developing novel therapeutic models for human kidney diseases and understanding the mechanisms of neurodegeneration in patients with chronic kidney disease and other pathological conditions. Featured Products and Resources: STEMCELL Science News STEMCELL Technologies’ Organoid Information Hub The Stem Cell Science Round Up Promoting Cardiac Repair after Injury – Investigators have found that lymphoangiocrine signals promote cardiac growth, repair and cardioprotection in mice — a process that is mediated by the extracellular protein reelin. Restoring Sight by Rewinding the Epigenetic Clock – Inducing the expression of three Yamanaka transcription factors in mouse retinal ganglion cells restored youthful DNA methylation patterns, promoted axon regeneration after injury, and reversed vision loss. Mesenchymal Stromal Cells Drive Fibrosis – Scientists have identified two bone marrow mesenchymal stromal cell subsets that drive fibrosis and progression of myeloproliferative neoplasms. They identified a drug that inhibits the mechanism involved. New Tool for Cell Engineering– A comprehensive library of human transcription factors has been created that enables systematic investigation of transcription factor-based programming for cell engineering. Photo Reference: Courtesy of Dr. Samira Musah Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Dec 1, 2020 · 1 hr 13 min
Ep. 182: “Stem Cells and Society” Featuring Dr. Christopher Scott
Guest: Dr. Christopher Thomas Scott is the Dalton Tomlin Professor of Medical Ethics and Health Policy at Baylor College of Medicine, and a member of the Daniel L. Duncan Comprehensive Cancer Center. Scott is also emeritus faculty of the Stanford University Center for Biomedical Ethics. His research centers on the ethical, legal, and social implications of emerging biotechnologies. Featured Products and Resources: STEMCELL Technologies Survey Report: Where Is Pluripotent Stem Cell Research Now? Mesenchymal Stromal Cell Updates and Debates The Stem Cell Science Round Up Renewed Funding for Stem Cell Research in California – Voters in California have passed Proposition 14, which authorizes new government funding for the California Institute for Regenerative Medicine. Genetics and Skin Cancer Susceptibility – Children with Fanconi anemia have extreme susceptibility to squamous cell carcinoma. Using patient-derived cells, investigators identified a critical DNA repair pathway that maintains the structure and function of human skin. Membrane Tension Regulates Exit from Naive Pluripotency – Scientists have found that a decrease in membrane-to-cortex attachment is a cell-intrinsic mechanism that is essential for stem cells to exit pluripotency. Memory T Cells in Human Skin – Researchers identify features of human skin tissue-resident memory T cells that differ from their murine counterparts, and reveal a role for the skin environment in their long-term persistence. Photo Reference: Courtesy of Dr. Christopher Thomas Scott Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Nov 17, 2020 · 1 hr 9 min
Ep. 181: “Printing Organoids” Featuring Dr. Matthias Lutolf
Guest: Dr. Matthias Lutolf is a Professor and Principal Investigator of the Laboratory of Stem Cell Bioengineering at the École Polytechnique Fédérale de Lausanne. The Lutolf lab uses cutting-edge bioengineering strategies for guiding stem cell-based development for the assembly of next-generation organoids with improved reproducibility and physiological relevance. Featured Products and Resources: Organoid News E-Book – Organoid Research Techniques: Evolution and Applications The Stem Cell Science Round Up Eardrum Stem Cells – Researchers have identified stem cells of the eardrum, and found that their migration over the tissue helps maintain homeostasis. Using “Monster Tumors” to Study Human Development – Investigators propose teratomas as a promising platform for studying human development. Biobank of Rare, Lethal Tumors – An organoid biobank of gastroenteropancreatic neuroendocrine neoplasms has been created and used to understand the genetics and pathology of the disease. Organoids Produce Embryonic Heart -Researchers grew embryonic organoids, called gastruloids, from mouse embryonic stem cells that mimicked the early stages of heart development in the embryo. Photo Reference: Courtesy of Dr. Matthias Lutolf Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Nov 3, 2020 · 1 hr 3 min
Ep. 180: “Next Generation Scientists” Featuring Naveed Tavakol, Nathasia Mudiwa Muwanigwa, and Sarthak Sinha
Guest: In this special episode of the Stem Cell Podcast, we speak with three PhD students from different parts of the world about their research in and outside of the lab. Naveed Tavakol (pictured, right) is a biomedical engineering PhD student in the Laboratory for Stem Cells and Tissue Engineering at Columbia University under the advisement of Dr. Gordana Vunjak-Novakovic. As a National Science Foundation graduate research fellow, he is working on translational approaches to integrated organ-on-a-chip systems, with a specific focus on the hematopoietic system. Nathasia Mudiwa Muwanigwa (pictured, left) is a PhD researcher in the Developmental and Cellular Biology group at the Luxembourg Center of Systems Biomedicine. She uses midbrain-specific organoids to model and study the molecular and cellular changes that occur in the midbrain during the progression of Parkinson’s disease. She is also the co-founder of Visibility STEM Africa. Sarthak Sinha (pictured, center) has been working in Dr. Jeff Biernaskie’s Lab at the University of Calgary since the ninth grade. Now as an MD-PhD Candidate and a Vanier Scholar, his doctoral project utilizes single-cell genomics to understand mechanisms driving skin fibrosis and regeneration across different mammals. Featured Products and Resources: STEMCELL Science News STEMCELL Technologies’ Organoid Information Hub The Stem Cell Science Round Up Using Organoids for COVID-19 Drug Screening – Researchers have developed lung and colonic organoid models to study SARS-CoV-2 infection and perform drug screening to identify candidate therapeutics. Making Airway Stem Cells from Patients’ Cells – iPSCs were directly differentiated into airway basal cells, a population resembling the stem cells of the airway epithelium. Photo Reference: Courtesy of Nathasia Mudiwa Muwanigwa, Sarthak Sinha, and Naveed Tavakol. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Oct 20, 2020 · 1 hr 1 min
Ep. 179: “The Human Segmentation Clock” Featuring Dr. Miki Ebisuya
Guest: Dr. Miki Ebisuya is a Group Leader at the European Molecular Biology Laboratory in Barcelona. Her lab focuses on synthetic developmental biology, where they reconstitute developmental mechanisms by making artificial gene circuits, and study interspecies differences by comparing organoids of different animals. Featured Products and Resources: ESC & iPSC News mTeSR™ Plus The Stem Cell Science Round Up Lab-Grown Tissue Grafts for Personalized Joint Replacement – Autologous fat-derived cells have been used to engineer cartilage-bone grafts that regenerated and repaired a jaw joint in a minipig model. SARS-CoV-2 Infection in the Brain – Using brain organoids, researchers have found that SARS-CoV-2 infects choroid plexus cells, but not neurons or glia. This infection damages the epithelium, leading to leakage. The Healing Power of Extracellular Vesicles – Using a heart-on-chip model, investigators have found that endothelial cell-derived extracellular vesicles contain cardioprotective proteins that rescue ischemia-reperfusion injury. How Plant Stem Cells Resist Infection – The meristem, the collection of stem cells that builds plants, is resistant to viral infection. Scientists have identified a transcription factor that triggers innate antiviral immunity in the meristem of Arabidopsis. Photo Reference: Courtesy of Dr. Miki Ebisuya Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Oct 6, 2020 · 1 hr 7 min
Ep. 178: “Muscle Stem Cell Quiescence” Featuring Dr. Tom Cheung
Guest: Dr. Tom Cheung is an S H Ho Associate Professor of Life Science at the Hong Kong University of Science and Technology. His lab investigates the molecular pathways that control muscle stem cell quiescence and stem cell-mediated tissue regeneration. Featured Products and Resources: Muscle Cell News STEMCELL Technologies Human MyoCult™ Workflow The Stem Cell Science Round Up Organoid Model of Rare Genetic Disorder – Scientists generated organoids from individuals 22q11.2 deletion syndrome. They found defects in electrical activity, and identified a possible target to rescue phenotypes associated with the disease. Susceptibility of SARS-CoV-2 Infection in Brain Organoids – hiPSC-derived brain organoids were used to investigate the ability of SARS-CoV-2 to infect brain cells. The susceptibility to infection was low for neurons and astrocytes, but high for choroid plexus epithelial cells. Mapping the Human Heart – Investigators used transcriptomic data to characterize six anatomical adult heart regions, creating the most extensive cell atlas of the human heart to date. A Contributor to Fanconi Anemia – Scientists found that high levels of MYC expression promote proliferation and DNA damage in hematopoietic stem and progenitor cells in individuals with Fanconi anemia. Photo Reference: Courtesy of Dr. Tom Cheung Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Sep 22, 2020 · 1 hr 10 min
Ep. 177: “Molecular Mechanisms of Differentiation” Featuring Dr. Ludovic Vallier
Guest: Dr. Ludovic Vallier is a Professor of Regenerative Medicine at the Cambridge Stem Cell Institute and Director of the NIHR Cambridge Biomedical Centre hiPSC core facility. His lab studies the basic mechanisms controlling the differentiation of pluripotent cells into endoderm progenitors from which the pancreas, lung, gut and liver originate. Featured Products and Resources: Technical Resource: Pluripotent Stem Cell Quality Control mTeSR™ Plus The Stem Cell Science Round Up iPSC-Derived MSC Trial for Graft-versus-Host Disease – A phase 1, open-label clinical trial showed that iPSC-derived mesenchymal stromal cells were well tolerated in patients with steroid-resistant acute graft-versus-host disease. Optimizing Drugs using Patient Cells – Scientists used hiPSC-cardiomyocytes from patients with a cardiac rhythm disorder to chemically refine a drug used to treat the disease. Intestinal Organoids Mimic Human Gut – A new and improved method has been developed to generate physiologically relevant organoids by using a scaffold to guide the self-organization of intestinal stem cells into functional epithelium. Making Induced Trophoblast Stem Cells – Researchers identified induced trophoblast cells during the reprogramming of human somatic cells. They could be cultivated, expanded, and potentially used to make placenta cells. Photo Reference: Courtesy of Dr. Ludovic Vallier Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Sep 8, 2020 · 1 hr 2 min
Ep. 176: “Stem Cells and the Skin” Featuring Dr. Valerie Horsley
Guest: Dr. Valerie Horsley is an Associate Professor of Molecular, Cellular, and Developmental Biology, and Associate Professor of Dermatology at Yale University. Her lab studies how adult stem cells within epithelial tissues maintain tissue homeostasis, wound healing and can contribute to cancer formation. Featured Products and Resources: Webinar: Building Brain Organoids and Assembloids to Study Human Development and Disease Dermal Cell News The Stem Cell Science Round Up Treating Obesity and Diabetes with CRISPR-Engineered Fat Cells – White adipocytes were engineered to resemble heat-generating brown fat cells. Transplantation prevented diet-induced obesity and improved glucose homeostasis in mice. A Map of Embryonic Mouse Foregut Development – Scientists have traced the signaling network of endoderm-mesoderm interactions that orchestrate mouse foregut organogenesis. Mechanisms of Trachea Formation – Scientists found that bidirectional Wnt signaling between endoderm and mesoderm promotes trachea development. Scarless Wound Healing – An FDA-approved cream used to treat skin cancers and warts promoted scarless tissue regeneration in wounded mice. Photo Reference: Courtesy of Dr. Valerie Horsley Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Aug 25, 2020 · 1 hr 3 min
Ep. 175: “Human Colon Organoids” Featuring Dr. Henner Farin
Guest: Dr. Henner Farin is a Young Investigator in the German Cancer Consortium, and a Junior Research Group Leader at the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapy. His group uses organoids to study cell signaling in intestinal stem cells and colorectal cancer. Featured Products and Resources: CRISPR-Cas9 Genome Editing of Human Intestinal Organoids Try STEMCELL Technologies’ IntestiCult™ Media The Stem Cell Science Round Up Immune Evading Organoids to Treat Type 1 Diabetes – Human islet-like organoids have been created that are glucose responsive, avoid immune detection, and restore glucose homeostasis in diabetic mice. Regenerating Cartilage in the Joints – By causing slight injury to the joint tissue, scientists were able to stimulate regeneration and growth of local skeletal stem cells in healthy and osteoarthritic mice. iPSC Model to Study Congenital Heart Disease – A human iPSC model of hypoplastic left heart syndrome was generated to investigate the abnormalities that disrupt healthy heart formation, and identify a therapeutic target. Modulating Wnt to Support Organoid Growth – Researchers have designed next-generation surrogate Wnts that support long-term expansion of multiple types of organoids. Photo Reference: Courtesy of Dr. Henner Farin Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Aug 11, 2020 · 1 hr 10 min
Ep. 174: “Functional Human Brain Models of Disease” Featuring Dr. Sergiu Pașca
Guest: Dr. Sergiu Pașca is an Associate Professor of Psychiatry and Behavioral Sciences at Stanford University, and the Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program. His team has developed methods for generating human brain organoids, and uses them to study the programs underlying brain development, assembly and dysfunction. To learn more about his research, register for his upcoming webinar, “Building Brain Organoids and Assembloids to Study Human Development and Disease” with STEMCELL Technologies. Featured Products and Resources: STEMCELL Technologies Organoid Hub Neurological Disease Modeling Resources The Stem Cell Science Round Up Autophagy Regulates Stemness – Researchers have found that autophagy regulates the balance between self-renewal and differentiation of embryonic stem cells. Injury Induces Astrocyte Neurogenesis – When Notch signaling is blocked, astrocytes transition to a neural stem cell-like state after injury. Expanding the Skin by Stretching – Investigators have shown that stretching leads to skin expansion by the self-renewal of epidermal stem cells. Functional Neural Stem Cell Grafts after Spinal Cord Injury – Scientists successfully implanted neural stem/progenitor cell grafts directly into spinal cord injuries in mice. The grafts integrated with and mimicked the animal’s existing neural network. Photo Reference: Courtesy of Dr. Sergiu Pașca Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Aug 4, 2020 · 25 min
ISSCR 2020 with Dr. Martin Pera
Intro: In June 2020, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting! Here is the second of three special episodes from the meeting featuring Dr. Martin Pera, Principal Investigator at the Jackson Laboratories, who presented on the unique properties of a subset of human pluripotent stem cells with a high capacity for self-renewal. Guest: Dr. Martin Pera is a Principal Investigator at the Jackson Laboratories and Editor-in-Chief of the ISSCR’s journal Stem Cell Reports. His lab studies the regulation of self-renewal and pluripotency, heterogeneity in pluripotent stem cell populations, and neural specification of pluripotent stem cells. We discuss his work presented at ISSCR 2020 on the unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal. Featured Products and Resources: Stem Cell Podcast ISSCR 2020 Video Series mTeSR™ Plus from STEMCELL Technologies Photo Reference: Courtesy of Dr. Martin Pera Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 28, 2020 · 1 hr 10 min
Ep. 173: “Blood Cells and the Bone Marrow” Featuring Dr. Dominique Bonnet
Guest: Dr. Dominique Bonnet is the Group Leader of the Hematopoietic Stem Cell Laboratory at the Francis Crick Institute in London, UK. Her lab is interested in the extrinsic mechanisms that regulate hematopoietic stem cells, and how they can intervene in order to eradicate the leukemic stem cell. Featured Products and Resources: Science News by STEMCELL Technologies MesenCult™-ACF-Plus medium The Stem Cell Science Round Up Tiny CRISPR System Discovered – A very compact CRISPR-Cas system has been identified in huge bacteriophages, which provides an addition to the genome editing toolbox. The Effects of Heart Attacks on Insulin Resistance – Scientists have found that heart attacks can affect glucose tolerance by acting on hematopoietic progenitor-derived macrophages in distal adipose tissue. The Hair-Raising Reason for Goosebumps – Investigators have found that certain cell types form a niche to regulate hair follicular stem cells and promote goosebumps. Combination Therapy to Treat Head and Neck Cancer – Combining a BMI1 inhibitor with approved PD1 blockade treatment successfully eliminated cancer stem cells in head and neck squamous cell carcinoma. Photo Reference: Courtesy of Dr. Dominique Bonnet Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 21, 2020 · 40 min
ISSCR 2020 with Dr. Kristy Red-Horse
Intro: In June 2020, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting! Here is the second of three special episodes from the meeting featuring Dr. Kristy Red-Horse, Associate Professor of Biology at Stanford University, who presented on using developmental biology to inform cardiac tissue regeneration. Guest: Dr. Kristy Red-Horse is an Associate Professor of Biology at Stanford University. The Red-Horse lab uses cardiovascular development as a model to study the signals that instruct cell fate and guide morphogenesis during organ formation in the mammalian embryo. We discuss her work presented at ISSCR 2020 on coronary vessel development and artery differentiation, as well as the use of single cell analysis and the future of cell therapy. Featured Products and Resources: Stem Cell Podcast ISSCR 2020 Video Series Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability Photo Reference: Courtesy of Dr. Kristy Red-Horse Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 14, 2020 · 1 hr 3 min
Ep. 172: “Organ Regeneration” Featuring Dr. Valentina Greco
Guest: Dr. Valentina Greco is the Carolyn Slayman Professor of Genetics at Yale University. Her lab has developed novel live imaging approaches to track and manipulate stem cells in live animals, allowing them to study the complex orchestration of tissue regeneration using the skin as a model system. She is also a fierce advocate for inclusivity in the scientific community. Featured Products and Resources: Dermal Cell News STEMdiff™ Cardiomyocyte Media and Supplements The Stem Cell Science Round Up Reducing Cell-to-Cell Contact Helps Heart Cell Proliferation – Researchers were able to induce massive expansion of hiPSC-derived cardiomyocytes by activating Wnt and reducing cell-cell contact. Growing Liver Vasculature from Stem Cells – Scientists have developed a strategy to generate liver sinusoidal endothelial cells from human PSCs by first optimizing arteriovenous specification. A Role For Sex Hormones in Stem Cell Control – A steroid hormone produced by the ovaries in Drosophila has been shown to stimulate intestinal stem cell growth, which may help with reproduction but cause gut dysfunction. Beneficial Bioartificial Livers – Investigators have developed a bioartificial liver system that expands liver progenitor-like cells from human primary hepatocytes. The treatment was able to relieve acute liver failure in pigs. Photo Reference: Courtesy of Dr. Valentina Greco Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 7, 2020 · 32 min
ISSCR 2020 with Dr. Madeline Lancaster
Intro: In June 2020, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting! Here is the first of three special episodes from the meeting featuring Dr. Madeline Lancaster, Group Leader at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, who presented on new directions for human brain organoids. Guest: Dr. Madeline Lancaster is a Group Leader at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK. The Lancaster lab has created cerebral organoids as a model system to better understand human brain evolution, development, and neurodevelopmental disorders. We discuss her work presented at ISSCR 2020, including her team’s latest publication in Science presenting a human central nervous system barrier-forming organoid model that produces cerebrospinal fluid. Featured Products and Resources: Stem Cell Podcast ISSCR 2020 Video Series Wiley E-Book: Organoid Research Techniques Photo Reference: Courtesy of Dr. Madeline Lancaster Subscribe to our newsletter! Never miss updates about new episodes. Subscribe