The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

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357 episodes
Updated July 21

Episodes357

Newest first

Oct 5, 2021 · 1 hr 12 min
Ep. 203: “Stem Cells and Science Communication” Featuring Dr. Paul Knoepfler
Guest: Dr. Paul Knoepfler is a Professor in the Department of Cell Biology and Human Anatomy, the Genome Center, and the Comprehensive Cancer Center at the University of California, Davis. His lab is interested in the epigenetics of stem cells and cancer, and uses cutting-edge molecular, cellular, and developmental biology methods as well as genomic and gene editing technologies to answer key questions in these areas of research. Dr. Knoepfler is also a well-known science communicator, regularly blogging about regenerative medicine and CRISPR in order to fact-check and educate patients about unproven stem cell clinics. Featured Products and Resources: Human Pluripotent Stem Cell Quality Survey Results: Pluripotent Stem Cell Research The Stem Cell Science Round Up Turning Back the Clock on Heart Damage – Researchers found that cardiomyocytes can be reprogrammed to a pluripotent state when the expression of pluripotency factors is sustained over an extended period. A New Hope for Epilepsy – Reprogramming glial cells into interneurons decreased seizures in a pre-clinical mouse model of epilepsy. Cell Communication in the Bone Marrow Niche – Scientists discovered that stress enhances the production of extracellular tRNA-containing vesicles by osteoblasts, which are taken up by hematopoietic progenitors. Attacking Autophagy in Cancer – Using patient-derived chronic myeloid leukemia cells, researchers showed that ULK1 is responsible for tyrosine kinase inhibitor resistance through the induction of autophagy. Photo Reference: Courtesy of Dr. Paul Knoepfler Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Sep 21, 2021 · 1 hr 9 min
Ep. 202: “Regulation of Stem Cells in the Blood” Featuring Dr. Jennifer Trowbridge
Guest: Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers. Featured Products and Resources: Use STEMvision™ for Automated Hematopoietic CFU Assay Imaging & Analysis. Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. The Stem Cell Science Round Up Reversing Cardiotoxicity from Chemotherapy – Doxorubicin-induced cardiotoxicity in patient-derived cardiomyocytes can be reduced with retinoic acid receptor-γ agonists. Heart Vascularization in Infant Development – Researchers showed that the embryonic coronary plexus expands through the DLL4–NOTCH1 signaling pathway to vascularize the myocardium. iPSC-Derived NK Cells for Immunotherapy – Scientists used gene-edited iPSCs to derive natural killer (NK) cells that showed anti-tumor activity in vivo. Origins of Pancreatic Cancer – Through lineage-tracing, researchers found a link between renewal mechanisms in the exocrine pancreas and initiation of pancreatic carcinogenesis. Photo Reference: Courtesy of Dr. Jennifer Trowbridge Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Sep 7, 2021 · 1 hr 19 min
Ep. 201: “The Future of Research” Featuring Drs. Bria Macklin, Matthew Sinton, and Leili Rohani
Guests: In this special episode of the Stem Cell Podcast, we speak with three postdocs from different parts of the world about their research in and outside of the lab. Dr. Bria Macklin is a Postdoc at the Gladstone Institutes. Her PhD research at Johns Hopkins used functional assays to characterize the interactions between different vascular cell types in 3D. Her current lab uses stem cell differentiation and morphogenesis to engineer three-dimensional, multicellular systems. Dr. Matthew Sinton is a Postdoctoral Research Assistant at the University of Glasgow. In his PhD, Dr. Sinton developed a new human pluripotent stem cell model of non-alcoholic fatty liver disease, and used it to explore the effects of hepatic lipid accumulation on mitochondrial energy metabolism. His current postdoctoral project centers around TH2 immunity, and how it is regulated by infection-associated metabolic changes. Dr. Leili Rohani is a Postdoc at the Centre for Heart Lung Innovation at the University of British Columbia. Her research focuses on engineering heart tissues for cell therapy, and she is a science communication and Twitter enthusiast. Featured Products and Resources: STEMCELL Technologies is Hiring! Subscribe to Science News for free weekly newsletters on the latest in cell biology research. The Stem Cell Science Round Up Microvessels Improve Islet Transplantation – Microvessels isolated from adipose tissue improved cell survival and glucose responses of human islets and hESC-derived pancreatic cells in mouse models of Type 1 diabetes. Beta Cell Biogenesis – Ngn3-expressing ductal cells are a source of adult β cell neogenesis in homeostasis and diabetes. Whole-Body Regeneration in Planaria – Scientists found that all three germ layers respond to amputation in Schmidtea mediterranea. From Nose to Knee: Cartilage Grafts for Osteoarthritis – Researchers generated cartilage grafts from the nasal chondrocyte and used them to treat osteoarthritis in mice, sheep, and two human patients. Stem Cell-Derived Steak – Scientists 3D printed muscle, fat, and vascular cell fibers to construct a Wagyu-like steak. Photo Reference: Courtesy of Drs. Bria Macklin, Matthew Sinton, and Leili Rohani Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Aug 24, 2021 · 1 hr 25 min
Ep. 200: “A Stem Cell Pioneer” Featuring Dr. Connie Eaves
Guest: Dr. Connie Eaves is a Distinguished Scientist at the Terry Fox Laboratory at the British Columbia Cancer Agency and a Professor of Medical Genetics at the University of British Columbia. Her research focuses on leukemia and breast cancer and the normal tissues in which these diseases originate. Her pioneering research in basic blood stem cell biology led to a breakthrough in treatment for leukemia. Featured Products and Resources: Keep current with the latest in mammary cell research. Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. The Stem Cell Science Round Up Brain Organoids with Optic Vesicles – Researchers generated human brain organoids with bilateral, light-sensitive optic vesicles. Clonal Mosaicism in Sperm – Scientists found that mosaic mutations, which can affect offspring and subsequent generations, arise in embryonic development and are present in the sperm of one in 15 men. Stem Cells in Skeletal Aging – Aging reduces the ability of skeletal stem cells to maintain a balance between bone formation and destruction. Maintaining HSC Fitness Ex Vivo – Heat shock factor 1 promotes HSC fitness and proteostasis in response to culture stress and aging. Photo Reference: Courtesy of Dr. Connie Eaves Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Aug 10, 2021 · 1 hr 8 min
Ep. 199: “Regeneration in Zebrafish” Featuring Dr. Ken Poss
Guest: Dr. Ken Poss is the James B. Duke Professor of Cell Biology and Head of the Duke Regeneration Center at Duke University. His lab investigates the initial morphogenesis and injury-induced regeneration of several tissues in zebrafish. He is also President of the newly-founded International Society for Regenerative Biology. Featured Products and Resources: Using Social Media to Advance Your Scientific Career Activate, Expand, and Differentiate with Cytokines, Chemokines, and Growth Factors The Stem Cell Science Round Up A 4D Atlas of C. elegans Embryogenesis – Researchers generated a single-cell spatiotemporal atlas of transcription factors in C. elegans embryogenesis. Lysosomal Regulation of Stem Cell Fate – Scientists found that lysosomal activity regulates hematopoietic stem cell fate. Ductal and Mesenchymal Cells in Liver Regeneration – Researchers generated liver organoids and found that the ratio and number of contacts between ductal and mesenchymal cells regulate regeneration. Extending Life Span with VEGF – Researchers found reduced VEGF signaling in key organs in aged mice, and showed that VEGF-treated mice lived longer and had an extended health span. Photo Reference: Courtesy of Dr. Ken Poss Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 27, 2021 · 1 hr 6 min
Ep. 198: “Printing Human Tissues” Featuring Dr. Anthony Atala
Guest: Dr. Anthony Atala is the Founding Director of the Wake Forest Institute for Regenerative Medicine and the Chair of Urology at the Wake Forest School of Medicine. His team developed the first lab-grown organ to be implanted into a human and he currently oversees a team of over 400 researchers who are working to develop cell therapies and engineer replacement organs and tissues. Featured Products and Resources: STEMCELL Science News Survey Results: Pluripotent Stem Cell Research The Stem Cell Science Round Up Generating Gametes from PSCs – Researchers generated functional mouse oocytes from PSCs that could be fertilized and result in viable offspring. Dicer for Protection from RNA Viruses – An alternatively spliced isoform of the enzyme Dicer, called aviD, protects mammalian stem cells from RNA viruses through RNA interference. Mechanical Forces in Engineered Heart Tissues – Scientists generated engineered heart tissue systems with dynamic loading to model diseases such as arrhythmogenic cardiomyopathy. Drug Screening for Pulmonary Hypertension – Researchers used transcriptomics and iPSC-derived endothelial cells from pulmonary hypertension patients to identify a tyrosine kinase inhibitor that improved vascular function in a rat model. Photo Reference: Courtesy of Dr. Anthony Atala Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 13, 2021 · 1 hr 12 min
Ep. 197: “Policy, Regenerative Medicine, and Human Cloning” Featuring Bernie Siegel
Guest: Bernie Siegel is an attorney and policy expert relating to stem cell research, regenerative medicine, and human cloning. He is the Executive Director of the Regenerative Medicine Foundation and the Founder of the World Stem Cell Summit. Featured Products and Resources: Keep current with the latest in cell therapy research. #StemCellfie Gallery The Stem Cell Science Round Up Airway-on-a-Chip – Researchers developed an airway-on-a-chip system using iPSCs to study ciliary function and model primary ciliary dyskinesia. Spatial Transcriptomics at Scale – Sci-Space is a new spatial transcriptomic method that can reveal spatially expressed genes across cell types on a large scale. Senescent Cells in Spinal Injuries– Researchers identified a difference in senescent profiles in zebrafish and mice after spinal cord injuries, and found that targeting senescent cells can promote recovery. A CRISPR Cure for Transthyretin Amyloidosis – A single dose of an in vivo gene-editing agent reduced transthyretin (TTR) levels in patients with TTR amyloidosis. Photo Reference: Courtesy of Bernie Siegel Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 29, 2021 · 1 hr 8 min
Ep. 196: “Human Brain Creation” Featuring Dr. Aparna Bhaduri
Guest: Dr. Aparna Bhaduri is an Assistant Professor of Biological Chemistry at the David Geffen School of Medicine at UCLA. Her lab studies how the human brain is created, with billions of cells spanning hundreds or thousands of cell types. They also explore how the cell building blocks of development can reappear later in life in brain cancers such as glioblastoma. Featured Products and Resources: Access resources for your neuroscience research. Learn about the STEMdiff™ Cerebral Organoid Kit from STEMCELL Technologies. The Stem Cell Science Round Up Hair Thinning in Obesity – Researchers found that obesity-induced stress depletes hair follicle stem cells in mice. Tracking Keratinocyte Stem Cells – Scientists used deep learning to track the motion of individual keratinocytes and keratinocyte stem cells, allowing them to identify the stem cells in a mixed population and study how culture conditions affect dynamics. Flipping a Switch in Heart Failure – Researchers identified a transcriptional switch that controls the activation of fibroblasts, and could be used to prevent fibrosis in the heart and other organs. Mapping Mouse Brain Development – Scientists used single cell sequencing to generate a comprehensive atlas of the developing mouse neocortex. Photo Reference: Courtesy of Dr. Aparna Bhaduri Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 26, 2021 · 45 min
“ISSCR 2021 Day 5” Featuring Dr. Nicolas Rivron
Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the last of five special episodes from the meeting featuring Dr. Nicolas Rivron from the Institute of Molecular Biotechnology (IMBA) at the Austrian Academy of Sciences, who presented during the Plenary IV: Self-Organization of Developmental Processes session. Guest: Dr. Nicolas Rivron is a Group Leader at IMBA. The Rivron group recreates embryonic development using mammalian stem cells in a dish to better understand the encoded principles of self-organization. They observe both blastocysts and blastoids to study how self-organization contributes to multicellular patterning and cellular decision making. They address these questions using high throughput microsystems, single cell genomics, single cell high-content imaging, and synthetic biology. We discuss his talk and his thoughts on the meeting. Featured Products and Resources: View the COREdinates Focus Session for best practices and new tools for gene editing PSCs Visit STEMCELL’s Virtual Conference Exhibition Photo Reference: Courtesy of Dr. Nicolas Rivron Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 25, 2021 · 45 min
“ISSCR 2021 Day 4” Featuring Dr. Sheila Chari
Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the fourth of five special episodes from the meeting, featuring Dr. Sheila Chari from Cell Stem Cell. Guest: Dr. Sheila Chari is Editor-in-Chief at Cell Stem Cell and Executive Editor at Cell Press. Her primary responsibilities are knowing and publishing the top stem cell discoveries, driving journal publishing strategy, and managing a global editorial staff. We discuss her thoughts on the meeting. Featured Products and Resources: View STEMCELL’s Virtual Conference Exhibition Reduce risk and obtain high-quality cells with TeSR™-AOF Photo Reference: Courtesy of Dr. Sheila Chari Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 25, 2021 · 41 min
“ISSCR 2021 Day 3” Featuring Dr. Shahin Rafii
Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting featuring Dr. Shahin Rafii from Weill Cornell Medical College. Guest: Dr. Shahin Rafii is a Professor of Reproductive Medicine and the Arthur B. Belfer Professor in Genetic Medicine at Weill Cornell Medical College, as well as Director of the Ansary Stem Cell Institute. His research focuses on stem cell biology and angiogenesis. We discuss his research and thoughts on the meeting. Featured Products and Resources: View the schedule for STEMCELL’s Innovation Showcases Generate, expand, and differentiate human liver organoids using the HepatiCult™ Organoid Kit Photo Reference: Courtesy of Dr. Shahin Rafii Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 24, 2021 · 34 min
“ISSCR 2021 Day 2” Featuring Dr. Madeline Lancaster
Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the second of five special episodes from the meeting featuring Dr. Madeline Lancaster from the Medical Research Council (MRC) Laboratory of Molecular Biology, who was honored with the Dr. Susan Lim Award for Outstanding Young Investigator Lecture at the meeting. Guest: Dr. Madeline Lancaster is a Group Leader in the Cell Biology Division at the MRC Laboratory of Molecular Biology at the University of Cambridge. Her lab studies the biological processes of human brain evolution using cerebral brain organoids as a model. We discuss her award and her thoughts on the meeting. Featured Products and Resources: View the schedule for STEMCELL’s Innovation Showcases Learn about neural organoids at STEMCELL’s Neural Organoid Hub Photo Reference: Courtesy of Dr. Madeline Lancaster Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 22, 2021 · 40 min
“ISSCR 2021 Day 1” Featuring Dr. Chuck Murry
Intro: In June 2021, we attended the International Society for Stem Cell Research (ISSCR) virtual annual meeting, and recorded daily video episodes discussing highlights of the previous 24 hours. Here is the first of five special episodes from the meeting featuring Dr. Chuck Murry from the University of Washington, who presented during the Presidential Symposium: What’s in a Germ Layer session on the first day of the meeting. Guest: Dr. Chuck Murry is a Professor of Laboratory Medicine & Pathology, Bioengineering, and Medicine & Cardiology at the University of Washington, as well as Director of the Institute for Stem Cell Regenerative Medicine and the UW Medicine Heart Regeneration Program and Co-Director of the UW Center for Cardiovascular Biology. His research focuses on stem cell biology, with an emphasis on understanding the differentiation of the human cardiovascular system and using these cells to study disease and regenerate damaged tissues. We discuss his talk at the Presidential Symposium and his thoughts on the meeting. Featured Products and Resources: View the schedule for STEMCELL’s Innovation Showcases Visit STEMCELL’s Virtual Conference Exhibition Photo Reference: Courtesy of Dr. Chuck Murry Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 15, 2021 · 1 hr 18 min
Ep. 195: “The Global Alliance for iPSC Therapies” Featuring Dr. Stephen Sullivan
Guest: Dr. Stephen Sullivan is the Program Manager and International Liaison Officer at the Global Alliance for iPSC Therapies (GAiT), an international initiative to support the implementation and clinical application of therapies derived from pluripotent stem cells to the benefit of patients globally. GAiT serves as a central, international resource for those organisations who are developing therapies from clinical-grade induced pluripotent stem cells and to support the expansion of this nascent field. Featured Products and Resources: ESC and iPSC News Human Pluripotent Stem Cell Quality The Stem Cell Science Round Up Stem Cells in Wound Healing – Scientists found that Lgr6 epidermal stem cells interact with nerves and specialize in wound resurfacing. A ‘Telescope’ Model for Hair Follicle Development – Researchers used long-term live imaging and single-cell transcriptomics to study the development of mouse whisker hair follicles. Base Editing Rescues Sickle Cell Disease – Scientists used base editing to correct the mutation that causes Sickle Cell Disease in HSPCs from patients. Age-Related Genetic Changes in HIV – Researchers found people with HIV had higher rates of clonal hematopoiesis, a condition caused by mutations in HSCs that may be associated with inflammation and contributes to comorbidities. Photo Reference: Courtesy of Dr. Stephen Sullivan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 1, 2021 · 1 hr 15 min
Ep. 194: “Evolution of Stemness Control and Multicellularity” Featuring Dr. Emma Hammarlund
Guest: Dr. Emma Hammarlund is an Associate Professor at the Division of Translational Cancer Research at Lund University. Her lab investigates how the rise of animals on Earth relates to the evolution of stemness control. They use both geobiology and tumor biology to explore the evolutionary roots of animal health and disease. Featured Products and Resources: Keep Current With the Latest in ESC and iPSC Research Try the New Standard in hPSC Maintenance: mTeSR™ Plus Medium The Stem Cell Science Round Up Cardioids That Beat – Scientists generated self-organizing cardiac organoids with hollow chambers that can contract rhythmically, like a heartbeat. Fluorescence Imaging with Low Phototoxicity – Researchers used high-speed, high-resolution 3D imaging to observe inter- and intracellular interactions on a millisecond scale. An Atlas Charting Human Development – Scientists generated a multi-organ, single-cell transcriptome atlas and used it to compare organ and organoid development. Rescuing Neurogenesis in Alzheimer’s– Researchers found that increasing miR-132, a microRNA downregulated in Alzheimer’s, restored neurogenesis and memory deficits in a mouse model. Photo Reference: Courtesy of Dr. Emma Hammarlund Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
May 18, 2021 · 1 hr 2 min
Ep. 193: “From Academia to Venture Capital” Featuring Dr. Themasap Khan
Guest: Dr. Themasap Khan is the Vice President at Civilization Ventures, a venture capital firm that invests in genomics, diagnostics, digital health, AI, and personalized and regenerative medicine. He leads the firm’s scientific due diligence and academic outreach programs. Dr. Khan earned his in PhD in stem cell biology and regenerative medicine in Dr. Sergiu Pasca’s lab at Stanford, where his research focused on genome engineering, cerebellar organoid models, and live imaging to elucidate biological mechanisms underlying neuropsychiatric disorders. Featured Products and Resources: Win Your Conference Registration Fee for ISSCR 2021 Are Your Pluripotent Stem Cells What You Think They Are? Explore Now The Stem Cell Science Round Up Gene Therapy for Adenosine Deaminase (ADA) Deficiency – Scientists treated patients with ADA severe combined immunodeficiency with a lentiviral vector encoding human ADA, which led to high overall and event-free survival. Lineage Tracing through Somatic Mutations – Researchers used somatic mutations in hematopoietic progenitors from human fetuses to study the divergence of embryonic and extra-embryonic tissues during development. A Small Molecule Cocktail to Enhance Cell Survival – Scientists used high-throughput screening to identify a cocktail that improves the viability of hPSCs and differentiated cells by blocking several stress mechanisms. 2-Photon Live Imaging of Single Corneal Stem Cells – Researchers identified discrete, functionally diverse stem cell niche compartments in the corneal limbus in the eyes of live mice. Photo Reference: Courtesy of Dr. Themasap Khan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
May 4, 2021 · 52 min
Ep. 192: “Gene Expression and the Brain” Featuring Dr. Johan Jakobsson
Guest: Dr. Johan Jakobsson is a Professor of Molecular Neurogenetics at the Lund Stem Cell Center. His research focuses on epigenetic mechanisms of the brain, including the role of microRNAs, long non-coding RNAs, and endogenous retroelements in neural stem cells and neurons. Featured Products and Resources: Win Your Conference Registration Fee for ISSCR 2021 Access Resources for Your Neuroscience Research The Stem Cell Science Round Up Intestinal Organoids to Model Self-Organization – Researchers found that stem cell zones in intestinal organoid cultures are shaped by fission events, and that organoid inflation drives stem cell differentiation. Wound Healing Without Scarring – Preventing Engrailed-1 activation during wound healing promotes skin regeneration with recovery of skin appendages, ultrastructure, and mechanical strength. Differentiation Unmasks Hidden Aspects of Aging in Stem Cells – Scientists used single-cell RNA sequencing to study age-related changes in muscle stem cells and fibro-adipose progenitors, and found an energy barrier in myogenic differentiation. Human-Monkey Chimeric Embryos – Researchers demonstrated that hEPSCs survived, proliferated, and generated several peri- and early post-implantation cell lineages inside monkey embryos. Photo Reference: Courtesy of Dr. Johan Jakobsson Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Apr 20, 2021 · 1 hr 6 min
Ep. 191: “Laser-Based Cell Manipulation” Featuring Dr. Marinna Madrid
Guest: Dr. Marinna Madrid is Co-Founder of Cellino, an early-stage biotechnology company seeking to make personalized, autologous cell therapies viable at large scale for the first time. Cellino’s platform combines label-free imaging and high-speed laser editing with machine learning to automate cell reprogramming, expansion, and differentiation in a closed cassette format, enabling thousands of patient samples to be processed in parallel in a single facility. Featured Products and Resources: Keep current with the latest in cell therapy research with Cell Therapy News. Show the world what stem cell research looks like from your perspective by taking part in this year’s #StemCellfie contest. The Stem Cell Science Round Up Using IGF1 to Rescue HSCs from the Hallmarks of Aging – Researchers found that a decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging, and that direct stimulation with IGF1 could reverse this phenotype. Krüppel-Like Factor 1 is Critical for Heart Regeneration in Zebrafish – Krüppel-Like Factor 1 stimulates new cardiomyocyte production by reprogramming gene networks that regulate cardiomyocyte differentiation and mitochondrial metabolism. How Aneuploid Embryos Can Lead to Healthy Births – Scientists showed that mosaic embryos can be rescued through BMP4-dependent apoptosis of aneuploidy in the primary germ layers. Patient-Derived Cervical Organoids – Generated from a pap smear sample, cervical organoids can be used as an experimental platform for sexually transmitted infection and cervical cancer research. Photo Reference: Courtesy of Dr. Marinna Madrid Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Apr 6, 2021 · 1 hr 5 min
Ep. 190: “Immunology and Podcasts” Featuring Drs. Brenda Raud and Jason Goldsmith
Guests: Dr. Brenda Raud is a postdoctoral researcher at the Netherlands Cancer Institute. Her research focuses on T cell-based immunotherapies and immuno-oncology. Dr. Jason Goldsmith recently completed his postdoctoral fellowship at the University of Pennsylvania, and is now the Director of Donor Medical Sciences at Seres Therapeutics, a biotechnology company working to revolutionize treatment of a wide range of diseases by modulating the function of the human microbiome. In addition to their work as researchers, Brenda and Jason are also hosts of the new Immunology Podcast, a sister podcast to the Stem Cell Podcast. Featured Products and Resources: Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center. Show the world what stem cell research looks like from your perspective by taking part in this year’s #StemCellfie contest. The Stem Cell Science Round Up Single-Cell Synthetic Organism with Less Than 500 Genes – Researchers fabricated an artificial single-cell organism that can grow and divide like a normal cell, giving them insights into which genes are required for cell growth and division. Humanized Skeletal Muscle Grown in Pigs – Scientists generated human-pig chimeric embryos with humanized skeletal muscle, as well as intraspecies chimeric pig embryos that were carried to term. A 3D Model for Macular Degeneration – Researchers developed a 3D iPSC model of the retinal pigment epithelium-choriocapillaris complex, a complex that is damaged in age-related macular degeneration. Human Brain Expansion Driven by an Early Cell Shape Transition – Scientists grew human and ape cerebral organoids and discovered a transition state that is characterized by a change in cell shape, regulated by ZEB2, and delayed in humans. Photo Reference: Courtesy of Drs. Brenda Raud and Jason Goldsmith Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Mar 23, 2021 · 1 hr 13 min
Ep. 189: “Stem Cells and Synthetic Biology” Featuring Dr. Krishanu Saha
Guest: Dr. Krishanu Saha is an Associate Professor in the Department of Biomedical Engineering at the University of Wisconsin-Madison. His lab utilizes quantitative and bioengineering methods including genome editing, biomanufacturing, and disease modeling to advance the next generation of cell and gene therapies. Featured Products and Resources: Subscribe to ESC & iPSC News Survey Report: Hurdles of Genome Editing Using CRISPR-Cas9 The Stem Cell Science Round Up Growing Advanced Embryos Outside the Uterus – Researchers removed mouse embryos from the uterus at five days of gestation and grew them for six more days in roller culture systems, allowing them to reach advanced organogenesis. Lacrimal Gland Organoids That “Cry” – Scientists established long-term 3D organoid cultures of human and mouse lacrimal glands and used neurotransmitters to induce tear secretion. Generating Human “Blastoids” – Starting with either human ESCs or iPSCs, researchers used a three-dimensional culture strategy to generate blastocyst-like structures in vitro. Reprogramming Fibroblasts into iBlastoids – Fibroblasts were reprogrammed in vitro into three-dimensional models of the human blastocyst, termed iBlastoids. SARS-CoV-2-Induced Cardiac Damage in iPSC-Derived Heart Cells – Scientists infected iPSC-derived cardiac cells with SARS-CoV-2 to better understand how the virus attacks the heart. Cytokine Storms in Cardiac Organoids – Using SARS-CoV-2-infected cardiac organoids and mice, researchers found that bromodomain and extraterminal domain family inhibition reduced infection and cardiac damage. Photo Reference: Courtesy of Dr. Krishanu Saha Subscribe to our newsletter! Never miss updates about new episodes. Subscribe