The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

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357 episodes
Updated July 21

Episodes357

Newest first

Aug 20, 2024 · 1 hr 20 min
Ep. 274: “Brain Organoids” Featuring Dr. Ziyuan Guo
Guest: Dr. Ziyuan Guo is an Assistant Professor of Pediatrics at the Center for Stem Cell & Organoid Medicine at Cincinnati Children’s Hospital. He talks about in vivo reprogramming and cell and gene therapy in neurodevelopmental and neurodegenerative disorders. He also discusses assembloids to model the blood-brain barrier and strategies for organoid vascularization. Featured Products and Resources: Use STEMdiff Cerebral Organoid Kits to mimic early brain development. Get a free wallchart showing how neural organoids are generated and can be used to better understand brain development. The Stem Cell Science Round Up Modeling Celiac Disease – Scientists generated air–liquid interface duodenal organoids from celiac disease patients. Intestinal Immuno-Organoids – Intestinal immuno-organoids can be used to study tissue-resident immune responses in tumorigenesis and other diseases. Naive PSCs in the Blastocyst – A blastocyst motif substrate reverts mouse and human PSCs to a naive state in vitro. Sensory Neuron Excitability – Schwann cell-secreted PGE2 promotes neuronal maturation and normal sensory function. Image courtesy of Dr. Ziyuan Guo Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Aug 6, 2024 · 1 hr 51 min
Ep. 273: “Hematopoiesis and Cancer” Featuring Dr. Irving Weissman
Guest: Dr. Irving Weissman is the Virginia and Daniel Ludwig Professor of Clinical Cancer Research and Professor of Pathology and Developmental Biology at Stanford University. Dr. Weissman was the first scientist to identify and isolate mammalian blood-forming stem cells in mice, and his work has contributed to the understanding of how a single hematopoietic stem cell can give rise to specialized blood cells. He talks about developing new treatments for metastatic breast cancer and severe combined immunodeficiency. He also discusses myeloid bias in aging and strategies for commercializing new therapies. Featured Products and Resources: Keep current with the latest in hematopoiesis news. Find educational resources to help you further your research on hematopoiesis and hematological malignancies. The Stem Cell Science Round Up Tracking Somitogenesis – Scientists used live imaging to track cellular and signaling dynamics during somite formation. Modeling Interstitial Flow in the Intestine – Researchers constructed a micro-small intestine system to study the mechanisms underlying intestinal tissue development. IL-11 Signaling in Aging – Inhibiting IL-11 extends the healthspan and lifespan of mice. Mapping Brain Vasculature – Scientists constructed a molecular atlas of the developing fetal, adult control, and diseased human brain vasculature. Image courtesy of Dr. Irving Weissman Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 23, 2024 · 59 min
Ep. 272: “Live at ISSCR 2024: Stem Cell Research in Space” Featuring Drs. Davide Marotta and Catriona Jamieson
Guests: Dr. Davide Marotta is the Program Director for In-Space Biomanufacturing at the International Space Station National Laboratory. Dr. Catriona Jamieson is the Director of the Sanford Stem Cell Institute at the University of California, San Diego. In this special episode recorded in front of a live audience at ISSCR 2024 in Hamburg, Germany, they talk about the opportunities and challenges of working with stem cells in a microgravity environment, and what this could mean for the future of stem cell-based therapies. They discuss the challenges of culturing cells in space, the need for risk reduction and collaboration, and how microgravity affects stem cell growth and aging. They also discuss the opportunities that come with the growing popularity of private spaceflight. Featured Products and Resources: The Stem Cell Podcast has been nominated for a People’s Choice Podcast Award! Vote now. Do you want to implement the new ISSCR Standards for Human Stem Cell Use in Research? Get a free checklist wallchart! Images courtesy of Drs. Davide Marotta and Catriona Jamieson Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jul 9, 2024 · 1 hr 20 min
Ep. 271: “Skin Regeneration” Featuring Dr. Valentina Greco
Guest: Dr. Valentina Greco is the Carolyn Walch Slayman Professor of Genetics and Co-Chair of the Committee on the Status of Women in Medicine at Yale University. Her research focuses on tissue homeostasis in the face of continuous cellular turnover, frequent injuries, and spontaneous mutations. She talks about her research on skin and hair follicle stem cells, the role of imaging techniques, and bridging science and art. She also discusses disease modeling and building an inclusive lab culture. Featured Products and Resources: Attend a live podcast show at ISSCR 2024. The Stem Cell Podcast has been nominated for a People’s Choice Podcast Award! Vote now. The Stem Cell Science Round Up Next-Generation Genome Editing – An RNA-guided recombinase enzyme enables the insertion, excision, or inversion of specific target DNA sequences. Maintaining HSC Function – Researchers identified the transcription factor Nynrin as a crucial regulator of HSC maintenance by modulating mitochondrial function. A Vascularized Heart-on-a-Chip – Primitive macrophages enhanced cardiac tissue functionality. Brain Chimeroids – A new multidonor human brain cortical organoid model was generated by co-developing cells from a panel of individual donors in a single organoid. Image courtesy of Dr. Valentina Greco Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 25, 2024 · 1 hr 20 min
Ep. 270: “Microvascular Regeneration” Featuring Dr. Sara Vasconcelos
Guest: Dr. Sara Vasconcelos is a Senior Scientist and the John Kitson McIvor Endowed Chair in Diabetes Research at University Health Network. She is also an Associate Professor at the Institute of Biomedical Engineering at the University of Toronto. Her lab studies microvascular regeneration in cardiovascular diseases and diabetes, and are working to develop personalized patient-derived organ-chip models for drug screening and other applications. In this episode, she talks about modeling cardiac fibrosis and studying pancreatic islet vasculature. She also discusses working with microchips and with large animal models. Featured Products and Resources: It’s almost time for ISSCR 2024! Check out the program here. Use STEMCELL’s STEMdiff™ Cardiomyocyte media and supplements to differentiate, enrich, expand, and cryopreserve functional hPSC-derived cardiomyocytes. The Stem Cell Round Up Gene Editing Lung Stem Cells – Scientists used a lipid nanoparticle delivery system to correct mutations in a mouse model of cystic fibrosis. Trophectoderm Expansion – The polar trophectoderm thickens substantially before the expected time of implantation. Liver Regeneration – Mouse hepatocytes required a functional electron transport chain to proliferate and compete with wild-type hepatocytes during liver regeneration. Revascularizing Limbs – Proangiogenic/arteriogenic monocytes increased circulation in patients with chronic limb-threatening ischemia. Image courtesy of Dr. Sara Vasconcelos Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jun 11, 2024 · 1 hr 23 min
Ep. 269: “iPSC Technology” Featuring Dr. Sebastian Diecke
Guest: Dr. Sebastian Diecke is a Group Leader and Stem Cell Core Director at the Max Delbrück Center, where his research focuses on iPSCs and organoid models. He talks about the early days of iPSC research, developing organoids from endangered rhinoceros, and modeling Huntington’s and other diseases. Featured Products and Resources: Check out the program for ISSCR 2024, happening July 10-13 in Hamburg! Keep current with the latest in ESC and iPSC news. The Stem Cell Science Round Up Blood Self-Renewal – Researchers identified a crucial regulator that modulates endocytosis and environmental sensing in hematopoietic stem cells. Cardiomyocytes After Heart Attack – iPSC-derived cardiomyocytes were successfully engrafted into two rhesus macaques with small, subclinical chronic myocardial infarctions. CHIP and Gum Disease – DNMT3A-driven clonal hematopoiesis of indeterminate potential (CHIP) and inflammatory bone loss are reversed by rapamycin. Turtle Liver Organoids – Scientists developed and characterized adult stem cell-derived turtle liver organoids. Image courtesy of Dr. Sebastian Diecke Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
May 28, 2024 · 1 hr 15 min
Ep. 268: “Tissue Formation” Featuring Dr. Shukry Habib
Guest: Dr. Shukry Habib is an Associate Professor in the Department of Biomedical Sciences at the Université de Lausanne. His lab works at the intersection of stem cell biology, biophysics, and tissue engineering to investigate how tissues form. He talks about developing a transplantable bandage for bone repair and the role of Wnt signaling and cytonemes in development. Featured Products and Resources: Explore the program for ISSCR 2024! Learn about pluripotent cell quality. The Stem Cell Science Round Up Unequal Blastomere Contribution – Prospective lineage tracing of human embryos revealed that the majority of the epiblast is derived from only one 2-cell stage blastomere. Epigenetic Reprogramming of Germ Cells – Epigenetic reprogramming resets parental epigenetic memories and differentiates primordial germ cells into mitotic pro-spermatogonia or oogonia. Blood-Brain Barrier Organoids – Researchers used patient-derived blood-brain barrier assembloids to model cerebral cavernous malformations. Treating Genetic Liver Disease – A new study combines ex vivo large-scale cell expansion and gene editing in patient-derived transplantable hepatocytes, which holds potential for treating human liver diseases. Image courtesy of Dr. Shukry Habib Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
May 14, 2024 · 1 hr 24 min
Ep. 267: “Embryo Morphogenesis” Featuring Dr. Shankar Srinivas
Guest: Dr. Shankar Srinivas is a Professor of Developmental Biology in the Department of Physiology Anatomy and Genetics based in the Institute for Developmental and Regenerative Medicine at the University of Oxford. He is also a Zeitlyn Fellow and Tutor in Medicine at Jesus College. Using mouse and human embryos as model systems, his group looks at the control of patterning and morphogenesis during the establishment of the anterior-posterior axis, gastrulation, and early cardiogenesis. He discusses how tissues respond to forces during early development, characterizing cardiac progenitors, and training internationally. Featured Products and Resources: Register now for ISSCR 2024! Explore mentorship resources. The Stem Cell Science Round Up Rat Forebrain Tissues in Mice – Reconstituted rat forebrains in mice exhibit normal structure and function. Interspecies Neural Circuits – Rat stem cells develop in mouse blastocysts to broadly populate two-species brains. Human Embryo Compaction – Researchers mapped cell surface tensions during compaction. Cell Crowding in the Stem Cell Epithelium – In human embryonic stem cells, cellular crowding leads to the blockade of FGFR1 endocytosis. Image Courtesy of Dr. Shankar Srinivas Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Apr 30, 2024 · 1 hr 23 min
Ep. 266: “From Stem Cells to Cortical Circuits” Featuring Dr. Pierre Vanderhaeghen
Guest: Dr. Pierre Vanderhaeghen is a Professor and Principal Investigator at VIB-KU Leuven Center for Brain & Disease Research. His lab studies the mechanisms of cortical development and brain evolution. He talks about species-specific neuronal development, human neuron excitability, and playing in a rock cover band! Featured Products and Resources: Register now for ISSCR 2024, taking place July 10-13 in Hamburg, Germany! The Lab Coats & Life™ has launched! Listen to conversations to help you thrive as a scientist. The Stem Cell Science Round Up Modeling Cancer Ex Vivo – Induced mini-colons recapitulated hallmarks of colorectal tumors. Human Embryo Gastrulation – Scientists reconstructed a 3D model of a gastrulating human embryo using spatial transcriptomics. Treating Timothy Syndrome – Antisense oligonucleotides rescued defects in patient-derived cortical organoids. Sympathetic Neurons in Jawless Vertebrates – Scientists identified trunk sympathetic neurons in the sea lamprey. Image courtesy of Dr. Pierre Vanderhaeghen Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Apr 16, 2024 · 1 hr 30 min
Ep. 265: “RNA Glycosylation” Featuring Dr. Ryan Flynn
Guest: Dr. Ryan Flynn is a Principal Investigator at Boston Children’s Hospital and an Assistant Professor in the Stem Cell and Regenerative Biology Department at Harvard University. His lab explores the interface between RNA and glycans. He talks about the discovery of glycoRNA and the chemistry of the RNA-glycan connection. He also discusses the effects of glycans on stem cell function and deciding between a career in medicine and basic science. Featured Products and Resources: Register now for ISSCR 2024, happening July 10-13 in Hamburg, Germany. Listen to the Lab Coats & Life™ Podcast to stay informed about useful soft skills and relevant trends to help you thrive as a scientist. The Stem Cell Science Round Up Modeling Traumatic Brain Injury – Researchers used mechanically injured organoids to identify a target to reduce neuronal death after brain injury. Spinal Cord Organoid Regeneration – The regenerative capabilities of the neonatal spinal cord may be due to proteins in the extracellular matrix. HSC Transplantation to Treat HIV – Scientists developed a gene editing strategy targeted for autologous HSPC transplantation as a functional cure for HIV. Hepatocyte Organoids to Treat Liver Failure – Encapsulated liver organoids rescued mice from liver failure. Image Courtesy of Dr. Ryan Flynn Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Apr 2, 2024 · 1 hr 19 min
Ep. 264: “Planarian Regeneration” Featuring Dr. Blair Benham-Pyle
Guest: Dr. Blair Benham-Pyle is an Assistant Professor at Baylor College of Medicine. She talks about how multipotent cells in Schmidtea mediterranea enable whole-body regeneration. She also discusses the effects of the mechanical environment on stem cell fate. Featured Products and Resources: Register for ISSCR 2024! Get updates about new mentorship content from Lab Coats & Life™ The Stem Cell Science Round Up Antibodies to Rejuvenate the Immune System – Depleting myeloid-biased HSCs in aged mice restores features of a more youthful immune system. Infant Intestinal Perforation and Brain Injury – Scientists identified subventricular zone echogenicity on cranial ultrasound in preterm infants following intestinal perforations. Cell Fate in Brain Development – Researchers studied fate decisions in cerebral organoids and early fetal tissue. Autofluorescence in Neural Stem Cells – Quiescent and activated neural stem cells have unique autofluorescence profiles. Image courtesy of Dr. Blair Benham-Pyle Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Mar 19, 2024 · 1 hr 11 min
Ep. 263: “ISSCR 2024: The Global Stem Cell Event” Featuring Drs. Amander Clark, Agnete Kirkeby, and Malin Parmar
Guests: Dr. Amander Clark is the President of the International Society for Stem Cell Research (ISSCR) and Founding Director of the Center for Reproductive Science, Health, and Education at the University of California, Los Angeles. Dr. Agnete Kirkeby is a Program Chair of the ISSCR Annual Meeting, Associate Professor at Lund University and the University of Copenhagen, and Group Leader at the Novo Nordisk Foundation Center for Stem Cell Biology – reNEW. Dr. Malin Parmar is a Program Chair of the ISSCR Annual Meeting, Professor at Lund University, and a New York Stem Cell Foundation – Robertson Investigator. They talk about the upcoming ISSCR 2024 meeting in Hamburg, Germany from July 10-13, 2024. They discuss the meeting’s clinical focus, spotlight and plenary sessions, and opportunities for students and postdocs. Featured Products and Resources: Submit your abstract for ISSCR 2024! Get updates about new mentorship content from Lab Coats & Life™ The Stem Cell Science Round Up Hypoblast Development in the Embryo – Scientists examined post-implantation signaling interactions using human embryos and stem cell models of the epiblast and hypoblast. Retinoic Acid in Tissue Regeneration – Manipulating retinoid availability in skin and in culture allowed researchers to direct stem cells to heal wounds or to make hair. Human Heart Development – Researchers developed a spatial map of the developing human heart. Bioprinting Cardiac Tissues – hPSC-atrioventricular canal cardiomyocytes can delay electrical impulse in 3D bioprinted tissue. Image courtesy of Drs. Amander Clark, Agnete Kirkeby, and Malin Parmar Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Mar 5, 2024 · 1 hr 15 min
Ep. 262: “Glia in the Gut” Featuring Dr. Marissa Scavuzzo
Guest: Dr. Marissa Scavuzzo is an HHMI Hanna H. Gray Fellow at Case Western Reserve University School of Medicine. Her research focuses on enteric glia regulation in the healthy and diseased gut. She talks about how glial cell subtypes affect intestinal motility and her experience receiving NYSCF and HHMI fellowships. She also talks about bringing science to underserved schools in Cleveland. Featured Products and Resources: Submit your abstract now for ISSCR 2024! Learn about mentorship and careers in science by listening to the new Lab Coats & Life™ Podcast. The Stem Cell Science Round Up Astrocytes in Organoids – Researchers generated a cortical organoid platform to investigate human astrocyte function. SOX17 in Immune Evasion – Scientists used AKP organoids to demonstrate that SOX17 orchestrates immune evasion in the early steps of colon cancer. Bone Marrow Organoids – Bone marrow organoids model aspects of hematopoietic development and inborn errors of hematopoiesis. Patient-Derived Lymphoma Organoids – Patient-derived lymphoma organoids recapitulate the tumor lymphoid microenvironment. Image Courtesy of Dr. Marissa Scavuzzo. Photographer: Jesse Zhan Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Feb 20, 2024 · 1 hr 17 min
Ep. 261: “Building Neuromuscular Tissues” Featuring Dr. Ritu Raman
Guest: Dr. Ritu Raman is the d’Arbeloff Career Development Assistant Professor of Mechanical Engineering at MIT, where her lab uses robotics and tissue engineering to treat muscle loss. She talks about light-activated muscle grafts, magnetic microparticles to control forces exerted on cells, and strategies for science communication. Featured Products and Resources: Register now for ISSCR 2024, happening July 10-13 in Hamburg, Germany. The Lab Coats & Life™ Podcast features conversations about useful soft skills, relevant trends, and important efforts from within the scientific community to help you thrive as a scientist. Listen now! The Stem Cell Science Round Up Cell Therapy for COPD – Researchers conducted an early, open-label clinical trial of autologous P63+ lung progenitor cells for the treatment of patients with COPD. Primary Hypoimmune Islets in Non-Human Primates – Hypoimmune pseudo-islets engraft and achieve insulin independence in a fully allogeneic monkey. Modeling Proteinopathies in Neural Stem Cells – Scientists developed a model of neural networks to study ALS and frontotemporal lobar degeneration. An Interactive Cardiomyocyte Exhibit – In a museum exhibit, visitors can synchronize live stem cell-derived cardiomyocytes’ beat rate to their own heartbeat in real time. Image Courtesy of Dr. Ritu Raman Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Feb 6, 2024 · 1 hr 24 min
Ep. 260: “Synchronized Tissue Regeneration” Featuring Dr. Shiri Gur-Cohen
Guest: Dr. Shiri Gur-Cohen is an Assistant Professor of Medicine in the Division of Regenerative Medicine at UC San Diego. Her lab studies epithelial stem cells throughout their lifetimes. She talks about lymphatics in the intestinal stem cell niche, 3D imaging techniques, and sharing her science with a wider audience. Featured Products and Resources: Submit your abstract for ISSCR 2024! Get updates about new mentorship content from STEMCELL. The Stem Cell Science Round Up Non-Invasive Organoid Monitoring – Flexible electronics enable chronic recording of cortical organoids for up to 120 days while preserving their morphology, cytoarchitecture, and cell composition. Human Neuronal Maturation – Researchers identified an epigenetic developmental program that sets the timing of human neuronal maturation. The Gut-Liver Axis and Intestinal Stem Cells – Liver-derived pigment epithelium-derived factor restrains intestinal stem cell proliferation. Recovery After Lung Infection – The TGF-β receptor 2 is important for lung endothelial cells to recover after injury due to influenza virus or SARS-CoV-2 infection. Image Courtesy of Dr. Shiri Gur-Cohen Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jan 23, 2024 · 1 hr 13 min
Ep. 259: “Regenerative Neurobiology” Featuring Dr. Malin Parmar
Guest: Dr. Malin Parmar is a Professor at Lund University and a New York Stem Cell Foundation – Robertson Investigator. Her research aims to understand cell fate specification in the developing brain and in human neural progenitor cells using cell-based models of neuronal differentiation. She talks about using assembloids to model the dopaminergic system, direct reprogramming somatic cells into induced neurons, and developing ESC-derived dopamine progenitor cells to treat Parkinson’s disease. Featured Products and Resources: Submit your abstract for ISSCR 2024 before February 14th! STEMdiff™ Neural Crest Differentiation Kit creates a serum-free medium for differentiation of hESCs and iPSCs to neural crest cells. The Stem Cell Science Round Up Fetal Brain Organoids – Human fetal brain organoids display cellular heterogeneity and can be expanded. SARS-CoV-2 in the Brain – hPSC-derived dopaminergic neurons are susceptible to SARS-CoV-2 infection. Conjuctiva Organoids – Human conjunctiva organoid cultures enable the study of conjunctival (patho)-physiology. Zebrafish Heart Regeneration – Scientists identified epicardial enhancer elements with specific activity during zebrafish development or during adult heart regeneration. Photo Reference: Courtesy of Dr. Malin Parmar Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Jan 9, 2024 · 1 hr 16 min
Ep. 258: “The Musculo-Skeletal Axis” Featuring Dr. Olivier Pourquié
Guest: Dr. Olivier Pourquié is the Frank Burr Mallory Professor of Pathology and Professor in the Department of Genetics at Harvard Medical School. His work focuses on the segmentation clock and the development of muscles and vertebrae. He talks about studying somitogenesis in vitro and his work on brown fat development. Featured Products and Resources: Register now for ISSCR 2024! Derive and expand with MyoCult™-SF Expansion Medium. The Stem Cell Science Round Up A GENtoniK Cocktail – A small molecule cocktail accelerates the maturation of hPSC-derived neurons. Pancreatic Cancer Organoids – Researchers identified a compound that can inhibit the growth and induce cell death of pancreatic organoids carrying a KRAS mutation. Multilineage Mammary Organoids – Multilineage ESC-derived mammary organoids contain mammary-specific epithelial cells, fibroblasts, and adipocytes, and can produce milk. Chimeric Super-SOX – The Yamanaka cocktail upgraded with Sox2-17 enhanced iPSC generation in five species. Photo Reference: Courtesy of Dr. Olivier Pourquié Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Dec 12, 2023 · 1 hr 29 min
Ep. 257: “Retinal Regeneration” Featuring Drs. Hwee Goon Tay and Beau Fenner
Guests: Dr. Hwee Goon Tay is an Assistant Professor at the Duke-National University of Singapore Medical School and Dr. Beau Fenner is an Ophthalmologist at the Singapore National Eye Centre. Their work focuses on cell therapy for degenerative retinal diseases. They talk about strategies to slow degeneration and potentially restore vision. Featured Products and Resources: Enter to win up to $500 USD towards your registration fee for a cell and gene therapy conference. Explore STEMCELL Technologies’ resources on PSC quality. The Stem Cell Round Up A Hypoblast from hPSCs – Researchers used genetic and non-genetic approaches to generate authentic hypoblast cells from naïve hPSCs. Culture Conditions for Mouse and Monkey Stem Cells – Stem cell co-cultures reveal crosstalk between embryonic and extraembryonic lineages. Modeling Parkinson’s and Addiction – Scientists developed midbrain–striatum–cortical organoids that enable investigations into the human dopaminergic system. Multi-Chamber Cardioids – A human cardioid platform recapitulates the development of all major embryonic heart compartments. Photo Reference: Courtesy of Drs. Hwee Goon Tay and Beau Fenner Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Nov 28, 2023 · 1 hr 22 min
Ep. 256: “Epigenetics and Reprogramming” Featuring Dr. Jose Polo
Guest: Dr. Jose Polo is a Professor of Epigenetics and the Director of the Centre for Epigenetics at the University of Adelaide. He is also a Professor in the Department of Anatomy and Developmental Biology at Monash University. His lab studies the transcriptional and epigenetic mechanisms that govern cell identity. He talks about his team’s work on cell fate, iBlastoids, and placental models for SARS-CoV-2. Featured Products and Resources: Enter to win up to $500 USD towards your registration fee for a cell and gene therapy conference. Explore STEMCELL Technologies’ resources for organoid research. The Stem Cell Science Round Up A Chimeric Monkey – Scientists produced the first live-born chimeric non-human primate to have a high proportion of cells originating from donor stem cells. Norepinephrine Neurons – Researchers generated locus coeruleus norepinephrine neurons from human pluripotent stem cells, enabling the investigation of their roles in psychiatric and neurodegenerative diseases. Mice with Rat Hearts – Intraspecies blastocyst complementation generated a functional cardiovascular system in mice. Cancer Risk in Gene Therapy – Scientists identified genetic drivers that could increase leukemia risk in gene therapy trials for sickle cell disease. Photo Reference: Courtesy of Dr. Jose Polo Subscribe to our newsletter! Never miss updates about new episodes. Subscribe
Nov 14, 2023 · 1 hr 5 min
Ep. 255: “Pathway to the Clinic” Featuring Drs. Stefan Irion and Viviane Tabar
Guests: Dr. Stefan Irion is the Chief Scientific Officer of BlueRock Therapeutics and Dr. Viviane Tabar is the Chair of the Department of Neurosurgery at Memorial Sloan Kettering Cancer Center. In this special episode, recorded in front of a live audience in New York, they talk about their work on BlueRock’s clinical trial for bemdaneprocel — a stem cell-derived investigational cell therapy for Parkinson’s disease. They also discuss what’s next for cell therapy and diversity in science and in patients. Featured Products and Resources: Enter to win up to $500 USD towards your registration fee for a cell and gene therapy conference. Subscribe to our newsletter! Never miss updates about new episodes. Subscribe