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The Stem Cell Podcast

The Stem Cell Podcast

A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

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  • 357 episodes
  • Updated July 21

Episodes357

Newest first
  • May 13, 2025 · 1 hr 26 min

    Ep. 294: “HSC Development and Regulation” Featuring Dr. Margaret Goodell

    Guest: Dr. Margaret “Peggy” Goodell is the Vivian L. Smith Chair in Regenerative Medicine and Director of the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine. Her research focuses on HSC regulation and aging. She talks about her discovery of a side population of HSCs, as well as her work on DNMT3A mutation and clonal hematopoiesis of indeterminate potential. She also discusses the rich research environment in Houston. (42:41) Featured Products and Resources: Check out the program for ISSCR 2025! Enter to win a custom lab coat, personalized with your name! The Stem Cell Science Round Up Human Fetal Ventral Mesencephalic Transplantation – Patients with Parkinson’s disease treated with fetal tissue were assessed three years after surgery. (1:48) Mechanosensing Inhibition for Cardiac Fibrosis – Researchers identified a dual-drug strategy to combat cardiac fibrosis by targeting fibroblast mechanosensing pathways. (14:26) Patterning of Brain Organoids – Orthogonal WNTs/SHH gradients pattern organoids into forebrain, midbrain, and hindbrain. (26:11) Hepatocyte Organoid Expansion – Combined activation of Wnt and STAT3 signaling enables long-term self-renewal of human adult hepatocyte organoids. (34:22) Image courtesy of Dr. Margaret Goodell Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Apr 29, 2025 · 1 hr 31 min

    Ep. 293: “Cell Atlases” Featuring Dr. Sarah Teichmann

    Guest: Dr. Sarah Teichmann is a Member of the Department of Medicine and Professor of Stem Cell Medicine at the Cambridge Stem Cell Institute. She talks about the plasticity of different cell types and developing whole-organ cell atlases for organs such as the thymus. She also discusses the Human Cell Atlas project and overcoming skepticism in its early days. Finally, she talks about integrating computational with wet lab biology, and running an interdisciplinary research group. (43:30) Featured Products and Resources: Register now for ISSCR 2025! Enter to win an EasySep™ kit and magnet, cell culture reagents, and more by May 30th! The Stem Cell Science Round Up Parkinson’s Disease Cell Therapy Trials – Two trials confirm the safety of stem cell-derived dopaminergic neurons for Parkinson’s disease. (1:30) Multi-Zonal Liver Organoids – Researchers developed a self-assembling zone-specific liver organoid to evaluate hepatic zonal polarity. (13:23) Protein Delivery to the Brain – iPSC-microglia can be harnessed to provide a promising new cell therapy platform. (22:00) Blood Vessel Organoids – Transcription factor-based programming of blood vessel organoids promotes brain vasculature specificity. (33:33) Image courtesy of Dr. Sarah Teichmann Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Apr 15, 2025 · 1 hr 28 min

    Ep. 292: “Biomedical Ethics” Featuring Prof. Hank Greely

    Guest: Professor Hank Greely is the Deane F. and Kate Edelman Johnson Professor of Law and Professor, by courtesy, of Genetics at Stanford University. He is also the Director of the Stanford Center for Law and the Biosciences. He talks about his career path into bioethics and ethical considerations for organoids, bodyoids, and embryo models. He also discusses the potential future of reproduction, including gametogenesis, ectogenesis, and genetic selection and editing of embryos. (35:47) Featured Products and Resources: Register now for ISSCR 2025, happening June 11-15 in Hong Kong! Register now to complete a virtual training course on pluripotent stem cell quality and maintenance. The Stem Cell Science Round Up Somatosensory Assembloids – A four-part assembloid integrates somatosensory, spinal, thalamic and cortical organoids to model the spinothalamic pathway. (1:25) Neural Grafts for Parkinson’s Disease – Cloaked human neural grafts evade immune detection in humanized mouse model. (11:00) Neural Stem Cells Outside the Central Nervous System – Peripheral neural stem cells display features similar to brain neural stem cells, including the ability to differentiate into mature neurons. (19:00) Cell Therapy for Kidney Disease – Expanded hiPSC-derived nephron progenitor cells may be useful cell therapies for acute kidney injury and chronic kidney disease. (28:00) Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Apr 1, 2025 · 1 hr 25 min

    Ep. 291: “Functional Precision Medicine” Featuring Dr. Scott Younger

    Guest: Dr. Scott Younger is the Director of Disease Gene Engineering within the Genomic Medicine Center at Children’s Mercy Hospital. His research focuses on producing patient-derived cellular models to develop functional precision medicine. He talks about using personalized antisense oligonucleotides to reverse disease phenotypes in organoid models of Duchenne muscular dystrophy. He also discusses his lab’s personal connections to the rare disease community and the opportunities for collaborations with clinicians at Children’s Mercy. (36:52) Featured Products and Resources: Register now for ISSCR 2025! Learn more about organoid applications for studying human health. The Stem Cell Science Round Up Chronic Stress and Intestinal Stem Cells – Chronic impairs the stemness of intestinal stem cells via the vagal pathway. (1:43) Liver Regeneration – Glutamate metabolically reprograms bone marrow-derived macrophages, subsequently boosting liver regeneration. (9:40) CRISPR Activation in Embryo Models – CRISPR activation-programmed embryo models mimic the pre-gastrulation embryonic stage. (18:30) Retinal Regeneration – Human neural retinal stem-like cells in fetal retinas exhibit substantial self-renewal and differentiation potential. (27:45) Image courtesy of Dr. Scott Younger Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Mar 18, 2025 · 1 hr 22 min

    Ep. 290: “ISSCR 2025: Illuminating the Future” Featuring Drs. Valentina Greco, Kathryn Cheah, and Eugenia Piddini

    Guests: Dr. Valentina Greco is the President of the International Society for Stem Cell Research (ISSCR), and Professor of Genetics and Co-Chair of the Status of Women in Medicine at Yale University. Dr. Kathryn Cheah is an ISSCR Program Committee Co-Chair and Emeritus Professor and Chair of Biochemistry at Hong Kong University. Dr. Eugenia Piddini is also an ISSCR Program Committee Co-Chair and Professorial Research Fellow in Cell Biology and School Research Director at the University of Bristol. They talk about the upcoming ISSCR 2025 meeting in Hong Kong from June 11-14, 2025. They discuss the meeting’s global focus, program highlights, opportunities for early-career researchers, and what they’re looking forward to in Hong Kong. (37:44) Featured Products and Resources: Submit your abstract for ISSCR 2025! Wallchart: Reporting Practices for Publishing Results with hPSCs The Stem Cell Science Round Up Intestinal Organoids with Enteric Neurons – Researchers transplanted human intestinal organoids into mice, where the organoids matured and demonstrated enteric nervous system function. (2:10) Liver Regeneration and Repair – Hepatic stellate cells regulate hepatocyte functions via R-spondin 3. (11:00) Epithelial Regeneration – The mesenchymal Aspn-producing niche modulates tissue repair by regulating epithelial fetal-like reprogramming. (19:45) Whole-Transcriptome Sequencing – Spotiphy is a computational toolkit that transforms sequencing-based spatially resolved transcriptomics data into whole-transcriptome images with single-cell resolution. (28:55) Images courtesy of the ISSCR Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Mar 4, 2025 · 1 hr 26 min

    Ep. 289: “Heart-Forming Organoids” Featuring Dr. Robert Zweigerdt

    Guest: Dr. Robert Zweigerdt is a Principal Investigator at Hannover Medical School, where his lab focuses on cardiac differentiation and the scalable culture of PSCs. He talks about regulating the lineage-specific differentiation of hPSCs and generating heart-forming organoids that mirror developmental cardiogenesis. He also discusses the importance of mentorship and the benefits of an international research group. Featured Products and Resources: Register now for ISSCR 2025, taking place June 11-14 in Hong Kong! Use STEMCELL’s STEMdiff™ Cardiomyocyte media and supplements to differentiate, enrich, expand, and cryopreserve functional hPSC-derived cardiomyocytes. The Stem Cell Science Round Up Dissecting Mouse Embryo Models – Researchers used deep learning to classify and dissect the experimental variability of stem cell-derived embryo models. Human Brain Evolution – Scientists used CRISPR interference to characterize human accelerated regions of the human genome and their chimpanzee orthologues. Preventing Skin Scarring – Verteporfin, a YAP inhibitor, promotes scarless healing and wound regeneration in pigs. Modeling Pulmonary Fibrosis – Induced respiratory airway progenitors provide a model for idiopathic pulmonary fibrosis drug discovery and validation. Image courtesy of Dr. Robert Zweigerdt Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Feb 18, 2025 · 1 hr 22 min

    Ep. 288: “Cerebellar Organoids” Featuring Dr. Giorgia Quadrato

    Guest: Dr. Giorgia Quadrato is Assistant Professor of Stem Cell and Regenerative Medicine at the University of Southern California. Her research focuses on brain developmental and neural organoids. She talks about protocols for generating cerebellar organoids, including those with functional Purkinje cells. She also discusses a transcriptomic atlas of neural organoids and the stem cell research landscape in California. (34:52) Featured Products and Resources: Submit Your Abstract for ISSCR 2025! Register for a Free On-Demand Neural Induction Course. The Stem Cell Science Round Up Liver Cell Fate Plasticity – Researchers identified PROX1 as a safeguard to prevent liver tumorigenesis. (1:48) Hepatocyte Gene Editing – Repair Drive is a platform technology for selectively expanding homology-directed repair-corrected hepatocytes in adult mice. (10:05) Autologous Cell Therapy for Parkinson’s – An autologous phase I clinical trial is underway to treat eight Parkinson’s disease patients. (17:13) Brain Tumor Organoids – Individualized patient tumor organoids revealed drug response patterns and underlying resistance mechanisms in brain cancers. (26:54) Image courtesy of Dr. Giorgia Quadrato Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Feb 4, 2025 · 1 hr 29 min

    Ep. 287: “Blood Development” Featuring Drs. Andrew Elefanty and Elizabeth Ng

    Guests: Drs. Andrew Elefanty and Elizabeth Ng are Senior Principal Investigator and Principal Investigator, respectively, at the Murdoch Children’s Research Institute. In the Blood Development group, they aim to develop innovative cellular therapies for blood and cartilage-related diseases. They talk about their recent study deriving and transplanting HSCs, their work on reporter lines, and their collaborative lab setup. Featured Products and Resources: Register now for ISSCR 2025! Register: On-Demand Hematopoietic Course The Stem Cell Science Round Up Heart Repair – An engineered epicardial engineered heart muscle allograft remuscularized a human heart. (2:04) Causes of Preimplantation Failure – Single-embryo proteomics of poor-quality embryos provided insights into preimplantation development failure. (14:57) Imprinting Abnormalities in Mammals – Researchers targeted imprinting abnormalities at their source — embryos from same-sex parents. (25:54) Temperature-Controlled Cell Fate – Melt is a protein that reversibly clusters and translocates to the membrane in response to small temperature changes. (35:47) Image courtesy of Drs. Andrew Elefanty and Elizabeth Ng Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Jan 21, 2025 · 1 hr 24 min

    Ep. 286: “Neural Lineage Identity” Featuring Dr. Marius Wernig

    Guest: Dr. Marius Wernig is a Professor of Pathology and a Co-Director of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University, where his research interests include direct reprogramming and neurological disease modeling. He talks about his early work reprogramming neuronal cells from fibroblasts, adopting iPSCs, and growing his lab. He also discusses his recent research on cell therapy for brain and skin diseases, as well as his musical talents outside of the lab. (39:58) Featured Products and Resources: Register now for ISSCR 2025! STEMdiff™ Neural Crest Differentiation Kit The Stem Cell Science Round Up Transplanting a Pig Heart – Researchers transplanted a gene-edited porcine heart into a patient with heart failure. (1:53) Regeneration after Viral Infection – Using single-cell transcriptomics and lineage tracing, scientists examined mouse lung regeneration after influenza. (13:18) Human Brain Development – A new single-cell atlas sheds light on the molecular and cellular dynamics of the developing human neocortex. (21:38) The Nuclear Matrix in hSPCs – Heterogeneous nuclear ribonucleoprotein U promotes the primed state in hPSCs. (30:40) Image courtesy of Dr. Marius Wernig Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Jan 7, 2025 · 1 hr 31 min

    Ep. 285: “Funding the Future” Featuring Dr. Jonathan Thomas

    Guest: Dr. Jonathan Thomas “JT” is the President and CEO of the California Institute for Regenerative Medicine (CIRM), an organization that provides funding for stem cell research with the purpose of accelerating treatments for patients in need. He talks about working to ensure diversity in clinical trials and developing treatments that are affordable and accessible to patients. He also discusses the progress during the twenty years since CIRM’s inception, training the next generation of scientists, and balancing support for basic and clinical research. (41:03) Featured Products and Resources: Register now for ISSCR 2025 in Hong Kong! Cell Quality Attributes of Human Pluripotent Stem Cells The Stem Cell Science Round Up Regulating Naive Pluripotency – Scientists used a targeted rapid protein degradation system to show that GABPA is a master pluripotency regulator. (1:36) Skin Wound Healing – A spatiotemporal atlas of human skin wound tissues identifies FOSL1 as a critical driver of re-epithelialization. (11:50) Bone Marrow Stem Cell Niches – The bone marrow niche orchestrates hierarchy in stem cells and immune tolerance. (20:49) Synthetic Organizer Cells – Synthetic organizer cells self-assemble around stem cells and produce morphogens. (30:50) Image courtesy of Dr. Jonathan Thomas Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Dec 10, 2024 · 1 hr 22 min

    Ep. 284: “Organ Chip Engineering” Featuring Dr. Milica Radisic

    Guest: Dr. Milica Radisic is a Professor and Canada Research Chair at the University of Toronto. Her lab uses organ-on-a-chip engineering to mimic physiology of the heart, kidney, and vasculature for the purpose of modeling human disease and discovering more effective drugs. In this episode, she talks about the challenges of studying the heart and strategies to mature cardiomyocytes. She also discusses using macrophages to vascularize heart-on-a-chip platforms and enhance cardiac tissue function, sustainability considerations for microfluidic chips, and how these disease models can reduce the use of lab animals. Finally, she talks about starting a company to commercialize her lab’s cardiac chip platform, the landscape for women entrepreneurs, and advice from her mentor, Dr. Bob Langer. Featured Products and Resources: Webinar: Modeling Arrhythmias Using hPSC-Derived Cardiomyocytes and Tracking Their Excitability Differentiate hPSCs using STEMdiff™ Ventricular Cardiomyocyte Differentiation Kit. The Stem Cell Science Round Up Human Fetal Pancreas Development – A human fetal tripotent stem/progenitor cell can expand in vitro and can generate all three pancreatic cell lineages. Hematopoiesis over the Human Lifespan – Researchers profiled individual transcriptome states of human hematopoietic stem and progenitor cells spanning gestation, maturation, and aging. Intestinal Homeostasis – Intestinal stem cell PIEZO channels sense changes in stiffness and stretching, which controls stem cell behavior. Cancer Risk in Aging – Aging of stem cells reduces their potential for tumorigenesis. Image courtesy of Dr. Milica Radisic Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Dec 3, 2024 · 1 hr 30 min

    Ep. 283: “Molecular Hematopoiesis” Featuring Dr. Cynthia Dunbar

    Guest: Dr. Cynthia “Cindy” Dunbar is National Institutes of Health (NIH) Distinguished Investigator and Chief of the Translational Stem Cell Biology Branch at the National Heart, Lung, and Blood Institute of the NIH. She talks about using macaques to study hematopoiesis and aging, and the challenges and considerations for using these models. She also discusses her collaborative study transplanting iPSC-derived cardiomyocytes into rhesus macaques, as well as the NIH’s unique research environment and her musical talents outside of the lab. Featured Products and Resources: Cell Quality Attributes of Human Pluripotent Stem Cells Free Wallchart: Directed Differentiation of ESCs and iPSCs The Stem Cell Science Round Up Enhancers in Neurogenesis – INST10 promotes epigenetic changes and transcription factor binding at enhancers that drive neural cell fate commitment. Hepatoblastoma Organoids – Researchers studied the molecular and drug sensitivity landscapes of hepatoblastomas and tumor-derived organoids. Sea Anemone Regeneration – In Nematostella vectensis, local regeneration triggers a systemic homeostatic response, leading to coordinated whole-body remodeling. iPSC-Derived Human Venous Endothelial Cells – Scientists developed a model of vascular malformations and identified potential drug treatments. Image courtesy of Dr. Cynthia Dunbar Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Nov 26, 2024 · 1 hr 34 min

    Ep. 282: “Whole-Body Regeneration” Featuring Dr. Mansi Srivastava

    Guest: Dr. Mansi Srivastava is Professor of Organismic and Evolutionary Biology at Harvard University and Curator of Invertebrate Zoology at the Harvard Museum of Comparative Zoology. Her lab uses distantly related species to study evolution and regeneration. She talks about establishing Hofstenia miamia, or the three-banded panther worm, as a model system. She also discusses her lab’s work on adult stem cell lineage tracing and whole-body regeneration in Hofstenia, as well as her scientific outreach efforts. Featured Products and Resources: Get a free wallchart on the directed differentiation of hPSCs. STEMdiff™ Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells. The Stem Cell Round Up Corneal Cell Therapy – Researchers used human iPSC-derived epithelial cell sheets to repair the corneas of patients with limbal stem cell deficiency. A Vascular Atlas – A vascular cell atlas identifies angiotypic and organotypic characteristics of endothelial and mural cells. Transcription Factors Before Animal Evolution – Sox and POU transcription factors emerged before the origin of animals. NODAL Signaling in Embryo Development – NODAL signaling is active in the human blastocyst, but is not required to initiate or maintain the pluripotent epiblast. Image courtesy of Dr. Mansi Srivastava Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Nov 12, 2024 · 1 hr 29 min

    Ep. 281: “Fertility Treatments” Featuring Drs. Dina Radenkovic and Bruna Paulsen

    Guest: Drs. Dina Radenkovic (now Dina Turner) and Bruna Paulsen are Co-Founder & CEO and VP of Manufacturing and Therapeutic development at Gameto, a biotech company developing treatment solutions to improve women’s reproductive health. Their lead platform, Fertilo, uses ovarian support cells to mature oocytes outside of the body with the goal of making IVF and egg freezing shorter, safer, and more effective. Featured Products and Resources: Learn more about organoid applications for studying human health with STEMCELL’s “Dynamic Modeling in Organoids” Wallchart. Generate functional fallopian tube organoids in 10 days with GyneCult™. The Stem Cell Science Round Up: Sleep Speeds Healing – Immune cells that promote sleep are recruited to the brain after myocardial infarction. Epigenetic Regulators of iPSC-T Cell Differentiation – CAR iPSC-T cells derived via G9a/GLP inhibition display enhanced antitumor activity. Minimizing Off-Target Toxicity – Researchers identified carbonic anhydrase 12 as a druggable target for doxorubicin-induced cardiotoxicity. Cell Division in Differentiation – Researchers have shown that cell state transitions are decoupled from cell division during early embryo development. Images courtesy of Drs. Dina Radenkovic and Bruna Paulsen Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Oct 29, 2024 · 1 hr 24 min

    Ep. 280: “Liver Regeneration” Featuring Dr. Meritxell Huch

    Guest: Dr. Meritxell Huch is a Scientific Director at the Max Planck Institute of Molecular Cell Biology and Genetics and an Honorary Professor at the Technical University of Dresden. Her research focuses on liver and pancreas organoid models. She discusses a protocol for liver mesenchyme and ductal cell organoid co-culture and generating bipotent stem cells from the liver. She also tells her story of moving throughout Europe to pursue her scientific passions. Featured Products and Resources: Keep current with the latest in hepatic cell news. Establish and maintain mouse hepatic progenitor organoids with HepatiCult™. The Stem Cell Science Round Up A Zebrafish Developmental Atlas – Zebrahub is a transcriptional and spatiotemporal resource of zebrafish development. Fertilization in Zebrafish and Humans – A conserved sperm complex binds to divergent egg proteins in mice and mammals to mediate sperm-egg interaction. Dedifferentiation and Limb Progenitors – Chemically-induced dedifferentiation generates progenitor-like cells similar to human embryonic limb bud progenitors. Yamanaka Factors in Neurodegeneration – Scientists induced Yamanaka factors in a mouse model of Alzheimer’s disease. Image courtesy of Dr. Meritxell Huch Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Oct 22, 2024 · 1 hr 27 min

    Ep. 279: “Direct Reprogramming” Featuring Dr. Samantha Morris

    Guest: Dr. Samantha Morris is an Associate Professor of Medicine at Brigham and Women’s Hospital and Associate Professor of Systems Biology at Harvard Medical School. She talks about dissecting and manipulating the genetic pathways that regulate cell identity. She discusses tools to measure cell fate transitions and incorporating in silico and in vitro experiments. Featured Products and Resources: Get a free wallchart on the derivation and applications of hPSCs. Take your human pluripotent stem cell cultures further with mTeSR™ Plus. The Stem Cell Science Round Up A Prenatal Skin Atlas – A skin atlas revealed that crosstalk between non-immune and immune cells underpins the formation of hair follicles. Human Pancreatic Differentiation – Researchers used single-nucleus RNA sequencing to characterize the human fetal pancreatic microenvironment. A Cardiac Fibrosis Therapeutic Target – High-throughput screening in iPSC-derived cardiac fibroblasts identified MD2 as a therapeutic target for cardiac fibrosis. Mammalian Gastrulation – Scientists identified a link between the pathways that produce energy for embryo growth and the systems that regulate cell specialization. Image courtesy of Dr. Samantha Morris Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Oct 15, 2024 · 1 hr 31 min

    Ep. 278: “Stembryo Engineering” Featuring Dr. Alfonso Martinez Arias

    Guest: Dr. Alfonso Martinez Arias is the CREA Research Professor in the Department of Systems Bioengineering of the Universitat Pompeu Fabra in Barcelona. He talks about his path to developmental biology research and developing gastruloids to model human development. He also discusses standards for embryo models and his recent research on hematopoiesis. Featured Products and Resources: Keep current with the latest ESC and iPSC news. Wallchart: Reporting Practices for Publishing Results with hPSCs The Stem Cell Science Round Up Tuft Cell Regeneration – Human tuft cells can survive irradiation damage and retain the ability to generate all other epithelial cell types. Heart-Forming Organoids – hPSC-derived heart-forming organoids recapitulate aspects of heart, vasculature, and foregut co-developments. Neural Stem Cell Aging – A CRISPR screen revealed genetic interventions that boost the function of old neural stem cells. Symmetry Breaking in Gastruloids – Researchers used synthetic ‘signal-recording’ gene circuits to trace the evolution of signaling patterns in gastruloids. Image courtesy of Dr. Alfonso Martinez Arias Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Oct 1, 2024 · 1 hr 14 min

    Ep. 277: “Lung Development” Featuring Dr. Behzad Yeganeh

    Guest: Dr. Behzad Yeganeh is an Associate Scientist at the Children’s Hospital of Eastern Ontario Research Institute and the University of Ottawa. His work focuses on lung development and injury. He talks about neonatal lung diseases and the mechanisms that regulate autophagy and apoptosis. Featured Products and Resources: Keep current with the latest in pulmonary cell news. Model the human respiratory system in vitro with PneumaCult™. The Stem Cell Science Round Up Cell Therapy for Type 1 Diabetes – Chemically induced PSC-derived islets were transplanted into a patient and led to insulin-independent glycemic control. Giant Panda iPSCs – Primary fibroblast cells were isolated from the giant panda and used to generate iPSCs. Pausing Blastocyst Development – Human blastoids under mTOR inhibition show a diapause-like response. Sustaining Epithelial Cultures – Epithelioids are a facile, cost-effective method of culturing multiple mouse and human epithelia Image courtesy of Dr. Behzad Yeganeh Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Sep 17, 2024 · 1 hr 37 min

    Ep. 276: “Musculoskeletal Disorders” Featuring Dr. Dmitriy Sheyn

    Guest: Dr. Dmitriy Sheyn is an Associate Professor in the Department of Orthopedics and Regenerative Medicine Institute at Cedars-Sinai Medical Center. His lab focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. He talks about ways to model disc degeneration and tendon injuries. He also discuses his lab’s work on tendon differentiation and the mechanisms of low back pain. Featured Products and Resources: Keep current with the latest in muscle cell news. Expand, maintain, and differentiate skeletal muscle progenitor cells with MyoCult™. The Stem Cell Science Round Up Skin Transparency for Live Imaging – Researchers used tartrazine to make the skin of a live rodent temporarily transparent. Muscle Regeneration – Scientists generated satellite cells from skeletal muscle tissue and transplanted them into mouse muscle. Cardiac Assembloids – Scientists used PSC-derived cardiac assembloids to model the atrioventricular conduction axis and study complex disorders affecting heart rhythm. Yamanaka Factors and Cellular Senescence – Partial cellular reprogramming improved health markers in mouse models of aging. Image courtesy of Dr. Dmitriy Sheyn Subscribe to our newsletter! Never miss updates about new episodes. Subscribe

  • Sep 3, 2024 · 1 hr 11 min

    Ep. 275: “Liver Organogenesis” Featuring Dr. Ludovic Vallier

    Guest: Dr. Ludovic Vallier is the W3 Einstein Strategic Professor for Stem Cells in Regenerative Therapies at the Berlin Institute of Health and a Max Planck Fellow at the Max Planck Institute for Molecular Genetics. His lab uses stem cells to model embryonic development in vitro and to produce liver cells with an interest for cell therapy. He talks about modeling non-alcoholic fatty liver disease and his lab’s pivot to SARS-CoV-2 research early in the pandemic. He also discusses how iPSCs could be used to regenerate the liver after injury. Featured Products and Resources: Keep current with the latest in hepatic cell news. Establish and maintain hepatic organoids with HepatiCult™. The Stem Cell Science Round Up Enhancing Compatibility in Interspecies Chimeras – Researchers used nanobody-antigen interactions to increase the chimerism of human PSCs in mouse embryos. Single-Nucleotide RNA Sequencing for Brain Aging – Scientists uncovered different cellular trajectories and cell communities in Alzheimer’s disease and normal aging. Glial Cells in Multiple Sclerosis – iPSC-derived multiple sclerosis models provide a unique platform for dissecting glial contributions to disease phenotypes. Organoids to Model Spinal Trigeminal Nucleus Development – Scientists differentiated hPSCs into region-specific brain organoids. Image courtesy of Dr. Ludovic Vallier Subscribe to our newsletter! Never miss updates about new episodes. Subscribe