Solving the Puzzle with Dr. Datis Kharrazian

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases.

Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.

His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life.

Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available.

You can find more information at drknews.com.

Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian.

Hosted on Acast. See acast.com/privacy for more information.

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Wednesday · 26 min
Episode 102: Using AI to Build Practical Functional Medicine Care Plans
AI can process enormous amounts of clinical information in seconds, but it has never seen a patient, built a clinical relationship, or developed clinical judgment through experience. This episode examines how AI can support treatment planning without replacing the clinician’s reasoning. Enroll now in: Clinical Applications of AI: A Competency-Based Masterclass for Integrative and Functional Medicine Practitioners, with Sunjya Schweig, MD at https://pages.kharrazianinstitute.com/schweig-ai-functional-medicine TIMESTAMPS: 00:00 Analyzing sleep data with custom GPT 03:05 Iterative refinement with AI 07:34 Creating a Fast Food Diet Plan 10:30 Evaluating AI in Clinical Diagnosis 16:23 AI's impact on clinical expertise 20:06 AI error vigilance in clinical notes 22:27 Discussing AI in clinical practice 25:26 Outro and resources for listeners Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
August 26 · 43 min
Episode 101: Navigating Functional Medicine in a Small Town with Dr. Edling
In today’s Practitioner Spotlight, we speak with Dr. Edling, a seasoned chiropractor and functional medicine practitioner from the small town of Osceola, Wisconsin. With over 20 years of experience integrating functional medicine into a rural practice, he shares the unique challenges and rewards of serving a close-knit community with limited resources, from adapting care to meet patients’ financial constraints to the importance of ongoing learning and genuine relationships. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians. If you're not a clinician, look for functional medicine patient courses at drknews.com. TIMESTAMPS: 00:00 Chiropractic and functional medicine journey 05:03 Mentoring young football coaches 06:37 Candidate selection and burnout discussion 10:03 Functional neurology focus and family 15:45 Discussing patient follow-through and rehab 18:32 Reflecting on Krause Experiences 21:01 Explaining the upstream health model 24:08 Family vacation and gluten challenge 26:59 Helping patients with financial struggles 32:43 Focus on personal health and fitness 35:07 Recovering from a major accident 39:27 Collaborating with Committed Clients 43:10 Encouragement for practitioners 45:33 Outro and program offerings Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
August 24 · 38 min
Episode 100: Understanding GLP-1 Risks: Navigating the Complexities of Weight Loss Medications
GLP-1 medications, widely celebrated for their ability to break the cycle of metabolic syndrome, obesity, and diabetes, are not without risks and lesser-known downsides. Dr. Kharrazian explains the long-term effects of a constant catabolic state, including its impact on muscle mass, digestion, motivation, and overall longevity. Interviewed by Elaine Marshall. Want the most comprehensive functional medicine training? Start your seven-day free trial at kharrazianinstitute.com and access over 300 hours of clinical training with Dr. Kharrazian and leading functional medicine clinicians. If you're not a clinician, look for functional medicine patient courses at drknews.com. TIMESTAMPS: 00:00 Impact of GLP-1s on Recovery 06:44 Importance of antioxidants for longevity 08:46 Impact of GLP-1 on Digestion 13:53 Impact of GLP-1s on Sleep 16:23 Challenges in hormonal health 18:40 Breaking the sugar-craving cycle 21:57 Preventing Muscle Loss While Fasting 27:55 Understanding SIBO and gut health 31:13 Galleri and cancer screening tests 33:43 Psychological impacts of body image 34:58 Insulin's Role in Autoimmune Response 38:02 Consult Your Healthcare Provider Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
August 14 · 29 min
Episode 99: Rewiring Unhealthy Behaviors in Functional Medicine
Today, David Musnick dives into the science and art of assessing and changing health habits. From identifying the unconscious routines that sabotage our wellness to learning practical strategies for breaking unhealthy patterns and stacking new positive behaviors, this episode guides practitioners and patients alike through the step-by-step process of lasting habit transformation. We explore powerful tools like environmental modifications, emotional awareness, tapping techniques, and structured rewards, plus, learn how mindset and self-talk play a pivotal role in overcoming obstacles and reaching health goals. Enroll now in: Attitudes, Limbic System, and Mind-Body Influence on Functional Medicine Outcomes, with David Musnick, MD at https://pages.kharrazianinstitute.com/musnick-mind-body TIMESTAMPS: 00:00 Identifying unhealthy habits 04:38 Discussing bad habits and solutions 07:41 Suggesting healthier morning routines 11:50 Identifying emotions to break habits 14:50 Using tapping and NLP for change 17:36 Establishing Healthy Habits with Rewards 19:16 Visualizing obstacles and successes 24:23 Nighttime eating and emotional triggers 27:11 Applying habits to health 28:45 Promoting health courses and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
August 5 · 26 min
Episode 98: Rewiring Your Mind: How Cognitive Distortions and Labeling Block Healing
In today’s episode, David Musnick dives into the concept of cognitive distortions, those faulty ways of thinking that can hold us back from healing and create barriers in our health journeys. Drawing on the influential work of Dr. David Burns, Dr. Musnick breaks down the most common cognitive distortions like negative forecasting, black-and-white thinking, labeling, and catastrophizing. You'll learn how these thought patterns manifest in patients, the impact they have on outcomes, and, most importantly, practical strategies to identify and counteract them in clinical practice or your own life. Enroll now in: Attitudes, Limbic System, and Mind-Body Influence on Functional Medicine Outcomes, with David Musnick, MD at https://pages.kharrazianinstitute.com/musnick-mind-body TIMESTAMPS: 00:00 Identifying negative thought patterns 03:51 Explaining negative forecasting 10:07 Dealing with side effects and positivity 10:46 Addressing healthcare catastrophizing 16:20 Positive self-talk exercise 18:59 Relabeling knees for better mindset 20:59 Using cognitive techniques for pain management 25:02 Podcast ending and resources offered Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
July 29 · 27 min
Episode 97: Key Steps to Help Patients Navigate Complex Functional Medicine Protocols
In this episode, we establish effective priorities and clear communication with patients to reduce overwhelm, improve compliance, and achieve better outcomes, especially when managing chronic health, gut, brain, or autoimmune conditions. We’ll explore strategies for setting mutually agreed priorities, communicating the reasons and duration for supplements and lab tests, and factoring in the mind-body connection, including habits, attitudes, and self-talk that impact results. Enroll now in: Attitudes, Limbic System, and Mind-Body Influence on Functional Medicine Outcomes, with David Musnick, MD at https://pages.kharrazianinstitute.com/musnick-mind-body TIMESTAMPS: 00:00 Assessing patient hope and understanding 06:01 Prioritizing Symptoms on First Visit 09:26 Discussing lab test costs upfront 11:38 Discussing food allergy testing options 15:12 Scheduling and preparing follow-up visits 20:05 Discussing Patient Supplement Guidance 22:52 Discussing patient supplement instructions 24:31 Timing and staging supplements Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
July 22 · 31 min
Episode 96: Diet, Sleep & Circadian Rhythm for Fatigue Syndromes
In this episode we dive into the metabolic and lifestyle foundations that drive chronic fatigue, ME/CFS, and energy dysfunction. Blood sugar stabilization is covered in depth, from managing hypoglycemia and insulin resistance to the role of ketogenic nutrition in difficult cases that have not responded to other approaches. We also look at hydration and electrolyte balance as an underappreciated piece of cellular energy production, and walk through practical sleep strategies including weighted blankets, white noise, mouth taping, and building a consistent sleep routine. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. TIMESTAMPS: 00:00 Discussing blood sugar and energy levels 06:17 Ketogenic diet benefits for ME/CFS 10:16 Getting started with intermittent fasting 12:01 Intermittent fasting and autophagy benefits 15:40 Hydration and fatigue management tips 18:58 Addressing sleep hygiene basics 23:14 Benefits of weighted blankets and calming aids 27:14 Improving sleep for chronic fatigue 30:00 Promoting educational health resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
July 15 · 36 min
Episode 95: The Truth About Hormone Replacement Therapy for Cardiovascular and Cognitive Health
In this episode, Randy Vawdrey dives into the world of hormone optimization, challenging decades of conventional wisdom that has stigmatized hormone therapy, especially for women. You'll hear an evidence-based exploration into the role hormones like DHEA, estrogen, progesterone, and testosterone play in cardiovascular prevention, brain health, and longevity. We’ll unpack landmark studies, expose misconceptions rooted in outdated research, and share powerful stories and expert interviews that reveal how proper hormone management can transform lives. Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardio TIMESTAMPS: 00:00 Understanding DHEA and DHEA-S 04:04 DHEA and cardiovascular health 08:05 DHEA's role in heart disease 12:24 Using DHEA for better health 14:31 Discussing hormone treatments 16:14 The impact of 2001 study 21:39 Debunking hormone replacement myths 25:19 FDA's stance on hormone therapy 27:03 Doctor's views on hormone therapy 30:21 Prescribing BHRT to older patients 35:13 Closing remarks and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
July 7 · 21 min
Episode 94: The Truth About Cholesterol, CAC Scores, and Heart Attack Risk
In today’s episode, Randy Vawdrey dives into cardiovascular prevention with a special focus on coronary artery calcium (CAC) testing. He guides us through why traditional cardiovascular risk factors like LDL cholesterol, HDL, and BMI may not be as predictive of heart attack risk as once thought, and how CAC scores can provide a much clearer picture. You'll hear about the latest research, practical steps for interpreting CAC scores, and the lifestyle and supplemental interventions that can help halt the progression of cardiovascular disease. Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardio TIMESTAMPS: 00:00 Discussing cardiac risk assessment factors 05:50 Predictive value of CAC scores 07:17 Understanding Agatston scores 10:22 Boulder cardiologist's health tips 13:52 Discussing methylfolic acid and statins 16:42 Managing stress with coronary scores 20:17 Podcast sponsor shout-out and disclaimers Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
July 2 · 24 min
Episode 93: Optimizing Omega 3 Levels for Brain and Heart Health
Today, we’re diving into the world of Omega 3 fatty acids with Randy Vawdrey, NP-C. He unpacks why they are so critical for brain and cardiovascular health, how dietary patterns and supplement choices can make or break your Omega 3 levels, and what the latest research tells us about optimal dosing and safety. Whether you're a clinician, health professional, or simply looking to optimize your own well-being, this episode will help you understand the science behind fatty acid ratios, how to properly interpret lab values, and the importance of choosing the right kind of supplementation. Enroll in the Master Class: Preventive Cardiology: Comprehensive & Integrative CV Risk Reduction with Randy Vawdrey, NP-C at https://pages.kharrazianinstitute.com/vawdrey-cardio 00:00 Omega 3s and cell membranes 05:37 Rise of Seed Oils in America 07:54 Omega 6:3 ratio in veterans 12:10 Understanding omega-3 sources and protocol 16:20 Omega 3 absorption discussion 17:14 Discussing Omega 3 dosage recommendations 22:03 Discussing Omega 3 supplements 23:34 Promoting online courses and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
June 23 · 26 min
Episode 92: Understanding Chronic Pain and Fatigue
Today, we’re diving into the enigma of chronic pain and fatigue. Dr. Kharrazian unpacks the science and physiology behind pain, revealing that it’s not simply a sensory experience but an intricate interaction between our nerves, brain, and even our emotions. From explanations of hyperalgesia and allodynia to the crucial role the limbic system and amygdala play in amplifying or diminishing our experience of pain, this episode bridges the gap between what’s happening beneath the surface and practical strategies for those suffering from ongoing discomfort. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 Understanding pain and sensitization 04:19 Understanding brain-based pain signals 08:28 Understanding referred pain mechanisms 12:02 Triggers and amplification of pain 15:07 Explaining gait control theory 17:07 How the sympathetic system works 22:08 Understanding central pain syndromes 25:06 Closing and listener resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
June 16 · 42 min
Episode 91: Managing Musculoskeletal Symptoms in Menopause
In this episode, Leslie Fuller, ND focused on the often-overlooked musculoskeletal symptoms experienced by women during perimenopause and menopause. She discusses strategies for effective management, including nutrition, resistance training, hormone assessment, and addressing both structural and functional health. This episode offers healthcare professionals and patients evidence-based approaches to support musculoskeletal health through the menopausall transition. Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause 00:00 Menopause-related musculoskeletal issues 06:32 Assessing musculoskeletal conditions 10:25 Identifying osteoporosis risk factors 13:48 Comprehensive management for inflammation repair 15:07 Discussing menopause and bone health 18:48 Future FDA approval and nutrition strategies 24:30 Effects of Isoflavones and Lignans 25:40 Calcium and vitamin D benefits 31:14 Creatine and CoQ10 for muscle health 33:42 Importance of aerobic and resistance training 38:13 Combating sarcopenia through referrals 39:17 Screening for menopausal musculoskeletal syndrome Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
June 9 · 32 min
Episode 90: GSM Essentials for 2025: Top Treatment Updates, Safety Guidance, and Patient Impact
In this episode, Jillian Moehle focused on the latest evidence-based strategies for recognizing and treating Genitourinary Syndrome of Menopause (GSM). She explored newly updated guidelines from the American Urological Association, emphasizing the importance of proactive screening, a comprehensive approach to patient history, and the range of therapeutic options available, from non-hormonal treatments like moisturizers and lubricants, to hormone-based therapies including low-dose vaginal estrogen. Several points were raised, including safety considerations, the removal of the FDA black box warning on vaginal estrogen, and the crucial role of pelvic floor health in patient outcomes. Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause 00:00 Vaginal treatment recommendations and concerns 05:26 Discussing hormone therapy alternatives 08:13 Treatment options for vaginal health 13:16 FDA removes black box warning 15:24 Support for vaginal estrogen use 18:13 Using GoodRx and applying cream 22:00 Possible side effects and management 24:54 Impact of GSM on women's health 30:59 Podcast outro and resources sharing Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
June 2 · 18 min
Episode 89: Why Millions of Women Were Failed by the Women’s Health Initiative Study
In this episode, we’re diving into the complex and often misunderstood topic of menopause and perimenopause. Despite affecting every woman who lives into late life, menopause has long been underfunded, understudied, and minimized both culturally and medically. Today, we’ll explore why clinical care for women in the menopause transition has lagged behind, examining the deep historical roots of gender bias in research, the fragmentation of women's healthcare, and the profound impact of the Women’s Health Initiative (WHI) study, which triggered decades of fear and misinformation about hormone therapy. Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause 00:00 Historical oversight in menopause care 06:00 Women's Health Initiative study flaws 08:29 Impact of WHI study miscalculation 10:28 Misinterpretation of breast cancer risks 13:44 Correcting hormone therapy myths 17:23 Podcast resources and educational courses Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
May 28 · 32 min
Episode 88: Hormone Therapy, Breast Cancer, and Menopause
In today's episode, Dr. Mark Holthouse dives into the fears surrounding breast cancer and hormone replacement therapy, separating myth from evidence with a critical look at the real data. Our expert speaker unpacks the latest clinical trials and position statements, clarifying the nuanced relationship between various hormone therapies and breast cancer risk. We’ll explore what the research says about synthetic versus bioidentical hormones, address common patient concerns, and provide actionable insights for risk assessment and individualized care. This episode delivers an integrative approach to hormone therapy and breast cancer, bridging the gap between scientific literature and real-world practice. To enroll in the Sex Steroid Optimization Master Class with Dr. Mark Holthouse, go to https://pages.kharrazianinstitute.com/holthouse-hormone To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 WHI study on hormone therapy 04:45 Hormone therapy risks discussion 07:58 Discussing natural vs synthetic HRT 13:11 Transdermal hormone therapy studies 17:55 Rethinking full-fat dairy for women 21:11 Time restricted eating for women 22:57 Assessing breast cancer risk 25:30 Understanding genetic risk factors 29:37 Evaluating breast cancer risk factors Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
May 20 · 28 min
Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health
In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue. We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You’ll discover why bagfuls of supplements aren’t enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. 00:00 Factors affecting mitochondrial function 03:55 Optimizing patient bioenergetics basics 09:27 Mitochondria and cell evolution 12:33 Focus on acquired mitochondrial dysfunctions 14:23 Mitochondrial ATP production process 20:22 Ketogenic diet and energy pathways 21:15 Ketogenic diet for chronic fatigue 27:02 Exploring functional medicine resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
May 5 · 30 min
Episode 86: Oral and Injectable Peptides for Recovery
In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, Lorazatide, TB4, and PeptiStrong, sharing case studies and practical strategies for supporting gut health, autoimmune recovery, muscle maintenance, and post-injury healing. Whether you're a healthcare practitioner, a certified nutritionist, or simply looking for ways to optimize your health, this episode bridges complex science with practical solutions you can implement today. Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Benefits and side effects of oral bpc 04:37 Addressing complex digestive issues 08:35 Managing gut inflammation 11:53 Using Pepti Strong for healing 15:15 Discussing growth hormone peptides 17:55 Growth hormone and cognitive function 20:38 Recognizing and managing drug reactions 26:00 Using peptides for post-op recovery 29:11 Podcast outro and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
April 29 · 32 min
Episode 85: Transforming Autism Care with Nutrigenetics and Methylation Pathways
In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient support can unlock profound change. We’ll explore personalized approaches from thought leaders like Amy Yasko, Ben Lynch, William Walsh, and Bob Miller, discussing practical protocols for methylation, balancing minerals, and managing inflammation. Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Balancing neurochemicals in children 04:16 Starting folate and B12 supplementation 07:00 Discussing William Walsh's approach 10:41 Understanding methylfolate tolerance 15:31 Patients help promote our practice 18:54 Genetic mutations and food sensitivity 23:19 Learning about methylation pathways 23:58 Evaluating a child's diet and genes 29:56 Discussing toxic exposures and genetics 31:06 Podcast resources and final thoughts Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
April 21 · 27 min
Episode 84: Exploring Oxidative Stress, GST Genes, and Hormonal Detox Strategies
In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance. Whether you're a healthcare professional seeking to advance your knowledge or an individual looking to understand the science behind fatigue, hormone imbalance, and detoxification, this episode bridges the gap between complex genetics and actionable solutions. Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Identifying high hydrogen peroxide symptoms 03:06 Addressing brain fog and fatigue 08:11 Combating jet lag with supplements 12:01 Understanding hormone breakdown genetics 13:36 Finasteride side effects and solutions 19:18 Importance of Selenium and Zinc 21:10 Initial treatment and Dutch test results 25:50 Podcast resources and disclaimers 26:53 End of the episode reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.
April 14 · 31 min
Episode 83: The Functional Anatomy of Pain
In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception. We’ll break down how the brain interprets, localizes, and emotionally responds to pain, revealing the roles of the somatosensory cortex, amygdala, insular cortex, and other regions. Discover why pain isn’t always proportional to tissue damage and how psychological and physiological variables, including mood and limbic system activation, shape your experience. Whether you're a healthcare professional, nutritionist, or someone managing chronic pain, this episode bridges scientific insight with practical understanding, helping you see pain from a whole new perspective. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required. ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Understanding types of pain 04:57 How mood affects pain perception 08:02 Why visceral pain feels external 12:04 How pain signals are amplified 15:58 How pain is blocked 19:44 How the brain processes pain 22:12 Understanding central pain syndromes 26:01 Explaining brain pathways for pain 30:06 Podcast outro and resources 31:09 Closing message and reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

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