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Health & FitnessMedicine

Physionic

Nicolas Verhoeven

I translate health studies for the public - from 'the macro to the micro'.

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  • 38 episodes
  • a few times a week
  • Avg 1 hr 3 min
  • English

Episodes 38

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  • Monday · 7 min

    These Two Molecules are Pushing Anti-Aging Science Forward!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderAnti-Aging Series: https://www.youtube.com/playlist?list=PLwiri7XRU2i-HLExt7W-5qp_z2tIP_UvU0:00 - Introduction0:55 - Senolytics: An Advanced Future3:44 - Bone, Kidneys, Liver, and…5:57 - Molecules and ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1093] Hickson LJ, Langhi Prata LGP, Bobart SA, et al. Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMedicine. 2019;47:446–456. doi:10.1016/j.ebiom.2019.08.069.[Study 1094] Farr JN, Atkinson EJ, Achenbach SJ, et al. Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial. Nat Med. 2024;30:2605–2612. doi:10.1038/s41591-024-03096-2.[Study 1095] Justice JN, Nambiar AM, Tchkonia T, et al. Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554–563. doi:10.1016/j.ebiom.2018.12.052.[Study 1096] Martyanov V, Whitfield ML, Varga J. Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response? Arthritis Rheumatol. 2019;71(10):1766–1767. doi:10.1002/art.40934.[Study 1097] Hambright WS, Duke VR, Goff AD, et al. Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes. Aging Cell. 2024;23. doi:10.1111/acel.14113.[Study 1098] Gao X, Roder J, Minas LT, et al. Effects of two fisetin dosing regimens on reducing senescence-related genes in peripheral blood mononuclear cells in aged humans. Preprints. Published online July 22, 2026. doi:10.20944/preprints202607.1685.v1.[Study 1099] Koning M, Kovynev A, Fondevila MF, et al. Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial. Nat Metab. 2026. doi:10.1038/s42255-026-01643-4.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • Saturday · 14 min

    ‘An Incredibly Common Food That Melts Clogged Arteries (Most Eat Them Wrong)’

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:08 - Artery Damage: Origin of Plaque?5:20 - Lycopene reduces Oxidation9:12 - A 'Healthy' Fat?9:50 - Cardiovascular Disease Outcomes and Plaque Reversal12:55 - Main PointsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Constantinides P, Harkey M. Ann N Y Acad Sci. 1990;598:113–124. DOI: 10.1111/j.1749-6632.1990.tb42283.x[2] Faggiotto A, et al. Arteriosclerosis. 1984;4:323–340. DOI: 10.1161/01.ATV.4.4.323[3] Huang L, et al. Nature. 2019;569:565–569. DOI: 10.1038/s41586-019-1140-4[4] Juul K, et al. Circulation. 1996;94:1698–1704. DOI: 10.1161/01.CIR.94.7.1698[5] Chang MY, et al. J Lipid Res. 2001;42:824–833. DOI: 10.1016/S0022-2275(20)31645-X[6] Story EN, et al. Annu Rev Food Sci Technol. 2010;1:189–210. DOI: 10.1146/annurev.food.102308.124120[7] Ghaffari MA, Ghiasvand T. J Food Biochem. 2011;35:228–240. DOI: 10.1111/j.1745-4514.2010.00378.x[8] Romanchik JE, et al. J Nutr Biochem. 1997;8:681–688. DOI: 10.1016/S0955-2863(97)00119-8[Study 592] Sesso HD, et al. J Nutr. 2003;133:2336–2341. DOI: 10.1093/jn/133.7.2336[Study 587] Zou ZY, et al. Br J Nutr. 2014;111:474–480. DOI: 10.1017/S0007114513002730[9] Schwab US, et al. J Nutr. 1998;128:1703–1709. DOI: 10.1093/jn/128.10.1703[10] Lichtenstein AH, et al. Arterioscler Thromb. 1994;14:168–175. DOI: 10.1161/01.ATV.14.1.168[11] Kiecolt-Glaser JK, et al. Brain Behav Immun. 2012;26:988–995. DOI: 10.1016/j.bbi.2012.05.011[12] Dong Y, et al. Nutrients. 2022;14:5307. DOI: 10.3390/nu14245307[13] Nestel P, et al. Am J Clin Nutr. 2002;76:326–330. DOI: 10.1093/ajcn/76.2.326[14] Sanders TA, et al. Am J Clin Nutr. 2011;94:973–980. DOI: 10.3945/ajcn.111.018036[15] Chan DC, et al. Nutr Metab Cardiovasc Dis. 2016;26:1140–1145. DOI: 10.1016/j.numecd.2016.07.012[16] Skulas-Ray AC, et al. Am J Clin Nutr. 2011;93:243–252. DOI: 10.3945/ajcn.110.003871[17] Ballantyne CM, et al. Am J Cardiol. 2012;110:984–992. DOI: 10.1016/j.amjcard.2012.05.031[18] Bays HE, et al. Am J Cardiol. 2011;108:682–690. DOI: 10.1016/j.amjcard.2011.04.015[19] Budoff MJ, et al. Eur Heart J. 2020;41:3925–3932. DOI: 10.1093/eurheartj/ehaa652[20] Kita Y, et al. J Am Heart Assoc. 2020;9:e015593. DOI: 10.1161/JAHA.119.015593[21] Albert MA, et al. JAMA. 2001;286:64–70. DOI: 10.1001/jama.286.1.64[22] Ridker PM, et al. N Engl J Med. 2008;359:2195–2207. DOI: 10.1056/NEJMoa0807646[23] Manson JE, et al. N Engl J Med. 2019;380:23–32. DOI: 10.1056/NEJMoa1811403[24] ASCEND Study Collaborative Group, et al. N Engl J Med. 2018;379:1540–1550. DOI: 10.1056/NEJMoa1804989[25] Bhatt DL, et al. N Engl J Med. 2019;380:11–22. DOI: 10.1056/NEJMoa1812792Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 29 · 4 min

    Put these in your Ears and Protect your Brain!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:29 - Long-term consequences4:28 - Social Isolation and More Considerations6:15 - A Disheartening Twist7:40 - Retwisting to a Heartening Twist, or something like that...8:54 - 24% Increased Risk10:04 - Use TheseReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)] [Study 346] Livingston et al. Dementia prevention and care: 2024 Lancet Commission. Lancet. 2024. [Study 1103] Yeo et al. Hearing devices, cognitive decline, and dementia: meta-analysis. JAMA Neurol. 2023. [Study 1104] Peribáñez García et al. Audiometric hearing loss, cognitive impairment, and dementia: meta-analysis. Am J Otolaryngol. 2026. [Study 1105] Lin et al. Hearing loss and cognitive decline in older adults. JAMA Intern Med. 2013. [Study 1106] Tai et al. Hearing impairment, hearing aids, and cognitive impairment: TLSA. BMC Geriatr. 2021. [Study 1107] Bucholc et al. Hearing aids, MCI-to-dementia conversion, and dementia progression. Alzheimers Dement (N Y). 2021. [Study 1108] Amieva et al. Hearing problems, mortality, depression, disability, and dementia: 25-year study. J Gerontol A. 2018. [Study 1109] Mahmoudi et al. Hearing aids and time to dementia, depression, or falls diagnosis. J Am Geriatr Soc. 2019. [Study 1110] Lin. Hearing loss and cognition in older US adults. J Gerontol A. 2011. [Study 1111] Davies et al. Hearing impairment and incident dementia: ELSA. J Am Geriatr Soc. 2017. [Study 1112] Chang et al. Hearing loss severity and dementia risk in South Korea. Sci Rep. 2020. [Study 1113] Lin et al. Hearing intervention and cognitive decline: ACHIEVE randomized trial. Lancet. 2023. [A] Fig. 3: Global cognition only—top two graphs (primary, secondary, and sensitivity analyses). [Study 1114] Chen et al. Hearing intervention in older adults with MCI: CHOICE randomized trial. JAMA Neurol. 2026. [1] Golub et al. Hearing loss and incident dementia in a multiethnic cohort. J Am Geriatr Soc. 2017. Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 24 · 13 min

    Dr. Rhonda Patrick: ‘Scientists discovered a Supplement that Repairs Aging Mitochondria!’

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderDr. Patrick's Video: https://www.youtube.com/shorts/1Du-MKJOjk80:00 - Introduction1:05 - It Clears out Old Mitochondria!4:30 - It Rejuvenates the Immune System!6:54 - VO2 Boost, Anti-Aging Benefits11:52 - A Huge Caveat!13:22 - Main PointsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Singh A, D'Amico D, Andreux PA, et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Eur J Clin Nutr. 2022;76(2):297-308. doi:10.1038/s41430-021-00950-1 [2] Alpert A, Pickman Y, Leipold M, et al. A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring. Nat Med. 2019;25(3):487-495. doi:10.1038/s41591-019-0381-y [3] Imboden MT, Harber MP, Whaley MH, Finch WH, Bishop DL, Kaminsky LA. Cardiorespiratory fitness and mortality in healthy men and women. J Am Coll Cardiol. 2018;72(19):2283-2292. doi:10.1016/j.jacc.2018.08.2166. [6] Bailey SJ, Winyard P, Vanhatalo A, et al. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol (1985). 2009;107(4):1144-1155. doi:10.1152/japplphysiol.00722.2009[7] Lansley KE, Winyard PG, Bailey SJ, et al. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. 2011;43(6):1125-1131. doi:10.1249/MSS.0b013e31821597b4[8] Cuenca E, Jodra P, Pérez-López A, et al. Effects of Beetroot Juice Supplementation on Performance and Fatigue in a 30-s All-Out Sprint Exercise: A Randomized, Double-Blind Cross-Over Study. Nutrients. 2018;10(9):1222. Published 2018 Sep 4. doi:10.3390/nu10091222[Study 230] D'Amico D, Olmer M, Fouassier AM, et al. Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell. 2022;21(8):e13662. doi:10.1111/acel.13662[Study 232] Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633[Study 549] Denk D, Singh A, Kasler HG, et al. Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. Nat Aging. 2025;5(11):2309-2322. doi:10.1038/s43587-025-00996-xPlease use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 22 · 9 min

    Why is Cheese immune to raising Cardiovascular Disease risk?

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=9i121BcPYlk&t=231s0:00 - Introduction1:03 - Assumptions make an Ass out of You and Me4:33 - The Matrix: Not the Movie6:57 - Keep this in mind...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1100] Feeney EL, Barron R, Dible V, et al. Dairy matrix effects: response to consumption of dairy fat differs when eaten within the cheese matrix—a randomized controlled trial. American Journal of Clinical Nutrition. 2018;108(4):667–674. doi:10.1093/ajcn/nqy146[Study 1101] Soerensen KV, Thorning TK, Astrup A, Kristensen M, Lorenzen JK. Effect of dairy calcium from cheese and milk on fecal fat excretion, blood lipids, and appetite in young men. American Journal of Clinical Nutrition. 2014;99(5):984–991. doi:10.3945/ajcn.113.077735[Study 1102] Rosqvist F, Smedman A, Lindmark-Månsson H, et al. Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study. American Journal of Clinical Nutrition. 2015;102(1):20–30. doi:10.3945/ajcn.115.107045Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 19 · 9 min

    TUDCA: A New Way of Addressing Insulin Resistance

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:50 - TUDCA2:59 - Mechanisms of Intrigue4:18 - TUDCA Results7:50 - Dosing & ConsiderationsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] She J, Tuerhongjiang G, Guo M, et al. Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner. Cell Metab. 2024;36(2):408–421.e5. doi:10.1016/j.cmet.2023.12.027.[2] Crosignani A, Battezzati PM, Cestari C, et al. Tauroursodeoxycholic acid for the treatment of chronic hepatitis: a multicentre dose-response study. Hepatol Res. 1998;13:10–19.[3] Ma H, Zeng M, Han Y, et al. A multicenter, randomized, double-blind trial comparing the efficacy and safety of TUDCA and UDCA in Chinese patients with primary biliary cholangitis. Medicine (Baltimore). 2016;95(47). doi:10.1097/MD.0000000000005391.[4] Pan XL, Zhao L, Li L, et al. Efficacy and safety of tauroursodeoxycholic acid in the treatment of liver cirrhosis: a double-blind randomized controlled trial. J Huazhong Univ Sci Technolog Med Sci. 2013;33(2):189–194. doi:10.1007/s11596-013-1095-x.[5] Poupon RE, Poupon R, Balkau B; UDCA-PBC Study Group. Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med. 1994;330(19):1342–1347.[Study 1078] Kars M, Yang L, Gregor MF, et al. Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes. 2010;59(8):1899–1905. doi:10.2337/db10-0308.[Study 1079] Walsh LK, Restaino RM, Neuringer M, Manrique C, Padilla J. Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. Clin Sci (Lond). 2016;130(21):1881–1888. doi:10.1042/CS20160501.[Study 1080] Panzhinskiy E, Hua Y, Culver B, Ren J, Nair S. Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B and impairs glucose uptake in cultured myotubes. Diabetologia. 2013;56(3):598–607. doi:10.1007/s00125-012-2782-z.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 15 · 9 min

    The ‘Berberine Signature’: A New Heart Disease Protection Uncovered!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - IntroductionYou talkin’ to me, ApoB?A Berberine Story: Genes, Associations, and TrialsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712–717. doi:10.1016/j.metabol.2008.01.013[Study 1076] Zhao JV, Sarsani V, Chen B, Yun H, Hu J, Liang L. Berberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization. npj Cardiovasc Health. 2026;3(1):15. doi:10.1038/s44325-026-00113-w[Study 1077] Zhao JV, Chen B, Chan YH, et al. Sex-specific lipid, apolipoprotein B, and lipoprotein(a) responses to berberine based on 2 randomized placebo-controlled trials. JACC Asia. Published online July 11, 2026. doi:10.1016/j.jacasi.2026.06.011Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 12 · 12 min

    15 Studies Later: Investigating Omega-3 Fats promoting Cancer

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:25 - The Study in Question2:05 - Worries Multiplied5:50 - A Counter-PunchReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1061] Aronson et al. J Clin Oncol. 2025. doi:10.1200/JCO.24.00608[Study 1062] Brasky et al. J Natl Cancer Inst. 2013. doi:10.1093/jnci/djt174[Study 1063] Brasky et al. Am J Epidemiol. 2011. doi:10.1093/aje/kwr027[Study 1064] Park et al. Cancer Causes Control. 2009. doi:10.1007/s10552-008-9236-4[Study 1065] Crowe et al. Am J Clin Nutr. 2008. doi:10.3945/ajcn.2008.26369[Study 1066] Chavarro et al. Cancer Epidemiol Biomarkers Prev. 2007. doi:10.1158/1055-9965.EPI-06-1033[Study 1067] Männistö et al. Cancer Epidemiol Biomarkers Prev. 2003. DOI not provided.[Study 1068] Harvei et al. Int J Cancer. 1997. doi:10.1002/(SICI)1097-0215(19970516)71:4%3C545::AID-IJC7%3E3.0.CO;2-U[Study 1069] Augustsson et al. Cancer Epidemiol Biomarkers Prev. 2003. DOI not provided.[Study 1070] Leitzmann et al. Am J Clin Nutr. 2004. doi:10.1093/ajcn/80.1.204[Study 1071] Chavarro et al. Am J Clin Nutr. 2008. doi:10.3945/ajcn.2008.26419[Study 1072] Brasky et al. Nutr Cancer. 2011. doi:10.1080/01635581.2011.553022[Study 1073] Torfadottir et al. PLoS One. 2013. doi:10.1371/journal.pone.0059799[Study 1074] Moreel et al. Cancer Prev Res (Phila). 2014. doi:10.1158/1940-6207.CAPR-13-0349[Study 1075] Outzen et al. Eur J Cancer Prev. 2018. doi:10.1097/CEJ.0000000000000330Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 8 · 10 min

    Bombshell Study Upends Low Carb Nutrition Science!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderOriginal Prediction on Ketone Mechanism: https://www.youtube.com/watch?v=q-uG5lMwHlU&t=228s0:00 - Introduction1:20 - Finally!2:59 - Agreement across Studies?4:50 - The Carbohydrate Twist5:15 - Protein Inequality6:06 - Time Matters?7:18 - Revisiting my PredictionReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 518] Queathem ED, Stagg DB, Nelson AB, et al. Ketogenesis mitigates metabolic dysfunction–associated steatotic liver disease through mechanisms that extend beyond fat oxidation. J Clin Invest. 2025;135(12). doi:10.1172/JCI191021.[Study 1056] Petersen MC, Smith GI, Farabi SS, et al. Effect of diet macronutrient content on the cardiometabolic response to weight loss: a randomized clinical trial. Cell Metab. 2026;38:1–12. doi:10.1016/j.cmet.2026.07.020.[Study 1057] Qadri SF, Porthan K, Dufour S, et al. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD. J Hepatol. 2026;85:26–36. doi:10.1016/j.jhep.2026.02.001.[Study 1058] London A, Richter MM, Sjøberg KA, et al. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutr. 2024;120:283–293. doi:10.1016/j.ajcnut.2024.06.006.[Study 1059] Kirk E, Reeds DN, Finck BN, et al. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology. 2009;136(5):1552–1560. doi:10.1053/j.gastro.2009.01.048.[Study 1060] Haufe S, Engeli S, Kast P, et al. Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects. Hepatology. 2011;53(5):1504–1514. doi:10.1002/hep.24242.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • October 5 · 7 min

    Oats, Heart Disease, and the Molecules within Oats

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Analysis: https://www.youtube.com/watch?v=c0Hm9tQ9zuc&t=1s0:00 - Introduction0:43 - Oats: Eat ‘em or Leave ‘em?1:52 - The Traditional3:10 - Something Suspicious about Oats…References[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Zhang J, Li L, Song P, et al. Randomized controlled trial of oatmeal consumption versus noodle consumption on blood lipids of urban Chinese adults with hypercholesterolemia. Nutrition Journal. 2012;11:54. doi:10.1186/1475-2891-11-54.[2] Thongoun P, Pavadhgul P, Bumrungpert A, Satitvipawee P, Harjani Y, Kurilich A. Effect of oat consumption on lipid profiles in hypercholesterolemic adults. Journal of the Medical Association of Thailand. 2013;96 Suppl 5–S32.[Study 1002] Klümpen L, Mantri A, Philipps M, et al. Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial. Nature Communications. 2026;17:598. doi:10.1038/s41467-026-68303-9.[Study 1003] Xu D, Feng M, Chu Y, et al. The prebiotic effects of oats on blood lipids, gut microbiota, and short-chain fatty acids in mildly hypercholesterolemic subjects compared with rice: a randomized, controlled trial. Frontiers in Immunology. 2021;12:787797. doi:10.3389/fimmu.2021.787797.[Study 1004] Hu Y, Willett WC, Manson JE, et al. Intake of whole grain foods and risk of coronary heart disease in US men and women. BMC Medicine. 2022;20:192. doi:10.1186/s12916-022-02396-z.[Study 1005] Helnæs A, Kyrø C, Andersen I, et al. Intake of whole grains is associated with lower risk of myocardial infarction: the Danish Diet, Cancer and Health Cohort. American Journal of Clinical Nutrition. 2016;103:999–1007. doi:10.3945/ajcn.115.124271.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 28 · 8 min

    4 Ways to Melt Visceral Fat!

    JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy JOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 HIRE ME FOR CONSULTING:Consulting: https://bit.ly/3dmUl2H Created with Biorender 0:00 - Introduction1:22 - Option 12:20 - Option 23:55 - Option 35:55 - Option 4 References[1] Kadowaki T, et al. Obes Res Clin Pract. 2025;19(2):146-153. doi:10.1016/j.orcp.2025.03.003. [2] Wilding JPH, et al. J Endocr Soc. 2021;5(Suppl 1):A16-A17. doi:10.1210/jendso/bvab048.030. [3] Arciero PJ, et al. Obesity. 2023;31(Suppl 1):139-149. doi:10.1002/oby.23660. [4] Zuo L, et al. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350. [Study 396] Zelicha H, et al. BMC Med. 2022;20:327. doi:10.1186/s12916-022-02525-8. [Study 427] Kaplan A, et al. Am J Clin Nutr. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001. [Study 780] Look M, et al. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275. [Study 790] Falutz J, et al. J Clin Endocrinol Metab. 2010;95(9):4291-4304. doi:10.1210/jc.2010-0490. [Study 793] Makimura H, et al. J Clin Endocrinol Metab. 2012;97(12):4769-4779. doi:10.1210/jc.2012-2794. [Study 509] Di Tano M, et al. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3. [Study 510] Vernieri C, et al. Cancer Discov. 2022;12(1):90-107. doi:10.1158/2159-8290.CD-21-0030. [Study 511] Ligorio F, et al. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701. [Study 512] Vernieri C, et al. Cell Metab. 2024;36(8):1644-1667. doi:10.1016/j.cmet.2024.06.014. [Study 606] Ni Y, et al. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002. [Study 607] Long X, et al. Cell Metab. 2025;37:2342-2361. doi:10.1016/j.cmet.2025.10.017. [Study 608] Li H, et al. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y. Please use the following link to submit your critique: https://bit.ly/PhysionicCritique Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 26 · 17 min

    Dr. Fung: ‘Cholesterol is barely relevant to Heart Disease’

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction2:13 - Blood Cholesterol is not Important13:08 - Something else matters WAY more than Blood Cholesterol16:45 - Main PointsReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association’s PREVENT equations. Circulation. 2024;149:430–449. doi:10.1161/CIRCULATIONAHA.123.067626.[2] Dugani SB, Moorthy MV, Li C, et al. Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. JAMA Cardiol. 2021;6(4):437–447. doi:10.1001/jamacardio.2020.7073.[3] Magnussen C, Alegre-Diaz J, Al-Nasser LA, et al. Global effect of cardiovascular risk factors on lifetime estimates. N Engl J Med. 2025;393(2):125–138. doi:10.1056/NEJMoa2415879.[4] Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153:e1154–e1276. doi:10.1161/CIR.0000000000001423.[5] Cannon CP, Blazing MA, Giugliano RP, et al; IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372(25):2387–2397. doi:10.1056/NEJMoa1410489.[6] Nordestgaard BG, Langlois MR, Langsted A, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM. Atherosclerosis. 2020;294:46–61. doi:10.1016/j.atherosclerosis.2019.12.005.[7] Prospective Studies Collaboration, Lewington S, Whitlock G, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829–1839. doi:10.1016/S0140-6736(07)61778-4.[8] Johannesen CDL, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. BMJ. 2020;371:m4266. doi:10.1136/bmj.m4266.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 24 · 10 min

    Manipulating Vitamin D to fight Cancer! [New Research]

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender750% increased Pancreatic Cancer: https://www.youtube.com/watch?v=_YPIO9CBuw8&t=1s0:00 - Introduction0:25 - CAFs, Vitamin D Receptor, and Cancer3:41 - What happens?5:57 - Why are the results the way they are?8:00 - Vitamin D39:30 - My backlight died and ConclusionsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)] [Study 1045] Perez KJ, et al. Gemcitabine and nab-paclitaxel ± paricalcitol for metastatic pancreatic cancer. Nat Cancer. 2026;7:928–943. [Study 1046] Sherman MH, et al. Vitamin D receptor-mediated stromal reprogramming enhances pancreatic cancer therapy. Cell. 2014;159:80–93. [Study 1047] Grierson PM, et al. Paricalcitol plus nanoliposomal irinotecan and 5-FU/LV in advanced pancreatic cancer. Clin Cancer Res. 2023;29:4733–4739. [Study 1048] Chung V, et al. Pembrolizumab ± paricalcitol in metastatic pancreatic cancer. Oncologist. 2025;30. [Study 1049] Easty D, et al. Paricalcitol with gemcitabine and nab-paclitaxel in advanced pancreatic cancer. BMC Cancer. 2026;26:255. [Study 1050] Viniotis AF, et al. NABPLAGEM and paricalcitol as neoadjuvant therapy in pancreatic cancer. Oncologist. 2026;31. [Study 1051] Rasmussen LS, et al. Vitamin D deficiency, inflammation, and survival in pancreatic cancer. Eur J Cancer. 2021;144:72–80. [Study 1052] Yuan C, et al. Prediagnostic 25-hydroxyvitamin D and pancreatic cancer survival. J Clin Oncol. 2016;34:2899–2905. [Study 1053] Cho M, et al. Vitamin D deficiency and prognosis in pancreatic adenocarcinoma. J Transl Med. 2013;11:206. [Study 1054] Van Loon K, et al. 25-Hydroxyvitamin D and survival in advanced pancreatic cancer. J Natl Cancer Inst. 2014;106. [Study 1055] Mukai Y, et al. Vitamin D supplementation with chemoradiation for pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2018;25:1868–1879. Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 21 · 9 min

    The Mortality Effect of Walnuts are Hard to Ignore - Why?

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Walnut-Mortality Analysis: https://www.youtube.com/watch?v=3DqCZZgDdF8&t=337s0:00 - Introduction0:45 - It’s a Meee, Cholesterol!3:15 - You heard me, I called you Endothelial5:12 - A New View of Inflammation7:35 - How much to eat?References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1037] Rajaram S, Cofán M, Sala-Vila A, et al. Effects of walnut consumption for 2 years on lipoprotein subclasses among healthy elders: findings from the WAHA randomized controlled trial. Circulation. 2021;144:1083-1085. doi:10.1161/CIRCULATIONAHA.121.054051.[Study 1038] Wu L, Piotrowski K, Rau T, et al. Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism. 2014;63:382-391. doi:10.1016/j.metabol.2013.11.005.[Study 1039] Ros E, Núñez I, Pérez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation. 2004;109:1609-1614. doi:10.1161/01.CIR.0000124477.91474.FF.[Study 1040] Katz DL, Davidhi A, Ma Y, et al. Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial. J Am Coll Nutr. 2012;31(6):415-423.[Study 1041] Berryman CE, Grieger JA, West SG, et al. Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia. J Nutr. 2013;143:788-794. doi:10.3945/jn.112.170993.[Study 1042] Chiang YL, Haddad E, Rajaram S, Shavlik D, Sabaté J. The effect of dietary walnuts compared to fatty fish on eicosanoids, cytokines, soluble endothelial adhesion molecules and lymphocyte subsets: a randomized, controlled crossover trial. Prostaglandins Leukot Essent Fatty Acids. 2012;87:111-117. doi:10.1016/j.plefa.2012.07.007.[Study 1043] Cofán M, Checa A, Serra-Mir M, et al. A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons. J Nutr. 2024;154:395-402. doi:10.1016/j.tjnut.2023.12.007.[Study 1044] Holscher HD, Guetterman HM, Swanson KS, et al. Walnut consumption alters the gastrointestinal microbiota, microbially derived secondary bile acids, and health markers in healthy adults: a randomized controlled trial. J Nutr. 2018;148:861-867. doi:10.1093/jn/nxy004.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 17 · 13 min

    A New Discovery: Serine, Stress, and Insulin Resistance

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:59 - You’re Stressin’ Me, Man, my Glucose is High!5:21 - Not all roads lead to Serine6:10 - A Serine StoryReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1032] He A, Zhu Y, Liang C, et al. Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia. Cell Metab. 2026;38:1385-1403. doi:10.1016/j.cmet.2026.03.006.[Study 1033] Roberts AL, Agnew-Blais JC, Spiegelman D, et al. Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry. 2015;72(3):203-210. doi:10.1001/jamapsychiatry.2014.2632.[Study 1034] Vaccarino V, Goldberg J, Magruder KM, et al. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014;56:158-164. doi:10.1016/j.jpsychires.2014.05.019.[Study 1035] Nowotny B, Cavka M, Herder C, et al. Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Horm Metab Res. 2010;42:746-753. doi:10.1055/s-0030-1261924.[Study 1036] Heresco-Levy U, Vass A, Bloch B, et al. Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol. 2009;12:1275-1282. doi:10.1017/S1461145709000339.Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

  • September 14 · 10 min

    Peptides with HUGE Cardiovascular Impact!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:18 - Peptides on Cardiovascular Disease3:09 - Peptides on Reversing Arterial Plaque6:58 - There is hope...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)] [Study 1018] Marso SP, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016. doi:10.1056/NEJMoa1607141. [Study 1019] Gerstein HC, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND). Lancet. 2019. doi:10.1016/S0140-6736(19)31149-3. [Study 1020] Gerstein HC, et al. The effect of dulaglutide on stroke: an exploratory analysis of REWIND. Lancet Diabetes Endocrinol. 2020. doi:10.1016/S2213-8587(19)30423-1. [Study 1021] Hernandez AF, et al. Albiglutide and cardiovascular outcomes in type 2 diabetes and cardiovascular disease. Lancet. 2018. doi:10.1016/S0140-6736(18)32261-X. [Study 1022] Lincoff AM, et al. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023. doi:10.1056/NEJMoa2307563. [Study 1023] McGuire DK, et al. Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes. N Engl J Med. 2025. doi:10.1056/NEJMoa2501006. [Study 1024] Gitto M, et al. GLP-1 receptor agonists and coronary plaque regression after acute coronary syndromes. Acta Diabetol. 2026. doi:10.1007/s00592-025-02606-z. [Study 1025] Kataoka Y, et al. GLP-1 analogues and delipidation of coronary atheroma. Atheroscler Plus. 2024. doi:10.1016/j.athplu.2024.03.001. [Study 1026] Heinsen LJ, et al. Liraglutide treatment and progression of coronary artery fibrous plaque. BMC Cardiovasc Disord. 2023. doi:10.1186/s12872-023-03228-5. [Study 1027] Zhang J, et al. Exenatide versus insulin and carotid intima-media thickness in type 2 diabetes. Cardiovasc Diabetol. 2020. doi:10.1186/s12933-020-01014-7. [Study 1028] Rizzo M, et al. Liraglutide decreases carotid intima-media thickness in type 2 diabetes. Cardiovasc Diabetol. 2014. doi:10.1186/1475-2840-13-49. [Study 1029] Rizzo M, et al. Liraglutide improves metabolic parameters and carotid intima-media thickness. Cardiovasc Diabetol. 2016. doi:10.1186/s12933-016-0480-8. [Study 1030] Patti AM, et al. Semaglutide and subclinical atherosclerosis in type 2 diabetes. Biomedicines. 2023. doi:10.3390/biomedicines11051362. [Study 1031] Sun L, et al. Liraglutide and atherosclerosis in impaired glucose tolerance. Exp Ther Med. 2023. doi:10.3892/etm.2023.11948. [Study 997] Lundgren JR, et al. Healthy weight loss maintenance with exercise, liraglutide, or both. N Engl J Med. 2021. doi:10.1056/NEJMoa2028198. Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 12 · 14 min

    Dr. Mason: Fiber’s Health Benefits are Built on FLAWED Research!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:09 - No Good Research on Health Effects of Fiber5:21 - This is what we Need!8:08 - Whoops.. Hypocrisy? 12:50 - Main PointsReferences [1] Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011;171(12):1061-1068. doi:10.1001/archinternmed.2011.18[2] Chuang SC, Norat T, Murphy N, et al. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2012;96(1):164-174. doi:10.3945/ajcn.111.028415[3] Buil-Cosiales P, Zazpe I, Toledo E, et al. Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study. Am J Clin Nutr. 2014;100(6):1498-1507. doi:10.3945/ajcn.114.093757[4] Li S, Flint A, Pai JK, et al. Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study. BMJ. 2014;348. doi:10.1136/bmj.g2659[5] Katagiri R, Goto A, Sawada N, et al. Dietary fiber intake and total and cause-specific mortality: the Japan Public Health Center-based prospective study. Am J Clin Nutr. 2020;111(5):1027-1035. doi:10.1093/ajcn/nqaa002[6] Burn J, Bishop DT, Mecklin JP, et al. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med. 2008;359(24):2567-2578. doi:10.1056/NEJMoa0801297[7] Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr. 2005;82(3):559-567. doi:10.1093/ajcn.82.3.559[8] Ziai SA, Larijani B, Akhoondzadeh S, et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J Ethnopharmacol. 2005;102(2):202-207. doi:10.1016/j.jep.2005.06.042[9] Abutair AS, Naser IA, Hamed AT. Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial). Nutr J. 2016;15(1):86. doi:10.1186/s12937-016-0207-4[10] Solà R, Bruckert E, Valls RM, et al. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. Atherosclerosis. 2010;211(2):630-637. doi:10.1016/j.atherosclerosis.2010.03.010[11] Burke V, Hodgson JM, Beilin LJ, Giangiulioi N, Rogers P, Puddey IB. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension. 2001;38(4):821-826. doi:10.1161/hy1001.092614[12] Wolever TM, Jenkins DJ, Mueller S, et al. Psyllium reduces blood lipids in men and women with hyperlipidemia. Am J Med Sci. 1994;307(4):269-273. doi:10.1097/00000441-199404000-00005Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 10 · 8 min

    Aging Genes can be Turned Off, if you do This Regularly

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:48 - Freezing Aging through Exercise4:18 - The Exercise Methylome7:02 - A Bit Gene CrazyReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1006] Janssens GE, Trętowicz MM, Grevendonk L, et al. Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle. Nat Aging. 2026;6:1482-1500. doi:10.1038/s43587-026-01150-x.[Study 1007] Voisin S, Seale K, Jacques M, et al. Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle. Aging Cell. 2024;23:e13859. doi:10.1111/acel.13859.[Study 1008] Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS One. 2007;2(5):e465. doi:10.1371/journal.pone.0000465.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 7 · 8 min

    Berberine: A Powerful New Metabolic Mechanism Discovered!

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:15 - The Classics1:57 - What’s the News?6:04 - BerberineReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654[Study 985] Sebo ZL, Chakrabarty RP, Grant RA, D’Alessandro KB, Koss AR, Blum JLE, et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab. 2026;8:1291-1304. doi:10.1038/s42255-026-01530-y[Study 986] Koffert JP, Mikkola K, Virtanen KA, Andersson AMD, Faxius L, Hällsten K, et al. Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial. Diabetes Res Clin Pract. 2017;131:208-216. doi:10.1016/j.diabres.2017.07.015[Study 987] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

  • September 5 · 28 min

    ‘They Lied about High LDL!’ - The Corrupt Science behind Heart Disease

    *JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Original Podcast: https://youtu.be/q57CNySsYxs?si=PIwVEVGj_-cYkDCU0:00 - Introduction1:54 - Genetics that cause High Cholesterol5:29 - The American Heart Association is lying to you8:05 - Extremely High Cholesterol doesn't Kill17:48 - High Cholesterol at 60? Protection from Death25:20 - Other ways of testing this?27:12 - Main PointsReferences[1] Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. *J Am Heart Assoc*. 2014;3(6):e001236. doi:10.1161/JAHA.114.001236[2] Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. *Proc Natl Acad Sci U S A*. 1974;71(3):788-792. doi:10.1073/pnas.71.3.788[3] Shishikura D, Harada-Shiba M, Michikura M, et al. Comparison of clinical characterization and therapeutic strategies between homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia. *J Atheroscler Thromb*. 2026;33. Advance publication online March 27, 2026. doi:10.5551/jat.65959[4] Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. *Lancet*. 2004;363(9406):369-370. doi:10.1016/S0140-6736(04)15467-6[5] EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). *Lancet*. 2021;398(10312):1713-1725. doi:10.1016/S0140-6736(21)01122-3[6] Clarke R, Emberson JR, Parish S, et al. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. *Arch Intern Med.* 2007;167(13):1373-1378.[7] Ding M, Wennberg A, Ek S, et al. The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age. *Sci Rep.* 2021;11(1):24440. doi:10.1038/s41598-021-03959-5.[8] Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort. *Lancet*. 2020;396(10263):1644-1652. doi:10.1016/S0140-6736(20)32233-9Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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