Engineering B Cells With Immusoft's Sean Ainsworth
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On this week's episode of the Business of Biotech, Sean Ainsworth, CEO and Chairman at Immusoft, talks about transitioning from the research bench to entrepreneurship, his M&A experiences as a biotech founder, and why engineered B cell therapies offer a better, more patient-friendly administration for lysosomal storage diseases currently treated with enzyme replacement therapies. Sean also discusses FDA pathways, incentives, and agency engagement, and offers thoughts on the regulatory outlook for cell and gene therapies.
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- 0:00Opening And Guest Introduction
- 1:03Navy Roots And Lab Beginnings
- 2:05Early Stem Cell Gene Work Lessons
- 3:30First Startup Compendia And Exit
- 6:03Optogenetics And Founding RetroSense
- 9:19Fundraising In Downturns And Team Building
- 12:15Designing For Acquisition And The Allergan Deal
- 15:14Why EmuSoft And Systemic Delivery Goals
- 18:00Redosing And Avoiding Immunosuppression
- 20:18How Autologous B Cells Become Biofactories
- 23:00Manufacturing Timeline And Patient Experience
- 24:45Choosing MPS I And Platform Criteria
- 27:12Beyond ERT: Continuous Protein Delivery
- 29:35Early Clinical Signals And Redose Update
- 32:17Pipeline Strategy And Platform Leverage
- 36:05Board Roles, Governance, And Leadership
- 39:10FDA Trends, Designations, And Pathways
- 43:05Priority Review Vouchers And Incentives
- 47:02Pivotal Trial Alignment And What’s Next
- 52:01Closing Remarks And Where To Subscribe