Targeting Tau in Alzheimer's Disease With Voyager Therapeutics' Al Sandrock, M.D., Ph.D.
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On this week's episode of the Business of Biotech, Al Sandrock, M.D., Ph.D., President and CEO at Voyager Therapeutics, talks about why tau is becoming a central target in Alzheimer’s drug development and how gene therapy delivery across the blood-brain barrier could change what treatment looks like at scale. Sandrock shares his current thinking on the amyloid vs. beta debate (it's likely both) in Alzheimer's disease treatment, the role of emerging tools like fluid biomarkers in diagnosis and prevention, and why small biotechs take bigger risks than big pharma.
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- 0:00Welcome And Guest Overview
- 1:39Falling In Love With Neurobiology
- 4:15Leaving Academia For Patient Impact
- 6:42Industry Lessons From MS Drug Development
- 9:10Aduhelm And The FDA Balancing Act
- 12:49Joining Voyager For Better Brain Delivery
- 15:18Learning The CEO Job Fast
- 18:14Building Culture With Transparency
- 19:57Amyloid And Tau How They Interact
- 24:05Gene Therapy Versus Antibody Approaches
- 26:14Combination Therapy And Early Treatment Bets
- 28:02Partnering Choices And Non Dilutive Cash
- 31:33Near Term Milestones And Tau PET Readouts
- 34:39De Risking Programs In Small Biotech
- 38:03Why Alzheimer’s Needs Big Partners
- 39:49Blood Tests And Prevention Like Cholesterol
- 44:08Lifestyle Factor Sleep And Amyloid Clearance
- 46:07Career Advice For Future Neuro Leaders
- 47:56Closing And Where To Follow