Developing Novel Cancer Drugs On A Budget With Iterion Therapeutics' Rahul Aras, Ph.D.
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On this week's episode of the Business of Biotech we speak with Rahul Aras, Ph.D., President and CEO at Iterion Therapeutics, about capital efficient drug development in oncology and progressing a novel therapeutic with relatively small funding amounts. Iterion is a clinical stage company developing cancer therapeutics targeting the Wnt/β-catenin pathway, a known signaling target in oncology, but one that has confounded drug development efforts for decades. Rahul talks about his path from academia to company building and early work in gene therapy, Iterion's partnership strategy, and operating a biotech in the Houston, Texas clinical hub.
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- 0:00Meet Rahul Aras, Ph.D. And Iterion
- 1:20From Bench Science To Dealmaking
- 4:20Spinning Out Juventus Therapeutics
- 8:10Lessons From Early Gene Therapy
- 11:20Enter Iterion And A New Target
- 13:40Tegavivint’s Early Clinical Signals
- 16:30Why Start With Liver Cancer
- 20:05Capital Efficiency By Design
- 23:10Building Monotherapy Then Combos
- 26:05Precision Targeting To Avoid Toxicity
- 28:20Partnering And Combo Strategies
- 31:00Fitting Into Modern Oncology
- 34:10Origin Of Tegavivint’s Chemistry
- 35:55Building Biotech In Houston
- 39:20Funding, Community And Access
- 42:00Talent, Costs And Flexible Teams
- 45:20Near-Term Clinical Priorities
- 48:05Pediatric Pathway And Voucher