Derisking CNS Drug Development With Tortugas Neuroscience's Jeff Jonas, M.D.
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On this week's episode of the Business of Biotech, Jeff Jonas, M.D., CEO of Tortugas Neuroscience, talks about the company's April 2026 launch and how in-licensed development assets were chosen. Jeff explains his strategy of chasing fast proof of safety and efficacy in humans, not animals, and talks about what product differentiation looks like in brain disorders, from adjusting indication targets to conducting head-to-head trials. He also reflects on the opportunity with psychedelics, RFK Jr.'s quest to curb SSRI prescriptions, the payer landscape in CNS disorders, and more.
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- 0:00Welcome And Tortugas Overview
- 1:05When Head-To-Head Trials Pay Off
- 4:25Leadership That Shares The Credit
- 7:15Search And Develop Into Humans
- 11:25Venture Versus Operator Views On Risk
- 15:40Building Tortugas And Choosing Assets
- 23:05Tinnitus Epilepsy And Encephalopathy Bets
- 31:35CNS Breakthroughs, SSRIs, Psychedelics And Payers
- 46:362026 Priorities, IPO Path, And Closing Thoughts