Authentic Biochemistry

Dr Daniel J. Guerra

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Sep 9, 2021 · 29 min
Summer Fades and Aging Advances through non-coding RNA's and the Immunological Axes. Dr Daniel J. Guerra. 9.9.2021 Authentic Biochemistry Productions.
Non coding RNA may regulate melanogenesis and in combination with plasma cell producing IgG the nutritional regulation of satiety. Aging results in alterations of this complex system thus resulting in localized melanogenesis and a corruption of the HPA axis. References: Aging (Albany NY). 2021 Jan 31; 13(2): 2700–2726. Stem Cells Int. 2020; 2020: 1047896. First Published online 2020 Jul 8 PNAS. 2002 Dec 24;99(26):17155-60
Sep 7, 2021 · 29 min
Hepatic Gluconeogenesis and Glycogen Metabolism: Canonical Allostery. Dr Dan Guerra. Authentic Biochemistry 07 Sept. 2021
Components of metabolic sequence toward gluconeogenesis in the human liver.
Sep 5, 2021 · 30 min
The hormonal and allosteric control over hepatic PFK2/FBPase2 via adenylate cyclase and Fructose 2,6 bis phosphate. DJGPhD.5Sept.2021. Authentic Biochemistry Productions.
Dr. Guerra details the glucagon and epinephrine mediated control through Stimulatory G-protein couple adenylate cyclase activating PKA over Hepatic Glycolysis and Gluconeogenesis.
Aug 27, 2021 · 29 min
Glycerol 3-phosphate dehydrogenase mechanism and the finale of glycolysis. Authentic Biochemistry. Dr. Daniel J. Guerra 27.8.21
Utilization of a protein cysteine SH derived thioester intermediate alters the free energy hurdle for the synthesis of 1,3 bis PGA thus allowing for glycolytic ATP and NADH synthesis.
Aug 20, 2021 · 29 min
Haemoglobin: Molecular Oxygen Binding Cooperativity and the role of 2,3 bis phosphoglyceric acid. DJGPhD 19.8.21
The interaction of glycolysis and lactic acid transport from skeletal muscle to the liver plays a significant role in oxygen uptake, transport and release in association with pulmonary carbon dioxide efflux . Dr. Daniel J. Guerra. An Authentic Biochemistry Production 19.8.21.
Aug 11, 2021 · 29 min
A Necessary Interruption in Amino Acid Catabolism: Haemoglobin and Oxygen Transport Lecture I. DJGPhD. 11 August 2021
Any chronic decrease in the ability for molecular oxygen to bind to circulating Hb will diminish its availability in the Central Nervous System and Skeletal Muscle resulting in the potential for long-term Pathophysiology and Illness. Dr. Dan Guerra Published 11 August 2021. Authentic Biochemistry.
Aug 9, 2021 · 24 min
Amino Acid Catabolism (Continued): Neurotransmitter and S-adenosyl MET interconversions. DJGPhD 09 Aug 2021
Classical Amino Acid Degradation Biochemistry : Emphasis on pathway interconversions and production of bioactive amines
Aug 2, 2021 · 30 min
Main Frame Amino Acid Degradation Pathways and Skeletal Muscle Performance and Ammonia Toxicity.02.Aug.2021. DJGPhD. Authentic Biochemistry
J Physiol. 2005 563:285-90 Eur J Appl Physiol(2011) 111:2837–2843
Jul 27, 2021 · 29 min
The Urea Cycle and the endothelial ARGININE-Nitric Oxide Connection. DJGPhD 27.7.21.Authentic Biochemistry Podcast
Biomedicines. 2020 Aug 6;8(8):277.
Jul 20, 2021 · 29 min
The Glutamate Dehydrogenase Axis Further Reveals the Role of Ischaemic Oxygen Availability for Neural Transmission in the Aging Brain. DJGPhD 20.7.21.
Journal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464
Jul 20, 2021 · 29 min
The Glutamate Axis of Bioenergetics, Neurotransmission and Potential Contribution to the Aging Senescent Phenotype. DJGPhD 20.7.21
Journal of Neurochemistry, Volume: 146, Issue: 4, Pages: 416-428, First published: 20 May 2018, DOI: (10.1111/jnc.14464) Life Sci . 2019 Sep 1;232:116612
Jul 12, 2021 · 29 min
Amino acid metabolism I: An initial primer for subsequent discussions in Aging. Dr Guerra. 07July2021. Authentic Biochemistry.
This is one of my classical biochemistry introductory lectures on amino acid utilization.
Jul 4, 2021 · 27 min
Mesenchymal stem cell fate and the mediation of age-associated senescence or plasticity in the elderly via immune response valency. DJGPhD 03 July 2021
Trends in Immunology Volume 36, Issue 4, 2015, 217–228 Carcinogenesis 2015;36:1180-1192
Jun 28, 2021 · 29 min
Detailing the Senescent to Mesenchymal Transition in Aging : Links to Cancer vs. Apoptosis. DJGPhD 28 June 2021.
Clinical and Molecular Allergy volume 15, Article number: 21 (2017) Front. Immunol., 25 September 2019 | https://doi.org/10.3389/fimmu.2019.02247
Jun 25, 2021 · 29 min
Genomic damage, DDR, and the roles of inflammation and DNA epigenetic retailoring in the senescent phenotype. DJGPhD 24.6.21
Oncotarget. 2013 Oct; 4(10): 1552–1553
Jun 12, 2021 · 29 min
Pharmacodynamics: General Considerations and Clinical Trials. Dr. Dan Guerra. Authentic Biochemistry 12 June 2021
In this episode Dr. Guerra provides the overview of Pharmacodynamics .
Jun 10, 2021 · 29 min
Pharmacokinetics Synoptic with an Introduction to Aging Phenomena. Dr Daniel J. Guerra. 09June2021 authentic Biochemistry.
A.D.M.E. Anesthesiology Clinics, 2019-09-01, Volume 37, Issue 3, Pages 475-492. Please subscribe and donate! Dr. Guerra needs your support!
Jun 8, 2021 · 28 min
Cardiovascular disease risk and malnutrition are associated with aging morbidity and obesity. Dr. Guerra. 8 June 2021. Authentic Biochemistry
Risk factors for aging morbidity are linked to large variations in protein synthesis and lack of adipose derived TAG utilization. The immune response becomes compromised during aging leading to states of hyperinflammation followed by hypo-immune sequalae opening up the potential for opportunistic respiratory infections and alterations in pulmonary endothelial membrane lipid fluidity restricting oxygen intake.
Jun 5, 2021 · 28 min
Ceramide mediated pathophysiology of aging-associated neurodegeneration. Dr. Dan Guerra. Authentic Biochemistry.05 June 2021.
Seminars in Cell & Developmental Biology Volume 40, April 2015, Pages 115-126 Pharmaceutical Research March 2018, 35:49 Journal of Molecular Endocrinology 2017. 58, 1; 10.1530/JME-16-0182 J. Lipid Res. 2018 59:(3) 488-506.
Jun 3, 2021 · 29 min
Immuno Endocrine Regulation of Metabolism May-June 2021. Dr. Dan Guerra Authentic Biochemistry.
Feng, T., Yang, X., Hao, S. et al. Immunol Res. 05 April 2020 Molecular Neurodegeneration volume 7, Article number: 45 (2012) J Biol Chem. 2019 Jun 7;294(23):9213-9224