Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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Jan 4, 2022 · 29 min
The Motor Neuron Association to Reward Pathway: Motor Neuron Disease , an Introduction. Dr. Daniel J. Guerra. 03 January 2022. Authentic Biochemistry Productions.
Introduction to motor neuron structure/function relationships and the MND's including Amyotrophic Lateral Sclerosis.
Jan 2, 2022 · 30 min
The CNS and Pandemic Obesity: The Appetitive Reward Pathway, Energy Expenditure, and Neuroendocrine Signaling. DJGPhD. 02.Jan.2022 Authentic Biochemistry Productions.
The CNS processes nutritional (biochemical) signaling from the external and internal environment during and subsequent to dietary ingestion. During the initiation phase, affective (limbic) and executive (PFC/OFC) attention is facilitative toward ingestive behavior linked to appetitive hunger stimulation via neural, visceral, and endocrine networking including memory cues that obtain opportunity to consume pleasurable high caloric density nutrition. Gastroenterology. 2017 May; 152(7): 1728–1738 Int J Obes (Lond). 2018 Mar;42(3):376-38 Trends Endocrinol Metab. 2019 Mar;30(3):163-176 https://www.genecards.org/cgi-bin/carddisp.pl?gene=TUB
Jan 1, 2022 · 29 min
A short Pharmacology lecture on New Year's Day 2022. Dr Daniel J. Guerra. Authentic Biochemistry
Pharmacokinetics are discussed.
Dec 31, 2021 · 29 min
Appetitive Reward Pathway III.-Neurobiochemistry and Epigenetics of Addiction. DJGPhD. 31.12.21 Authentic Biochemistry
Dopaminenergic pathways are corrupted by addictive behaviors especially the use/abuse of psychoactive drugs that may become behavioral reward saliencies linked to epigenomic modifications.
Dec 31, 2021 · 29 min
Anhedonic and MDD- Associated Appetitive Reward Pathway Biochemistry and Pathophysiology II. DJGPhD. Authentic Biochemistry.30..12.21.
References Front Neurosci. 2019; 13: 707 Nature Metabolism 2019. 1:754–764 Int. J. Mol. Sci. 2019, 20(6), 1505 Neuropsychiatr Dis Treat. 2015; 11: 875–888 Mol Psychiatry. 2016 Oct; 21(10): 1358–1365.
Dec 29, 2021 · 30 min
Appetitive Reward Pathway Biochemistry and Neural Circuitry Regulation I. Dr. Daniel J. Guerra. 29.12.21. An Authentic Biochemistry Production.
References Biol Psychiatry. 2020 Jan 1; 87(1): 64–73 Front. Neurosci., 26 November 2019
Dec 28, 2021 · 29 min
AMPK and Immuno-Epigenetic Biochemistry Part 2/2/ DJGPhD. Authentic Biochemistry 27.12.21
J Neuroinflammation. 2019; 16: 34 Nature Cell Biology, 02 Sep 2011, 13(9):1016-1023 Critical Reviews in Clinical Laboratory Sciences Volume 56, 2019 - Issue 7 Pages 472-492
Dec 27, 2021 · 29 min
AMPK and Immuno-Epigenetic Biochemistry Part 1. Dr. Daniel J. Guerra. 27.12.21. Authentic Biochemistry
References Nat Cell Biol. 2019 Mar; 21(3): 397–407 CELL Volume 126, Issue 3, 11 August 2006, Pages 503-514 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Int J Biol Sci. 2015; 11(11): 1272–1280 Sci Signal. 2017 Jan 31; 10(464): eaaf7478. Front Immunol. 2019; 10: 345. J Neuroinflammation. 2019; 16: 34.
Dec 23, 2021 · 29 min
AMPK negatively regulates lipogenesis by phosphorylating ACCase 1&2 plus HMGCoA reductase thus supporting beta oxidation of fatty acids . Dr. Daniel J. Guerra. 22.12.21. Authentic Biochemistry
Cell Metabolism 2020 31472-492 Amino Acids. 2012 Oct;43(4):1803-7 Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690
Dec 21, 2021 · 29 min
AMPK is associated with the POMC vs, NPY neuronal axis under Leptin Control. DJGPhD. 20.12.21 Authentic Biochemistry
References HORMONES 2013, 12(2):172-191 Proc Natl Acad Sci U S A . 2002 Dec 24;99(26):17155-60 Eur J Endocrinol. 2017 176(5): R235–R246.
Dec 20, 2021 · 30 min
AMPK Allosteric Regulation and Interaction with the Opposing mTORC Network. Part 2. Dr. Daniel J. Guerra. Authentic Biochemistry 19.12.21
Eur J Endocrinol. 2017 176(5): R235–R246 Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690
Dec 19, 2021 · 30 min
Bio-Molecular Regulator Series . AMPK. Part One. Dr. Daniel J. Guerra. Authentic Biochemistry Podcast Production.19.12.21.
An introductory lecture on the biomolecular sensor kinase, Adenosyl Mono-Phosphate (protein) Kinase; AMPK. References Mol Genet Metab. 2013 Jul;109(3):260-8 PLoS One. 2016 Aug 16;11(8):e0161252. Experimental & Molecular Medicine volume 48, 224 (2016) Molecular Cell Volume 81, Issue 18, 16 September 2021, Pages 3677-3690
Dec 12, 2021 · 29 min
T-lymphocyte and macrophage membrane CD38 ecto-enzyme mediated NAD catabolism is associated with ageing and the decline in Sirtuin-mediated deacylase activity. DJGPhD.11.Dec.21' Authentic Biochemistry
References Cell Metabolism. 2016. 23, 1127–1139 Cells 2020, 9(1), 228 Front. Immunol., 31 May 2019 Int J Mol Sci. 2020 Nov; 21(22): 8609 Circ Res. 2018 Sep 14; 123(7): 868–885. Int J Mol Sci. 2019 Mar; 20(5): 1223
Dec 10, 2021 · 29 min
Aposteriori synthesis of neuroendocrine linked clock chronicity and the Senescent associated Secretory Phenotype through the synthetic apriori lens of NAD+. DJGPhD.10Dec21. Authentic Biochemistry
References Nat Cell Biol. 2019 Mar; 21(3): 397–407 J Diabetes Metab Disord. 2020 Jul 21;19(2):1797-1825 Int. J. Mol. Sci. 2014, 15, 16848-16884
Dec 8, 2021 · 30 min
How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21
Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppressor genes like p16INK4a while DNA Damage Repair (DDR) from pro-inflammatory cytokine production from senescent cells and Th1 lymphocytes can inhibit commitment to mitosis and cytokinesis by generating the paracrine SASP paradigm. Refs. Am J Physiol Cell Physiol 2012;302:C1026-C1034 Steroids Volume 75, Issue 10, October 2010, Pages 625-631 Oncotarget. 2013 Oct; 4(10): 1552–1553 Cancer Metastasis Rev. 2020; 39(3): 681–709
Dec 7, 2021 · 29 min
Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21
Cell fate from Either ageing associated senescence to programmed cell death OR cell proliferation is finely tuned to the splice variant expression of Cell Cycle dependent kinase inhibitors and the relative production of pro-inflammatory cytokines under the synchrony of DNA Damage Repair (DDR), telomerase expression decline, and the protective role of the Senescence Associated Secretory Phenotype (SASP). Dr. Daniel J. Guerra. 06 Dec 2021 Authentic Biochemistry Productions References: Oncotarget. 2013 Oct; 4(10): 1552–1553 Cancer Rep Rev. 2018 Mar; 2(2): 10 Nat Med. 2017 Jun; 23(6): 775–781 Cancer Genet Cytogenet. 1999 Mar;109(2):108-13. EBioMedicine 2016 830-39DOI: (10.1016/j.ebiom.2016.04.017
Nov 25, 2021 · 29 min
Ageing and Asymmetric Dimethylarginine (ADMA)in Endothelial Nitric Oxide Synthase inhibition-associated decrease in respiratory vasodilation. Dr Dan Guerra 24.11.21 Authentic Biochemistry
Age Ageing, Volume 48, Issue 6, November 2019, Pages 776–782 Biomedicines. 2020 Aug 6;8(8):277
Nov 21, 2021 · 29 min
Closing the window and drawing the curtain: cancer phenotypes are resolute signatures of Immunosenescence and inflammaging induced epigenetic collapse of vital biochemical homeostasis. DJGPhD.20/11/21
Dr. Guerra authentically arrives at the inveighing cancer paradigm contribution to the sickness unto death.
Nov 18, 2021 · 29 min
Sealing Fate: Immunosenescent and inflammatory mechanisms combine the ineffectual with the increscent pathophysiology of sickness unto death. DJGPhD. 17.11.21
Nutrients. 2020 Mar; 12(3): 622. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43.The Immune System and Its Dysregulation with Aging Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Springer Publishers
Nov 14, 2021 · 29 min
The interplay between Immunosenescence and inflammaging conduct the innate and acquired immune response toward functional cellular rigidity and incompetence obtaining morbidity and mortality. DJGPhD.
1.Biochemistry and Cell Biology of Ageing: Part II Clinical Science. 2019. pp 21-43. The Immune System and Its Dysregulation with Aging. Ludmila Müller, Svetlana Di Benedetto, and Graham Pawelec. Springer Publishers. 2. Aging (Albany NY). 2019 Apr 30; 11(8): 2343–2351. 3. Immun Ageing. 2020; 17: 2