Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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May 26, 2021 · 29 min
Aging and Cancer Via Immunosenescence and Pro-inflammatory Cytokines: Relative loss of Naive T cell Populations in the Elderly. DJGPhD. 26 March 2021
Annu. Rev. Physiol. 2013. 75:685–705 Nutrients. 2020 Mar; 12(3): 622
May 19, 2021 · 29 min
Pathobiochemical linkages between Alzheimer's Disease and Autism Spectrum Disorders: Associative Molecular Patterns with Diverse Pathologies. DJGPhD. 18 May 2021
FASEB J. 2013 Jun; 27(6): 2458–2467. Scientific Reports volume 7, Article number: 13763 (2017)
May 18, 2021 · 29 min
Immunomodulatory effects on neuropsychiatric states: classic rodent model studies. Dr. Guerra. 17.5.21 Authentic Biochemistry
Scientific Reports volume 9, Article number: 1220 (2019) Prog Neuropsychopharmacol Biol Psychiatry. 2005 Oct 12 Bulletin of Experimental Biology and Medicine.2003. 136.(3). 1573-8221 Pharmacological reports 2005, vol. 57, no6, pp. 811-817 Brain Res Bull, December 11, 2006; 71(1-3): 279-86. Journal of Endotoxin Research, Vol. 4, No. 5, 363-370 (1997) Scientific Reports volume 7, Article number: 13763 (2017)
May 17, 2021 · 29 min
Linking TLR's with the VTA and NE circuitry: Immune mediated neurodegeneration and neuroprotection in the balance. DJGPhD 16 May 2021
Brain Behav Immun. 2019 Oct;81:41-51 Neuroimmunomodulation 2002/2003;10:101-121 Front. Neurol., 23 January 2018
May 14, 2021 · 30 min
Microglial TLR activation mediates Aging-Associated CNS Neurodegeneration. Dr. Daniel Guerra. Authentic Biochemistry Podcast. 13 May 2021.
TLRs recognize molecular patterns associated with invasive pathogens. TIR domain-containing adaptors define the specificity of TLR signaling. TLR interactions from CNS-resident microglia can obtain a pro-inflammatory environment that leads to neuronal degeneration as associated with classical aging related diseases like Parkinson's. J Neuroinflammation. 2014 Sep 20;11:166 Brain Behav Immun. 2019 Oct;81:41-51 J Mol Neurosci. 2021 Mar 9
May 8, 2021 · 30 min
The Innate Immune Response Instantiates the Pattern for future Inflammatory Prodromal Neurodegeneration. DJGPhD. 08May 2021
Pathogens, and abiotic ischaemic damage manifest a constellation of molecular interactions triggering pattern recognition receptors such as TLR's, with canonical protein binding domains that signal through intracellular cascades such as activating Ca2+ signaling; eo ipso obtaining potent hyperimmune inflammation, providing event ontological foundation and episodic contribution to the aging morbidity in human decline and mortality.
May 7, 2021 · 29 min
Pattern Recognition Receptors: Some molecular detail. DJGPhD Authentic Biochemistry. 07 May 2021
Oncotarget. 2016 Jan 26; 7(4): 4195–4209 Nature Reviews Immunology volume 6, pages644–658(2006)
May 6, 2021 · 29 min
Ischemic Infarct as a model for immune mediated CNS regeneration or degeneration via microglial stimulation. Dr. Daniel J Guerra. Authentic Biochemistry . 06May2021
The removal of damaged neurons and associated synaptic connections with the simultaneous repair of other neuronal circuits is a mechanism for the sculpting of the brain network and thus a means by which the highly innervated and connected prefrontal cortex can receive and respond to neurotransmission from the limbic system. Reference: Genes (Basel). 2019 Mar; 10(3): 249
Apr 28, 2021 · 29 min
Lymphocyte and Resident Microglia participate in CNS formation, Epigenetic Modifications and Neurodegeneration via RAG-Recombinase. Authentic Biochemistry Podcast by DJGPhD. 27 April 2021
Authentic Biochemistry Podcast 27 April 2021 References Clin Diagn Lab Immunol. 2003 Jan;10(1):13-8 J Exp Med (2012) 209 (1): 187–199. Cell Reports 2020. V 30, (Issue 5) :1585-1597.e6
Apr 26, 2021 · 29 min
The RAG Recombinase Interacts with T lymphocyte Programmed Cell Death Loci. Dr Dan Guerra Authentic Biochemistry Podcast 26 April 2021
References Experimental & Molecular Medicine volume51, Article number: 80 (2019) Am J Nephrol.2017;46(5):371-379 EMBO Rep . 2003 Aug;4(8):774-80 J Biol Chem. 2020 Jul 3;295(27):9052-9060 Mol Immunol. 2017Aug;88:125-134
Apr 24, 2021 · 29 min
Dr. Guerra presents: The CNS and the Immune System are linked to Recombination and the Epigenome. Lecture IV. 24.4.21 Authentic Biochemistry
As an hypothetico-deduction, Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity. In conjunction with a neutral sphingomyelinase and the subsequent synthesis of diacylglycerol thence promoting activation of a PKC-Zeta, T cell receptor translocation and activation are obtained. Prior RAG mediated recombination events in CNS-resident lymphocytes, associated microglia and neurons can lead to recombination event epigenomic ontologies that either promote or curtail a resident hyperimmune response leading to classical neurodegenerative diseases of the elderly. References: J. Biol. Chem. 1998;273:14550-14559 Frontiers in Immunology.2014. 5:100 Front Cell Dev Biol. 2019; 7: 226.
Apr 21, 2021 · 29 min
Authentic Biochemistry Neuroimmune and Epigenetic Interactions in Aging III. DJGPhD 21.4.21
Single-nucleotide polymorphisms and copy-number variations (CNV’s) result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in the accumulation of chromosomal variation. Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene proteins RAG1 & RAG2 that are canonically linked to V(D)J recombination of the T cell receptor and the B cell immunoglobulins. FEBS J. 2017 Jun; 284(11): 1590–1605.
Apr 20, 2021 · 29 min
The immune system is both genetically programmed and environmentally adaptable to epigenetic states. Lecture II DJGPhD 19 April 2021
Neuroinflammatory mediators play a critical role in the pathophysiology of brain ischemia, exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. These processes occur throughout life and involve the immune system, biochemical pathways, cellular turnover and alteration of gene expression. Signal transduction cascades allow for genome editing to epigenomic mediation of metabolic event ontologies. Aging is a process whereby these processes lose specificity and valence, increasingly functioning without appropriate fine control leading to the potential for chronic and more rarely, acute disease states that ultimately result in mortality
Apr 18, 2021 · 29 min
The Immuno-Epigenome Contribution to Aging Foundation Lecture I. DJGPhD 18.4.21
An Introduction to the theory of immunoepigenetic tailoring of human instanence. Dr. Guerra Authentic Biochemistry Podcast Studios
Apr 4, 2021 · 28 min
T lymphocyte caveolae and the efficiency of effector cell differentiation. DJGPhD 4.4.21 Authentic Biochemistry
J Immunol August 1, 2017, 199 (3) 874-884 Ann Rev Cell Dev Biol 2018. 34:111-136 Blood. 2016 Apr 14;127(15):1930-9 J BiolChem. 2017 Aug 25; 292(34): 14292–14307
Mar 31, 2021 · 23 min
Involving Instanence. A Philosophical Episode on Authentic Biochemistry. DJGPhD 31 March 2021
What is involved to make a sound decision? Biochemistry is a scientific discipline; one that examines and interprets the foundational structures and functions of living systems. As with any judgment, as there are reasons for believing, there are also reasons for disbelieving, and the freely willed decision to choose which, should involve the discovery of truths to use as exemplars for seeking coherence and foundation to the premises that necessarily and sufficiently support the better argument for that decision Listen to my lecture to learn the details of this unfolding discussion that recombines epistemology with metaphysics as re-purposed to find Authentic Biochemistry. DJGPhD 31 March 2021
Mar 27, 2021 · 29 min
Caveolae and Alzheimer's Disease. The Micro-vasculature Paradigm: Endothelial Cell Corruption in the CNS Authentic Biochemistry . Dr Guerra. 26 March 2021
Annual Review of Cell and Developmental Biology Vol. 34:111-136 Journal of Neuroscience 23 October 2019, 39 (43) 8576-8583 Archivum Immunologiae et Therapiae Experimentalis 2013 Apr;61(2):119-25.
Mar 25, 2021 · 29 min
Lipoprotein synthesis, turnover and trafficking in concert with caveolae-mediated lipid transport. Dr Dan Guerra Authentic Biochemnistry. 25.3.21.
In this foundational lipid absorption lecture, Dr. Guerra address the roles of apo- lipoproteins, triacylglycerol and cholesteryl esters with membrane associated caveolae transport in adipocytes, endothelia and skeletal muscle. An Authentic Biochemistry Podcast Production. 25 March 2021.
Mar 22, 2021 · 29 min
Condensed Bioenergetics : Dr Guerra Drives the Electron Transport Chain via Standard Oxidation Reduction Potentials. 21.3.21
Electron transport and the anapleurotics of intermediary metabolism. Dr. Daniel J. Guerra Authentic Biochemistry Studios 21.3.21
Mar 21, 2021 · 29 min
Landing on epithelial-mesenchymal transition and T lymphocyte selection to explore Senescence-Associated Cancer-like Stem Cells. DJGPhD 20.3.21
•Impaired immunological responsiveness is common in the elderly •The immunological competence of an individual is determined by the presence of mature lymphocytes formed in primary lymphoid organs, and secondary lymphoid tissues such as the liver, lung and GI tract. •Immunological equilibrium requires steady lymphocyte output, and controlled expansion •Thymic and lymph-node stromal microenvironments thus represent key elements in the development of the adaptive immune system. Consequently, impairment of the lymphoid microenvironment will ultimately lead to insufficient primary and secondary immune responses or to the decline of thymic selection, manifesting in immune senescence accompanied by late-onset autoimmune disorders, often observed in elderly. •Self-tolerant cytotoxic and helper T-lymphocytes, the crucial regulator cells in adaptive immune responses, develop in the specialized epithelial network of the thymus. The thymus, however, gradually loses its capacity to support lymphopoiesis in an involution process that results in a decline of de novo T-cell production. •Cancers of epithelial origin (carcinomas) are the most frequent type of malignancy in humans, with their incidence and aggressiveness increasing with age •This observation raises the question as to whether the aging process itself contributes to tumor progression •. In this regard, telomere biology seems to play a pivotal role since shortening of telomeres has been associated with cellular senescence and organismal aging as well as with cancer incidence and mortality . • •In the multistep carcinogenesis model, telomere shortening has been observed together with increased chromosome instability (CIN) in early precancerous conditions •Experimental models have also shown that a transient period of telomere instability followed by reactivation of telomerase contributes to the acquisition of the metastatic phenotype