Authentic Biochemistry

Dr Daniel J. Guerra

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1,269 episodes
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Episodes1269

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Jun 21, 2022 · 29 min
Membrane Biochemistry IV. Synaptic Plasticity and Oncological Phenomena involving DNA Methylation. Dr. Daniel J. Guerra. 20.6.22 Authentic Biochemistry
References Dr Guerra's notes Sci Signal. 2016 Aug 23; 9(442): ra83 Front. Pharmacol., 24 April 2019
Jun 6, 2022 · 29 min
CytoEpigenetics XIX. Some examples of epigenetic methylation and acetylation patterns in disease and the concept of maintenance methylation. Dr Daniel J. Guerra. 06June2022
References Dr Guerra's notes Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25:436 JAMA. 2008;299(11):1345-1350
Jun 5, 2022 · 20 min
CytoEpigenetics XVIII. Membrane lipid architectonics organized for cell cycle and both nuclear and mitochondrial biochemical mediation of gene expression. Dr. Dan Guerra. 05 June 2022
References Dr Guerra's synthesis of lecture material Histochemistry and Cell Biology volume 145, pages275–286 (2016) Biol Rev Camb PhilosSoc.. 2018 May;93(2):827-844.
Jun 4, 2022 · 29 min
CytoEpigenetics XVII. The role of ceramide metabolism in epigenetic and bioenergetic cross talk among multiple subcellular compartments. Dr Dan Guerra. 03June2022 Authentic Biochemistry Podcast
References Dr Guerra's synthesis of lectures Scientific Reports volume 5, Article number: 15292 (2015)
Jun 2, 2022 · 29 min
CytoEpigenetics XVI. The Mt DNA replicase and helicase enzymes are epigenetically nuclear encoded and localize to the mitochondrial membrane into lipid rafts containing cholesterol. DJGPhD. 2June2022
References Dr Guerra's lecture sytheses Scientific Reports volume 5, Article number: 15292 (2015)
May 28, 2022 · 29 min
CytoEpigenetics XV.An AMPK phosphorylation cascade promoting mTOR pro-translational induction of NFkappa-B SASP transcription is modulated by NAD+ Sirtuin and PARP during Chromatin retailoring.DJGPhD
References Dr Guerra's synthesis of the relevant literature BioEssays, Volume: 39, Issue: 5, First published: 20 February 2017. Front Cardiovasc Med. 2020; 7: 2.
May 26, 2022 · 29 min
CytoEpigenetics XIV. The details of AMPK mediated control over DNA methyl transferase thus coordinating bioenergetics with cell fate via the epitranscriptome. DJGPhD. 25.5.22
References Dr. Guerra's synthesis of the epitranscriptome lecture notes Sci Signal. 2017 Jan 31; 10(464): eaaf7478.
May 22, 2022 · 29 min
CytoEpigeneticsXIII. Epitranscriptomics of Fatty acid Utilization is a driver of Heart-Failure associated Cardiorenal disease. Dr daniel J. Guerra. Authentic Biochemistry.22.5.22
References Sci Signal. 2017 Jan 31; 10(464): eaaf7478 Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55 Nat Commun. 2020; 11: 4664. Int J Biol Sci. 2015; 11(11): 1272–1280
May 21, 2022 · 30 min
CytoEpigenetics XII. The central role of mitochondria in regulating cell fate and metabolic switching is necessary and universal in epigenetic modification of gene expression. DJGPhD.20.5.22
References Dr Guerra's lecture notations and synthesis Cell. 2014 Dec 18; 159(7): 1615–1625 Nat Commun. 2020; 11: 102.
May 18, 2022 · 29 min
CytoEpigenetics XI. The interactive intermediary metabolic architectonic of methylation and acetylation in epigenetic mediation of gene expression between the mitochondria and nucleus. DJGPhD.17.5.22
References Dr Guerra's lecture notes Nat Commun. 2020; 11: 102. Cold Spring Harb Perspect Biol. 2013 Sep; 5(9): a017947.
May 16, 2022 · 29 min
CytoEpigenetics X. The IDH isofrom roles of mutant, hypoxic and constitutive activities mediate DNA, RNA and Histone3 Lys methylation patterns thus redirecting gene expression.DJGPhD.15.5.22
References Dr Guerra's letures/reasoning SCIENCE ADVANCES • 22 May 2019 • Vol 5, Issue 5 Cell MetabolismVolume 22, Issue 2, 4 August 2015, Pages 304-311 Cell Chem Biol. 2020 May 21; 27(5): 538–550.e7.
May 12, 2022 · 29 min
Cytoepigenetics IX. c-MYC controls transcription of two dehydrogenases that alter the ratio of 2-HG/alphaKG thus controling epigenetic signatures on DNA and RNA in a cancer mouse model.DJGPhD.11May22
References Dr Guerra's Lecture notes Cell Chem Biol. 2020 May 21; 27(5): 538–550.e7 Circulation. 2020 Dec 15;142(24):2356-2370
May 9, 2022 · 25 min
CytoEpigenetics VIII. The epigenetic processors, TET and BRD4, mediate control over fatty acid oxidation, pyruvate metabolism, the electron tranport chain and OXPHOS. DJGPhD.8May22. Authentic Biochem
References Dr Guerra's notes Circulation. 2020 Dec 15;142(24):2356-2370 Cancer Science June 2014. 105(9)
May 7, 2022 · 29 min
Cytoepigenetics VIIB. Warburg glycolysis explained from an epigenetic perspective plus some details of DNA methylation/demethylation. DJGPhD. Authentic Biochemistry Podcast 06May2022
References Dr. Guerra's notes Cancer Res. 2011 May 1; 71(9): 3400–3409 Front. Neurosci., 17 May 2017
May 4, 2022 · 21 min
Cytoepigenetics VIIa. Micro RNA control over the electron transport chain and oxidative phosphorylation via binding to nuclear and mitochondrial transcripts. DJGPhD03.may 2022. Authentic Biochemistry
References Dr Guerra's pathbiochemistry lecture notes Cancer Res. 2011 May 1; 71(9): 3400–3409
May 3, 2022 · 29 min
CytoEpigenetics V!. The 'magmatic' alteration of nuclear and mitochondrial gene expression via microRNA processing and translocalization is under bioenergetic control. DJGPhD. 2 May 2022.
References Radiol Oncol. 2021 Dec; 55(4): 379–392
Apr 29, 2022 · 29 min
Cytoepigenetics V. Small interfering and micro RNA mediate mitochondrial and nuclear transcripts thus rendering cell fate, bioenergetics, and immunogenicity. DJGPhD.29.4.22. Authentic Biochemsitry
References Guerra lecture notes/ideas Genes (Basel). 2014 Dec; 5(4): 865–886. Molecular Therapy—Nucleic Acids (2015) 4, e252 Int. J. Mol. Sci. 2016, 17(5), 719
Apr 26, 2022 · 29 min
Cytoepigenetics IV. Using Raman and IR spectroscopy to analyze the physical chemistry of pyrimidine nucleotide methylation. Dr. Daniel J. Guerra. 26.4.22. Authentic Biochemistry Podcast Productions
References J of Computational Chemistry 2011 Volume32, Issue10: Pages 2077-2083
Apr 25, 2022 · 27 min
Cytoepigenetics IIIB. The Geometrical constraints decribed by the valence shell electron pair repulsion in biochemical reactivity. DJGPhD.25.4.22
Dr Guerra organic chemistry notes and concepts
Apr 25, 2022 · 15 min
Cytoepigenetics IIIA. Dissection of the PPAR-gamma epigenetic retailoring. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 25.4.2022
Review mini lecture