

What We Know About Rapamycin with Matt Kaeberlein
One of the world's most respected gerontologists, Dr. Matt Kaeberlein has published more than 250 research papers and spent nearly three decades studying what slows aging. He joins Almost Forever hosts Renee and Melanie to separate what's real in longevity from what's hype, and to explain why he's staked his reputation on telling people the truth. Along the way: the remarkable study tracking tens of thousands of dogs, the compound he believes is the field's most promising, and a candid guide to telling a real expert from a talking head. In our Mailbag: whether a healthy 45-year-old should consider rapamycin, if metformin really slows aging in people who aren't diabetic, and — if you could keep just one longevity supplement — which? Myth or Method: Detox foot pads and castor oil packs — do they really draw toxins out of your body, or is something else going on? Chapters: 0:00 The signal-to-noise problem in longevity 2:40 Myth or Method: Do detox foot pads and castor oil packs actually pull toxins out? 9:40 Meet Matt Kaeberlein — one of the world's leading aging scientists 10:33 The longevity hill he'll die on: the field's signal-to-noise problem 13:48 How to spot longevity misinformation — and the shift back toward science 17:42 The origin of the Dog Aging Project — and the light-bulb moment 22:32 Why companion dogs are the perfect model — and what 55,000 dogs reveal 28:29 Dobby: the German Shepherd who inspired it all 31:42 What rapamycin is, and why he chose it 37:09 mTOR as a "volume knob" — and why ours is always turned up 39:04 Rapamycin vs. caloric restriction — and why 800 calories isn't the answer 42:38 Cycling, dosing, and what we still don't know about rapamycin in humans 45:40 Rapamycin, fasting, the FMD, and autophagy — overlapping but distinct 51:16 What we can safely say about rapamycin in people 52:47 "Everything has side effects" — even exercise 54:10 The real evidence: dementia risk, vaccines, and the immune question 1:00:16 mTOR, protein, and the high-protein trend 1:04:33 Does rapamycin work better for women? The sex-difference data 1:07:47 Muscle, exercise, and what the New Zealand trial actually showed 1:11:20 What's next: the big trials that will finally give us answers 1:13:22 Mailbag: Should a healthy 45-year-old consider rapamycin? 1:15:06 Mailbag: Does metformin actually slow aging in healthy people? 1:20:00 Mailbag: If you could keep only one longevity supplement, which survives? Guest Bio: Dr. Matt Kaeberlein is one of the world's foremost researchers on the biology of aging, with more than 250 peer-reviewed publications. He is the co-founder of the Dog Aging Project — a landmark study following tens of thousands of companion dogs to understand aging in real time — and a longtime investigator of rapamycin and the mTOR pathway. He has become a leading voice for scientific rigor and honesty in a field crowded with hype. Learn more about the Dog Aging Project at dogagingproject.org. Have a longevity question? DM us @prolon on Instagram and you might make it into our mailbag! Learn more about Prolon's 5-Day Fasting Mimicking Diet and longevity lifestyle products at prolonlife.com. Almost Forever is brought to you by Prolon, powered by L-Nutra, the longevity technology company. This podcast is for entertainment purposes only and is not intended as medical advice, diagnosis, treatment, or a substitute for professional healthcare services. Always consult a qualified healthcare provider before making changes to your diet, exercise, supplement, or health routine. Guest views are their own and may not reflect those of Prolon or its parent company L-Nutra.
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