ScienceLife Sciences

Unhealthy Curiosity

Dr Sarah Holper

Neurologist, author and science communicator Dr Sarah Holper explores the fascinating science behind the human body's strangest features, flaws and quirks.

Using medicine, history and curious case studies, she explains why we work the way we do, one wonderfully weird question at a time. From sweating blood to voice transplants, each episode explores a curious corner of medicine and biology.

Learn more at drsarahholper.com.

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20 episodes
weekly
Avg 14 min
English

Episodes 20

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October 2 · 19 min
Why Pain Is Good For You
Pain is miserable, but living without it is considerably worse. This episode explores the extraordinary lives of people born unable to feel pain, from a 1930s vaudeville performer (the "Human Pincushion") to a man who had both legs amputated without painkillers, to discover why pain hurts quite so much – and why your survival depends on it.
September 20 · 14 min
Are You Actually Asleep Right Now?
How do you know whether you’re actually asleep? People with paradoxical insomnia can spend the night convinced they’re wide awake, while their brainwaves insist otherwise. This episode explores what happens when your experience of sleep disagrees with the electrical evidence, why the sleeping brain may be more awake than we once thought, and whether you might actually be getting more sleep than you realise.
September 8 · 16 min
How to Turn Your Skin Any Colour of the Rainbow
This episode explores how drugs, foods, poisons, cosmetics and assorted bodily malfunctions can produce human skin in all 7 colours of the rainbow (and how Isaac Newton is to blame for us thinking a rainbow has 7 colours in the first place).
August 27 · 14 min
Why Muscles Cramp (And What to Do About It)
Dehydration. Too much water. Too much exercise. Not enough exercise. Apparently almost anything can cause a muscle cramp. This episode explores why your muscles occasionally seize without permission, what your nervous system has to do with it, and whether magnesium actually helps.
August 12 · 19 min
How Does Your Tongue Know What Things Taste Like?
How can the hunk of meat in your mouth ‘know’ what the food smeared over it tastes like? This episode explores what actually makes something sweet, sour, salty, bitter or umami, and what maggot-infested cheese, antifreeze and a poisoned Roman emperor have to do with it.
August 3 · 15 min
Can a Nosebleed Kill You?
Spoiler alert: yes. A nosebleed may have finished off one of history's most feared warlords. This episode explores why noses bleed so dramatically, the ingenious anatomy hidden inside your nostrils, exactly what to do the next time your nose starts gushing... and one of the strangest nosebleed case reports ever published.
July 26 · 15 min
Why Your Bruises Change Colour
Your blood is always red. So why the bruise rainbow? This episode explores the colourful chemistry of bruises, from love bites and cupping to creatures with blue, green and yellow blood - and what Tiffany & Co.'s famous turquoise packaging has to do with it.
July 20 · 13 min
What Does Your Belly Button Say About You?
This episode explores the history hidden inside your belly button, from Renaissance arguments over whether Adam had a navel, to the doctor who classified sixty different types of belly button, to the German students who deliberately collected facial scars to improve their marriage prospects. Classify your own belly button using Thomas Cullen's 1916 guide.
July 13 · 13 min
Why Modern Marathons Are So Easy
The marathon wasn't designed by sports scientists. It was shaped by an ancient legend, a royal whim, and one spectacularly bad Olympic experiment involving purposeful dehydration, brandy, and rat poison.
July 3 · 12 min
How to Map Your Taste Buds
A famous biology textbook diagram. A Harvard psychologist called Edwin Boring. And somehow... netball. This episode explores the mad history of the tongue map, and why taste exists in the first place.
June 24 · 12 min
So You Think You Want a Six-Pack?
If you thought doing sit-ups would give you a six-pack, think again. This episode explores the gruelling reality of competitive bodybuilding, and how a 19th century circus strongman used a tape measure, Greek statues, and a little mathematics to define the ‘perfect’ physique. (Do you measure up?)
June 14 · 13 min
How Long Can You Go Without Sleep?
In one experiment, a man who didn't sleep for a week ended up sobbing about an imaginary gorilla. This episode explores what science has uncovered about the effects of sleep deprivation, from hallucinations to frank psychosis – and whether the brain recovers afterwards.
June 8 · 13 min
The Doctor Who Invented Corn Flakes
The inventor of Corn Flakes believed cinnamon was morally suspicious and flavour was a threat to virtue. This episode explores the strange story of John Harvey Kellogg, his wellness empire, his obsession with chewing, vibrating chairs for constipation, and why evolution made flavour far too appealing for his crusade to succeed.
May 31 · 13 min
When Flight Attendants Started Sweating Blood
In 1980, flight attendants began apparently sweating blood on flights between New York and Florida. The CDC investigated. The explanation was not what anyone expected. Also featuring blue sweat, pink sweat, and the only diagnostic dilemma ever solved by a dermatologist ringing a snack-food manufacturer.
May 24 · 13 min
Why Do We Itch? The Itchy and Scratchy Show
This episode explores the biology of itching. Including NASA’s emergency Velcro patches, exploding lice in World War I trenches, contagious scratching, "amphetamites", mosquito mouth-javelins, and the imaginary insects produced by the human brain itself.
May 17 · 12 min
What Does Your Urine Say About You?
This episode explores what urine can reveal about you — from pregnancy and diabetes to drugs, disease, and genetic disorders. Including ancient Egyptian pregnancy tests, beetroot-induced panic, blue urine pranks, and why IKEA once asked women to wee on their catalogue.
May 10 · 15 min
The Strange Science of Sneezing
This episode examines the odd biology and even odder rituals surrounding sneezing. Including sunlight sneezes, chocolate sneezes, and why on earth we feel compelled to bless them.
May 3 · 13 min
Doctor, Or Piss Prophet? The History of Uroscopy
For thousands of years, doctors believed urine revealed the hidden workings of the body. By peering at a patient’s wee, they diagnosed everything from epilepsy to death — sometimes without even meeting the patient. This episode explores the strange history of uroscopy, the rise of the “piss prophets”, and why modern doctors still occasionally ask you for a wee sample today.
April 26 · 12 min
When Doctors Prescribed Sunlight
If you were feeling sickly 100 years ago, your doctor might have prescribed a loincloth, a bed, and a sun-drenched balcony in the Swiss Alps. No blood tests or scans — your degree of tan would determine your prognosis. From sun worship to sun-gazing to Coco Chanel accidentally making bronzed skin chic, this episode explores the many ways medicine and mankind have misunderstood the sun.
April 19 · 12 min
Can DNA Evidence Be Wrong?
Your DNA can build a body, grow a tumour, or implicate you in a crime. This episode explores what happens when DNA evidence meets identical twins, and why one of Europe’s most feared serial killers turned out to be much stranger than anyone expected.

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