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This Week in Cardiology

Medscape

This podcast delivers Dr. John Mandrola's summary and perspective on top news of the week that cardiologists can't miss. This podcast is intended for US health professionals only.

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#429
Friday · 30 min
Nov 06, 2026 This Week in Cardiology
The moderate aortic stenosis TAVR trial, blinded withdrawal in the DECISION digoxin trial, CTO-PCI vs no CTO-PCI 10-year results, and the P4 trial are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I PROGRESS Trial PROGRESS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607326 PROGRESS Trial Editorial https://www.nejm.org/doi/full/10.1056/NEJMe2613400 Genereux Classification https://academic.oup.com/eurheartj/article/38/45/3351/4002776 II Withdrawing Digoxin in the DECISION trial DECISION Trial Substudy https://academic.oup.com/eurheartj/article/47/38/5545/8674856 DECISION Trial - Main Trial https://www.nature.com/articles/s41591-026-04406-6 Efficacy and Safety of Digitalis Glycosides in HF: Meta-analysis https://jamanetwork.com/journals/jama/fullarticle/2848972 RADIANCE trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101 PROVED trial https://www.jacc.org/doi/10.1016/0735-1097(93)90403-N III DECISION CTO Trial at 10 Years DECISION-CTO Trial 10-Year Outcomes 10.1016/j.jacc.2026.10.068 DECISION-CTO Main paper https://doi.org/10.1161/CIRCULATIONAHA.118.031313 EURO-CTO trial https://eurointervention.pcronline.com/article/three-year-outcomes-of-eurocto-a-randomized-multicentre-trial-comparing-revascularization-and-optimal-medical-therapy-for-chronic-total-coronary-occlusions COMET-CTO trial https://pmc.ncbi.nlm.nih.gov/articles/PMC9868942/ EXPLORE Trial https://www.ahajournals.org/doi/10.1161/JAHA.123.033556 ORBITA-CTO trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.027 IV The P4 Trial Coronary CT Angiography Cuts Procedural Time Relative to IVUS-Guided PCI https://www.medscape.com/viewarticle/coronary-ct-angiography-cuts-procedural-time-relative-ivus-2026a1001684 P4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2610771 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
#428
October 30 · 32 min
Oct 30 2026 This Week in Cardiology
The ASPIRED syncope RCT, two studies in coronary artery calcium scoring, and the LEAP-Block trial of CSP vs RV pacing are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Syncope ASPIRED Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605812 REMOSYNCED Trial https://clinicaltrials.gov/study/NCT05066347 II TWO CAC Studies Atherosclerosis in Young Adults and Risk of Mortality Over 30 Years https://jamanetwork.com/journals/jamacardiology/fullarticle/2855732 Predictive Utility of CAC Score Added to PREVENT Score https://jamanetwork.com/journals/jama/fullarticle/2853347 III Conduction System Pacing vs Standard RV Pacing for AV block LEAP-Block Trial https://jamanetwork.com/journals/jama/fullarticle/2855975 Meta-analysis: CSP vs RV Pacing in Preserved or Mildly Reduced EF https://doi.org/10.1016/j.cjca.2026.04.009 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
#427
October 23 · 32 min
Oct 23, 2026 This Week in Cardiology Podcast
Listener feedback on the nonobstructive HCM trials, AI-enhanced visits, timing of non-culprit PCI in STEMI, new tricuspid valve intervention, and EP at a crossroads are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Koelemen meta-analysis https://www.medrxiv.org/content/10.64898/2026.09.08.26362195v1.full.pdf Improving SCD Risk Stratification in HCM https://pmc.ncbi.nlm.nih.gov/articles/PMC11026183/ II More on Nonobstructive HCM Communication on Post-Hoc Analysis of ODYSSEY (mavacamten) Mavacamten in Nonobstructive HCM 10.1016/j.jacc.2025.12.092 III Complete vs Staged PCI in STEMI With Multivessel Disease Immediate vs Staged CR in Multivessel Disease and STEMI: Meta-Analysis https://doi.org/10.1016/j.jcin.2026.07.033 Timing of Nonculprit PCI for STEMI and Multivessel Disease: Editorial https://doi.org/10.1016/j.jcin.2026.08.009 COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775 FLOWER MI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2104650 FRAME AMI Trial https://doi.org/10.1093/eurheartj/ehac763 iMODERN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2512918 COCUA Trial https://doi.org/10.1016/j.ahj.2023.01.020 MULTISTARS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2307823 OPTION STEMI Trial 10.1016/S0140-6736(25)01529-6 External Link CULPRIT SHOCK Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1710261 BioVasc Trial Substudy https://eurointervention.pcronline.com/article/immediate-versus-staged-complete-revascularisation-in-patients-presenting-with-stemi-and-multivessel-disease Main BioVasc Trial 10.1016/S0140-6736(23)00351-3 External Link FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149 IV A Call to Action for Electrophysiologists Twenty Years at the Crossroads 10.1016/j.jacep.2026.09.023 EP at a Crossroads - Josephson 2007 https://doi.org/10.1016/j.hrthm.2006.12.045 EP at a Crossroads: A Revisit - Josephson 2016 https://doi.org/10.1016/j.hrthm.2016.07.024 V FDA Approves Another Tricuspid Valve Repair System Press release https://www.edwards.com/newsroom/news/2026-10-21-fda-approval-of-edwards-lifesciences--pascal-preci TRIC I HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934 CLASP II TR Trial https://pubmed.ncbi.nlm.nih.gov/42855029/ The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
#426
October 16 · 33 min
Oct 16, 2026 This Week in Cardiology Podcast
Some promising studies in amyloidosis, aficamten in nonobstructive HCM, costs of the microaxial flow pump in cardiogenic shock, and more on the VESALIUS trial of evolocumab are the topics John Mandrola, MD, discusses in this week’s podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Light Chain Amyloidosis – A Potentially Helpful Drug Anselamimab Does Not Reduce Light-Chain Amyloidosis Deaths https://www.medscape.com/viewarticle/anselamimab-does-not-reduce-light-chain-amyloidosis-deaths-2026a1000z79 II Aficamten in Nonobstructive HCM: The ACACIA trial III Microaxial Flow Pump Cost Analysis of Danger Shock IV More on Evolocumab at ESC: Vesalius Trial Substudies The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net https://www.medscape.com/viewarticle/1003092 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
#425
October 9 · 28 min
Oct 09 2026 This Week in Cardiology
Listener feedback on POET II, sham control trials in atrial fibrillation, ICDs in HCM, and agenda laundering are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback POET II Response-Tailored or Standard-Duration ABX for Infectious Endocarditis POET I Trial https://www.nejm.org/doi/10.1056/NEJMoa1808312 POET II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607887 II PVI-SHAM-AF trial Back in the News GAP-AF Trial https://www.ahajournals.org/doi/10.1161/circep.115.003337 PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link Why Sham Studies Are a Sham in 2026 10.1016/j.hrthm.2026.09.056 External Link The Indispensable Role of Sham Controls in Evaluating Interventional Therapies 10.1016/j.hrthm.2026.10.001 External Link III ICDs in HCM I CDs for the Prevention of SCD in High-Risk Patients with HCM https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.078597 ICDs in HCM: Editorial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079687 IV Agenda Laundering How Commercial “Agenda Laundering” Shapes Critical Care https://www.bmj.com/content/395/bmj-2026-100963 The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
#424
October 2 · 32 min
Oct 02 2026 This Week in Cardiology
Listener feedback on DANISH-CRT, the POET II trial, a mechanistic study in obesity and AF, the DANCODE trial of slowing CAC progression, and more on GLP-1 drugs are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7 Identifying LV Posterior Wall Delay in RBBB Using Lead V8 http
#423
September 25 · 34 min
Sep 25 2026 This Week in Cardiology
Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback LBBP ICD Lead LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/ TRIC-I-HF trial TRIC-I-HF Tri
#422
September 18 · 31 min
Sep 18 2026 This Week in Cardiology
Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Correction on PROFID Trial II Listener Feedback III Fifth Universal Definition of MI Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101 Foy/Mandr
#421
September 11 · 29 min
Sep 11 2026 This Week in Cardiology
A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Lp(a) Disappointment HORIZON https://clinicaltrials.gov/study/NCT04023552 Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-
#420
September 4 · 41 min
Sep 04 2026 This Week in Cardiology
ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I SINGLE-AF Trial To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulat
#419
August 28 · 26 min
Aug 28 2026 This Week in Cardiology
Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback on Mechanical Compression Devices for OHCA Mechanical CPR Device Use and Cardiac Arrest Survival https://www.ahajournals.org/doi/10.1161/CIRC
#418
August 21 · 33 min
August 21 2026 This Week in Cardiology
Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Mechanical Compression Devices for OHCA · Mechanical CPR Device Use Cardiac Arrest Survival https://www.ahajournals.org/doi/10.1161/CIRCULA
#417
August 14 · 28 min
Aug 14 2026 This Week in Cardiology
Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I ZEUS Fails Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-
#416
July 31 · 31 min
Jul 31 2026 This Week in Cardiology
Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 II Another Failure of Posterior
#415
July 24 · 25 min
July 24 2026 This Week in Cardiology
The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Enlicitide Approved First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https:
#414
July 17 · 34 min
Jul 17 2026 This Week in Cardiology Podcast
DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Antiplatelet Therapy After Stenting DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 HOST-
#413
July 10 · 31 min
Jul 10 2026 This Week in Cardiology
Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Oct 10, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle
#412
June 26 · 33 min
Jun 26 2026 This Week in Cardiology
Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137 II Statins and Frailty Statin Initia
#411
June 19 · 36 min
Jun 19 2026 This Week in Cardiology
Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback ICD Trends and Outcomes: 15-Year Analysis https://doi.org/10.1093/europace/euag110 MADIT-RIT https://w
#410
June 12 · 30 min
Jun 12 2026 This Week in Cardiology
Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD therapies are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335 ARREST-AF Trial https:

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