
Antimicrobial Resistance - Dr. Jitka Viktorová and Dr. Dominik Rejman
U labu 114 (s05e04) Guests: Dr. Jitka Viktorová Dr. Dominik Rejman Recorded on: 2026-06-25 (approximately) Location: Juraj Dobrila University of Pula Authors: Srđan, Brane and Miloš U labu Discord Notes:00:40 Meet our guests: Jitka Viktorová and Dominik Rejman 03:00 Antimicrobial resistance (AMR): why it matters 03:40 Antibiotics: history and evolution of resistance 06:25 The global AMR burden and the antibiotic discovery crisis 08:20 How antibiotics work and how bacteria resist them 12:05 Why bacteria evolve so rapidly 14:50 Mutations and horizontal gene transfer 17:15 Discovering antibiotics: natural and synthetic approaches 21:25 The challenge of getting antibiotics into bacterial cells 24:55 Why antibiotic discovery is so difficult 29:30 Economics of antibiotic development 33:15 MRSA and pan-drug-resistant bacteria 34:55 Antibiograms, sepsis and empirical antibiotic treatment 38:15 The microbiome and beneficial bacteria 39:00 Reviving old antibiotics with adjuvants 40:40 Quorum sensing, biofilms and bacterial dormancy 44:25 Antibiotic stewardship 45:55 Emerging antimicrobial technologies and phage therapy 48:50 Synthetic bacteriophages 51:30 The EURESTOP project 53:40 The immune system and antimicrobial resistance 54:15 AMR as a ticking time bomb 55:10 Antibiotic resistance and cancer: efflux pumps 58:10 Outro References