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The Age Reversal Project

Orshi McNaughton

How close are we to actually reversing aging — and what will it take to get there?
The Age Reversal Project goes inside the rapidly evolving world of longevity, age-reversal science and healthy aging to explore the breakthroughs that could help us live longer, healthier and more capable lives.
Host Orshi McNaughton talks with the scientists, researchers, biotech founders, physicians and pioneers working at the edge of human longevity — from regenerative medicine, cellular reprogramming and gene therapy to AI, longevity therapeutics, emerging medications, advanced diagnostics and human trials.
We follow the technologies moving from the laboratory into the real world, the companies trying to turn longevity science into medicine, and the experiments testing what's possible in humans today. We also explore the interventions available now — from health optimization and biohacking to new approaches designed to extend healthspan, slow biological aging and potentially reverse aspects of aging itself.
And Orshi isn't only reporting on the longevity frontier. She's participating in it — documenting her own experiments, tracking biomarkers and performance, and exploring what these emerging technologies can actually do.
The Age Reversal Project is your front-row seat to the longevity frontier — and the race toward longevity escape velocity.
If you're fascinated by longevity, age reversal, biotechnology, AI, anti-aging science, regenerative medicine, healthspan and the future of human lifespan, this is where you'll meet the people building that future and follow the breakthroughs that could change how we age.

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  • 21 episodes
  • Avg 57 min
  • English

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  • Monday · 1 hr 4 min

    Hormone Therapy, GLP-1s & Peptides for Women’s Longevity | Dr. Shoma Datta-Thomas

    Description Hormone replacement therapy, testosterone, GLP-1 medications and peptides are changing how women approach menopause, metabolic health and longevity. Dr. Shoma Datta-Thomas explains how declining hormones can affect brain fog, sleep, insulin resistance, visceral fat, muscle mass and cardiovascular health, and why hormone health extends far beyond reproductive health. We explore the evolving science of HRT after the Women’s Health Initiative, testosterone therapy for women, GLP-1s for metabolic optimization, resistance training, peptides, supplements, advanced lab testing and the growing role of AI in personalized longevity medicine. LET'S CONNECT Guest: Dr. M. Shoma Datta-Thomas, MD, FACOG Website: https://www.next-health.com/team/dr-shoma-datta-thomas Instagram: https://www.instagram.com/shomadatamd/ Host: Orshi McNaughton Website: https://orshimcnaughton.com/ Instagram: https://www.instagram.com/orshimcnaughton Substack: https://substack.com/@orshimcnaughton Enjoying the podcast? ⭐⭐⭐⭐⭐ Don’t forget to subscribe and leave a review to help spread the word!

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  • August 19 · 22 min

    Can We Reverse Human Aging? Inside the $101M XPRIZE | Rabbit Hole #1

    Can we actually reverse human aging? XPRIZE has put $101 million behind that question, challenging scientists to demonstrate something far more meaningful than a younger biological-age score: measurable improvements in muscle function, cognition, and immune resilience. In the first episode of The Rabbit Hole, I dig into the science behind the XPRIZE longevity competition and some of the approaches now being tested—from repurposed drugs and multimodal protocols to stem cells, gene therapy, extracellular vesicles derived from plants, and cellular reprogramming. We explore why XPRIZE is shifting the conversation from biomarkers to actual human function, what the latest human data tells us, and the critical difference between longevity therapies you can access today and those that have actually been proven to work. Read the full article + explore my writing: https://orshimcnaughton.substack.com/ https://www.instagram.com/orshimcnaughton/ https://www.linkedin.com/in/orshimcnaughton/ AI Disclosure: Portions of this episode feature AI-generated voices used to turn my original reporting and research into a conversational format. The underlying research, sources, editorial direction, and final review are my own. This podcast is for informational and educational purposes only and is not intended as medical advice. Always consult a qualified healthcare provider.

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  • July 15 · 51 min

    Microdosing GLP-1s: Can Less Actually Work Better? | Dr. Karen Mann

    Microdosing GLP-1s is quickly becoming one of the most talked-about topics in obesity medicine, but can taking less actually produce better long-term results for some people? In this episode, Dr. Karen Mann shares how personalized GLP-1 dosing, food noise, behavior change, and identity-based habits may be the missing pieces to sustainable weight management. We also discuss preserving muscle, optimizing protein intake, resistance training, menopause, hormone replacement therapy, and why lasting health depends on changing who you become—not just what you weigh. #GLP1 #Microdosing #FoodNoise #WeightLoss TIMESTAMPS [00:00] Why discomfort is the key to lasting behavior change [00:43] Welcome to The Optimized Woman [01:15] Dr. Karen Mann's personal journey into obesity medicine [02:51] Why weight management requires a personalized approach [04:18] Why standard GLP-1 dosing isn't right for everyone [08:08] Why behavior change matters more than motivation [10:45] Finding your "why" and building identity-based habits [14:56] Becoming the person you want to become [16:32] Coaching, accountability and habit formation [18:46] What microdosing GLP-1s actually means [22:09] New oral GLP-1 medications explained [26:15] Food noise, emotional eating and impulse control [29:43] Ultra-processed foods and why we're still hungry [34:16] Can you lose weight eating unhealthy foods? [36:10] Protein, muscle loss and resistance training [39:42] Why strength training becomes essential with age [42:21] Hormone replacement therapy and healthy aging [47:49] Self-talk, self-compassion and changing your mindset [50:56] Redefining discomfort as an act of self-love LET'S CONNECT Guest: Dr. Karen Mann, MD Instagram: https://www.instagram.com/drkarenmann/ Host: Orshi McNaughton Podcast: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton Substack: https://substack.com/@orshimcnaughton

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  • March 4 · 55 min

    Methylene Blue for Brain Fog, Anxiety and Low Energy | Dr. Scott Sherr, MD

    Methylene blue is one of the most talked-about tools in biohacking for mitochondrial function, brain fog, and energy—and the nuance is in dosing, quality, and context. In this episode, Dr. Scott Sherr explains how chronic stress and hormone shifts can trap women in a “wired but tired” state, why HRV drops when your nervous system can’t recover, and how sleep architecture, minerals, and mitochondrial support may help restore resilience. You’ll also learn the red flags of low-quality methylene blue, why low-dose and high-dose effects are different, and how to think about redox balance without making your stress physiology worse. KEY TOPICS Methylene blue benefits dosing and quality concerns Mitochondrial dysfunction behind brain fog fatigue and anxiety HRV and nervous system resilience in midlife women Sleep architecture REM sleep and why waking at night happens Minerals electrolytes cortisol and the wired but tired stress loop TIMESTAMPS [00:00] Metabolic health crisis and why mitochondrial dysfunction is so common [01:06] Show introduction and what this episode will help you fix [01:37] Scott Sherr’s integrative path and Health Optimization Medicine approach [03:57] The Sympathetic Spiral of Doom and what it looks like in real life [05:10] Why midlife hormones reduce stress tolerance and recovery capacity [06:45] How chronic vigilance and modern stress keep you stuck in fight or flight [08:10] HRV trends over time and why “doing everything right” still isn’t enough [09:54] What HRV measures and how to use it for real-world experiments [11:40] The cell danger response and how mitochondria downshift energy production [12:55] Why “wired but tired” signals mitochondrial and nervous system overload [14:35] Why mood changes and irritability show up when the brain lacks energy [16:34] GABA vs glutamate and the neurochemistry of anxiety and insomnia [18:20] Why SSRIs don’t map cleanly to “low serotonin” in depression [19:55] Short-term calming tools vs medium-term nutrient and gut foundations [21:08] Sleep architecture explained deep sleep REM sleep and recovery biology [22:55] Why waking at night happens and why progesterone alone may not solve it [24:10] Sleep starts in the morning sunlight meals timing and daytime stress [26:05] Why REM sleep is mitochondrially demanding and easier to disrupt [27:37] Minerals under stress why magnesium sodium and potassium get depleted [28:55] Personalizing electrolytes for travel training and high-stress periods [30:05] Cortisol rhythm and why late exercise and late meals can tank recovery [31:20] Why minerals and antioxidants matter for energy production and detox [32:14] Your methylene blue Goldilocks dose and how to cycle it [33:27] What methylene blue does for mitochondria energy and detox together [34:50] Low-dose vs high-dose methylene blue and when higher doses get stressful [36:10] Hydrogen peroxide production at higher doses and why antioxidants matter [37:20] Redox balance explained energy production plus detox capacity [38:20] Quality risks heavy metals potency issues and why liquids are risky [40:02] Why redox-active compounds can backfire if your nervous system is dysregulated [43:40] Breaking the stress loop support mitochondria first then downregulate stress [45:10] The parasympathetic edge why “calmer performs better” is real physiology [48:03] Where health optimization is heading mitochondrial medicine and healthspan [50:25] Organ-level thinking vs cellular-level optimization holobiont framework [52:30] N-of-1 tracking wearables and why personalization beats population advice [53:09] AI caution why models can mislead and why human clinical context matters [54:18] Where to find Dr. Scott Sherr and related work LET'S CONNECT Guest: Dr. Scott Sherr, MD Website: https://drscottsherr.com Instagram: https://www.instagram.com/drscottsherr Host: Orshi McNaughton Podcast: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton Enjoying the podcast? ⭐⭐⭐⭐⭐ Don’t forget to subscribe and leave a review to help spread the word!

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  • Dec 30, 2025 · 1 hr 13 min

    Weight Loss Resistance in Midlife: What the Research Reveals I Dr. Bill Campbell, PhD

    If you’re strength training, eating “clean,” and still gaining fat or losing muscle after 40, it’s not just willpower—it’s physiology. In this episode we break down what actually changes during perimenopause and menopause (lean mass, central fat gain, estrogen shifts), plus the research-backed levers that still move the needle: resistance training intensity, protein targets, smart cardio, recovery, and when HRT may help. If you feel like the old playbook stopped working, this is your reset with a real framework. KEY TOPICS Why weight loss resistance shows up in midlife even for active women How menopause shifts body composition toward central fat gain and lean mass loss HRT and estradiol research for muscle gain and inconsistent fat loss outcomes Protein targets for midlife women and how to hit them consistently Training strategy that works: heavy lifting, cardio for VO2 max, power, agility, and recovery TIMESTAMPS [00:00] Why Bill Campbell shifted his research to menopause after his wife’s experience [00:24] Female physiology matters: women are not “small men” and body composition changes hit hard [00:57] First generation of strength-trained women entering menopause and why the research gap matters [01:40] What’s really happening: gaining fat and losing muscle isn’t just about effort after 40 [09:13] Menopause vs aging debate: what the SWAN data suggests about the transition [12:40] DEXA findings: lean mass loss begins and fat gain accelerates during the transition [14:10] Why fat shifts to the middle: central adiposity, FSH rise, and estradiol decline [15:00] HRT question: what changes when women use hormone therapy during training [16:46] Estradiol and muscle: why estrogen therapy may be anabolic in trained women [18:30] Estradiol and fat loss: why results are variable and not a guaranteed solution [20:28] Hormone balance and nuance: estradiol, progesterone, testosterone, and body fat context [22:55] Estradiol target ranges discussed for bone and muscle support [27:53] Progesterone vs progestins: why older research can be misleading [29:21] Protein targets: 0.75–1.0 g/lb ideal body weight and why most women under-eat protein [33:47] Practical protein strategy: distribute evenly across meals to hit your daily target [38:17] Protein timing around workouts: why pre vs post doesn’t matter much [40:39] Supplements that matter: creatine, whey/complete protein, omega-3s [43:22] Magnesium and vitamin D: common deficiencies and bone-health relevance [45:00] Strength training minimum effective dose: 1 day for maintenance, 2+ days for best results [47:16] Training doesn’t change by decade: intensity and proximity to failure are the difference [49:46] Benchmarks: squat bodyweight and deadlift ~1.25x bodyweight as aspirational goals [54:47] Cardio after menopause: VO2 max, HIIT, and why walking isn’t the same stimulus [58:41] Stress resiliency: when pulling back is smarter than pushing harder [01:00:16] Ideal weekly structure: resistance, aerobic fitness, power, agility, plus daily movement [01:03:16] BFR/Kaatsu for joint pain and training around injuries [01:05:02] What turned it around for Bill’s wife: progesterone first, then estradiol, plus patience [01:07:46] HRT isn’t one-and-done: adjust, track, and combine with training, sleep, and recovery [01:11:26] Where to follow Bill Campbell and his menopause fitness content [01:12:00] Support the show and join the free community at optimizedwomen.com Guest: Dr. Bill Campbell Website: https://billcampbellphd.com Instagram: https://www.instagram.com/billcampbellphd/ LET'S CONNECT Host: Orshi McNaughton Podcast Links: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton

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  • Dec 2, 2025 · 50 min

    Women’s Hormones & the Future of Longevity Medicine | Dr. Amy Killen

    This episode explores how women’s hormones, aging, regenerative therapies, and technology are shaping the next era of longevity medicine. Dr. Amy Killen shares her evolution from ER doctor to multi-company entrepreneur, her work in stem cells and full-body regenerative procedures, and the role of diagnostics, AI, and hormone optimization in midlife women’s health. You’ll get an inside look at the queen phase of perimenopause, the future of longevity clinics, and how women can stay proactive as they age. KEY TOPICS Estrogen, perimenopause and the queen phase of women’s midlife Dr. Killen’s shift from ER medicine to entrepreneurship in longevity Stem cells, exosomes and whole-body regenerative therapies Reputable Health, Hop Box and Humanát Health’s tech-enabled clinical model AI-driven care plans, advanced diagnostics and the future of preventive longevity care TIMESTAMPS [00:00] Estrogen as a forgotten longevity drug and the mental health impact of perimenopause [00:56] Show intro and framing women’s health, resilience and personal transformation [01:27] ER burnout, single motherhood and the moment everything shifted [03:23] Leaving the ER and confronting criticism around hormones and regenerative medicine [04:08] Partnering with Docere Clinics and developing the Full Body Stem Cell Makeover [06:33] Stacking stem cells, exosomes, peptides, light therapy and sound therapy [08:10] Transformations in pain, sexual health and functional recovery using stem cells [10:09] Musculoskeletal outcomes and delaying joint replacement surgeries [10:57] Skin quality improvements, subtle rejuvenation and hair restoration in women [13:33] Stem cells vs PRP and when each modality is most effective [13:51] Founding Reputable Health to modernize clinical trials using wearables [15:11] How biohackers join studies and test real supplements and devices [16:28] Using AI to extract insights from sleep, HRV and wearable data [16:57] Creating Hop Box as a simple, evidence-based female longevity stack [18:17] Supplements tailored to female physiology, insulin resistance and skin health [19:29] Why Hop Box is not a multivitamin and how ingredients like spermidine fit in [21:06] Defining the queen phase and why women lose hormonal protection [23:11] Men’s gradual testosterone decline vs women’s hormonal cliff in midlife [24:52] Stress load in midlife and why so many women struggle in their 40s and 50s [25:43] Hormone therapy as a foundational pillar for women’s longevity [26:18] Building Humanát Health as a next-gen longevity clinic franchise [28:21] Core pillars of longevity care: lifestyle, diagnostics and prevention [30:39] Comparing Humanát to other longevity and biohacking clinics [32:36] Evidence-based hormone protocols and training providers at scale [35:31] How Humanát uses advanced diagnostics and AI-generated care plans [39:45] Why the franchise model expands access to longevity medicine [42:54] Membership tiers, affordability and the future of nationwide rollout [43:41] Inside the Humanát gym: VO2 max, strength, balance and kinetic testing [44:34] Advice to clinicians entering longevity entrepreneurship [45:42] The next decade of regenerative medicine and the role of women [46:41] Balancing motherhood, procedures, multiple companies and travel [47:45] Where to find her clinics, supplements and platforms [49:14] Closing reflections on the women’s longevity revolution Guest: Dr. Amy Killen Website: https://dramykillen.com/ Instagram: https://www.instagram.com/dr.amybkillen/ LET’S CONNECT Host: Orshi McNaughton Podcast: https://optimized-women.captivate.fm/listen Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️ Don’t forget to subscribe and leave a review to help spread the word!

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  • Nov 11, 2025 · 48 min

    A Female Bodybuilder’s Guide to Muscle & Metabolism Over 50 I Carol Covino

    Discover how to build lean muscle, balance hormones, and reignite metabolism after 50. In this episode, you’ll learn the science behind muscle as a metabolic organ, how to train smarter (not harder) through menopause, and why recovery and hormone balance are key for strength and longevity. Perfect for women who want to stay strong, lean, and vibrant at any age. Muscle as metabolic medicine for women in midlife Smart strength training splits and recovery for hormone health Balancing HIIT, Zone 2, and daily movement for longevity Hormone replacement therapy and testosterone in women Protein, creatine, and supplement strategies for women over 50 TIMESTAMPS [00:00] Why muscle is key to metabolic health and glucose control in midlife [00:44] Starting bodybuilding at 50 and transforming your body at any age [01:33] Perimenopause, insulin resistance, and how strength training helps [03:19] Common training mistakes: too much cardio and skipping a coach [05:44] How to find the right trainer for women 40–60+ [09:46] Bodybuilding lessons: muscle splits, compound lifts, and progression [12:37] The best full-body plan for busy women (2–3 days a week) [14:21] How to train with balance and recovery between workouts [15:14] Heavy lifting, volume, and tempo — finding your intensity sweet spot [17:55] Conditioning vs cardio: HIIT, Zone 2, and power training explained [19:07] The ideal weekly mix for fat loss, recovery, and stress control [22:30] Daily walking, HRV tracking, and training around your stress load [27:26] Injury prevention: knees, shoulders, hips, and posture correction [33:17] Midlife recovery tools: mobility, foam rolling, flexibility, and rest [34:12] Men vs women in training — why women won’t “bulk up” [35:04] Estrogen decline, sarcopenia, and how to preserve muscle in menopause [36:23] HRT and testosterone therapy — benefits, myths, and what to watch for [41:13] Protein goals and timing for women 40+ [42:54] Carbs, fats, and how to eat for energy and body composition [44:22] Creatine, protein shakes, and supplement stack for strength [46:47] Carol’s book, podcast, and where to connect with her online Guest: Carol Covino Website: https://carolcovino.com/ Instagram: https://www.instagram.com/carolcovinofitness/ LET’S CONNECT Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ YouTube: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton

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  • Oct 14, 2025 · 1 hr 8 min

    How AI Is Revolutionizing Longevity Medicine | Jim Donnelly

    Discover how precision diagnostics, regenerative therapies, and AI are redefining the future of personalized healthcare. In this episode, you’ll learn how data-driven medicine, early disease detection, and foundational lifestyle strategies are transforming longevity and empowering women to take control of their healthspan. 💡 KEY TOPICS 💡 AI and data-driven longevity medicine Democratizing access to precision health care Foundations of health optimization and lifestyle medicine Regenerative therapies and therapeutic plasma exchange Women’s hormones, midlife vitality, and personalized care ⏰ TIMESTAMPS ⏰ [00:00] Adding 20 good years of life and redefining longevity [02:15] The story behind Restore Hyper Wellness and the birth of Humanot Health [07:31] Building the wellness franchise model and scaling innovation [12:03] From athlete recovery to chronic inflammation relief [19:40] Defining health optimization and the role of foundational habits [23:53] How Humanot bridges fragmented longevity solutions [28:08] Making advanced therapies more affordable and accessible [34:24] Standardizing longevity medicine and women’s hormone care [46:32] How AI is transforming diagnostics and personalized medicine [54:07] Cutting-edge therapies like therapeutic plasma exchange [59:54] Preventative and minimally invasive healthcare approaches [01:00:30] What health optimization means for women in midlife [01:06:45] Final insights and how to connect with Humanot Health 🌿 GUEST 🌿 Jim Donnelly | CEO & Founder, Humanot Health Website: https://www.humanauthealth.com Instagram: https://www.instagram.com/humanauthealth/ LinkedIn: https://www.linkedin.com/in/jimdonnellyhumanaut 💫 LET'S CONNECT 💫 Host: Orshi McNaughton Website: https://www.optimizedwomen.com Podcast: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/ LinkedIn: https://www.linkedin.com/in/orshimcnaughton/

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  • Oct 7, 2025 · 1 hr

    Hormonal Imbalances & Hair Thinning: What Every Woman Should Know | Faraz Khan

    Hair thinning, gray hair, and hair loss don’t have to be inevitable! In this episode, we explore the science of hair health and dive into the root causes of these issues—hormonal imbalances, nutritional deficiencies, and stress. Learn how to restore your hair naturally using a proven system that promotes growth, prevents gray hair, and reverses thinning. Plus, we uncover the effectiveness of popular treatments like PRP, red light therapy, and micro-needling, and share what truly works to help you achieve vibrant, healthy hair. 🔹 What You'll Learn in This Episode: The root causes of hair thinning and gray hair in women How hormonal imbalances and stress accelerate hair loss—and what to do about it The best nutrients, vitamins, and minerals for hair regrowth A step-by-step system for reversing gray hair naturally What works (and doesn’t) in hair restoration treatments like PRP and red light therapy 🔑 KEY TOPICS 🔑 Hormones & Hair Loss: How cortisol, estrogen, and thyroid affect your hair Gray Hair Reversal: Natural ways to reduce hydrogen peroxide buildup Nutrition for Hair Health: Key vitamins, minerals, and protein sources Effective Hair Growth Treatments: PRP, microneedling, and red light therapy The Ultimate Hair Restoration System: Proven steps to regrow and strengthen your hair 🕐 TIMESTAMPS 🕐 [00:00] Introduction & Common Hair Loss Treatments [03:30] Hormonal Imbalances & Hair Loss Causes [10:30] Early Signs of Hair Thinning & Genetic Factors [17:00] Nutritional Deficiencies & Hair Growth Support [23:30] Stress, Cortisol, and Their Impact on Hair Health [31:30] Effective Hair Loss Treatments: PRP, Red Light & More [42:00] The Science Behind Gray Hair & Reversing It [50:00] How Hair Dyes & Chemicals Affect Hair Health [57:00] Building a Complete Hair Restoration Routine [62:00] Final Longevity & Anti-Aging Tips for Hair & Health 🎙️ GUEST: Faraz Khan 🎙️ Website: https://FullyVital.com Instagram: https://instagram.com/fullyvitalhair 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/

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  • Aug 26, 2025 · 1 hr 3 min

    Why Testosterone Levels Dropped 50% Worldwide | Shalin Shah

    Testosterone levels have dropped by nearly 50% over the past 40 years, creating ripple effects in metabolism, mood, fertility, and longevity. In this episode, you’ll learn why hormones are declining across both men and women, the hidden role of endocrine disruptors, and how lifestyle, TRT, and new oral formulations are changing the conversation about hormone health. Discover the metabolic, cardiovascular, and brain benefits of testosterone and what myths need to be debunked once and for all. TIMESTAMPS [00:00] Testosterone decline over the last 40 years and why it matters [03:27] Causes of low testosterone: obesity, endocrine disruptors, poor sleep [06:09] Symptoms and metabolic consequences of testosterone deficiency [09:45] Can lifestyle changes restore testosterone without TRT? [15:09] How low testosterone shows up in women and its health impacts [17:01] History of testosterone therapy, stigma, and FDA regulation [22:16] Current TRT options: injectables, pellets, gels, and compounded creams [33:06] Innovation in oral testosterone and SHBG reduction [42:00] Fertility, LH/FSH suppression, and pilot study data [55:33] Testosterone’s connection to longevity, chronic disease, and healthspan [58:23] Myths about cardiovascular risk, prostate cancer, and testosterone use [01:00:51] Hormones as a foundation of health and how to get tested Guest: Shalin Shah Website: https://kaisertrex.com Instagram: https://www.instagram.com/themetabolicceo 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/ Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️ Don’t forget to subscribe and leave a review to help spread the word!

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  • Aug 19, 2025 · 43 min

    Closing the Gender Gap in Women’s Health Research I Katie Moore & Mackenzie De Jesus

    Women’s health research has historically overlooked critical differences in female biology. In this episode, Katie Moore and Dr. Mackenzie De Jesus join me to uncover the persistent gender gap in health studies. We discuss the implications of male-centric research, the rise of wearable health tech, and how women can take charge of their health with personalized solutions. Discover how new technologies and innovative studies are shaping the future of women’s health research. 🕐 TIMESTAMPS 🕐 [00:00] Introduction to Women’s Health Research [01:13] Meet Katie Moore and Dr. Mackenzie De Jesus [02:57] How autoimmune issues uniquely affect women [05:56] Male-centric health research: The historical context [11:21] Wearable devices and women’s health [16:26] Using personalized health data for better outcomes [25:10] The impact of gender-specific research on health care [33:38] Participating in health studies with Reputable Health 🎙️ GUESTS 🎙️ Katie Moore and Dr. Mackenzie De Jesus Join Women's Health Study: https://www.reputable.health/orshi Instagram: https://www.instagram.com/reputablehealth LinkedIn: https://www.linkedin.com/company/reputable-health 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen https://www.linkedin.com/in/orshimcnaughton/ Enjoying the podcast? Don’t forget to subscribe and leave a review to help spread the word!

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  • Aug 12, 2025 · 1 hr 6 min

    How to Improve Vision & Brain Performance | Dr. Bryce Appelbaum

    Your vision is more than just seeing clearly—it's a direct reflection of your brain function and overall health. In this episode, we explore the groundbreaking field of neuro-optometry and how vision training can improve focus, mental clarity, energy levels, and even stress resilience. Learn how screen time is impacting your eyesight, why more kids are becoming nearsighted, and what you can do to optimize your vision at any age. Discover natural solutions beyond glasses and contacts to train your eyes and brain for peak performance. What You'll Learn in This Episode: 🔹 How vision training enhances mental clarity, focus & energy 🔹 The truth about screens & their impact on eyesight 🔹 Why nearsightedness is skyrocketing & how to prevent it 🔹 How hormones, stress & aging affect vision health 🔹 The best strategies to strengthen your eyes & brain 🕐 TIMESTAMPS 🕐 [02:10] What is neuro-optometry & how does it go beyond glasses? [10:45] The impact of screen time on vision, sleep & mental clarity [18:30] The nearsightedness epidemic & why kids are affected more [27:15] How hormones, aging & stress affect women’s eye health [35:40] Vision training for cognitive function & productivity [44:00] Concussion recovery, motion sickness & vision therapy [50:20] How to reduce eye strain & improve digital endurance [58:00] Nutrition & lifestyle strategies for long-term eye health 🎙️ GUEST: DR. BRYCE APPELBAUM 🎙️ 🔗 Website: https://www.myvisionfirst.com/ 📸 Instagram: @drbryceappelbaum 📺 ScreenFit Training – Get $200 OFF! Use promo code OPTIMIZED at checkout: https://www.screenfit.com/ 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/ ⭐️⭐️⭐️⭐️⭐️ Enjoying the podcast? Don’t forget to subscribe & leave a review to help spread the word!

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  • Aug 5, 2025 · 1 hr 5 min

    Reverse Hashimoto’s and Autoimmunity Naturally | Ryan Monahan

    If you're struggling with fatigue, weight gain, brain fog, or unexplained symptoms despite “normal” labs, this episode will help you uncover what’s really going on. We explore how thyroid dysfunction—especially Hashimoto’s—is often missed, misdiagnosed, or mistreated. Learn the real root causes behind low thyroid function, the truth about lab testing, and what to do when meds aren't working. You’ll walk away with real-world strategies to begin healing your thyroid naturally and reclaim your energy. TIMESTAMPS [00:00] Why adrenal exhaustion causes thyroid to slow down [01:42] Ryan’s decade-long struggle to get diagnosed [05:06] His TSH was over 150—what that really means [06:56] Why Hashimoto’s goes undiagnosed in women [09:27] Why TSH is not a thyroid marker [13:02] Why doctors dismiss thyroid antibodies [17:53] Going gluten-free to reverse autoimmune markers [23:32] Study: gluten increases leaky gut in everyone [25:51] What is leaky gut and why it matters for Hashimoto’s [28:53] Molecular mimicry and immune system crossfire [30:30] Food sensitivity testing and the best elimination diets [32:17] Cortisol, inflammation, and thyroid damage [34:53] The role of glutathione in thyroid hormone production [36:38] Why stress shuts down your thyroid and metabolism [37:50] Hashimoto’s vs. hypothyroid symptoms [38:55] Chronic inflammation and autoimmunity [42:31] The 6 markers you need on every thyroid panel [47:11] Why Synthroid doesn’t always work [49:20] Ryan’s antibodies dropped from 1700+ to normal [54:33] Full testing strategy: gut, toxins, mitochondria [57:29] Healing strategies to reverse Hashimoto’s naturally [59:10] Free guide: 10 steps to heal from Hashimoto’s [1:00:19] What every woman should know about healing GUEST: Ryan Monahan Website: https://themindfulnutrivore.com/ Instagram: https://www.instagram.com/themindfulnutrivore/ 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/ Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️ Don’t forget to subscribe and leave a review to help spread the word!

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  • Jul 22, 2025 · 1 hr 4 min

    Inside the Biohacking Routine of a Mom and CEO I Lindsay O’Neill

    What happens when a tech executive and mom of three uses biohacking to heal herself and her child from autoimmune dysfunction, chronic UTIs, and fatigue? Lindsay O’Neill shares her daily routine, the Immortal Chamber experience, and the testing tools that reversed years of inflammation. Learn how to combine intuition, diagnostics, and health tech to rebuild your body from the ground up. KEY TOPICS Gut health testing and food inflammation Healing trauma and low muscle tone in children Using the Immortal Chamber for nervous system reset Daily hormone support and perimenopause protocols Building the Biohacking Index to help more women personalize wellness TIMESTAMPS [00:00] Why doctors need to understand biohacking tools [02:18] The car accident that triggered Lindsay’s health collapse [03:33] Healing her daughter with eastern and western modalities [06:02] The Immortal Chamber experience and its emotional impact [08:27] UTIs, antibiotics, and bladder dysfunction in children [13:36] Supplements and tools that helped her daughter recover [14:47] Food inflammation test: IGG, IGA, C3D, and gut markers [18:20] Why inflammation is the root cause of most symptoms [23:18] MTHFR, folic acid overload, and detox risks [25:08] The danger of cumulative toxic load and burnout [26:33] Educating doctors through experience, not theory [31:47] What the Biohacking Index platform offers [34:50] Lindsay’s own autoimmune reversal journey [36:38] Full-body detox and emotional healing after trauma [39:44] Adjusting routines during perimenopause [41:02] How poor sleep blocks hormone repair [44:07] A full day of supplements, stacking, and self-care [50:22] Why you shouldn’t drink while eating [53:29] Lindsay’s non-toxic skincare and grounding routine [58:22] Letting go of perfection and chasing health sustainably [59:10] Why intuition is your best data point [1:03:02] Teaching children to trust their body’s signals [1:04:45] Final thoughts on faith, intuition, and healing Guest: Lindsay O’Neill Website: https://www.lindsayoneill.com Instagram: https://www.instagram.com/smallhinges 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/orshimcnaughton/ Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️ Don’t forget to subscribe and leave a review to help spread the word!

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  • Jul 15, 2025 · 1 hr 9 min

    Gut Health: The Missing Key to Sustainable Weight Loss | Joel Greene

    If you're stuck in the cycle of restrictive dieting and rebound weight gain, your gut may be the root cause. In this eye-opening episode, Joel Greene shares how gut diversity, immune signaling, and adipose tissue health impact fat loss—and why most diets fail without nature’s built-in rhythms. Learn how to reset your microbiome, restore key bacteria, and train your metabolism to work with you, not against you. KEY TOPICS Gut-immune signaling and why your body protects fat The microbiome’s role in fat storage and cravings How to reset fat-burning bacteria like Akkermansia The truth about old fat, fibrosis, and weight loss resistance 7-day and seasonal rhythms that reprogram your metabolism TIMESTAMPS [00:00] Why modern diets fail without nature’s rhythms [02:00] The fat loss trap: clean eating, shakes, and metabolic chaos [05:30] Muscle doesn’t fix fat—why bulking leads to rebound weight [07:00] Joel’s gut-focused breakthrough and the birth of The Immunity Code [12:00] Akkermansia, bifidobacteria, and the fat-burning microbiome [14:30] Foraging, fasting, and mimicking natural dietary rhythms [19:30] Rebuilding the gut after antibiotics and immune dysfunction [28:00] The 7-day rhythm protocol for metabolic reset [35:00] Fasting for women: age, cycle, and cortisol timing [42:00] Cold exposure, mechanical massage, and adipose rejuvenation [47:00] What makes fat “old” and impossible to lose [51:00] How inflammation and ECM fibrosis block fat loss [57:00] Joel’s 3-phase supplement stack for gut and fat reset [01:03:00] Why weight rebound hardwires future resistance [01:04:30] Fast twitch muscle training for women over 50 🎙️ GUEST: Joel Green Instagram: https://www.instagram.com/realjoelgreene Website: https://veevpnutrition.com 🌐 LET’S CONNECT Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen ⭐️⭐️⭐️⭐️⭐️ Enjoying the podcast? Please subscribe & leave a review to help spread the word!

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  • Jul 8, 2025 · 42 min

    Unlocking Your Inner Strength: The Right Way to Do Cold Therapy for Women | Kristin Weitzel

    Cold therapy can be a powerful tool for fat loss, metabolic health, stress resilience, and recovery—but women need a different approach than men. In this episode, we break down the best way to use ice baths and cold exposure to support energy, hormones, and longevity without overstressing the body. Learn how to time your cold plunges, what temperature delivers the best results, and how breathwork can enhance the benefits while keeping your nervous system in balance. 🔹 How cold exposure impacts women’s metabolism & hormones 🔹 The best breathwork techniques for getting through an ice bath 🔹 How long, how cold, and how often you should plunge 🔹 The biggest mistakes women make with cold therapy 🔹 The surprising mental & emotional benefits of cold exposure 🔑 KEY TOPICS 🔑 How cold therapy affects women’s physiology differently than men The best cold exposure & breathwork protocols for stress resilience Why cold plunges help with fat loss, metabolism & longevity When NOT to do cold therapy and how to avoid overdoing it The right temperature & duration for maximum benefits TIMESTAMPS [00:00] Cold exposure as a tool for nervous system training and empowerment [01:12] Why The Optimized Woman exists: taking back your health and energy [02:35] Introduction to Kristin Weitzel and her cold + breathwork framework [04:03] The mental benefits of cold exposure and neurochemical reset [08:14] Cold therapy as a response to chronic stress and post-pandemic burnout [09:09] How cold therapy protocols should differ for women [13:46] Breathwork techniques before, during, and after a cold plunge [19:05] The myth of “more is better” and when cold becomes overstimulation [24:43] Contrast therapy, sauna pairing, and optimizing recovery windows [30:03] Ice bath highs, dopamine chasing, and stress-recovery balance [34:17] Using cold therapy during grief and heartbreak [38:52] Reentering cold therapy after trauma or burnout Guest: Kristin Weitzel Website: https://www.sherpabreathandcold.com Instagram: https://www.instagram.com/kristinweitzelofficial 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Co-Host: Katie Moore: https://www.youtube.com/ ⁨@katie_moore⁩ Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen

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  • Jul 1, 2025 · 46 min

    Sleep Optimization & Circadian Health Explained | Mollie Eastman

    If you're exhausted but can't sleep, stuck in a cycle of sleeping pills, or struggling to fix your sleep despite trying everything—this episode is for you. Sleep expert Molly Eastman reveals the overlooked causes of chronic insomnia, how modern life sabotages your circadian rhythm, and the breakthrough strategies that actually work. Learn how to reset your body clock, identify hidden sleep disorders, and optimize HRV for long-term health. ✅ Discover the real root of your sleep issues ✅ Learn why sleeping pills often backfire and what to do instead ✅ Understand social jet lag and how to fix it ✅ Explore powerful ENT procedures that can transform sleep ✅ Get actionable tips to boost HRV, energy, and metabolism KEY TOPICS Why women are misdiagnosed with insomnia The link between breathing disorders and poor sleep Circadian disruption from indoor living and artificial light Chronobiology strategies for deep sleep and HRV recovery ENT procedures and sleep trackers that actually work TIMESTAMPS [00:00] The misunderstood struggle of women with insomnia [01:25] Molly’s personal journey with sleep anxiety and panic attacks [04:12] Why sleeping pills aren’t the solution—and what is [08:32] The truth about sleep quality and REM suppression [13:54] Sleep apnea vs upper airway resistance syndrome explained [17:24] ENT interventions like tongue tie release and nasal optimization [21:07] How chronobiology helps reset your body clock [26:53] Social jet lag, cortisol rhythm, and melatonin misfires [30:58] Balancing social life with sleep goals [35:14] Best sleep trackers and HRV tools for recovery [42:44] How to connect with Molly and get started Guest: Molly Eastman Website: https://www.sleepisaskill.com/ Instagram: https://www.instagram.com/sleepisaskill/ 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen

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  • Jun 24, 2025 · 1 hr 6 min

    Real Talk on Perimenopause, Hormones, and HRT I Dr. Salome Masghati

    This episode reveals the hidden risks of hormonal birth control, how it alters your gut, mood, and long-term health, and why most OB/GYNs are missing the mark on hormone therapy. Learn how estrogen and progesterone rhythms affect everything from your brain to your bones — and what you need to know about bioidentical HRT, perimenopause symptoms, fertility decline, and why synthetic hormones can derail your metabolism. If you’ve ever been dismissed by a doctor or handed a pill without options, this episode is a must-listen. KEY TOPICS How birth control affects mood, gut health, and nutrient absorption Why rhythmic estrogen and progesterone cycles are vital for healthspan The difference between synthetic hormones and bioidentical HRT Perimenopause symptoms that are often misdiagnosed or ignored How thyroid, adrenal, and insulin imbalances intersect with female hormones TIMESTAMPS [00:00] Birth control, mood changes, and neurotransmitter disruption [01:38] Meet Dr. Salome Masghati and her shift from surgery to root-cause care [04:02] Gaps in OB/GYN training around menopause and hormone prevention [06:52] Why birth control is overprescribed and how functional care differs [09:26] The critical role of estrogen-progesterone rhythm in women's health [15:08] Long-term effects of oral contraceptives and synthetic progestins [21:10] Risks and misconceptions around IUDs and systemic effects [26:18] When to consider bioidentical hormones and signs of perimenopause [34:26] How to prepare the body for pregnancy and optimize egg quality [40:30] Hormones and weight gain, insulin resistance, and gut health [42:19] Adrenal, thyroid, and sex hormone interplay in perimenopause [43:53] Why skipping HRT may accelerate aging and long-term health decline [48:02] What are optimal hormone levels for estradiol, progesterone, testosterone [51:10] Should you bleed postmenopause? Pros and cons of cyclical HRT [55:15] Testosterone therapy myths, administration routes, and risks [59:46] Estrogen detox, gut flora, and hormone metabolism explained [61:08] Mental health, ADHD, and red flags for hormonal imbalance 🎙️ GUEST 🎙️ Dr. Salome Masghati Website: https://www.drsalomemasghati.com/ Instagram: https://www.instagram.com/dr.salomemasghati/ 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen 💚Calocurb is a 100% plant-based supplement that helps curb cravings and support healthy appetite control. 👉 Get 10% off, use discount code: 10OFF to purchase Calocurb @ https://www.calocurb.com/10OFF Enjoying the podcast? ⭐️⭐️⭐️⭐️⭐️ Don’t forget to subscribe and leave a review to help spread the word!

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  • Jun 17, 2025 · 54 min

    Osteoporosis Prevention & Hormone Replacement Therapy I Dr. Doug Lucas

    Osteoporosis isn’t just a concern for older women—it often starts much earlier than you think. Bone health is deeply connected to hormones, metabolism, and nutrition, and the right approach can not only prevent bone loss but reverse it. In this episode, we dive deep into osteoporosis, the critical role of hormones, the best nutrition for strong bones, and the most effective strength training strategies for long-term health. What You'll Learn in This Episode: 🔹 Why osteoporosis starts earlier than most women realize 🔹 How menopause accelerates bone loss & how to prevent it 🔹 The essential role of hormone replacement therapy for bone health 🔹 Nutrition & supplements that support bone density 🔹 Best strength training & weight-bearing exercises for strong bones 🕐 TIMESTAMPS 🕐 [00:00] Why osteoporosis is more than just a bone density problem [05:45] How hormone imbalances accelerate bone loss [12:30] Best nutrition & supplements for bone health [18:40] Why weight training & impact exercises are crucial [25:55] How gut health & inflammation affect bone metabolism [32:10] Breaking myths about osteoporosis & HRT [37:45] Can older women still benefit from HRT? [42:20] The role of testosterone for women’s bone health [45:35] Best strength training exercises for bone density [49:10] OsteoStrong & other bone-building therapies – do they work? [52:30] Dr. Doug’s #1 tip for preventing osteoporosis 🎙️ GUEST: DR. DOUG LUCAS 🎙️ 🔗 Website: https://www.optimalhumanhealth.com/ 📺 YouTube: The Dr. Doug Show 📸 Instagram: @dr_douglucas 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen 💚 Calocurb is a 100% plant-based supplement that helps curb cravings and support healthy appetite control. 👉 Get 10% off, use discount code: 10OFF to purchase Calocurb @ https://www.calocurb.com/10OFF

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  • Jun 12, 2025 · 57 min

    A Holistic Take on GLP-1s for Weight Management | Nat Niddam

    Struggling to lose weight despite a healthy lifestyle? In this episode, holistic nutritionist Nat Niddam joins us to uncover the science and strategy behind GLP-1 weight-loss peptides. We explore their transformative potential—not just for weight loss, but for enhancing insulin sensitivity, reducing inflammation, and curbing emotional eating. Nat shares expert tips for avoiding muscle loss, navigating metabolic plateaus, and using GLP-1s as part of a holistic health plan. Whether you're navigating menopause, managing PCOS, or looking for sustainable weight loss solutions, this conversation is packed with essential advice for achieving your optimal body composition. 🔑 KEY TOPICS 🔑 -The role of GLP-1 peptides in managing weight loss resistance and enhancing insulin sensitivity. -Why muscle loss is a concern when using GLP-1s—and how to prevent it with nutrition and resistance training. -The importance of a holistic approach: addressing hormone imbalances, gut health, and nutrient deficiencies. -Practical ways to reset your body’s weight set point and achieve long-lasting results. -Complementary peptides and supplements to support your body during GLP-1 use. -Strategies for managing common side effects like constipation and reflux. 🕐 TIMESTAMPS 🕐 [00:00] Introduction & Overview of GLP-1s for Weight Loss [02:51] Nat Niddam’s Approach to Holistic Nutrition & Peptide Therapy [05:00] Common Mistakes When Using GLP-1s [08:55] Why Testing Is Crucial Before Starting Peptides [12:30] The Importance of Protein Intake for Preserving Muscle [15:45] Resistance Training & Preventing Sarcopenia [19:25] How GLP-1s Impact Appetite and Food Cravings [21:40] Addressing Common Side Effects: Reflux and Constipation [24:24] Supporting the Liver, Thyroid, and Adrenals During Peptide Use [28:29] Nat’s Personal GLP-1 Journey and Lessons Learned [36:00] Overcoming Metabolic Plateaus [38:40] Complementary Peptides: BPC-157, CJC-1295, and More [43:10] Next-Generation Weight Loss Peptides and Future Innovations [48:30] The Role of Digestive Health in Weight Loss Success [52:27] Measuring Progress Beyond the Scale: Body Composition Insights [54:09] Nat’s Top Three Tips for Living an Optimized Life 🎙️ GUEST 🎙️ Guest: Nat Niddam Website: https://www.natniddam.com Instagram: https://www.instagram.com/nathalieniddam 🌐 LET'S CONNECT 🌐 Host: Orshi McNaughton Website: https://www.optimizedwomen.com/ Podcast Links: https://optimized-women.captivate.fm/listen YouTube Channel: https://www.youtube.com/@optimizedwomen Instagram: https://www.instagram.com/optimizedwomen 💚 Calocurb is a 100% plant-based supplement that helps curb cravings and support healthy appetite control. 👉 Get 10% off, use discount code: 10OFF to purchase Calocurb @ https://www.calocurb.com/10OFF

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Showing 1–20 of 21 episodes