
Dr Scott Murray – Is IVUS Plaque ‘Regression’ Just Measurement Noise?
In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardiac fuel metabolism and heart failure with preserved ejection fraction, and the challenges of conducting and interpreting cardiovascular trials. 🔥 This episode is sponsored by us -- Own Your Labs 👉 `https://ownyourlabs.com/sp/47` Private blood testing services 🩸Over 300 blood tests 💰Extremely affordable ❤️ We love our customers (Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏) 🔗 CONNECT WITH DAVE FELDMAN: Main Channel: `https://youtube.com/@realDaveFeldman` X/Twitter: `https://x.com/realDaveFeldman` Instagram: `https://instagram.com/realDaveFeldman` Website: `https://thefeldmanprotocol.com` ⏱ Chapters 0:00 – Cold open & Scott's intro 14:21 – Scott's cardiology practice 17:28 – Invasive vs. CT angiography 24:49 – Collaterals & microvascular function 34:31 – Glycocalyx & endothelial health 40:28 – Perivascular fat & imaging 51:14 – Imaging, CAC, and plaque noise 1:00:04 – Lipid hypothesis & population context 1:07:05 – CT plaque measurement variability 1:19:42 – Perivascular inflammation & Caristo scoring 1:29:07 – Lipid energy model discussion 1:49:43 – LP(a), acute-phase markers & reverse causation 2:05:01 – LMHR study timeline & next scans 2:22:57 – Heart fuel preference & HFpEF 2:39:08 – PCSK9 trials & all-cause mortality 2:52:06 – Run-in periods & trial design concerns 3:05:00 – Context, guidelines & patient conversations 3:17:35 – GLP-1 peptides & obesity biology 3:26:28 – Where to find Scott & closing thoughts #FeldmanProtocol #DaveFeldman #ScottMurray #PreventiveCardiology #HeartHealth #LipidHypothesis #LeanMassHyperResponder #CTAngiography #PlaqueImaging #CardiovascularResearch #MetabolicHealth #LipidEnergyModel #HeartFailure #LPa #GLP1 #TrialDesign #Cardiology #LowCarb #BloodWork