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PsyDactic

T. Ryan O'Leary

A resource for psychiatrists and other medical or behavioral health professionals interested in exploring the neuroscientific basis of psychiatric disorders, psychopharmacology, neuromodulation, and other psychiatric interventions, as well as discussions of pseudoscience, Bayesian reasoning, ethics, the history of psychiatry, and human psychology in general.

This podcast is not medical advice.  It strives to be science communication.  Dr. O'Leary is a skeptical thinker who often questions what we think we know.  He hopes to open more conversations about what we don't know we don't know.

Find transcripts with show-notes and references on each episodes dedicated page at psydactic.buzzsprout.com.

You can leave feedback at https://www.psydactic.com.

The visual companions, when available, can be found at https://youtube.com/@PsyDactic.

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  • 22 episodes
  • Avg 43 min
  • English

Episodes 22

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  • #67
    Jan 9, 2025 · 26 min

    Meet the Psychiatry Bootcamp Podcast brought to you by Dr. Mark Mullen

    Dr. O'Leary is excited to introduce you to Psychiatry Boot Camp (PBC), a podcast created by Dr. Mark Mullen during his psychiatry residency to help prepare medical students for psychiatry residency. It covers fundamental topics in psychiatry and inspires young psychiatrists to think critically about their approach to the field. The curriculum is based on published literature on psychiatry crash courses and boot camps, and features interviews with experts in the field. Some specific PBC episodes that are discussed include those introducing students to psychiatry as a discipline with unique challenges, including interviews with Dr. Awais Aftab, Clinical Professor of Psychiatry at Case Western University, and Dr. Allen Frances, Chair of the DSM-4 Task Force and Chair Emeritus at Duke. We also discuss Dr. Mullen's eye-opening interview with Dr. Tyler Black, a suicidologist and child psychiatrist at British Columbia Children's Hospital who provides the best foundational discussion of the suicide assessment that Dr. O'Leary has ever encountered. Enjoy this interview and afterward, please check out Psychiatry Boot Camp. https://pubmed.ncbi.nlm.nih.gov/38724723/ https://podcasts.apple.com/us/podcast/psychiatry-boot-camp/id1671902940 https://open.spotify.com/show/4Vjlz4CO0G5D6nGo74O0jE https://www.audible.com/podcast/Psychiatry-Boot-Camp/B0BVK4HYLW https://x.com/markrmullen Please leave feedback at https://www.psydactic.com or send any comments to feedback@psydactic.com. References and readings (when available) are posted at the end of each episode transcript, located at psydactic.buzzsprout.com. All opinions expressed in this podcast are exclusively those of the person speaking and should not be confused with the opinions of anyone else. We reserve the right to be wrong. Nothing in this podcast should be treated as individual medical advice.

    • Transcript
  • #66
    Dec 27, 2024 · 24 min

    In a Word - Agonist

    --In today's episode, Dr. O'Leary explores agonists, inverse agonists, partial agonists, and antagonists. These terms describe how molecules bind to receptors and either increase, decrease, or prevent changes in receptor signaling. Agonists increase receptor activity, with full agonists like dopamine and serotonin raising activity to its maximum. Partial agonists can increase activity in the absence of full agonists but decrease it in their presence. Inverse agonists reduce the baseline activity of receptors. Antagonists block receptor activity without changing the baseline rate. We also discussed the complex interactions between these molecules and how their effects can vary depending on the presence of other molecules and the specific receptors involved. Below are a couple of helpful references: https://pmc.ncbi.nlm.nih.gov/articles/PMC2804881/ https://link.springer.com/article/10.2165/00023210-199605050-00007 Please leave feedback at https://www.psydactic.com or send any comments to feedback@psydactic.com. References and readings (when available) are posted at the end of each episode transcript, located at psydactic.buzzsprout.com. All opinions expressed in this podcast are exclusively those of the person speaking and should not be confused with the opinions of anyone else. We reserve the right to be wrong. Nothing in this podcast should be treated as individual medical advice.

    • Transcript
Showing 21–22 of 22 episodes