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Neurology: Disease Deep Dive

Practical Neurology

The field of neurology is vast and complex. This series provides thorough conversations with key expert physicians on neurologic conditions including the evolution of our understanding and treatment of these conditions.

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15 episodes
Avg 21 min
English

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Friday · 16 min
Tavapadon Treatment for Early Parkinson Disease: Findings from the TEMPO Trials
Hubert Fernandez, MD, Cleveland Clinic, Cleveland, OH, discusses findings from the TEMPO trials evaluating tavapadon, a selective dopamine D1/D5 receptor partial agonist, as monotherapy in early Parkinson disease and as an adjunct to levodopa in patients with motor fluctuations. He examines efficacy, tolerability, adverse events, and where tavapadon could fit within the evolving Parkinson disease treatment landscape.
September 3 · 21 min
Could a Novel Oral Therapy Change How Clinicians Treat Obstructive Sleep Apnea? Insights From the SynAIRgy Trial
In this episode, Patrick J. Strollo Jr, MD, FACP, FCCP, FAASM, of the University of Pittsburgh Department of Medicine, Pittsburgh, PA, discusses the data from the phase 3 SynAIRgy clinical trial for AD109, an investigational once-nightly oral treatment targeting neuromuscular dysfunction in obstructive sleep apnea, and its potential role in a more personalized approach to OSA care.
June 12 · 19 min
Part II: Early Alzheimer Disease Detection through a Davos Alzheimer's Collaborative Initiative: Lessons from Real-World Implementation
This episode explores the real-world implementation of the Davos Alzheimer’s Collaborative Healthcare System Preparedness (DAC-SP) US Early Detection Program at Virtua Health, examining outcomes in identifying cognitive impairment, streamlining referrals, and supporting efficient use of clinical resources. Elyse Perweiler, RN, MPP, Professor, Rowan–Virtua School of Osteopathic Medicine, Stratford, NJ, and Tim MacLeod, PhD, Executive Director, Healthcare System Preparedness Program, DAC, Toronto, Ontario, Canada, return for part 2 of this 3 part series.
February 12 · 18 min
Part I: Early Alzheimer Disease Detection with the DAC-SP Blueprint Program: Overview of a Scalable Health System Approach
Elyse Perweiler, RN, MPP, Professor, Rowan–Virtua School of Osteopathic Medicine, Stratford, NJ, and Tim MacLeod, PhD, Program Director, Healthcare System Preparedness Program, Davos Alzheimer’s Collaborative (DAC), Toronto, Ontario, Canada, examine how health systems can operationalize early cognitive screening to better prepare patients for specialty evaluation. Learn how standardized workflows, digital cognitive tools, and primary care–neurology collaboration can enhance diagnostic efficiency and access to Alzheimer disease care.
Dec 15, 2025 · 29 min
Detecting Multiple Sclerosis Earlier: PRLs and the Evolving McDonald Diagnostic Criteria
This episode explores new evidence showing that paramagnetic rim lesions (PRLs) are highly prevalent early in multiple sclerosis (MS) and can differentiate MS from mimics with striking accuracy. Dr. Daniel Ontaneda, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, and Dr. Pascal Sati, Cedars-Sinai Medical Center, Los Angeles, CA, discuss how PRLs, paired with optimized susceptibility-based MRI, are reshaping diagnostic confidence and informing the latest revisions to the McDonald criteria.
Dec 3, 2025 · 13 min
Modern Glioma Management: Integrating Molecular Markers and New Targeted Therapies
Patrick Y. Wen, MD, Dana-Farber Cancer Institute, Boston, MA, discusses current standards of care for low- and high-grade gliomas, including the importance of comprehensive molecular testing, the World Health Organization classification of tumors of the central nervous system, and newly available therapies.
Dec 2, 2025 · 23 min
Maturing with Migraine: Practical Guidelines for Transitioning Adolescent Migraine and Headache Patients into Adult Practice
Hope O’Brien, MD, MBA, FAHS, FAAN, Founder and CEO of the Headache Center of Hope, Cincinnati, OH, discusses challenges and considerations for adult headache neurologists who are onboarding adolescent patients as they transition from pediatric practice. Dr. O’Brien highlights a framework with strategies for a seamless transition, while noting best practices for promoting patient autonomy and mental wellbeing.
Oct 27, 2025 · 14 min
Advances in ALS: New Targets, Trials, and Care Strategies
Merit Cudkowicz, MD, Julieanne Professor of Neurology, Harvard Medical School, Boston, MA, discusses the evolving landscape of treatment for ALS, including FDA-approved disease-modifying therapies, the importance of genetic testing, the emergence of gene therapies, and the promising clinical trial pipeline targeting genetic and sporadic forms of ALS.
Oct 22, 2025 · 19 min
Cerebrovascular Inflammatory Conditions: Diagnostic Challenges and Treatment Considerations
Abbas Kharal, MD, MPH, Neurologist at Cleveland Clinic Neurological Institute, Cleveland, OH, provides a review of cerebrovascular inflammatory conditions, with an emphasis on diagnostic challenges, the evolving treatment landscape, and the use of imaging and clinical responses to assist clinicians with early detection and differentiation of these conditions.
Jun 6, 2025 · 20 min
The Evolving Therapeutic Landscape for Parkinson Disease
Mark Stacy, MD, William E. Murray Professor of Neurology, Medical University of South Carolina, Charleston, SC, discusses the evolving therapeutic landscape for Parkinson disease, highlighting promising advances in neuroprotective therapies, biomarkers, personalized medicine, and innovative clinical trial designs that aim to improve both treatment outcomes and accessibility.
Jun 4, 2024 · 20 min
Advances in the Evaluation of TBI
Welcome to Neurology: Disease Deep Dive. In this episode, Dr. Beth McQuiston, MD, RD, Medical Director at Abbott Laboratories, and Dr. David Okonkwo, MD, PhD, Professor of Neurological Surgery, Clinical Director of the Brain Trauma Research Center, and Director of the Neurotrauma Program at University of Pittsburgh Medical Center discuss evaluation and advances in evaluation of traumatic brain injury. Dr. McQuiston is talking with us today on behalf of Abbott, which is sponsoring this podcast. Dr. Okonkwo is a physician scientist whose research on blood biomarkers was instrumental for advancing traumatic brain injury biomarker diagnostics. Resources from this episode: More information on concussions Information on i-STAT TBI test cartridge with the i-STAT Alinity instrument Information on Alinity i TBI test
Feb 29, 2024 · 20 min
NMOSD Part 3 - Overview of treatment, including goals, triggers, and considerations for switching therapies
In this series, Derrick Robertson, MD, Director of the Multiple Sclerosis Division at the University of Southern Florida discusses multiple aspects of NMOSD. Dr. Robertson is talking with us today on behalf of Horizon Therapeutics which is compensating him for his services and is sponsoring this podcast. In this episode, Dr. Robertson presents an overview of NMOSD treatment, including goals, triggers, and considerations for switching therapies. DA-UNBR-US-02296-2 05/2024 Sponsored by Horizon Therapeutics
Feb 15, 2024 · 22 min
NMOSD Part 2 - The importance and tools for monitoring NMOSD, and signs, symptoms and evaluation of disease activity
In this series, Derrick Robertson, MD, Director of the Multiple Sclerosis Division at the University of Southern Florida discusses multiple aspects of NMOSD. Dr. Robertson is talking with us today on behalf of Horizon Therapeutics which is compensating him for his services and is sponsoring this podcast. In this episode, Dr. Robertson presents the importance and tools for monitoring NMOSD, and signs, symptoms and evaluation of disease activity. DA-UNBR-US-02295-2 05/2024 Sponsored by Horizon Therapeutics
Feb 1, 2024 · 31 min
NMOSD Part 1 - Overview and important considerations for diagnosis
In this series, Derrick Robertson, MD, Director of the Multiple Sclerosis Division at the University of Southern Florida discusses multiple aspects of NMOSD. Dr. Robertson is talking with us today on behalf of Horizon Therapeutics which is compensating him for his services and is sponsoring this podcast. In this episode, Dr. Robertson presents an overview of NMOSD, and important considerations for diagnosis. DA-UNBR-US-02294-2 05/2024 Sponsored by Horizon Therapeutics
Dec 5, 2023 · 27 min
Narcolepsy, Idiopathic Hypersomnia, and General Sleep Disorders
In this episode, Rajkumar Dasgupta, MD, Clinical Associate Professor at Keck School of Medicine of USC and sleep specialist, provides an in-depth review of what's new in sleep disorders, with a special focus on updates in narcolepsy and idiopathic hypersomnia.

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