

MeSsy with Christina Applegate & Jamie Lynn Sigler
Wishbone Production
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
- 20 episodes
- Updated Thursday
- Explicit
Episodes20
Thursday · 58 min- MW
Tuesday · 1 hr 7 minHope Can Exist Alongside Fear with Myriam Sandler
This week, Jamie sits down with Mothercould creator Myriam Sandler. They discuss her recent MS diagnosis, trusting your intuition, and finding hope even when life doesn't go as planned.
- MW
July 23 · 55 minIt's Okay Not to Be Okay with Amy Kurtz
On the first episode of Living With It, Jamie sits down with Amy Kurtz, a patient advocate and author. They discuss the grief of chronic illness, learning to trust yourself again, and why healing is about so much more than getting better.
- MW
July 21 · 48 minAll Eyes on Me
This week, Jamie reads listener emails and opens up about the feeling of all eyes on you when you're struggling, the anxiety of the lead up, caregiving, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and deli
- MW
July 14 · 56 minTamsen Fadal
This week, Jamie sits down with journalist, author, and menopause advocate Tamsen Fadal. They discuss the physical and emotional realities of perimenopause, why so many women feel dismissed by the medical system, and how speaking honestly about aging, identity, and women's health can help us all feel less alone. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition
- MW
July 7 · 51 minYou Do Not Have to Become Someone Else to Heal
This week, Jamie reads listener emails and discusses the invisible weight of living with chronic illness, the courage it takes to keep showing up, and the small moments that can bring us back to ourselves. She also shares the reminder she received from a recent on stage performance. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformatio
- MW
June 30 · 1 hr 2 minErin Moriarty
This week, Jamie sits down with Erin Moriarty. They discuss Erin's journey with Graves' disease while starring in "The Boys," the invisible toll chronic illnesses can take on your mental health, learning to advocate for yourself, and why vulnerability may be the greatest form of strength. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transfo
- MW
June 23 · 50 minMia Calabrese
This week, Jamie is joined by Summer House’s Mia Calabrese. She opens up about her journey with grief and what’s helped her to find joy again. They also discuss the Summer House scandal and Mia shares her thoughts on the reunion and bonus episode. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with
- MW
June 16 · 49 minChoose Yourself
This week, Jamie reads emails from listeners. She also discusses mom guilt, PMS and MS, letting people know how their actions affect you, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering inno
- MW
June 9 · 1 hr 3 minOur Favorite Bravo Men
This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological c
- MW
June 2 · 55 minAida Turturro
This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with seve
- MW
May 26 · 48 minWhat the F*ck Is Normal Anyway?
This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and thei
- MW
May 19 · 1 hr 10 minLena Hall
This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discoverin
- MW
May 12 · 1 hr 10 minRevisiting Our Convo with Martin Short
In honor of 'Marty, Life is Short,' we are revisiting our conversation with Martin Short. He reminisces, shares funny stories, discusses colonoscopy parties, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medici
- MW
May 5 · 1 hr 27 minA Conversation with Jamie’s Therapist
This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Selva Wellness Collective. They discuss how she helped Jamie through processing what came up while writing her memoir, the way the body stores trauma, ketamine therapy, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuro
- MW
April 28 · 1 hr 1 minThe Friendship Episode
This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving grace to yourself and others, finding your people, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience Our ambition is to create a transformational impact for people living with severe neurological conditions and t
- MW
April 21 · 1 hr 3 minA Conversation with Jamie's Husband
This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's acceptance and outlook, advice for other partners, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and th
- MW
March 31 · 14 secA MeSsy Update!
We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episodes!
- MW
March 24 · 1 hr 10 minOlivia Munn
This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor, why you shouldn’t tell someone going through something to look on the bright side, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Veracity - Head to https://VeracityHealth.co and use code MESSY for up to 60% off your order. Jones Road
- MW
March 17 · 1 hr 16 minCarl Radke
This week, Christina and Jamie are joined by Carl Radke, Summer House cast member and host of "More Life with Carl Radke.” They discuss his journey to sobriety, holding in shame, forgiveness, behind-the-scenes of the show, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go