MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production

On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

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124 episodes
Updated Thursday
Explicit

Episodes124

Newest first

March 10 · 1 hr 14 min
How to Heal Your Relationship With Life
This week, Christina and Jamie are joined by Jamie’s friend Ryan Weiss. They discuss how he helped her through a difficult time, the power of dance, emotional avoidance, why it’s so hard to look inward, and more. Check out Ryan's course "How to Be Okay When Things Are Not Okay" and use code MESSY at checkout for 10% off Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Lola- Get 40% off select L
March 3 · 41 min
We Don’t Want to Be Defined by This
This week, Christina and Jamie read listener emails and discuss the fragility of life, fighting against your body, and more, Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/MESSY #honeylovepod
February 24 · 1 hr 3 min
Kelly Ripa
This week, Christina and Jamie are joined by their friend Kelly Ripa. They discuss Kelly's career and how it began at a toy fair, the processing she had to do while writing her own book, the challenges of playing yourself on television, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com
February 17 · 1 hr 2 min
Stop Talking About It for a Minute
This week, Christina and Jamie read listener emails and discuss skincare products from childhood, crazy animal stories, not thinking too far into the future, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgrain.com/MESSY to start your subscription today. J
February 10 · 53 min
How You Feel on the Inside Can Be Up to You
This week, Christina and Jamie read listener emails and discuss the Married... with Children reunion, catch up on their TV shows, Jamie opens up about a recent experience, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Veracity - For up to 45% off your order, head to https://VeracityHealth.co and use code MESSY
February 3 · 58 min
I Can't Worry About Tomorrow
This week, Christina and Jamie read listener emails and discuss MS fatigue, finding little moments of self care, how to better communicate with friends, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Jones Road - Use code messy at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with yo
January 27 · 1 hr
Bobbi Brown
This week, Christina and Jamie are joined by Bobbi Brown. They discuss overcoming obstacles, how to elevate your mood, taking baby steps, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Lola - Get 40% off your entire order at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets. AG1 - Go to https://DRINKAG1.com/MESSY to
January 20 · 45 min
I’m a F**king Warrior
This week, Christina and Jamie read listener emails and discuss Jamie’s recent trip, pregnancy and MS, asking for help, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Wildgrain - Wildgrain is offering our listeners $30 off your first box - PLUS free Croissants for life - when you go to Wildgrain.com/MESSY to start your subscription today. Veracity - For up to 45% off your order, head
January 13 · 1 hr 1 min
The Impact of Inflammation with Dr. Will Cole
This week, Christina and Jamie are joined by Dr. Will Cole, a functional medicine expert. They discuss how to calm inflammation, medical gaslighting, the interactions between all our systems, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/messy #mudwtrpod Grow TherapyWh
January 6 · 57 min
This Is Not Your Fault
This week, Christina and Jamie read listener emails and discuss repeat reality stars, being a mother with MS, not blaming yourself, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod Jones Road Beauty - Use code Messy at https://jonesroadbeauty.com to get a Free Cool Gloss with your first purchase! #
Dec 30, 2025 · 58 min
There’s a Lot of Unknown in Life
This week, Christina and Jamie read listener emails and discuss Christmas elves, setting goals, reclaiming your voice, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Calm - Calm has an exclusive offer just for listeners of our show – get 40% off a Calm Premium Subscription at https://calm.com/messy Ridwell - Go to ridwell.com/messy to get $10 off your first pickup or mail-in kit. Bec
Dec 16, 2025 · 1 hr 14 min
Are You Mad At Me? with Meg Josephson
This week, Christina and Jamie are joined by Meg Josephson, author of “Are You Mad at Me?: How to Stop Focusing on What Others Think and Start Living for You.” They discuss the fawn response, how to start healing, the importance of taking a pause, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: ZocDoc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and
Dec 9, 2025 · 1 hr 16 min
Montel Williams
This week Christina and Jamie are joined by Montel Williams. They discuss his experience living with MS, bedside manner, why being ill doesn’t make you weak, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Fatty15 - Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness -Get an additional 15% off their 90-day subscription Starter Kit a
Dec 2, 2025 · 55 min
We're All Crushing It
This week, Christina and Jamie read listener emails and discuss perspective, not stuffing your feelings down, journaling, and much more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Nobl - Don’t miss NOBL’s biggest Sale of the Year! Head to NOBLTravel.com for up to 62% off your entire order! #NOBL #ad Lola Blankets - Get 40% off your entire order at Lolablankets.com by using code MESSY at ch
Nov 25, 2025 · 1 hr 22 min
How to Feel Safe in Your Body with Deb Dana (Re-Release)
This week, Christina and Jamie are revisiting their conversation with Deb Dana, LCSW, a clinician and speaker specializing in complex trauma. They discuss how to understand our nervous systems, polyvagal theory, how to feel safe in a body that may feel unsafe, and more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This show is sponsored by: Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-
Nov 18, 2025 · 1 hr 5 min
You Don’t Deserve to Feel Guilt
This week, Christina and Jamie read listener emails and discuss big feelings, reality dating shows, guilt, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a top-rated doctor today. MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR at mudwtr.com/messy #mudw
Nov 11, 2025 · 1 hr 10 min
Best of MeSsy: Edie Falco, Jean Smart, and Katey Sagal
This week, we revisit conversations with three incredible guests: Edie Falco, Jean Smart, and Katey Sagal. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Ridwell - Try Ridwell at ridwell.com/messy to get $10 off your first pickup or mail-in kit.Hollow Socks - For a limited time Hollow Socks is having a Buy 3, Get 3 Free Sale. Head to Hollowsocks.com today to check out their huge sale. #Hollow
Nov 4, 2025 · 59 min
Robert Iler
This week, Christina and Jamie are joined by Robert Iler, who starred on "The Sopranos" with Jamie. They discuss memories from their time on the show, his path to becoming sober, his friendship with Jamie, and much more. Executive Producers: Christina Applegate, Jamie-Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Ridge - Upgrade your wallet today! Get 10% Off @Ridge with code MESSY at https://www.Ridge.com/messy #Ridgepod Fatty15 - Fatty1
Oct 28, 2025 · 1 hr 13 min
How Vulnerable Can I Be? with Craig Thomas
This week Christina and Jamie are joined by Craig Thomas, an author and Co-Creator, Executive Producer and Writer of How I Met Your Mother. He shares his experience raising a son with Jacobsen Syndrome, discusses the power of storytelling to make people feel less alone, and talks about his new novel, “That’s Not How It Happened.” Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: AG1 - Go to drin
Oct 21, 2025 · 56 min
We Don’t Move Past It, We Move With It
This week, Christina and Jamie read listener emails and discuss aging, being able to express emotions authentically, where to turn when you’re feeling stuck, and more. Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick Audio Engineer: Josh Windisch This episode is sponsored by: Lola - Get 35% off your entire order at Lolablankets.com by using code Messy at checkout. Experience the world’s #1 blanket with Lola Blankets. GoPure - Get the Tighten & Lift Neck