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MedEvidence! Truth Behind the Data

Dr. Michael Koren

Welcome to the MedEvidence! podcast, hosted by Dr. Michael Koren. MedEvidence, where we help you navigate the real truth behind medical research with both a clinical and research perspective. In this podcast, we will discuss with physicians with extensive experience in patient care and research. How do you know that something works? In medicine, we conduct clinical trials to see if things work! Now, let's get to the Truth Behind the Data. Contact us at www.MedEvidence.com

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Yesterday · 35 min
More Than the Winter Blues: The Science and Treatment of Depression
Send us Fan Mail The winter months can bring more than colder weather and shorter days. For many people, this time of year can make depression symptoms harder to manage. But depression is much more than the winter blues, and the science behind it is more complex than a simple chemical imbalance. In this episode, Dr. Michael Koren talks with psychiatrist Dr. Heather Luing about the science of depression, how seasonal changes can affect mood, and when it's time to seek professional help. They explore lifestyle changes, psychotherapy, antidepressants, light therapy, transcranial magnetic stimulation (TMS), vagus nerve stimulation, ketamine, and emerging treatments being investigated through clinical research. They also discuss why traditional antidepressants don't work for everyone, how new treatment approaches are expanding options, and why there's reason for hope in the future of depression care. In this episode: - Why the holiday season and shorter days can be difficult for some people - What distinguishes major depressive disorder from everyday mood changes - How sleep, exercise, nutrition, and time in nature can support mental health - The limitations of the traditional serotonin-based approach to depression - How TMS, light therapy, and vagus nerve stimulation work - Emerging medications, ketamine, and psychedelic research - How clinical trials are helping advance depression treatment - When to seek help and how to support someone experiencing depression If you're struggling, help is available. Call or text 988 to connect with the Suicide & Crisis Lifeline for mental health or substance use support. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#421
October 28 · 26 min
Standing Up And Taking the Lid of of POTS
Send us Fan Mail Dr. Mitchell Rothstein joins Dr. Michael Koren to discuss Postural Orthostatic Tachycardia Syndrome, also called POTS. This condition, where heart rate rises when a person stands up, is often misunderstood and/or takes years to properly diagnose. The two doctors discuss the background and symptoms of POTS, but really dig deep into the broad problem of autonomic dysfunction. They distinguish between POTS and other autonomic problems, and look at how COVID and autoimmune diseases can cause autonomic dysfunction. Finally, the two doctors look at treatment options for POTS, including hydration, salt, medications, and new clinical trials. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#420
October 21 · 3 min
How to Lose Weight While Protecting Muscle
Send us Fan Mail Weight loss can come with muscle loss, even when medication is involved. Dr. H. Jackson Downey shares practical guidance on strength training, protein intake, balanced meals, and smaller portions to help support muscle maintenance and make weight-loss treatment easier to manage. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#419
October 14 · 48 min
Trust the Media for Medical News?
Send us Fan Mail Medical headlines shape our food, our drugs, and our fears. But how much should we believe? In this episode, Dr. Michael Koren and Dr. Mitchell Rothstein explore how medical news is made, why headlines can be misleading, and how to tell the difference between evidence and hype. Learn a simple 4-step practical framework to evaluate health claims: check the claim, evidence, source, and incentives. We discuss study design, relative vs. absolute risk, and reporting on topics like Lp(a), daily aspirin, coconut oil, ivermectin, omega-3 supplements, and others. We also cover dietary supplements, FDA oversight, and marketing claims that may mislead consumers. Learn to read medical news with more confidence and make more informed health decisions. What health headline has you wondering what to believe? Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#418
October 7 · 42 min
Gene Editing Moves from Science Fiction to Medical Miracle
Send us Fan Mail Dr. Michael Hafran joins Dr. Michael Koren to discuss new investigational gene editing therapies. They talk about what genes and gene editing are, the history of gene editing, and some of the FDA-approved therapies on the market today. They also address fears people have about gene editing and clinical trials, explain the long and intensive safety measures in place, and reveal that these therapies aren't too different from what the body does naturally, just in a more guided and specific way to address genetic problems. They finish up by talking about an investigational medication designed to reduce an overactive cholesterol-related gene and lower the incidence of heart problems. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#417
September 30 · 25 min
Leading the Way in Clinical Research
Send us Fan Mail Leslie Byatt joins Dr. Michael Koren to talk about leadership in the clinical research space. The two research professionals discuss the importance of qualified researchers in a research trial and the qualities that make for a good clinical research leader. They also talk about research as a treatment option and the benefits observed in research patients (even those in the placebo arm). They explain that the attention, care, and time with research professionals leads to better understanding and health for those who join, and that's on top of the altruistic benefits to science and health in general. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#416
September 23 · 42 min
The Great Blood Pressure Showdown
Send us Fan Mail A Cardiologist & Nephrologist Go Head-to-Head, er... "Heart-to-Kidney" Nephrologist Dr. Ali Rawabdeh joins Cardiologist Dr. Michael Koren to debate which is the bigger contributor (and problem) with high blood pressure: the heart or the kidneys. The two doctors discuss this extremely prevalent condition from their competing perspectives and give information on how different body systems can influence blood pressure. they also talk about the importance of understanding that blood pressure varies over time and that individual measurements are not the end-all of determining hypertension. They also dig into lifestyle and medical treatments for high blood pressure and upcoming genetic treatments that are currently being investigated. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#415
September 16 · 22 min
Pelacarsen Failed To Meet Its Primary Endpoint, But The Science Keeps Going
Send us Fan Mail Cardiologists Dr. Seth Baum and Dr. Michael Koren discuss the newly released top-line results from a big Lp(a) study investigating the effects of the drug pelacarsen. They talk about what Lp(a) is, why it matters, happened in the study, and what this means for other pelacarsen and Lp(a) studies worldwide. They take a deep dive into some of the factors that can reduce the effectiveness of clinical trials and explain that this particular failure doesn't undermine the theory behind controlling Lp(a) levels or the potential effectiveness of competing investigational medications. Finally, the companion cardiologists talk about what this means for people who have high Lp(a) and what they can do to help control their risks of associated heart problems. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#414
September 9 · 6 min
How GLP-1s Suppress Hunger And What That Does To The Body
Send us Fan Mail Dr. Mitchell Rothstein explains that GLPs have been with us for thousands of years. He gives a brief overview of how these medications work, some of the side effects they can cause, and to mitigate things like muscle loss and GI issues through exercise and dose management. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#413
September 2 · 32 min
Why Were Peptides Banned, Why Are They Back, And Are They Any Good?
Send us Fan Mail Dr. Mitchell Rothstein joins Dr. Michael Koren to discuss a current trend in unapproved medicine: peptides. They investigate what peptides are, why they have become so popular, and the very real problems with getting off-market medicines through the "grey market." They also talk about the history of peptides, including why they were banned from compounding pharmacies and why they are back on the market. Tune in for history, medicine, technical detail, and politics. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#412
August 26 · 44 min
Vaccines in 2026: Separating Evidence and Politics
Send us Fan Mail Dr. Steve Dorman joins Dr. Michael Koren to talk about vaccines, vaccine hesitancy, and the impact of politics on one of our most effective tools against disease. The doctoral duo, recorded in front of a live audience, talk about the big impacts of vaccines, including wiping out entire diseases like smallpox. They continue by cataloging success stories of vaccines, vaccine efficacy, and the emerging role of politics in vaccine adoption. They discuss the current administration's role in affecting vaccine science and adoption and weigh the importance of individual circumstance against herd immunity and population-wide effects. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#411
August 19 · 21 min
Building Doctors Who Can Fix Healthcare
Send us Fan Mail Dr. John Shufeldt joins Dr. Mitchell Rothstein to discuss his life and the need for change in the US healthcare system. Dr. Shufeldt talks about the changes he has made in the healthcare space, from starting urgent care clinics in the 1990s to his healthcare venture capitol to his focus on indigenous populations and training the new generation of doctors. The two discuss the need for doctors to have a more flexible mind frame, the burgeoning role of AI in healthcare, and a focus on treating to biomarkers instead of treating to symptoms. Join the fascinating conversation with this healthcare disruptor. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#410
August 12 · 29 min
The Hidden Killer: Lp(a)
Send us Fan Mail In this MedEvidence rebroadcast, Dr. Albert Lopez explains lipoprotein(a), a genetically determined heart disease risk factor which still strikes people with “good” cholesterol. He also explains that plaque behaves like an inflammatory volcano that can rupture without warning. Dr. Lopez goes into how lipoprotein(a) increases the risk of heart attack, stroke, and aortic valve disease. Dr. Lopez then hammers home how important testing for Lp(a) is, especially for those at an increased risk. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#409
August 5 · 49 min
The History and Future of Medicine with What the Health Just Happened
Send us Fan Mail Cardiologist and Clinical Researcher Dr. Michael Koren joins Eric Ross from "What the Health Just Happened" to talk about a wide range of topics. They discuss the history of clinical research in healthcare, the changing landscape of research in America and around the world, what's healthy (and what's not) in popular culture, and the emerging field of gene editing. They even talk about Dr. Koren's misadventures trying to get tickets to the FIFA World Cup! Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#408
July 29 · 43 min
Can We Edit Genes to Lower Cholesterol?
Send us Fan Mail Dr. Michel Koren and Dr. Mitchell Rothstein host a presentation in front of a live audience to discuss the current state of gene editing. The doctoral duo discuss developments including new-to-market medical therapies, clinical trials, and the legal issues surrounding gene therapy patents. They also explain the difference between gene silencing techniques, which temporarily stop genes from creating proteins, and gene editing techniques which permanently alter the genome. They also touch on controversies, risks, and the comprehensive considerations that take place before a participant can partake in a gene editing clinical trial. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#407
July 22 · 37 min
Dr. AI and Health 4.0
Send us Fan Mail Dr. Robin Blackstone joins Dr. Mitchell Rothstein to talk about the intersection of technology, empathy, and the healthcare system. The doctoral duo discuss the emerging role of AI in healthcare and how specialized, individualized, non-chatbot systems may be able to sift through the masses of health data that plague doctors to provide individualized, patient-specific recommendations and revelations. The two also briefly discuss the history of healthcare in order to present Dr. Blackstone's vision for the future, Health 4.0. They finish the discussion with more details about Dr. Blackstone's Public Benefit Corporation, The H4 Alliance Trust, a 5013c project focusing on a person-centered health system. Find more about the H4 Alliance Trust at h4alliancetrust.org Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#406
July 15 · 12 min
Early Risk Detection and Early Treatment: 2026 Lp(a) & Cholesterol Guidelines
Send us Fan Mail Join internist and cholesterol expert Albert Lopez, DO, FACP, FASPC, as he reviews the new 2026 Cholesterol Guidelines. In this segment, he focuses on new risk assessment guidelines, including the genetic risk factor Lipoprotein(a) and a sign of damage, the CAC score, and the recommendation that risk assessment starts much younger, around 30 years old. He discusses treatment options for high cholesterol, including sound evidence for statins and newer treatments for rare cholesterol manifestations. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#405
July 8 · 14 min
The Carousel Of Chronic Cough
Send us Fan Mail Allergist and immunologist Dr. Steve Dorman joins Dr. Michael Koren to discuss the causes, complications, and carousel of chronic cough. Dr. Dorman reviews what chronic cough is and how it may be due to anatomical changes, acid reflux, allergies, and so on. Because of this, the doctor explains, sufferers of cough may end up going around the "carousel" of chronic cough, where they end up seeing their primary care specialist, a GI doctor, an Ear, Nose & Throat (ENT) specialist, pulmonary physicians, and an allergist and immunologist like himself. The duo then tackle what can be done, from medications, new research, and non-medicinal treatments. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#404
July 1 · 22 min
PCOS to PMOS, Changes in Name and Treatment Options
Send us Fan Mail OBGYN Dr. Richard Myers joins Dr. Erich Schramm to discuss the name change from Polycystic Ovarian Syndrome (PCOS) to Polyendocrine Metabolic Ovarian Syndrome (PMOS). This syndrome is the combination of three parts: increased polyendocrine hormones (like insulin and androgens), changing metabolism, and differences in ovarian function Dr. Myers explains that the name change to PMOS reflects the changing understanding and focus of the syndrome from a purely ovarian-centered approach to a more holistic, full-body treatment regimen. The doctors also discuss how different patient desires drive different treatment options and the need for individualized, patient-centered care. They finish by looking at new treatments, including GLP-1 and GIP medications that can help address the underlying metabolic components of the PMOS. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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#403
June 24 · 38 min
Skin Deep: What's New in Treating Chronic Skin Conditions
Send us Fan Mail Dermatologist Dr. Michael Bernhardt joins Dr. Mitchell Rothstein to discuss the rapidly changing and improving world of chronic skin condition. The two doctors discuss the correlation between chronic skin conditions and allergies, and the role that inflammation play in both. The docs then dive deep into our inflammation system. This informs the next section of the podcast, where the Drs. Bernhardt and Rothstein talk about the landscape of chronic skin condition medications. They explain that these conditions had poor outcomes and ineffective medicines for decades, and that this picture has only changed in the last 4-5 years with new medications that work from the inside out instead of the outside in. They talk about new generations of medication that target the inflammatory signals themselves inside the body, showing rapid relief to otherwise untreatable conditions. They finish with a brief look at what is coming down the pipeline of clinical trials. Be a part of advancing science by participating in clinical research. Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com Listen on Spotify Listen on Apple Podcasts Watch on YouTube Share with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released. Follow us on Social Media: Facebook Instagram X (Formerly Twitter) LinkedIn Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com Music: Storyblocks - Corporate Inspired Thank you for listening!
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