October 18 · 10 min
DJ
Dr. John Campbell
Campbellteaching
Hello Everyone, My name is John Campbell and I am a retired Nurse Teacher and former clinical nurse based in England. I also do some teaching in Asia and Africa when time permits. These videos are to help students to learn the background to all forms of health care. My PhD focused on the development of open learning resources for nurses nationally and internationally. LinkedIn profile, https://www.linkedin.com/in/dr-john-campbell-5256223b/ Twitter, https://twitter.com/Johnincarlisle Disclaimer; These media including videos, book, e book, articles, podcasts are not peer-reviewed. They should never replace individual clinical judgement from your own health care provider. No media-based material on this channel is suitable for using as professional medical advice. All comments are also for educational purposed only and must never replace advice from your own health care provider
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October 18 · 17 minOmicron science, promising news
New science explains South Africa's low rates of omicron severe disease SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against Omicron https://www.medrxiv.org/content/10.1101/2021.12.26.21268380v1 https://www.medrxiv.org/content/10.1101/2021.12.27.21268278v1 Institute of Infectious Disease and Molecular Medicine, University of Cape Town SARS-CoV-2 Omicron variant has multiple Spike (S) protein mutations These contribute to escape from the neutralizing antibody responses, reducing vaccine protection from infection We assessed the ability of T cells to react with Omicron spike In participants who were vaccinated with Ad26.CoV2.S (J and J) (n = 20) or BNT162b2 (Pfizer) (n = 15 or in unvaccinated convalescent COVID-19 patients (n = 15) SARS-CoV-2-specific T cells play a key role in modulating COVID-19 severity and provide protective immunity Results 70-80% of the CD4 and CD8 T cell response to spike was maintained across study groups The magnitude of Omicron cross-reactive T cells was similar to that of the Beta and Delta variants These results demonstrate that, despite Omicron’s extensive mutations and reduced susceptibility to neutralizing antibodies, the majority of T cell response, induced by vaccination or natural infection, cross- recognises the variant. Well-preserved T cell immunity to Omicron, is likely to contribute to protection from severe COVID-19, supporting early clinical observations from South Africa. Further explanation The limited effect of Omicron’s mutations on the T cell response suggests that vaccination or prior infection may still provide substantial protection from severe disease. Indeed, South Africa has reported a lower risk of hospitalisation and severe disease compared to the previous Delta wave Cross-reactive T cell responses acquired through vaccination or infection may contribute to these apparent milder outcomes for Omicron. The resilience of the T cell response demonstrated here also bodes well in the event that more highly mutated variants emerge in the future. Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 2 minD and K2 together
Link to whole video, https://www.youtube.com/watch?v=0Ken0luasu0 Free download John’s textbooks in high res pdf. https://drjohncampbell.co.uk Order my Physiology Notes in hard copy if you live in the UK, https://www.ebay.co.uk/itm/154973392319?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=K6raxMZrQnm&sssrc=2047675&ssuid=&widget_ver=artemis&media=EMAIL Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 24 minEveryone was susceptible
COVID, the untold story. So much more makes sense after this book and my first illuminating discussion with Dr. Craig. Get your copy in the UK here: https://www.amazon.co.uk/Expired-untold-Dr-Clare-Craig/dp/1739344707 Uploaded 28-11-23 For friends in the US get your copy here, https://www.amazon.com/Expired-untold-Dr-Clare-Craig/dp/1739344707 Have you ever felt the covid story did not entirely add up? Expired contains multiple eye-opening revelations about covid with compelling evidence that provides a coherent, sober and clear explanation that better fits the data we have so far. Meticulous research by pathologist Dr Clare Craig sheds light on the largely overlooked evidence of airborne virus transmission, examining twelve related beliefs on spread, lockdowns, asymptomatic infections, and masks. In addition, Expired champions the importance of Western ethical principles, damaged by pandemic actions and calls for their restoration. The covid debate has proved incredibly polarising. One side believed every intervention was saving lives, while the other emphasised the harms caused. Biased modelling based on a worst-case scenario led to fearful assumptions presented as fact. By dint of sheer repetition these ‘facts’ became unquestionable. Those scientists who dared to question were proclaimed dangerous. Welcome to Cloud-Covid-Land. Let’s bring back nuance. It’s time to return to reality." Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 11 minTrip to Davos
With Consultant Cardiologist, Dr. Aseem Malhotra, Uploaded 22-08-25 First do on Pharm, https://nopharmfilm.com/ https://www.imdb.com/title/tt33511587/ Aseem's work site, https://draseemmalhotra.co.uk/ Hope Accord link, https://thehopeaccord.org http://drjohncampbell.co.uk/C.mp4 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 9 minWhat is a jab
Third part of this excellent talk with Professor Robert Clancy, doctor, immunologist, consultant physician, professor of pathology and professor of medicine, highly published medical researcher, author, teacher, doctor of science, doctor of philosophy, holder of the Australia Medal. Link to buy the book, https://covidthroughoureyes.com.au/products/covid-through-our-eyes-an-australian-story-of-mistakes-mistreatment-and-misinformation Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 19 minWho fact checks the fact checkers
Now all of the facts were equal, but some facts were more equal than others. Uploaded 10-10-22 Institute for Scientific Freedom https://www.scientificfreedom.dk/strategy/?utm_source=substack&utm_medium=email 1 All science should strive to be free from financial conflicts of interest. 2 All science should be published as soon as possible and made freely accessible. 3 All scientific data, including study protocols, should be freely accessible, allowing others to do their own analyses. Open letter from BMJ to Facebook about inappropriate censoring of serious data integrity issues in Pfizer’s COVID-19 vaccine trial https://www.scientificfreedom.dk/2021/12/18/open-letter-from-bmj-to-facebook-about-inappropriate-censoring-of-serious-data-integrity-issues-in-pfizers-covid-19-vaccine-trial/ https://www.bmj.com/content/375/bmj.n2635/rr-80 Fiona Godlee, editor in chief Kamran Abbasi, incoming editor in chief The BMJ Competing interests: As current and incoming editors in chief, we are responsible for everything The BMJ contains. Dear Mark Zuckerberg, The BMJ, one of the world’s oldest and most influential general medical journals. https://www.bmj.com/about-bmj/history-of-the-bmj 3rd October 1840 Serious concerns about the “fact checking” being undertaken by third party providers on behalf of Facebook/Meta. In September, a former employee of Ventavia, a contract research company helping carry out the main Pfizer covid-19 vaccine trial, began providing The BMJ with dozens of internal company documents, photos, audio recordings, and emails. These materials revealed a host of poor clinical trial research practices occurring at Ventavia that could impact data integrity and patient safety. We also discovered that, despite receiving a direct complaint about these problems over a year ago, the FDA did not inspect Ventavia’s trial sites. The BMJ commissioned an investigative reporter to write up the story for our journal. The article was published on 2 November, (2021) following legal review, external peer review and subject to The BMJ’s usual high level editorial oversight and review. Covid-19: Researcher blows the whistle on data integrity issues in Pfizer’s vaccine trial https://www.bmj.com/content/375/bmj.n2635 But from November 10, readers began reporting a variety of problems when trying to share our article. Some reported being unable to share it. Many others reported having their posts flagged with a warning about “Missing context … Independent fact-checkers say this information could mislead people.” Those trying to post the article were informed by Facebook that people who repeatedly share “false information” might have their posts moved lower in Facebook’s News Feed. Group administrators where the article was shared received messages from Facebook informing them that such posts were “partly false.” Readers were directed to a “fact check” performed by a Facebook contractor named Lead Stories. Fact Check: The British Medical Journal Did NOT Reveal Disqualifying And Ignored Reports Of Flaws In Pfizer COVID-19 Vaccine Trials https://leadstories.com/hoax-alert/2021/11/fact-check-british-medical-journal-did-not-reveal-disqualifying-and-ignored-reports-of-flaws-in-pfizer-vaccine-trial.html We find the “fact check” performed by Lead Stories to be inaccurate, incompetent and irresponsible. – It fails to provide any assertions of fact that The BMJ article got wrong – It has a nonsensical title: “Fact Check: The British Medical Journal Did NOT Reveal Disqualifying And Ignored Reports Of Flaws In Pfizer COVID-19 Vaccine Trials” – The first paragraph inaccurately labels The BMJ a “news blog” – It contains a screenshot of our article with a stamp over it stating “Flaws Reviewed,” despite the Lead Stories article not identifying anything false or untrue in The BMJ article – It published the story on its Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 24 minChildhood hepatitis outbreaks
In the UK, US and Europe If you would like John’s text books, (it is free to download the PDFs), use this link, http://159.69.48.3/ Uploaded 17-04-22 Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland https://www.who.int/emergencies/disease-outbreak-news/item/acute-hepatitis-of-unknown-aetiology---the-united-kingdom-of-great-britain-and-northern-ireland WHO monitoring cases of hepatitis in children across UK Children up to 10 years Hepatitis viruses (A, B, C, E, D), excluded Six had liver transplants Scotland, 10 cases of severe acute hepatitis in children Scotland, 13 cases reported Rest of the UK, 74 cases England, 49 Wales and NI, 12 Ireland, 5 Spain, 3 (22-month-old to 13-year-old) Denmark Netherlands ECDC (European Centre for Disease Prevention and Control) https://www.euronews.com/next/2022/04/15/europe-on-alert-as-uk-investigates-mysterious-cases-of-severe-hepatitis-in-young-children Jaundice, vomiting, stomach problems muscle and joint pain fever nausea tired all the time general sense of feeling unwell loss of appetite localised pain dark urine pale, grey-coloured poo itchy Alabama https://www.medscape.com/viewarticle/972272 Cases, 9 Between 1 and 6 years old 2 liver transplants No epidemiological links so far Adenovirus 41 About half have tested positive No viral genetics as yet Known to cause hepatitis in immunocompromised More cases expected to report As of 11th April No hepatitis deaths recorded One epidemiologically linked case detected (patient contact with a sufferer or point source of infection) Dr Meera Chand, director of clinical and emerging infections, UK Health Security Agency investigate a wide range of possible factors which may be causing children to be admitted to hospital with liver inflammation known as hepatitis One of the possible causes that we are investigating is that this is linked to adenovirus infection However, we are thoroughly investigating other potential causes SARS-CoV-2 detected in several cases Officials stressed no link Covid-19 vaccine none of the children affected by hepatitis had received a jab Wating for Infections, chemicals, toxins Dr Chand Normal hygiene measures such as good handwashing, including supervising children, and respiratory hygiene, help to reduce the spread of many of the infections that we are investigating. We are also calling on parents and guardians to be alert to the signs of hepatitis, including jaundice, and to contact a healthcare professional if they are concerned Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 58 minShroud, Biblical and historic aspects
Links for Rich, YouTube videos: "Biblical Mysteries Explained" https://www.youtube.com/@BiblicalMysteriesExplained Uploaded 29-06-25 Article sites: academia.edu, researchgate.net, richardsorensen.com, unholygrail.net/blog Watch this excellent film from David Rolfe, https://whocanhebe.com/Stream.html Watch this excellent film from David Rolfe, https://whocanhebe.com/Stream.html Link to download my PowerPoint, https://drjohncampbell.co.uk/ Shroud.com https://www.shroud.com/menu.htm Shroudphotos.com https://shroudphotos.com 3D Image https://shroud3d.com/introduction/3d-studies-of-the-shroud-of-turin-history/ Shroud fabric https://www.shroud.com/pdfs/ssi3233part3.pdf 3D reconstruction https://www.shroud.com/pdfs/ssi3233part3.pdf STURP conclusions https://www.shroud.com/78conclu.htm Study on radiocarbon result https://www.sciencedirect.com/science/article/abs/pii/S0040603104004745 New dating study on X ray scattering https://www.mdpi.com/2571-9408/5/2/47 Polon studies https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:210758-1 1. ca. 33 Jesus is crucified and buried by Nicodemus and Joseph of Arimathea, with burial cloth and tomb provided by the latter. Then Jesus rises from the dead. When the disciples enter the empty tomb, they see the burial cloths according to the Gospels. 2. ca 33-38 The burial cloth of Christ was said to be brought to Edessa by Thomas or Thaddeus at the request of King Abgar V of Edessa, who was miraculously healed. Edessa becomes a Christian city. A mosaic tile was made of face on the Shroud, known as the Keramion, and placed over the city gate. In addition to the Shroud, this tile may have been the model used for future pictures of Christ. 3. 57 Ma’nu VI becomes king of Edessa and reverts the city to paganism. The Shroud and the Keramion are hidden in the city walls to protect them from destruction, and the location was apparently forgotten. 4. 525 The Shroud and the Keramion are rediscovered during the rebuilding of Edessa after a flood. 5. 544 Edessa is besieged by a Persian army and the Shroud and/or the Keramion purportedly save the city. Following this, the Hagia Sophia church (named after its analog in Constantinople) is constructed to house and venerate the Shroud and the Keramion. The Shroud is shown to the public every Easter, but in an air of secrecy and mystery. In this era the appearance of Christ as depicted in Christian art suddenly changes from a smooth Greco-Roman style to a Semitic man, with the characteristics of the face from the Shroud and/or the Keramion. Syriac artists become the main source of Christian art. 6. 944 - 1204 The Byzantine emperor, Romanus Lacapenus sends an army to Edessa to capture the Shroud and bring it to Constantinople as a means of divine protection. The Shroud was received with great ceremony and paraded through the city – a copy of the sermon given by on that occasion still exists. The Shroud is kept in the imperial relic treasury and periodically presented to private audiences. 7. 1204 The knights of the 4th Crusade come to Constantinople, supposedly on their way to Jerusalem, but due to a complex and unfortunate series of political events, they sack Constantinople instead. The Shroud is taken by the crusaders. 8. 1204 – 1355 This period is known as the “missing years” of the Shroud. The explanation with the most documentary evidence is that the Shroud was given to or taken by the knight Othon de la Roche, a knight from the Burgundy region of France who became the Lord of Athens in Greece. The Shroud may have been in Greece but was eventually brought to Besançon, the capital of Burgundy. In any case the Shroud eventually became the property of Geoffrey de Charny and his family. Geoffrey de Charny, a Templar and high counselor to King John II of France, and the Lord of Lirey and Savoisy in France, had built a chapel in Lirey to commemorate his res Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 1 hr 19 minOutstanding podcast with Hearts of Oak
Original link, https://www.youtube.com/watch?v=YkRg5dyvGPE&t=2735s Check out Hearts of Oak, for some great talks, https://www.youtube.com/@UCy7r6GYTGA1gpHEZfqnscQA Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 25 minNew treatment for depression
Boom in psychedelic therapies? Uploaded 23-08-22 https://www.telegraph.co.uk/news/2022/08/20/magic-mushrooms-set-become-uks-ultimate-weapon-against-depression/ https://www.theguardian.com/science/2022/apr/12/psilocybin-depression-brain-break-out-of-a-rut-magic-mushrooms Short-acting drugs, psychedelic experience, two-hour therapy session. Resetting brain networks Helping to end ingrained negative patterns of thought, and making patients far more receptive to therapy. Small Pharma https://smallpharma.com Leading the world’s first regulated clinical trial, DMT (dimethyltryptamine) with psychotherapy for major depressive disorder. Phase one done on healthy volunteers Next few months, reports from 42 patients Dr Carol Routledge, chief medical and scientific officer We think that this treatment will really get to the root cause, rather than just dampening symptoms Almost immediate benefits Based on initial data that we already have, and other companies have, there’s going to be a fairly immediate impact In terms of the psychedelic experience, we’re talking about 20 minutes, and then the integration therapy afterwards, we expect the antidepressant activity to be extremely durable … to last maybe three, four or five months Imaging data Psychedelics work on the brain networks Making neural connections more flexible to brain plasticity You can reset those networks in the brain, and then that leaves the brain much more receptive to therapy, which is why we bring it in straight afterwards Medicines and Healthcare products Regulatory Agency (MHRA) Innovative Licensing and Access Pathway (ILAP) Brings organisations together Speed up the time getting meds to patients Other companies testing MDMA 3,4-Methylenedioxymethamphetamine Therapy for post-traumatic stress disorder (PTSD) Psilocybin, (Clerkenwell Health) Depression Smoking Terminal illness Psychedelic experience Out-of-body sensations Visual or aural hallucinations Psilocybin microdosers demonstrate greater observed improvements in mood and mental health at one month relative to non-microdosing controls https://www.nature.com/articles/s41598-022-14512-3#Tab2 University of British Columbia, Vancouver, July, 2022 Psilocybin microdosing Repeated self-administration of mushrooms containing psilocybin, at doses small enough to not impact regular functioning. 3–5 times per week, of 0.1 to 0.3 g of dried mushrooms Naturalistic, observational design Study approved, University of British Columbia Research Ethics Board (H19-03051) Psilocybin microdosers (n = 953) Non-microdosing comparators (n = 180) For approximately 30 days Identified small- to medium-sized improvements in mood and mental health, that were generally consistent across gender, age and presence of mental health concerns Improved psychomotor performance in older adults. Depression, Anxiety and Stress Scale https://proceduresonline.com/trixcms2/media/11957/depression-anxiety-and-stress-scale-dass21.pdf Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers https://www.nature.com/articles/s41598-021-01811-4 Large international sample of adults microdosers (n = 4050) non-microdosers (n = 4653) Psilocybin, 85% of microdosers, (LSD, 11%) microdosers exhibited lower levels of depression, anxiety, and stress across gender microdosers were less likely to use alcohol regularly and were more likely to abstain from alcohol entirely microdosers were more likely to abstain from the use of nicotine Psilocybin, in 10mg or 25mg doses, has no short- or long-term detrimental effects in healthy people https://www.kcl.ac.uk/news/psilocybin-in-10mg-or-25mg-doses-has-no-short-or-long-term-detrimental-effects-in-healthy-people https://journals.sagepub.com/doi/full/10.1177/02698811211064720 The therape Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 20 minFDA full approval for Pfizer
FDA Approves First COVID-19 Vaccine Uploaded 24-08-21 EUA since December 11, 2020 https://www.fda.gov/news-events/press-announcements/fda-approves-first-covid-19-vaccine U.S. Food and Drug Administration Pfizer-BioNTech COVID-19 Vaccine Will now be marketed as Comirnaty (koe-mir’-na-tee) for the prevention of COVID-19 disease in individuals 16 years of age and older Continues to be available under emergency use authorization (EUA), 12 to 15s and for a third dose in immunocompromise Acting FDA Commissioner Janet Woodcock, M.D While this and other vaccines have met the FDA’s rigorous, scientific standards for emergency use authorization, as the first FDA-approved COVID-19 vaccine, the public can be very confident that this vaccine meets the high standards for safety, effectiveness, and manufacturing quality the FDA requires of an approved product we recognize that for some, the FDA approval of a vaccine may now instill additional confidence to get vaccinated. Today’s milestone puts us one step closer to altering the course of this pandemic in the U.S. FDA statement The mRNA in Comirnaty is only present in the body for a short time and is not incorporated into - nor does it alter - an individual’s genetic material. Comirnaty has the same formulation as the EUA vaccine and is administered as a series of two doses, three weeks apart. Analyzed effectiveness and safety data from 20,000 vaccine and 20,000 placebo recipients Vaccine was 91% effective in preventing COVID-19 disease Safety, approximately 12,000 recipients have been followed for at least 6 months. The most commonly reported side effects Pain, redness and swelling at the injection site Fatigue, headache, muscle or joint pain, chills, and fever Rigorous evaluation of the post-authorization safety surveillance data Myocarditis and pericarditis Chest pain, shortness of breath, or feelings of having a fast-beating, fluttering, or pounding heart https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-june-25-2021 https://www.cdc.gov/mmwr/volumes/70/wr/mm7027e2.htm 52 million doses to 12–29 years 1,226 reports of myocarditis after mRNA vaccination 42,414 One in 42,414 Data demonstrate increased risks, particularly within the seven days following the second dose The observed risk is higher among males under 40 years of age compared to females and older males Risk is highest in males 12 through 17 years of age Short-term follow-up suggest that most individuals have had resolution of symptoms Some individuals required intensive care support Information is not yet available about potential long-term health outcomes FDA and CDC, monitoring systems in place for early detection Pfizer will Conduct postmarketing studies to further assess the risks of myocarditis and pericarditis Include an evaluation of long-term outcomes Conducting a pregnancy registry study to evaluate pregnancy and infant outcomes after vaccination during pregnancy Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
- DJ
October 18 · 25 minEgregious excess deaths
Direct link to TV Parliament site, https://parliamentlive.tv/Event/Index/168f642a-5708-4b1a-9857-d8eacf475252 That this House has considered the covid-19 pandemic response and trends in excess deaths; and calls on the covid-19 inquiry to move onto its module 4 investigation into vaccines and therapeutics as soon as possible. We are witnesses to the greatest medical scandal in this country in living memory, and possibly ever: the excess deaths in 2022 and 2023. Its causes are complex, but the novel and untested medical treatment described as a covid vaccine is a large part of the problem. I have been called an anti-vaxxer, as if I have rejected those vaccines based on some ideology. I want to state clearly and unequivocally that I have not: in fact, I am double vaccinated and vaccine-harmed. Intelligent people must be able to tell when people are neither pro-vax nor anti-vax, but are against a product that does not work and causes enormous harm to a percentage of the people who take it. I am proud to be one of the few Members of Parliament with a science degree. It is a great shame that there are not more Members with a science background in this place; maybe if there were, there would be less reliance on Whips Office briefings and more independent research, and perhaps less group-think. I say to the House in all seriousness that this debate and others like it are going to be pored over by future generations, who will be genuinely agog that the evidence has been ignored for so long, that genuine concerns were disregarded, and that those raising them were gaslit, smeared and vilified. One does not need any science training at all to be horrified by officials deliberately hiding key data in this scandal, which is exactly what is going on. The Office for National Statistics used to release weekly data on deaths per 100,000 in vaccinated and unvaccinated populations—it no longer does so, and no one will explain why. The public have a right to that data. There have been calls from serious experts, whose requests I have amplified repeatedly in this House, for what is called record-level data to be anonymised and disclosed for analysis. That would allow meaningful analysis of deaths after vaccination, and settle once and for all the issue of whether those experimental treatments are responsible for the increase in excess deaths. Far more extensive and detailed data has already been released to the pharma companies from publicly funded bodies. Jenny Harries, head of the UK Health Security Agency, said that this anonymised, aggregate death by vaccination status data is “commercially sensitive” and should not be published. The public are being denied that data, which is unacceptable; yet again, data is hidden with impunity, just like in the Post Office scandal. Professor Harries has also endorsed a recent massive change to the calculation of the baseline population level used by the ONS to calculate excess deaths. It is now incredibly complex and opaque, and by sheer coincidence, it appears to show a massive excess of deaths in 2020 and 2021 and minimal excess deaths in 2023. Under the Toggle showing location of Column 505 old calculation method, tried and tested for decades, the excess death rate in 2023 was an astonishing 5%—long after the pandemic was over, at a time when we would expect a deficit in deaths because so many people had sadly died in previous years. Some 20,000 premature deaths in 2023 alone are now being airbrushed away through the new normal baseline. Shocking things happened during the pandemic response. In March 2020, the Government conducted a consultation exercise on whether people over a certain age or with certain disabilities should have “do not resuscitate” orders, known as DNRs, imposed upon them. A document summarising the proposals was circulated to doctors and hospitals; it was mistakenly treated as for Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 16 minMonkeypox, excellent news
Monkeypox Uploaded 12-10-22 New Microbes and New Infections https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375638/ it is believed that African squirrels and other rodents might be the primary reservoirs Current epidemiological situation as of 10 October 2022 https://www.gov.uk/government/publications/monkeypox-outbreak-epidemiological-overview/monkeypox-outbreak-epidemiological-overview-11-october-2022 Confirmed cases, 3,523 Highly probable cases, 150 Scotland, 94 Northern Ireland, 34 Wales, 46 England, 3,499 Cases were confirmed in England from 6 May 2022 The outbreak has mainly been in gay, bisexual, and men who have sex with men, without documented history of travel to endemic countries. https://www.gov.uk/government/publications/monkeypox-outbreak-technical-briefings/investigation-into-monkeypox-outbreak-in-england-technical-briefing-8 Level 2 Transmission within a defined sub-population. Out of 3,390 cases with known gender, 99% are men, and there are 45 women. Nowcast and growth Incidence remains low. Multiple factors in reduction Vaccination, (moderate confidence) Behavioural modification, (low confidence) (Reduction in some other sexually transmitted infections) Route of transmission Close or sexual contact Monkeypox virus has been detected in air and environmental samples (hospital room of infected patients) No confirmed instances of airborne transmission Limited household transmission Assessment (confidence): Transmitting primarily through close or sexual contact (moderate) Observed clinical severity No reported deaths in the UK Morbidity amongst people admitted to hospital, severe pain, secondary bacterial infection Encephalitis, reported, appears uncommon US situation https://www.cdc.gov/poxvirus/monkeypox/response/2022/us-map.html Confirmed cases, as of 11th October 2022 = 26,778 Vaccinations = 873,552 (as of 4th October) UK ethnicity data US Ethnic mix https://www.medscape.com/viewarticle/982173?src=wnl_edit_tpal&uac=127834AR&impID=4739080&faf=1 Kaiser Family Foundation https://www.kff.org/racial-equity-and-health-policy/issue-brief/national-data-show-continuing-disparities-in-mpx-monkeypox-cases-and-vaccinations-among-black-and-hispanic-people/ MPX case rates among Black people are over five times those of White people (14.4 vs. 2.6 per 100,000) Hispanic people account for larger shares of cases compared with their shares of the population American Indian or Alaska Native Native Hawaiian or Other Pacific Islander Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 29 minOmicron, trajectory and unknowns
I'm hoping the pandemic will be essentially over in a few weeks and move into an endemic phase. The question is of course, how will the next month pan out? US cases and deaths data https://covid.cdc.gov/covid-data-tracker/#trends_dailycases Colorado https://covid19.colorado.gov/data California https://covid19.ca.gov/state-dashboard/#todays-update Florida http://ww11.doh.state.fl.us/comm/_partners/covid19_report_archive/covid19-data/covid19_data_latest.pdf New York https://coronavirus.health.ny.gov/covid-19-data-new-york Illinois https://dph.illinois.gov/covid19/data.html https://health.ny.gov/press/releases/2021/docs/2021-12-24_health_advisory.pdf UK data https://www.gov.uk/government/publications/covid-19-omicron-daily-overview https://covid.joinzoe.com/data#levels-over-time https://coronavirus.data.gov.uk Zoe https://covid.joinzoe.com/post/cases-set-to-break-200k https://www.youtube.com/watch?v=WH7ISb-ReAo&t=139s https://covid.joinzoe.com SA hospital data https://www.nicd.ac.za/diseases-a-z-index/disease-index-covid-19/surveillance-reports/daily-hospital-surveillance-datcov-report/ https://www.worldometers.info/coronavirus/country/south-africa/ UK, 30th December 2021 Omicron hospital patients, + 261 + 98 + 49 = 815 Total omicron deaths, + 10 + 4 + 1 = 54 ONS, 23 December prevalence increases https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsights England – 1,202,300 people (1 in 45) Wales – 54,400 people (1 in 55) Northern Ireland – 37,800 people (1 in 50) Scotland – 76,200 people (1 in 70) Third-dose and booster vaccinations lowest among ethnic minorities As of 24th December 2021 Adults aged 50 years and over in England, three vaccinations, 74.7% Pakistani, 42.2% Black Caribbean, 44.4% Black African, 45.4% Occupations with the lowest coverage Elementary trades and related occupations, 37.0% (14.5%) Skilled construction and building trades, 39.8% (12.0%) Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 56 minWhite clots common
With Major Tom Haviland Uploaded 08-02-24 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 23 minCheap neglected cancer treatments
Professor of Oncology, Angus Dalgleish gives vital information on a repurposed drug he uses for his cancer patients, given at a very low dose. This is Low Dose Naltrexone. Uploaded 07-06-25 Check out the LDN trust website for much more, https://ldnresearchtrust.org Naltrexone at low doses (LDN) and its relevance to cancer therapy https://openaccess.sgul.ac.uk/id/eprint/114135/ Naltrexone was designed to inhibit opioid receptors without activating them and hence used to block the stimulatory effects of morphine and heroin. It was noted that in certain patients being treated with naltrexone for an opioid addiction many reported significant secondary benefit when being weaned off naltrexone. This group of patients had chronic inflammatory and autoimmune conditions and reported improvements whilst using the lower dosages of naltrexone. There have also been recent anecdotal reports of cancer resolution following the use of low doses of naltrexone (LDN). However, the mechanism of action is unclear. Areas covered We review three mechanisms through which LDN can influence cancer progression; namely, (a) antagonism of receptors to which LDN binds, which include toll-like receptors 7–9 that lead to IL-6 suppression b) modulation of immune function in patients; and c) direct inhibition of signaling pathways involved in cancer cell control, including the priming of pro-apoptotic pathways. Expert opinion Considering the increase in the number of anecdotal reports of activity, there will likely be a bigger drive toward using LDN in the oncological setting. These reports support clinical trials of LDN in cancer, especially when given in combination with certain chemotherapy. https://ldnresearchtrust.org/angus-dalgleish-md-role-ldn-management-cancer-2018-conference-ldn-low-dose-naltrexone Major clinical evidence on the use of low-dose naltrexone in the treatment of cancer: a systematic review https://www.researchgate.net/publication/384236060_Major_clinical_evidence_on_the_use_of_low-dose_naltrexone_in_the_treatment_of_cancer_a_systematic_review https://www.tandfonline.com/doi/full/10.1080/14737140.2022.2037426#abstract Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 10 minClip, Moderna expands, UK, Canada and Australia locations
Full video first posted 24th December 2022. Moderna Chief Executive Stephane Bancel https://www.cnbc.com/2022/06/22/moderna-to-build-new-vaccine-facility-in-britain.html That capacity that we’re building in the UK, that they are committed to buying the product for the next ten years NOTES TO EDITORS: the details of the strategic partnership between the government and Moderna are commercially sensitive UK, Prime Minister, Moderna (2020) https://www.theguardian.com/politics/2020/nov/17/rishi-sunak-refuses-to-say-if-he-will-profit-from-moderna-covid-vaccine Mr. Sunak refused to disclose whether he will profit from a surge in the share price of Moderna Theleme has a $500m investment in US-based Moderna Mr. Sunak was a founding partner of Theleme Partners and one of the executives managing its US office. He left the firm in 2013 Theleme is registered in the Cayman Islands (which does not make company records public) Moderna goes global https://globalnews.ca/news/9258211/groundbreaking-moderna-mrna-vaccine-factory-montreal/ Canada New factory in Montreal area, Laval, Que Mr. Trudeau took part in a groundbreaking ceremony Completed in 2024 or 2025 mRNA vaccines, 100 million doses per year Covid, influenza, respiratory syncytial virus Innovation Minister François-Philippe Champagne Canada committed to purchase a certain number of vaccines Part of a seven-year agreement 200+ workforce No to leave out Australia https://www.monash.edu/news/articles/moderna-to-build-manufacturing-facility-at-monash Monash Technology Precinct, Victoria COVID-19, influenza and respiratory syncytial virus (RSV) 100 million doses per year mRNA vaccines Monash Vice-Chancellor, Professor Margaret Gardner bring together all of the elements of an mRNA innovation ecosystem that will deliver long-term health and economic benefits for the community Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 24 min15 million excess deaths
Official reported deaths Uploaded 06-05-22 https://covid19.who.int Cases, 513,384,685 Deaths, 6,246,828 Technical Advisory Group on COVID-19 Mortality Assessment https://www.who.int/data/technical-advisory-group/covid-19--mortality-assessment/membership Five working groups e.g. group one https://www.who.int/data/technical-advisory-group/covid-19--mortality-assessment/working-group-1 Convened jointly by the WHO and the United Nations Department of Economic and Social Affairs (UN DESA) Methods used https://www.who.int/publications/m/item/methods-for-estimating-the-excess-mortality-associatedwith-the-covid-19-pandemic https://cdn.who.int/media/docs/default-source/world-health-data-platform/covid-19-excessmortality/who_methods_for_estimating_the_excess_mortality_associated_with_the_covid-19_pandemic.pdf?sfvrsn=5a05fa76_1&download=true 14.9 million excess deaths associated with the COVID-19 pandemic in 2020 and 2021 https://www.who.int/news/item/05-05-2022-14.9-million-excess-deaths-were-associated-with-the-covid-19-pandemic-in-2020-and-2021 Full death toll associated directly or indirectly with the pandemic That is, excess mortality 1 January 2020 and 31 December 2021 Range 13.3 million to 16.6 million Dr Tedros Adhanom Ghebreyesus, WHO Director-General These sobering data not only point to the impact of the pandemic but also to the need for all countries to invest in more resilient health systems that can sustain essential health services during crises, including stronger health information systems Generate better data for better decisions and better outcomes Excess mortality Number of deaths that have occurred and the number expected (in the absence of the pandemic) Direct and indirect deaths (due to the pandemic’s impact on health systems and society) Health care systems overburdened Deaths averted during the pandemic Motor-vehicle accidents, occupational injuries Most of the excess deaths (84%) South-East Asia, Europe, the Americas High-income and low-income countries, 15% of total 14.9 m Low income countries, 4% of total 14.9 m Sex Male, 57% of total 14.9 m Female, 43% of total 14.9 m Dr Samira Asma, Assistant Director-General for Data, Analytics and Delivery, WHO Measurement of excess mortality is an essential component to understand the impact of the pandemic. Shifts in mortality trends provide decision-makers information to guide policies to reduce mortality and effectively prevent future crises. Because of limited investments in data systems in many countries, the true extent of excess mortality often remains hidden These new estimates use the best available data and have been produced using a robust methodology and a completely transparent approach Dr Ibrahima Socé Fall, Assistant Director-General for Emergency Response Data is the foundation of our work every day to promote health, keep the world safe, and serve the vulnerable. Need to track outbreaks in real-time, everywhere We know where the data gaps are Mr Liu Zhenmin, United Nations Under-Secretary-General for Economic and Social Affairs The United Nations system is working together to deliver an authoritative assessment of the global toll of lives lost from the pandemic. This work is an important part of UN DESA’s ongoing collaboration with WHO and other partners to improve global mortality estimates Mr Stefan Schweinfest, Director of the Statistics Division of UN DESA Data deficiencies make it difficult to assess the true scope of a crisis, with serious consequences for people’s lives. The pandemic has been a stark reminder of the need for better coordination of data systems within countries and for increased international support for building better systems, including for the registration of deaths and other vital events. Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
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October 18 · 10 minWHO Parliament debate
Mr. Mark Francois. Link to poorly attended UK Parliament debate on the International Health Regulations, Westminster Hall, Monday 18th December 2023, https://parliamentlive.tv/Event/Index/5e1f14d2-72b3-488f-a53c-fc94fee92dac Uploaded 19-12-23 Full transcript https://hansard.parliament.uk/commons/2023-12-18/debates/945EBBB4-D052-4CF7-8109-B39FF7FF919D/InternationalHealthRegulations2005 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices