DiabetesBio

American Diabetes Association

DiabetesBio co-hosts Darleen Sandoval (University of Colorado), Kirk Habegger (University of Alabama-Birmingham), and Kevin Williams (UT Southwestern) interview authors of editor-selected biomedical research articles published in the journal Diabetes, the American Diabetes Association's flagship research publication.

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20 episodes
Updated July 22

Episodes20

Newest first

July 22 · 46 min
Special Edition: Highlights from the ADA's 2026 Scientific Sessions
In this special crossover episode, recorded live at the American Diabetes Association's Scientific Sessions in New Orleans, the hosts of the ADA's professional podcasts—DOC Updates, Diabetes Care "On Air", DiabetesBio, and The Points of CARE—come together to discuss key highlights and groundbreaking research presented at the 2026 meeting. They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year's findings mean for clinical practice and future research. Available now across all ADA professional podcast channels. Featured Podcasts: DOC Updates – ADA's podcast for primary care Diabetes Care "On Air" – From ADA's clinical research journal, Diabetes Care DiabetesBio – From ADA's flagship research journal, Diabetes The Points of CARE - The official podcast of Diabetes, Obesity, and CardioMetabolic CARE Join the Discussion with: Alice Cheng, MD – Co-host of Diabetes Care "On Air" Kirk Habegger, PhD – Co-host of DiabetesBio Michael Rickels, MD, MS – Co-host of Diabetes Care "On Air" Neil Skolnik, MD – Co-host of DOC Updates and Diabetes Day by Day Kevin Williams, PhD – Co-host of DiabetesBio Richard Beaser, MD – Co-host of The Points of CARE 🔗 Learn more about ADA's full podcast portfolio: https://diabetesjournals.org/journals/pages/podcasts Subscribe to DOC Updates, Diabetes Care "On Air", DiabetesBio, and The Points of CARE on Apple Podcasts, Amazon Music, Spotify, or your preferred platform.
July 9 · 1 hr 17 min
Jennifer Thompson & Taylor Scheidl on Estrogen, Hyperplastic Adipose Expansion and Preserving Adipose Progenitor Cell Availability in Subcutaneous Depots of Female Mice, plus "Sweet Talk" with ghrelin hormone researcher Jeffrey Zigman
Welcome to the July 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2026 issue of Diabetes. 5:40 Kirk welcomes Jennifer Thompson, PhD, Associate Professor in the Department of Biochemistry and Molecular Biology at the University of Calgary, and Taylor Scheidl, a doctoral student in Thomson's lab. Their article, "Estrogen Mediates Capacity for Hyperplastic Adipose Expansion and Preserves Adipose Progenitor Cell Availability in Subcutaneous Depots of Female Mice," is the latest Paper of the Month, and available for free at doi.org/10.2337/db25-0773. 36:20 In the latest edition of "Sweet Talk," our hosts speak with Jeffrey Zigman, MD, PhD, Professor in the Department of Internal Medicine at UT Southwestern Medical Center and a member of the Division of Endocrinology. Dr. Zigman, who has type 1 diabetes himself, has spent his career studying ghrelin as a hormone to regulate food intake, body weight, blood glucose regulation, and many other aspects of metabolism. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
June 12 · 1 hr 30 min
T-Cell Memory and Metabolic Response to Weight Cycling, Gut-Derived FGF15 Modulating Lean Mass, Bone, and Bile Acid Responses to Weight Loss, plus "Sweet Talk" with Myers, past recipient of the Outstanding Scientific Achievement Award
Welcome to the June 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2026 issue of Diabetes. 7:00 To discuss this issue's Paper of the Month, our hosts speak with Alyssa Hasty, PhD, Vice Provost and Senior Associate Dean of Faculty Affairs at UT Southwestern in Dallas, and Jamie Garcia, PhD, Associate Director for Scientific Partnerships and Engagement at Jane Coffin Childs Memorial Fund for Medical Research. Their article, "Interrupting T-Cell Memory Ameliorates Exaggerated Metabolic Response to Weight Cycling," is available for free at doi.org/10.2337/db25-0605. 27:35 Next, Darleen is joined by Randy J. Seeley, PhD, Henry King Ransom Professor of Surgery and Professor of Internal Medicine and Nutritional Sciences at the University of Michigan School of Medicine, as well as Nadejda Bozadjieva Kramer, PhD, Assistant Professor of Surgery at the University of Michigan School of Medicine. Their article, "Gut-Derived FGF15 Modulates Lean Mass, Bone, and Bile Acid Responses to Weight Loss," is available for free at doi.org/10.2337/db25-0466. 57:40 In the latest edition of "Sweet Talk," our hosts speak with Martin Myers, MD, PhD, Marilyn H Vincent Professor of Diabetes Research at the University of Michigan, Director of the Elizabeth Caswell Diabetes Institute, and recipient of the 2010 Outstanding Scientific Achievement Award from the American Diabetes Association. They talk about his work in leptin receptor signaling and the way brain circuitry works alongside GLP-1 based drugs to induce weight loss. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
May 5 · 1 hr 20 min
Sushant Bhatnagar on Maintaining Glucose Homeostasis via Tomosyn-2, Vladimer Darsalia on insulin resistance and stroke outcomes, plus "Sweet Talk" with Timo Mueller, recipient of the 2026 Outstanding Scientific Achievement Award
Welcome to the May 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2026 issue of Diabetes. 6:45 Our hosts speak with Sushant Bhatnagar, PhD, an associate professor in the Division of Endocrinology, Diabetes, and Metabolism in the Department of Medicine at the University of Alabama at Birmingham. He is corresponding author of May's Paper of the Month, "Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis," available for free at doi.org/10.2337/db25-0644. 30:45 Next, Darleen is joined by Vladimer Darsalia, PhD, a docent in neuroscience in the Department of Clinical Science and Education at the Karolinska Institute in Solna, Sweden. He is co-corresponding author of the article "Normalization of Insulin Resistance Rather Than Hyperglycemia Before Stroke Improves Functional Outcomes in a Mouse Model of Type 2 Diabetes," available for free at doi.org/10.2337/db25-0532. 48:30 In the latest edition of "Sweet Talk," our hosts speak with Dr. Timo Mueller, Director of the Institute for Diabetes and Obesity at Helmholtz in Munich and professor at the Walter Straub Institute for Pharmacology and Toxicology at Ludwig Maximilian University of Munich. Mueller is the current recipient of the American Diabetes Association's Outstanding Scientific Achievement Award for his work with brain GIP receptors, crucial for understanding the functionality of GLP-1s. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
April 8 · 1 hr 35 min
Fabriciova & Pavlinkova on Sex Differences in Diabetes Progression, Delgado-Corrales & Kim on Children with Islet Autoimmunity, plus "Sweet Talk" with Lora K. Heisler, recipient of the 2018 Outstanding Scientific Achievement Award.
Welcome to the April 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2026 issue of Diabetes. 5:30 Our hosts speak with Valeria Fabriciova, a PhD student in the group of Gabriela Pavlinkova, PhD, DSc, laboratory head at the Institute of Biotechnology at the Czech Academy of Sciences in Prague. They are co-authors of the article, "ISL1 Restricts Progenitor Programs and Promotes β-Cell Maturation, Revealing Sex Differences in Diabetes Progression," available for free at doi.org/10.2337/db25-0673. 40:00 Next, Darleen is joined by Beatriz Delgado-Corrales, a postdoctoral fellow in the lab of Ki Wook Kim, PhD, senior lecturer and principal investigator at the University of New South Wales in Sydney, Australia. They are the authors of "Distinct Enterovirus Antigen Landscape in Children With Islet Autoimmunity," available for free at doi.org/10.2337/db25-0805. 1:07:35 In the latest edition of "Sweet Talk," Kevin and Darleen speak with Lora K. Heisler, PhD, Chair in Human Nutrition and Head of the Obesity and Food Choice Division of the Rowett Institute at the University of Aberdeen, Scotland. Dr. Heisler was also the recipient of the 2018 Outstanding Scientific Achievement Award from the American Diabetes Association for her work on harnessing brain circuits to improve type 2 diabetes. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
March 9 · 1 hr 17 min
Matthew Merrins on Amino Acid Sensing, Noah Levi & Alejandro Caicedo on controlling pancreatic cell function through muscarinic receptor signaling, plus "Sweet Talk" about the upcoming Scientific Sessions with Mark Atkinson
Welcome to the March 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2026 issue of Diabetes. 8:15 Kirk speaks with Matthew Merrins, PhD, Joseph F. Hoffman Professor of Cellular and Molecular Physiology at Yale School of Medicine. He is senior author on the article "Amino Acid Sensing by the α-Cell Mitochondrial Phosphoenolpyruvate Cycle Regulates Intracellular Ca2+Levels Without Affecting Glucagon Secretion," available at doi.org/10.2337/db25-0510. 29:25 Next, Darleen is joined by Noah Levi, an MD-PhD student in the group of Alejandro Caicedo, PhD, professor in the Division of Endocrinology, Diabetes and Metabolism, Department of Medicine at the University of Miami Miller School of Medicine. They are corresponding authors of the article "Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function," available at doi.org/10.2337/db25-0604. 51:20 In the latest edition of "Sweet Talk," Kevin speaks with Mark Atkinson, PhD, about the American Diabetes Association's annual conference, Scientific Sessions. Atkinson is Eminent Scholar for Diabetes Research at the University of Florida and chair of the Scientific Sessions Programming Committee. More information about this year's Scientific Sessions, taking place June 5-8 in New Orleans, is available at professional.diabetes.org/scientific-sessions. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
February 6 · 1 hr 40 min
Wilson & Moore on B Lymphocytes and eroding islet tolerance in type 1 diabetes, Mittendorfer on the effects of marked weight loss on postprandial glucose disposal in type 2 diabetes, plus "Sweet Talk" with Sir Stephen O'Rahilly
Welcome to the February 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2026 issue of Diabetes. 6:10 To discuss this issue's Paper of the Month, our hosts are joined by authors Christopher Wilson, PhD and Daniel J. Moore, MD, PhD, both of Vanderbilt University. Their article, "B Lymphocytes Impede Tregs to Erode Islet Tolerance in Type 1 Diabetes," is available for free at doi.org/10.2337/db25-0241. 37:05 Next, Darleen speaks with Bettina Mittendorfer, PhD. Dr. Mittendorfer is Senior Associate Dean for Research and Director of NextGen Precision Health, Clinical and Translational Science Unit at the University of Missouri and the lead author of "Effects of Marked Weight Loss Induced by Gastric Bypass Surgery or Low-Calorie Diet Alone on Postprandial Glucose Disposal in Type 2 Diabetes," available for free at doi.org/10.2337/db25-0737. 56:00 In the latest edition of "Sweet Talk," Kevin introduces Sir Stephen O'Rahilly, a clinical scientist at the University of Cambridge and past recipient of the American Diabetes Association's Banting Medal for Scientific Achievement. They discuss O'Rahilly's career, which reshaped scientists' understanding of metabolism and metabolic disease. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
January 6 · 56 min
Masaya Oshima on the effects of killing human β-cells by CD8+ T cells and "Sweet Talk" with Sarah Stanely on the neural regulation of blood glucose in acute stress
Welcome to the January 2026 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2026 issue of Diabetes. 17:40 After sharing their predictions for the new year, our hosts are joined by Masaya Oshima, PhD, a contract researcher at Institut Cochin in Paris, France. He is the lead author on the January Paper of the Month, "Killing of Human β-Cells by CD8+ T Cells Triggers Inflammatory Paracrine Signaling and Neighboring β-Cell Dysfunction," available for free at doi.org/10.2337/db25-0473. 33:10 In the latest edition of "Sweet Talk," Kevin speaks with Sarah Stanley, MBBCh, PhD, an associate professor at the Icahn School of Medicine at Mount Sinai in New York and recipient of the American Diabetes Association's Pathway to Stop Diabetes Award. Her article, "Neural Regulation of Blood Glucose in Acute Stress: A Report on Research Supported by Pathway to Stop Diabetes," is available for free at doi.org/10.2337/dbi24-0051 To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Dec 5, 2025 · 1 hr 35 min
Bergman on altering lipid localization and adipose tissue cellular composition through weight loss and exercise, Walters, Castro-Gutierrez, Mukherjee & Russ on HLA immune presentation on Human β-Cells, metabolic "Sweet Talk" with Banks, Holman, & Lan
Welcome to the December 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2025 issue of Diabetes. 13:10 After discussing their favorite interviews of the past two years, our hosts are joined by Bryan Bergman, PhD, a professor in the Division of Endocrinology, Metabolism, and Diabetes at the University of Colorado Anschutz Medical Campus. He is the corresponding author of "Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition," a featured article in this month's issue. The article is available for free at doi.org/10.2337/db25-0492. 35:25 To discuss the latest Paper of the Month, our hosts are joined by authors Kathryn Walters, PhD, postdoctoral researcher at CU Anschutz, Roberto Castro-Gutierrez, PhD, a postdoctoral fellow at the University of California San Francisco, Neelanjan Mukherjee, PhD, Assistant Professor in the Department of Biochemistry and Molecular Genetics at the CU Anschutz, and Holger Russ, PhD, Associate Professor in the Department of Pharmacology and Therapeutics at the University of Florida. Their article, "Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells," is available for free at doi.org/10.2337/db24-0527. 1:00:50 In the latest edition of "Sweet Talk," Kevin and Kirk explore how new technologies shape the ways we assess metabolism. They are joined by Alexander Banks, PhD, Director of the Energy Balance core facility at Beth Israel Deaconess Medical Center (BIDMC) at Harvard Medical School, Corey Holman, PhD, Technical Director of the Rodent Metabolic Phenotyping Core at the University of Pennsylvania, and Louise Lantier, PhD, Metabolic Pathophysiology Core Managing Director at Vanderbilt University Medical Center. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Nov 7, 2025 · 1 hr 6 min
Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus "Sweet Talk" with Banting Medal recipient Jens Juul Holst
Welcome to the November 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2025 issue of Diabetes. 6:00 In the first segment, our hosts are joined by Kaylia Reynolds, MS and Nora Franceschini, MD, MPH, FAHA, both of the Department of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina. Their paper, "Diabetes Genetic Clusters and Clinical Outcomes in American Indians," is available for free at doi.org/10.2337/db25-0322. 20:40 To discuss the latest Paper of the Month, our hosts are joined by first author Stephanie K. Holm, a postdoctoral student in the Clemmensen group, and Christoffer Clemmensen, Associate Professor in the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. Their paper, "Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice," is available for free at doi.org/10.2337/db24-1056. 38:15 In the latest edition of "Sweet Talk," Kevin and Kirk speak with Banting Medal recipient Jens Juul Holst, MD, DMSc, of the University of Copenhagen, whose work with incretin hormones laid the foundation for therapies now used around the world. His article, "Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture," is available for free at doi.org/10.2337/dbi21-0026. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Oct 8, 2025 · 1 hr 7 min
Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, "Sweet Talk" on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity
Welcome to the October 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2025 issue of Diabetes. 5:50 In the first segment, our hosts are joined by Tessa M. Cacciottolo, PhD, a Chain Florey TTI Fellow in the MRC Laboratory of Medical Sciences at Imperial College London. She is the first author of the article "Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis," available for free at doi.org/10.2337/db25-0209. 22:15 In honor of last month being Childhood Obesity Month, in this month's edition of "Sweet Talk", our hosts speak with Kristen Nadeau, MD, MS, a professor of pediatrics at the University of Colorado Anschutz Medical Campus, and Bethany Cartwright, MD, PhD, an Assistant Instructor in the Department of Pediatrics at UT Southwestern Medical Center. They discuss the complications children with obesity can face, as well as the stigma and weight biases that accompany these diagnoses. Cartwright's article, "Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity," is available for free at doi.org/10.2337/dbi24-0044. 49:10 In a special segment, Nadeau and Cartwright take questions directly from kids of various ages on the topics of diabetes and obesity. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Sep 9, 2025 · 1 hr 6 min
Quarta on GLP-1-mediated targeting of inflammation and obesogenic memory in mice, Hsueh on dulaglutide and hepatic steatosis in obesity via a weight-independent mechanism, & "Sweet Talk" with Pathway to Stop Diabetes Award recipient Alexander Nectow
Welcome to the September 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2025 issue of Diabetes. 5:25 In the first segment, our hosts are joined by Carmelo Quarta, PhD, a principal investigator at INSERM (National Institute of Health and Medical Research) and a group leader at the Bordeaux Neurocampus at the University of Bordeaux in France. He is the co-corresponding author of "GLP-1–Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice," available for free at doi.org/10.2337/db24-1071. 27:30 Next, Darleen and Kirk speak with Willa A. Hsueh, MD, Professor of Medicine in the Division of Endocrinology at the Ohio State University College of Medicine. She is a corresponding author on this month's Paper of the Month, "The GLP-1 Receptor Agonist Dulaglutide Attenuates Hepatic Steatosis in Obesity via a Weight-Independent Mechanism," available for free at doi.org/10.2337/db24-0861. 46:20 Lastly, in this month's edition of "Sweet Talk," Kevin and Darleen are joined by Alexander R. Nectow, MD, PhD. A recipient of the American Diabetes Association's Pathway to Stop Diabetes Award, Dr. Nectow lab at Columbia University studies the dorsal raphe nucleus (DRN) and its relation to metabolism. His article, "The Dorsal Raphe Nucleus and the Integrative Control of Feeding: A Report on Research Supported by Pathway to Stop Diabetes," is available for free at doi.org/10.2337/dbi24-0015. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Aug 15, 2025 · 38 min
Special Edition: Highlights from the ADA's 2025 Scientific Sessions
In this special crossover episode, recorded live at the American Diabetes Association's 85th Scientific Sessions in Chicago, the hosts of ADA's professional podcasts—Diabetes Core Update, Diabetes Care "On Air", and DiabetesBio—come together to discuss key highlights and groundbreaking research presented at the 2025 meeting. They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year's findings mean for clinical practice and future research. Available now across all ADA professional podcast channels. Featured Podcasts: DiabetesBio – From ADA's flagship research journal, Diabetes Diabetes Care "On Air" – From ADA's clinical research journal, Diabetes Care Diabetes Core Update – ADA's podcast for primary care Join the Discussion with: Alice Cheng, MD – Co-host of Diabetes Care "On Air" Kirk Habegger, PhD – Co-host of DiabetesBio Michael Rickels, MD, MS – Co-host of Diabetes Care "On Air" Darleen Sandoval, PhD – Co-host of DiabetesBio Neil Skolnik, MD – Co-host of Diabetes Core Update and Diabetes Day by Day Kevin Williams, PhD – Co-host of DiabetesBio 🔗 Learn more about ADA's full podcast portfolio: https://diabetesjournals.org/journals/pages/podcasts Subscribe to Diabetes Core Update, Diabetes Care "On Air", and DiabetesBio on Apple Podcasts, Amazon Music, Spotify, or your preferred platform.
Aug 1, 2025 · 59 min
A special extended "Sweet Talk" episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD.
Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes. 6:55 For this month's episode, a special extended edition of "Sweet Talk," exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by Daniel J. Drucker, OC, MD, FRCPC, FRSC, FRS, recipient of the American Diabetes Association's (ADA) 2014 Banting Medal for Scienfitic Achievement for his research with GLP-1s. They also speak with Jonathan Campbell, PhD, Associate Professor in Medicine at the Duke Molecular Physiology Institute at Duke University. They discuss the history of endocrine biology research and their article, "Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies," available for free at doi.org/10.2337/db25-0393. 42:00 As the conversation continues, our guests discuss the controversy of the GIP receptor agonism, antagonism debate. These arguments are highlighted in a special debate series in the August issue of Diabetes, featuring a point article, "A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity," available for free at doi.org/10.2337/dbi24-0026, and a counterpoint article titled "GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale," also available for free at doi.org/10.2337/dbi24-0027. And don't forget to reach out! Let us know your stance in the debate between agonism and antagonism, and share your favorite science-related podcasts! To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Jul 17, 2025 · 1 hr 18 min
Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, "Sweet Talk" with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan
Welcome to the July 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2025 issue of Diabetes. 6:50 In the first interview segment, our hosts discuss July's Paper of the Month, titled "Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis." They're joined by corresponding authors Dr. Takayoshi Suganami, professor in the Department of Molecular Medicine and Metabolism, the Research Institute of Environmental Medicine at Nagoya University in Nagoya, Japan, and Miyako Tanaka, a lecturer in the same department. This article is available for free at doi.org/10.2337/db24-0762. 22:25 Our hosts speak with Richard M. Watanabe, PhD, Professor of Population and Public Health Sciences in the Department of Population and Public Health Sciences at the University of Southern California Keck School of Medicine. His paper, "Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver," is available at doi.org/10.2337/db24-0923. 46:50 In this month's edition of "Sweet Talk," our hosts are joined by Barbara B. Kahn, MD, recipient of the American Diabetes Association's Albert Renold Distinguished Career Award, to discuss her work uncovering key molecular mechanisms contributing to type two diabetes and the role of adipose tissue in regulating systemic insulin sensitivity. Dr. Kahn is the George Richards Minot Professor of Medicine at Harvard Medical School and Vice Chair for Research Strategy at Beth Israel Deaconess Medical Center in Boston. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Jun 4, 2025 · 55 min
Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura
Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and "Sweet Talk" with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura. Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of Diabetes. 4:40 In the first interview segment, our hosts discuss June's Paper of the Month, titled "Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk." They're joined by corresponding author Dr. Haruka Okamoto, Director of Obesity Research at Regeneron Pharmaceuticals, and lead author Dr. Kehan Bao, a postdoctoral fellow at Regeneron. This article is available for free at doi.org/10.2337/db24-0958. 17:25 Our hosts speak with Greg M. Kowalski, PhD, Associate Professor with both the School of Medicine and the Institute for Physical Activity and Nutrition at the Deakin University's Faculty of Health in Victoria, Australia. He is the corresponding author of a featured article in the June issue, "The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans," available for free at doi.org/10.2337/db24-0388. 33:55 In this month's edition of "Sweet Talk," our hosts are joined by Shingo Kajimura, PhD, professor at Beth Israel Deaconess Medical Center in Boston and the recipient of the ADA's 2025 Outstanding Scientific Achievement Award. They discuss his work with brown and beige fat control and their effects on energy balance and metabolic health. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
May 1, 2025 · 1 hr 15 min
Michael Rickels on predicting metabolic outcomes through beta cell secretory capacity, Mark Atkinson on the ADA's upcoming Scientific Sessions, and 2025 Banting Medal recipient Steven Kahn
Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes. 6:25 In the first interview segment, our hosts discuss May's Paper of the Month, titled "β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation." They're joined by corresponding author Michael R. Rickels, MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at doi.org/10.2337/db24-0729 25:30 It's a special two-part edition of "Sweet Talk." In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They're joined by Mark A. Atkinson, American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year's Scientific Sessions programming committee. 48:10 In part two, our hosts speak with Steven Kahn, MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association's Banting Medal for Scientific Achievement, and he discusses his landmark paper, "Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function," available for free at doi.org/10.2337/diab.42.11.1663. They also discuss the legacy of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at diabetesjournals.org/collection/2745/NIDDK-75th-Anniversary-Collection. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Apr 3, 2025 · 1 hr 12 min
Jennifer Bruin & Lahari Basu on cisplatin exposure and the dysregulation of insulin, Amit Majithia on AF-1 domain inhibition as an insulin sensitization target, and a Sweet Talk special remembrance with Maren Laughlin, Julio Ayala, and Shawn Burgess
Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes. 6:30 In the first interview segment, our hosts discuss an article titled "Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice." They're joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419. 25:20 Our hosts discuss the latest Paper of the Month, entitled "An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target." They're joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497. 38:55 In the special edition of "Sweet Talk," our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They're joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD, professor at UT Southwestern Medical Center in Dallas, Texas. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Mar 5, 2025 · 1 hr 6 min
Anne Gresch & Martina Düfer on resolving spatiotemporal electrical signaling within the islet, Delnaz Roshandel on the genetics of C-peptide and age, and a Sweet Talk history lesson with Jeffrey Flier & Christopher Newgard
Welcome to the March 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2025 issue of Diabetes. 3:20 In the first interview segment, our hosts discuss the Paper of the Month, "Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays." They're joined by Anne Gresch, PhD, a postdoctoral fellow at the University of Colorado's Anschutz Medical Campus, and Prof. Dr. Martina Düfer, from the Department of Pharmacology at the University of Munster Pharmaceutical and Medicinal Chemistry in Munster, Germany. This article is available for free at doi.org/10.2337/db23-0870. 22:40 Our hosts discuss an article from the February issue of Diabetes, entitled "Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes." They're joined by lead author Delnaz Roshandel, PhD, Senior Research Associate, and Andrew Paterson, MD, both of the Genetics and Genome Biology Program at the Hospital for Sick Children in Toronto, Canada. This article is available for free at doi.org/10.2337/db24-0340. 36:20 In the special edition of "Sweet Talk," our hosts welcome Jeffrey S Flier, MD, former Dean of Harvard Medical School and past recipient of the ADA's Banting Medal, as well as Christopher Bang Newgard, PhD, leader in pancreatic islet biology and metabolic disease at Duke University School of Medicine and previous recipient of the ADA's Outstanding Scientific Achievement Award. They discuss an article by Diabetes editor-in-chief, David A. D'Alessio, on the historic development of the insulin radioimmunoassay, available for free at doi.org/10.2337/dbi24-0055. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Feb 10, 2025 · 50 min
Francis C. Lynn on tracking insulin- and glucagon-expressing cells, David C. Wraith & Michael J. Price on antigen-specific immunotherapy for T1D, and Sweet Talk with Bret H. Goodpaster
Welcome to the February 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2025 issue of Diabetes. 3:55 In the first interview segment, our hosts our joined by Francis C. Lynn, BSc PhD, Associate Professor in the Department of Surgery and School of Biomedical Engineering at the University of British Columbia in Vancouver. He is the corresponding author of the article "Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line." The article is available for free at doi.org/10.2337/db24-0756. 18:25 Darleen, Kevin, and Kirk speak with David C. Wraith, PhD, Emeritus Professor of Immunology, and Michael J. Price, PhD, a research fellow, both at the Institute of Immunology and Immunotherapy at the University of Birmingham in the UK. They discuss their article, "Pre-clinical development of a tolerogenic peptide from glutamate decarboxylase as a candidate for antigen-specific immunotherapy in type 1 diabetes," available at doi.org/10.2337/db23-0996. 35:50 In the latest edition of "Sweet Talk," our hosts welcome Bret H. Goodpaster, PhD, Scientific Director and Senior Investigator at the AdventHealth Translational Research Institute for Metabolism and Diabetes in Orlando, FL, and Professor of Medicine at Johns Hopkins University. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!

DiabetesBio

Special Edition: Highlights from the ADA's 2026 Scientific Sessions

Jennifer Thompson & Taylor Scheidl on Estrogen, Hyperplastic Adipose Expansion and Preserving Adipose Progenitor Cell Availability in Subcutaneous Depots of Female Mice, plus "Sweet Talk" with ghrelin hormone researcher Jeffrey Zigman

T-Cell Memory and Metabolic Response to Weight Cycling, Gut-Derived FGF15 Modulating Lean Mass, Bone, and Bile Acid Responses to Weight Loss, plus "Sweet Talk" with Myers, past recipient of the Outstanding Scientific Achievement Award

Sushant Bhatnagar on Maintaining Glucose Homeostasis via Tomosyn-2, Vladimer Darsalia on insulin resistance and stroke outcomes, plus "Sweet Talk" with Timo Mueller, recipient of the 2026 Outstanding Scientific Achievement Award

Fabriciova & Pavlinkova on Sex Differences in Diabetes Progression, Delgado-Corrales & Kim on Children with Islet Autoimmunity, plus "Sweet Talk" with Lora K. Heisler, recipient of the 2018 Outstanding Scientific Achievement Award.

Matthew Merrins on Amino Acid Sensing, Noah Levi & Alejandro Caicedo on controlling pancreatic cell function through muscarinic receptor signaling, plus "Sweet Talk" about the upcoming Scientific Sessions with Mark Atkinson

Wilson & Moore on B Lymphocytes and eroding islet tolerance in type 1 diabetes, Mittendorfer on the effects of marked weight loss on postprandial glucose disposal in type 2 diabetes, plus "Sweet Talk" with Sir Stephen O'Rahilly

Masaya Oshima on the effects of killing human β-cells by CD8+ T cells and "Sweet Talk" with Sarah Stanely on the neural regulation of blood glucose in acute stress

Bergman on altering lipid localization and adipose tissue cellular composition through weight loss and exercise, Walters, Castro-Gutierrez, Mukherjee & Russ on HLA immune presentation on Human β-Cells, metabolic "Sweet Talk" with Banks, Holman, & Lan

Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus "Sweet Talk" with Banting Medal recipient Jens Juul Holst

Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, "Sweet Talk" on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity

Quarta on GLP-1-mediated targeting of inflammation and obesogenic memory in mice, Hsueh on dulaglutide and hepatic steatosis in obesity via a weight-independent mechanism, & "Sweet Talk" with Pathway to Stop Diabetes Award recipient Alexander Nectow

Special Edition: Highlights from the ADA's 2025 Scientific Sessions

A special extended "Sweet Talk" episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD.

Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, "Sweet Talk" with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan

Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura

Michael Rickels on predicting metabolic outcomes through beta cell secretory capacity, Mark Atkinson on the ADA's upcoming Scientific Sessions, and 2025 Banting Medal recipient Steven Kahn

Jennifer Bruin & Lahari Basu on cisplatin exposure and the dysregulation of insulin, Amit Majithia on AF-1 domain inhibition as an insulin sensitization target, and a Sweet Talk special remembrance with Maren Laughlin, Julio Ayala, and Shawn Burgess

Anne Gresch & Martina Düfer on resolving spatiotemporal electrical signaling within the islet, Delnaz Roshandel on the genetics of C-peptide and age, and a Sweet Talk history lesson with Jeffrey Flier & Christopher Newgard

Francis C. Lynn on tracking insulin- and glucagon-expressing cells, David C. Wraith & Michael J. Price on antigen-specific immunotherapy for T1D, and Sweet Talk with Bret H. Goodpaster