Chain Reaction by ACS

Better Science Through Belonging: Chemistry at Its Core, Episode 4

This episode explores inclusion and belonging through conversations with leaders from three scientific societies: NOBCChE, AISES, and SACNAS. Bridgette Shannon reflects on becoming the first Black woman to earn a chemistry Ph.D. at the University of Arkansas and the importance of being authentically yourself while creating space for quieter voices. Mary Jo Ondrechen discusses how community and cultural identity can help scientists overcome feelings of isolation and imposter syndrome. Ingrid Montes shares her experiences navigating gender and language barriers and argues that diverse perspectives strengthen science. Together, their stories show that scientific excellence depends on ensuring everyone feels they belong. Related episodes you may enjoy: The Modern Chemist Breaking Barriers Transcripts and episode sources at acs.org/chainreaction

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Where Safety Meets Sustainability: Chemistry at Its Core, Episode 3

“Sustainability” has become quite the buzzword, but what does it mean in the world of chemistry? In this episode of Chain Reaction, we explore ACS’ core value of sustainability through two conversations that reveal how chemistry can help solve some of society’s biggest challenges while keeping people and the planet safe. First, we hear from Amy Cannon, co-founder and executive director of Beyond Benign and the recipient of the first degree in green chemistry. Amy shares her unexpected path into the field, how she helped launch one of the world’s first green chemistry educational programs, and why educating future scientists is essential for building a more sustainable world. Next, we talk with Mary Beth Mulcahy, scientist at Sandia National Laboratories and editor-in-chief of ACS Chemical Health & Safety. Drawing from her own experience surviving a serious laboratory accident, Mary Beth explains why safety is a critical component of sustainability. From managing risk to designing systems that account for error, she highlights the often-overlooked human side of scientific work. Related episodes you may enjoy: The Soil and Superfund Sites Beneath Us It’s a Watery World Transcripts and episode sources at acs.org/chainreaction

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Always a Student: Chemistry at Its Core, Episode 2

This episode explores lifelong learning, one of ACS’s core values, through conversations with two educators whose careers have been shaped by curiosity and growth. High school chemistry teacher Amiee Modic reflects on 40-plus years in the classroom, sharing how hobbies like baking, sailboat racing, and reading continue to teach her new skills and inform her teaching. ACS education professional Karen Trimmer then discusses returning to school mid-career, finding purpose in mission-driven work, and embracing learning beyond traditional classrooms. Together, they show that lifelong learning isn't just about acquiring knowledge — it’s about staying curious, adaptable, and open to new possibilities. Related episodes you may enjoy: The Modern Chemist: The Origin Story of Chemistry, Episode 3 150 Years of ACS: The Origin Story of Chemistry, Episode 4 Transcripts and episode sources at acs.org/chainreaction

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When Passion Meets Real Life: Chemistry at Its Core, Episode 1

This episode kicks off a special Chain Reaction miniseries exploring the American Chemical Society’s core values, beginning with a deep dive into “passion for science.” Miniseries co-host Shane Hanlon interviews former ACS President Judy Giordan, who shares how childhood curiosity about how things work took her from chemistry research to leading innovation teams at companies including Polaroid and PepsiCo. The episode also features chemist Annabelle Lolinco, a AAAS Science and Technology Policy Fellow, who reflects on the life circumstances that shaped her career and how she is always finding new things to be passionate about! Together, their stories highlight how curiosity, resilience, and community help sustain a lifelong passion for science. Related episodes you may enjoy: The Poison Squad and Urinalysis: The Fascinating Lives of ACS Presidents Harvey Wiley and Helen M. Free A Conversation with Chemical Kim: Chemistry is Everyone, Episode 4 Transcripts and episode sources at acs.org/chainreaction

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Teaser: Chemistry at Its Core

What do passion for science, lifelong learning, sustainability, and inclusion and belonging look like in action? The latest miniseries focuses on people who exemplify some of the values that are most important to the American Chemical Society. From one person’s childhood science aspirations being shaped by the Cold War to another’s pioneering work in green chemistry, these episodes will provide a window into the ideas and lives of people molding chemistry’s future. Transcripts and episode sources at acs.org/chainreaction

[Bonus] When a Last Resort Antibiotic Fails

On this bonus episode we answer a listener's question about antibiotic resistance arising from agriculture by diving into the story of colistin, an antibiotic that is used as a last resort treatment. When colistin resistance was first reported in animals and humans, the public health community was understandably panicked, prompting governments to take action to regulate its use. Transcripts and episode sources at acs.org/chainreaction

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From Insulin to GLP-1s — a Peptide Saga: The Drugs That Shape Us, Episode 4

If you’re on social media, you may feel bombarded by influencers promoting peptides for a range of ailments so broad it almost seems like a brand-new trend. But peptide-based therapies actually date back to 1922, when insulin was first administered to treat diabetes. But it wasn’t until semaglutide (better known as Ozempic) entered the market that peptides truly captured public attention. In today’s episode, we explore how what chemists and other scientists learned from insulin paved the way for the remarkable effectiveness of GLP-1 drugs, and how treatments originally developed for diabetes are now being used to address obesity, substance use, and more. Transcripts and episode sources at acs.org/chainreaction

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Three Theories of Depression and the Promise of Psychedelics: The Drugs That Shape Us, Episode 3

In the late 1950s, a tuberculosis drug was repurposed as the world’s first antidepressant. Then the selective serotonin reuptake inhibitor (SSRI) Prozac ushered in a new era of antidepressants. Today SSRIs are some of the most widely prescribed drugs in the country, but gaps still exist in our biological understanding of mental health, the overall efficacy of antidepressants, and predicting serious side effects. In response, some scientists and physicians are turning to different classes of drugs altogether to treat depression. Transcripts and episode sources at acs.org/chainreaction

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Beyond the Pill: The Drugs That Shape Us, Episode 2

The discovery of sex hormones in the 1930s led to the development of female birth control, a widely used class of drugs that reshaped cultural norms surrounding fertility and bodily autonomy. But contraception remains largely the responsibility of women. On today’s episode: the evolution of birth control and the future of male contraception. Transcripts and episode sources at acs.org/chainreaction

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The Antibiotics Boom, Bust, and Search for What's Next: The Drugs That Shape Us, Episode 1

Through a few serendipitous discoveries, antibiotics changed the course of history by turning deadly infections into manageable sicknesses. But it didn’t take long for bacteria to begin outsmarting these wonder drugs. On today’s episode: The fascinating world of antibiotics and the efforts to tackle antibiotic resistance, including using AI to come up with new drugs that will only become more essential. Transcripts and episode sources at acs.org/chainreaction

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Teaser: The Drugs That Shape Us

You’ve likely relied on a drug at one point or another, whether it be a prescribed medication or something over the counter. The upcoming miniseries of Chain Reaction explores the history, impact, and future of major drug classes, including antibiotics, birth control, antidepressants, and GLP-1s. Margot and Sam will chat with experts about the history and scientific breakthroughs behind these medicines and the ongoing research that could shape the next generation of drugs. Transcripts and episode sources at acs.org/chainreaction

[Bonus] The Poison Squad and Urinalysis: The Fascinating Lives of ACS Presidents Harvey Wiley and Helen M. Free

This bonus episode continues the celebration of the American Chemical Society’s 150th anniversary by spotlighting two remarkable ACS presidents whose work helped shape public health in very different ways. Hosts Margot and Shane trade stories about these pioneering chemists. Harvey Wiley, ACS president in the 1890s, investigated dangerous food additives like formaldehyde and borax and presided over the infamous “Poison Squad” experiments. He was part of the impetus behind the “Wiley Act,” also known as the Pure Food and Drug Act of 1906. Helen M. Free, ACS president in the 1990s, transformed urinalysis diagnostics, co-inventing the first glucose test and countless other tests. Free’s innovations made health monitoring more accessible for millions of people and her legacy continues through the ACS award that bears her name. Learn more and send in your nominations here. Transcripts and episode sources at acs.org/chainreaction

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A Conversation with Chemical Kim: Chemistry is Everyone, Episode 4

To cap off this special #ACS150 miniseries, we chat with chemistry educator, science communicator, and social media creator Kim Hilton — better known as Chemical Kim (follow @chemicalkim). Kim reflects on her unexpected path into teaching, from struggling to understand chemistry as a college student to becoming a professor who has spent three decades helping others discover their place in STEM. The conversation explores Kim’s passion for outreach, from creating hands-on science experiences for children in hospitals and community programs to building an online audience that spans generations. Along the way, Kim explains why making chemistry accessible is not the same as making it easier, and why educators must meet learners where they are to help them succeed. Transcripts and episode sources at acs.org/chainreaction

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Chemistry in the New Space Age: Chemistry is Everyone, Episode 3

Space is the place . . . for chemistry! ACS president-elect Chris Bodurow and three colleagues chat about the role of chemistry in space exploration and how they ended up working in such an exciting field. Luke Roberson, Ken Savin, and George Rodriguez highlight the expanding space industry, the technologies that chemistry has enabled in space, and how chemistry might change the industry in the future by, for instance, enabling long-term life-support systems. Across all conversations, one thing becomes clear: Chemistry is enabling humanity to explore, live, and innovate in space. Transcripts and episode sources at acs.org/chainreaction

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Mentoring Across Generations: Chemistry is Everyone, Episode 2

ACS president Rigoberto Hernandez invites colleagues to speak about mentorship, communication, and the human side of science. One of Rigoberto’s former students, Ashley Ringer McDonald, talks about the power of multi-directional mentorship and the importance of nurturing growth and confidence in students. Michelle Francl and Rigoberto discuss the evolving role of theoretical chemistry, the need to balance basic and applied research, and the importance of communicating science in accessible, engaging ways. The episode closes with Angel Martí, who reflects on inclusive mentoring, community-building, and creating a sense of belonging to retain diverse talent in STEM. Across these conversations, a central theme emerges: science is fundamentally a human endeavor shaped by relationships, communication, and shared curiosity. Transcripts and episode sources at acs.org/chainreaction

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Breaking Barriers: Chemistry is Everyone, Episode 1

This episode of Chain Reaction launches a special series celebrating the American Chemical Society’s 150th anniversary. Immediate past president, Dorothy Phillips, interviews three chemists whose journeys emphasize resilience, representation, and inclusion. Cary Supalo, a blind chemist, describes overcoming barriers in education and research by developing collaborative techniques and accessible technologies that allow visually impaired scientists to participate fully in chemistry. Zemen Berhe, a refugee and first-generation scholar, reflects on the importance of representation and mentorship in shaping her path to becoming a professor and supporting underrepresented students. Simon Shannon shares his transition from bench chemistry to business leadership at 3M, highlighting the value of interdisciplinary skills and diverse perspectives. Throughout, the episode underscores how mentorship, community, and increased access can help broaden participation in STEM and ensure that chemistry truly belongs to everyone. Transcripts and episode sources at acs.org/chainreaction

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Teaser: Chemistry is Everyone

In celebration of the 150th anniversary of the American Chemical Society, our upcoming miniseries features the past, present, and future presidents of ACS in conversation with colleagues about topics they’re passionate about, including mentorship, representation, and … space! Transcripts and episode sources at acs.org/chainreaction

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[Bonus] From the Cutting Room Floor: Anthrax Decontamination Following the 2001 Attacks

In the inaugural “From the Cutting Room Floor” — where we take parts of interviews that didn’t quite fit in our regular episodes — we talk about anthrax. Well not exactly… we talk about what happens with the chemicals that we use to kill anthrax. In 2001, some high profile people like news anchors and senators received mail laced with anthrax — a spore-forming bacteria that can be deadly. Afterwards, there were many spaces that had to be decontaminated. And Richard Corsi was tapped to study these decontaminants. How did they interact with indoor spaces? Where did they go? How long did they last for? When was it safe for people to return to these spaces? It was a multi-year study that helped explain why sometimes the spaces deemed safe after decontamination still caused harm. Enjoy the episode? Please rate and review us! And, as always, if you have ideas email chainreaction@acs.org Transcripts and episode sources at acs.org/chainreaction

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Does Earth Have Limits?: The Chemistry of Pollution, Episode 4

Pollution is only one way humans are altering our planet. There’s climate change, sea level rise, biodiversity loss, and much more. Earth system scientists, including biological oceanographer Katherine Richardson, developed the nine planetary boundaries, a framework to understand what Earth systems are critical for life, and what will happen if human-caused changes to our planet continue. Katherine unpacks these boundaries, revealing how chemistry sits at the heart of both the problems and solutions to the equilibrium of many of these critical systems. It’s a sobering yet hopeful look at humanity’s future on a finite planet. Transcripts and episode sources at acs.org/chainreaction

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The Soil and Superfund Sites Beneath Us: The Chemistry of Pollution, Episode 3

Water and air pollution may capture the headlines, but there’s another threat looming beneath our feet: soil. We farm on it, build cities on it, and pull water from it. But pollutants from industrial waste, mining, and trash settle in soil, wreaking havoc on existing ecosystems and threatening our food and water supply. Soil and environmental chemist Owen Duckworth shares how chemists study soil, the unique qualities of soil pollutants, and the role chemists play in protecting public health. After understanding what’s polluting our soil, then comes the difficult task of cleaning up those pollutants. Biogeochemist William Burgos discusses the little known world of soil remediation, including storing waste in landfills or allowing adaptable microbes to slowly remediate pollutants on their own. This episode transports you to the Superfund sites, old mining caves, and acid pits where waste hides away, and reveals chemistry’s role in understanding — and fixing — soil pollution. Transcripts and episode sources at acs.org/chainreaction

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