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ScienceLife Sciences

This Week in Parasitism

Vincent Racaniello

TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

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  • 24 episodes
  • Avg 56 min
  • English

Episodes 24

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  • #268
    Nov 9, 2025 · 1 hr

    TWiP 268: A loyal parasite

    TWiP discusses a 41-year long human infection with Schistosoma mansoni, and CRISPR screens that reveal genes essential for Cryptosporidium survival in the host intestine. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server 41 year old Schistosoma infection (J Travel Med) Genes essential for Cryptosporidium survival in host intestine (Nat Comm) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

  • #267
    Oct 21, 2025 · 54 min

    TWiP 267: It dropped from her scalp

    TWiP solves the case about the female who traveled to Brazil and upon returning home felt movements under her scalp on the back of her head, and present another case for your solving, a man with abnormal brain MRI. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Eyal Leshem Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Life cycle of Dermatobia hominis (CDC) Letters read on TWiP 267 TWiP study - information and survey New Case Man in his 40s, married with 2 children, on Eliquis for a prior DVT, diet-controlled diabetes, who is admitted for evaluation of an abnormal brain MRI. He left AMA but then developed vomiting and returned. CT- Large peripherally enhancing mass lesion in the deep left cerebral hemisphere is associated with considerable vasogenic edema/infiltrative nonenhancing tumor. Mass effect results in left-to-right subfalcine herniation and entrapment of the right lateral ventricle. Findings are typical for glioblastoma. Intracranial abscess tumefactive multiple sclerosis and brain metastasis may mimic this appearance. Recommend supplemental imaging evaluation including gadolinium-enhanced MR brain. MRI- Dominant heterogeneously enhancing mass in the left basal ganglia/peri-insular region measuring 3.1 cm AP by 2.8 cm TR by 2.9 cm cc, with surrounding vasogenic edema resulting in mass effect and midline shift, as detailed above, concerning for high grade glial neoplasm versus metastasis. Additional leptomeningeal nodule in the right postcentral sulcus. Additional smaller peripherally enhancing lesion in the right lateral temporal region with suggestion of leptomeningeal component and measures approximately 0.8 x 0.8 cm, with mild surrounding vasogenic edema. They do a biopsy and pathology comes back as: – Brain tissue with extensive necrosis acute chronic inflammation, and rare microorganisms (on permanent section) -Brain, designated "left brain lesion", excision: – Brain tissue with extensive necrosis acute and chronic inflammation, reactive gliosis and occasional microorganisms Become a patron of TWiP Send your questions and comments to twip@microbe.tv

  • Oct 6, 2025 · 1 hr

    TWiP 266: Wraps and ivermectin for malaria

    TWiP explains research showing that treatment of baby wraps with an insect repellent, and oral dosing with ivermectin, are both effective measures to prevent malaria. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Treated baby wraps prevent malaria (NEJM) Oral ivermectin prevents malaria (NEJM) Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

  • #265
    Sep 26, 2025 · 40 min

    TWiP 265: Things that jump are cleaner than things that squat

    TWiP solves the case about the parasite check in summer camp, and presents a new case about a woman who traveled to Brazil and developed furuncles on the back of her head. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Hero: Francesco Redi Wikipedia: https://en.wikipedia.org/wiki/Francesco_Redi Linda Hall Library, Kansas: https://www.lindahall.org/about/news/scientist-of-the-day/francesco-redi/ Habermehl, G., (1994). Francesco Redi—Life and work, Toxicon 32 (4) https://doi.org/10.1016/0041-0101(94)90292-5. Letters read on TWiP 265 New Case From Eyal Leshem, a returning case "provider" 43 years old female who travelled to Brazil on May 2025 for a two week dance class. The dance school is located in a farm two hour drive West of Rio de Janeiro. Upon return to Israel she started feeling pricking and "movements" and under her scalp on the back of her head. She noted three non-healing furuncles on the back of her head A month after she returned movement and pricking in the back of her scalp increased, the furuncles enlarged and produced serous discharge. Several days before her ED visit she thinks an "object" dropped from the back of her scalp, but being outdoors, she could not locate the object. On physical examination she is afebrile and her vitals are normal, and on the back of her head two indurated were detected under the hair on the back of her head. Serous discharge was produced by pushing the furuncles. A non-surgical office procedure led to immediate recovery and confirmed the diagnosis. What was the parasite? What was the procedure? Become a patron of TWiP Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Showing 21–24 of 24 episodes