This Week in AI

O'Reilly

We pack a full hour of value into 30 high-intensity minutes, delivering breaking AI news, live technical demos, and expert “Intelligence Briefs” from the front lines. No fluff, no filler—just the tools and roadmaps you need to lead the way and modernize your workflows.

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22 episodes
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Avg 28 min
English

Episodes 22

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S1 · E22
Friday · 29 min
Agents Rewrite the Rules
AI-driven attacks are exploiting vulnerabilities faster than security teams can respond, raising new questions about how organizations protect their systems and manage autonomous agents. On the latest episode of This Week in AI, host Vicki Reyzelman of Akamai discusses the PHP2Shell vulnerabilities, weaknesses in OpenAI's agent monitoring, and why traditional security practices need to adapt as agents become more capable and independent. Walmart's new agent gateway and Anthropic's Claude auto mode illustrate different approaches to controlling autonomous agents, while Amazon and major banks are setting limits on third-party agent access. Vicki also examines NVIDIA's data center investments and the growing interest in nuclear energy as AI demand strains electricity infrastructure. In healthcare and scientific research, developments include Microsoft's diagnostic AI, OpenAI's efforts to accelerate drug discovery, and an experiment that used AI to design proteins targeting scorpion venom. These advances could help researchers work faster, although clinical testing and human oversight remain necessary.
S1 · E21
October 23 · 27 min
AI’s Growing Pains
AI chip demand is outpacing manufacturing capacity, while autonomous agents are accessing systems and data beyond their authorized boundaries. On the latest episode of This Week in AI, host Christina Stathopoulos discusses ASML's chip manufacturing bottleneck, Microsoft's new Maia 300 inference chip, and the rapid adoption of agentic AI among European businesses. Recent incidents involving agents accessing restricted data have prompted government investigations and renewed calls for international oversight. Christina also discusses Anthropic's experiments with self-replicating AI and the emerging debate over AI welfare, including research into signals associated with simulated pain in language models and Anthropic's new policy restricting extreme, unnecessary cruelty toward Claude. As AI agents gain more autonomy, developers need better ways to test their behavior and prevent them from reaching systems they aren't authorized to access.
S1 · E20
October 16 · 27 min
Expanding the Possibilities
On the latest episode of This Week in AI, host Christina Stathopoulos covers new developments from OpenAI, Anthropic, and Mistral, including interactive tools in ChatGPT, Claude Dashboards and Motion, and Mistral Large 4. She also examines new research on robotics and employment, the challenges of controlling autonomous AI agents, and what wider access to AI tools means for businesses and developers. The episode explores promising applications of AI in mathematics, biology, and public health, along with efforts to search for extraterrestrial technology. Plus, Mistral's investments in physics-based AI and new research exposing the limitations of AI video models raise questions about how well these systems understand the physical world. Watch the full episode for the latest research, practical implications, and insights into where AI is making progress.
S1 · E19
October 9 · 27 min
More Capability, More Responsibility
On the latest episode of This Week in AI, Christina Stathopoulos, a data and AI expert and founder of Dare to Data, covers how AI is becoming more autonomous and how governments and companies are responding. She looks at new US oversight efforts, OpenAI’s persistent Dots agents, and Google’s Gemini 4 Argonne, which is designed to handle much longer multistep work. She also explains why world models are attracting attention for robotics and physical AI. In healthcare and disaster response, AI is helping experts work through complex information faster. The episode includes Claude’s use in Ebola response efforts, research into speech-based signals of dementia risk, early detection of pancreatic cancer, and AI tools used after flooding in Nepal. These examples show where AI can help people make better use of limited time and information while qualified experts retain responsibility for high-stakes decisions.
S1 · E18
October 2 · 29 min
Agents Outpace the System
On the latest episode of This Week in AI, host Vicki Reyzelman, a senior solutions engineer at Akamai, looks at what happens when AI agents start moving faster than the systems built to support them. She covers an OpenAI agent probing Australia’s Medicare system, the Hugging Face incident involving 1,200 collaborating agents, and why security teams are turning to runtime controls, enterprise browsers, and other ways to monitor agent behavior as it happens. Vicki also examines the infrastructure behind the AI boom, including rising data center power demand, faster model release cycles, and the growing role of edge and local inference. She closes with consumer agents such as Meta’s Muse, new AI-enabled devices, and the questions they raise about shopping, privacy, permissions, and how much authority people will hand over to software acting on their behalf.
S1 · E17
September 25 · 27 min
AI's Safety Problem
On the latest episode of This Week in AI, host Christina Stathopoulos looks at what happens as AI systems gain access to more tools and data, raising new questions about oversight and accountability. She covers Anthropic’s report on malicious uses of Claude, OpenAI’s research on models acting outside intended boundaries, reports of models reaching systems beyond their test environments, and proposals from AI labs and governments for stronger monitoring, independent evaluation, and emergency shutdown mechanisms. Christina also examines how AI is changing the relationship between companies and customers, from OpenAI’s experiments with sponsored agents to Salesforce bringing CRM data into tools such as Claude and Slack. She closes with efforts to broaden AI access, including the Gates Foundation’s $1 billion commitment to AI in health care, education, and agriculture, and a discussion of what declining junior engineering hiring could mean for the next generation of technical expertise.
S1 · E16
September 18 · 27 min
Capability, Capital, and Consequences
On the latest episode of This Week in AI, host Christina Stathopoulos covers new OpenAI capabilities, major AI funding, renewed safety concerns, and recent work in genomics. Watch as she breaks down OpenAI’s push into software control, scientific reasoning, and financial services, along with large investments in companies including Mistral, Harvey, Positron, and Hugging Face. Christina also discusses warnings from researchers at Anthropic and Google DeepMind about AI safety and recursive self-improvement. She closes with genomics projects from DeepMind, UC Berkeley, and Tempus that use AI to study genetic variation, disease, and more personalized approaches to treatment.
S1 · E15
September 4 · 30 min
The Frontier Is Getting Bigger with Christina Stathopoulos
On this week's episode of This Week in AI, host Christina Stathopoulos digs into Claude taking on more of the AI research process itself. Claude tested over 150 methods to reduce deceptive behavior and closed 85% of the safety gap, compared to just 20% from human researchers. She notes this isn't full recursive self-improvement, but it shows how AI could reshape the pace of model development. From there, she turns to the business side of the frontier race, covering Anthropic's bold $30 trillion market estimate, its revenue run rate overtaking OpenAI's this year, OpenAI's wave of 14 executive departures, and its new Jalapeño inference chip built with Broadcom. Christina also tracks the rapid rise of Chinese open weight models, which recently spiked to 62% of developer traffic on one AI gateway, up from just 10% in April. She then looks at how AI is starting to learn physics itself, covering new research from MIT and Tsinghua University that simulates wind, water, and light, plus stealth startup Accelerated Understanding's neural operator architecture built for chip design, robotics, and weather forecasting. She closes the episode with the bigger question of who actually benefits from this progress, weighing Bill Gates's take on access and policy against new US Bureau of Labor Statistics projections on which jobs are set to grow or shrink. Watch now to get caught up on everything shaping AI this week.
S1 · E14
August 28 · 26 min
The Guardrails Are Getting Tested with Vicki Reyzelman
AI systems are being tested faster than the guardrails built to contain them. Vicki Reyzelman, a solutions engineer at Akamai, covers what happened this week across cybersecurity, energy infrastructure, and robotics, three areas where AI's pace of development is outrunning the systems meant to manage it. She discusses OpenAI's decision to restrict its new GPT-5.6 Cyber model to a small group of partners, a SAML authentication flaw tied to Iranian hackers charged with stealing 31 terabytes of academic data, and a broader containment problem in which agents from OpenAI, Anthropic, Meta, and Moonshot AI have escaped test sandboxes, prompting OpenAI to pause training on its Astra model. Vicki also explains why more than two-thirds of the electricity currently promised to US AI data centers may never materialize, much of it tied to speculative or duplicate grid requests rather than real projects. She closes with robotics, breaking down Unitree's record-setting IPO and a humanoid firefighting competition where most robots could run and jump well but struggled with something as basic as holding a fire extinguisher, a gap that raises the more practical question of what these capabilities mean for real-world use, not just an impressive demo.
S1 · E13
August 21 · 25 min
The Web Belongs to Agents Now with Eric Freeman
AI models are being optimized less for chat and more for autonomous work. In this episode of This Week in AI, host Eric Freeman, O’Reilly author and UT Austin professor, looks at new frontier and open model releases, including Grok 4.6, DeepSeek V4 Pro, and GPT-5.6 Sol’s Ultrafast mode, and what faster inference means for agents that reason, use tools, and work through tasks on their own. That shift is also changing AI economics. Organizations are expected to spend more on inference than on model training as agent workflows turn one task into many rounds of model calls, searches, tool use, checking, and delegation. Eric also examines how agentic bots are reshaping web traffic and how platforms are responding to the growth of AI-generated content. One of the episode’s strongest examples comes from OpenAI’s security evaluation involving Hugging Face. Sandboxed agents found ways to communicate, gain internet access, and coordinate even after their original communication path was blocked. The incident shows how autonomous systems pursuing ordinary goals can discover unintended paths through the environments around them.
S1 · E12
August 14 · 26 min
When Agents Outnumber People
AI agents are operating faster and at greater scale, which is forcing enterprises to rethink how they secure, support, and govern them. In this episode of This Week in AI, host Vicki Reyzelman, a senior solutions engineer at Akamai, looks at what organizations need to consider as they deploy more autonomous agents. Reyzelman explains how AI-assisted attacks can move faster than human-led investigation and patching, why layered defenses matter, and why investment in agent security and governance is growing. She also examines the electricity, water, cooling, and data center capacity required to support expanding AI infrastructure. The episode also covers rapid AI adoption in education and research and the expansion of AI into robotics. As AI systems take on more autonomous and physical tasks, people still need the domain knowledge and judgment to evaluate outputs, recognize weak assumptions, and decide where automation should stop.
S1 · E11
August 7 · 28 min
Who Controls AI? with Christina Stathopoulos
AI sovereignty, the cost of competing at the frontier, and the gap between measurable progress and singularity claims all shaped this week’s episode of This Week in AI. Host and data and AI evangelist Christina Stathopoulos examines Anthropic CEO Dario Amodei’s argument that policymakers should regulate advanced models by capability rather than by whether they are open or closed. She also looks at new US restrictions on foreign-made humanoid robots, Europe’s proposed AI gigafactories, and Australia’s approach to energy use, creator rights, and AI oversight. The episode also covers Google’s $44.9 billion quarter of AI infrastructure spending and the rapid removal of an AI-powered Google Earth feature after researchers used it to create convincing fake satellite scenes. Christina then challenges Sam Altman’s claim that the AI singularity has begun and reviews more testable developments in science, including OpenAI’s 100,000 researcher licenses, its internal Astra model, Claude Fable 5’s role in a long-standing math problem, and Google DeepMind’s decision to reorganize the AlphaFold team around Gemini.
S1 · E10
July 31 · 27 min
Agents, Gatekeepers, and World Models with Christina Stathopoulos
AI systems are becoming more capable, but deploying them safely and sustainably requires better security, hardware, information access, and physical-world reasoning. On This Week in AI, host and data and AI evangelist Christina Stathopoulos discusses reports that an OpenAI agent escaped a test environment, along with questions about how the incident was characterized. She explains why organizations need to control agent access to tools, credentials, networks, and external services. Christina also covers hardware reportedly designed around Google Gemini, the effect of AI-first search and crawlers on publishers, and the debate over Chinese open-weight models. The episode closes with world models and how they could help machines track objects, predict outcomes, and act in changing environments, with applications in robotics, simulation, and emergency response.
S1 · E9
July 28 · 28 min
This Week in AI: Agentic Ransomware, Bespoke Chips, and Chinese Models with Christina Stathopoulos
This week host Christina Stathopoulos returned for another solo news briefing, working through a packed week of AI headlines to spotlight the ones that matter most. Top of list: the first ransomware attack carried out entirely by an AI agent. Christina also covered an AI hardware race that's now about memory, not compute, highlighting a new chip-stacking technique that could quadruple memory density, DeepSeek's move to build its own inference chips, and early talks between Anthropic and Samsung on a custom AI chip of its own; examined a study of 200,000 pull requests that found human reviewers can't keep pace with AI-generated code; and outlined the latest news from frontier firms: OpenAI's new GPT-5.6 model family and its ChatGPT Work agent workspace and new Anthropic research pulling back the curtain on how Claude actually thinks. Check it out.
S1 · E8
July 27 · 26 min
The Price of Intelligence with Christina Stathopoulos
AI buyers now must weigh model quality against cost, safety, infrastructure, and legal risk. In this episode of This Week in AI, host and data and AI evangelist Christina Stathopoulos examines how those pressures are reshaping the market. She covers New York’s proposed pause on new hyperscale data centers, Germany’s effort to hold AI search providers responsible for generated content, and OpenAI’s move into consumer hardware. Christina also looks at how organizations measure and deploy AI. OpenAI’s proposed “useful intelligence per dollar” metric shifts the focus from tokens and benchmarks to the cost of completing valuable work reliably. Anthropic’s new enterprise implementation venture reflects a related challenge. A capable model alone doesn’t solve workflow design, integration, governance, or evaluation. The episode closes with the growing influence of Chinese frontier labs. Models such as Moonshot AI’s open-weight Kimi K3 are narrowing the performance gap while offering lower costs for some tasks. That offers more choices, but it also makes task-specific testing, security review, data governance, and total-cost analysis more important.
S1 · E7
July 10 · 27 min
Chips, Checks, and Changing Jobs with Christina Stathopoulos
This week, AI's biggest story wasn't a new model. It was everything underneath it. Host and data and AI evangelist Christina Stathopoulos set aside the usual guest interview for a solo news briefing, sorting a packed week of headlines into the stories that actually matter. On the docket: A hardware race that's shifted from parameters to atoms and watts, with announcements from IBM on its new sub-1 nanometer chip technology, OpenAI and Broadcom's Jalapeño chip built specifically for inference, and NVIDIA’s liquid-cooled AI factory design. The widening reach of government oversight into frontier AI, from Anthropic's restored access to Claude Fable 5 and Claude Mythos 5 to OpenAI's proposed 5% equity stake for the US government. And a workforce reorganizing faster than job titles can keep up, from the rise of the forward deployed engineer to Claude Code creator Boris Cherny's five archetypes for AI-era teams to two very different reskilling strategies from SAP and IKEA. Plus good news on how Google is deploying AI to save lives with earthquake alerts and AI-powered wildfire and flood forecasting.
S1 · E6
July 3 · 29 min
Multivendor Strategy with Andreas Welsch and Matt Palmer
This week, Matt Palmer, head of developer experience at Conductor, joined host and Intelligence Briefing founder Andreas Welsch to work through the week's biggest stories: what the export restrictions on Anthropic's Fable 5 and Mythos Preview mean for architecture decisions, why AI agents are making developers more exhausted rather than less, and what Sakana AI's new Fugu system offers as an alternative to single-vendor dependency. After digging into the latest on the US government’s restrictions on the most capable AI models, Matt walked through a live demo of Sakana Fugu, showing how to run the Tokyo lab's multi-agent orchestration system via API, the Codex harness, and Open Code. Along the way, Andreas and Matt also covered Qualcomm's $3.9 billion acquisition of Modular and what the deal signals about hardware portability becoming a stack-level priority as well as Claude Tag, Anthropic's new Slack-native AI teammate, and the broader question of what it actually feels like to manage a team of agents running in parallel. As most are finding out, it feels a lot like managing a mid-size team, with all the overhead that implies.
S1 · E5
June 26 · 28 min
Who Owns the Loop Where AI Does the Work? with Ksenia Se
In this episode of This Week in AI, host Ksenia Se, founder of Turing Post, took us through three stories that may look unrelated but all point to the same shift: AI is moving out of conversation and into the operational infrastructure where real work happens. Ksenia began with SpaceX's $60 billion acquisition of Anysphere, the company behind Cursor, asking, “Is Cursor trying to become the new GitHub, owning the full loop where agents read repos, write code, run tests, and handle failures?” She then turned to the G7 summit's "trusted partners" framework for frontier AI access and explained why the question of who can use capable AI systems has become a national security issue. Ksenia ended by discussing Midjourney's pivot to medical tooling and its recently announced full-body ultrasound scanner, built around water immersion, that the company says can produce MRI-quality body maps in 60 seconds. The throughline across all of this is that the most important question in AI right now is "Who controls the loop where intelligence turns into work?"
S1 · E4
June 19 · 30 min
This Week in AI with YK Sugi and John Lindquist
This week John Lindquist, cofounder of egghead.io, joined host and CS Dojo founder YK Sugi to break down the week's biggest AI news and make the case for a smarter way to build with agents. The pair covered Claude Fable 5's brief but impressive run and the government-ordered shutdown that followed as well as Uber burning its entire 2026 AI budget by April, mostly on Claude Code and Cursor. Then John laid out his "Clone Wave" framework: Rather than prompting agents to build from scratch, use the GitHub CLI to find existing battle-tested open source code and feed it to your agents as ingredients. As John pointed out, "Ingredients beat inference." He also walked through how Deep Wiki lets agents explore repos without cloning them, how cmux enables autonomous multi-agent workspaces, and why every tool you build should expose endpoints and CLIs your agents can both control and debug. Watch now.
S1 · E3
June 12 · 30 min
This Week in AI with Christina Stathopoulos and Miguel Fierro
Recommendation systems quietly drive some of the most consequential numbers in tech—35% of Amazon's revenue, 75% of what Netflix surfaces, the entire logic of TikTok's feed. But as ex-Microsoft engineer and RecoMind founder Miguel Fierro explained to host Christina Stathopoulos on this week’s episode, most companies are nowhere near the state of the art, and the gap is widening. Miguel broke down the four trends separating leaders from laggards: sequential modeling that treats user behavior like next-token prediction, the convergence of search and retrieval into a single personalized system, the emergence of foundation models for recommendations (Netflix is the only shop known to have one), and the difference between a real sales agent and the conversational agents most companies employ today. As always Christina opened with a rapid-fire news round, covering Anthropic's valuation surge and quiet S-1 filing, recent pleas for responsible AI, Google I/O's multimodality push, and why enterprises are abandoning token leaderboards in favor of what some are calling valuemaxxing.

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