
Jack Szostak - Life's Next Transition May Not Be Biological (Stewarding the Flame, Episode 10)
This installment of the Stewarding the Flame series is an interview with Jack Szostak, University Professor in the Department of Chemistry at the University of Chicago, recipient of the 2009 Nobel Prize in Physiology or Medicine for his work on telomeres, and one of the world's leading researchers on the origin of life. Jack argues that the fundamental aspect of biology is evolution, and that the origin of life is really the question of how chemistry gets to a system that can do Darwinian evolution. He is reluctant to draw a hard line between life and non-life, and open to the possibility that life could get started in more than one way. We explore possible steps and open questions on the path from heritable information to cells and multicellular life, why Jack sees no overarching conceptual barriers to understanding how life got started, why he doubts consciousness would emerge spontaneously in AI but could be designed in, and how self-improving AI might lead to new types of physically instantiated minds. The interview is the tenth installment of The Trajectory's newest series, Stewarding the Flame, where we explore what intelligence is and ask what "flame" life possesses that non-life does not. This episode referred to the following other essays and resources: -- Stewarding the Flame - How to Build an Ideal Future for Intelligence: https://danfaggella.com/stewarding/ -- Mario Livio & Jack Szostak - Is Earth Exceptional? The Quest for Cosmic Life (Basic Books, 2024): https://www.hachette.com.au/mario-livio-jack-szostak/is-earth-exceptional-the-quest-for-cosmic-life -- Eric Smith - AI May be a Prosthetic for the Living Process (Stewarding the Flame, Episode 9): https://danfaggella.com/smith1 -- Stuart Kauffman - Why Open-Ended Evolution Has Never Happened in a Machine (Stewarding the Flame, Episode 5): https://danfaggella.com/kauffman1 -- Yoshua Bengio - Why We Shouldn't Blast Off to AGI Just Yet (The Trajectory Series 1: AGI Destinations, Episode 1): https://danfaggella.com/bengio1 -- Stuart Russell - Avoiding the Cliff of Uncontrollable AI (AGI Governance, Episode 9): https://danfaggella.com/russell1 -- Martin Rees - If They're Conscious, We Should Step Aside (Worthy Successor, Episode 12): https://danfaggella.com/rees1 Watch the full episode on YouTube: https://youtu.be/xGaME_qUpyo See the full article from this episode: https://danfaggella.com/szostak1 … About The Trajectory: AGI and man-machine merger are going to radically expand the process of life beyond humanity -- so how can we ensure a good trajectory for future life? From Yoshua Bengio to Nick Bostrom, from Michael Levin to Peter Singer, we discuss how to positively influence the trajectory of posthuman life with the greatest minds in AI, biology, philosophy, and policy. Ask questions of our speakers in our live Philosophy Circle calls: https://bit.ly/PhilosophyCircle Stay in touch: -- Newsletter: https://bit.ly/TrajectoryTw -- X: https://x.com/danfaggella -- Blog: https://danfaggella.com/trajectory -- YouTube: https://www.youtube.com/@trajectoryai


















