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The a16z Show

Andreessen Horowitz

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

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108 episodes
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#1250
Today · 50 min
The New CFO: How AI Is Rewriting the Finance Function | Figma CFO Praveer Melwani
AI is moving finance from reconciling what happened last month to helping decide what the business should do next. Figma CFO Praveer Melwani argues that the best finance teams are becoming builders themselves, automating repetitive work so they can spend more time understanding customers, running experiments, and shaping strategy. Praveer joins a16z’s Seema Amble and Ivan Makarov to share what that shift looks like inside Figma, from collections and expense analysis to M&A diligence, where the c
#1249
Yesterday · 51 min
The New AI Agents That Shop, Plan, and Gossip
Will we have one AI assistant that does everything, or an entire network of agents that know different parts of our lives? David Pawlan, creator of Assistant Benchmark, returns with Anish Acharya and Josh Elman to take stock of how quickly the agent landscape has changed. David has now tested more than 140 AI assistants, and they unpack what separates them, from memory and judgment to trust, shopping, and social experiences. They also explore what happens when agents start talking to each other,
#1248
Tuesday · 49 min
Andrew Huberman’s Three Rules for Better Health and Focus
If you could do only three things for your health, what should they be? Andrew Huberman’s answer is surprisingly straightforward: get bright light shortly after waking, resistance train, and make the sleep you can get as high-quality as possible. Andrew joins a16z General Partner Daisy Wolf to walk through the protocols he actually follows, from exercise and nutrition to meditation, supplements, and locking his social media phone in a box. He also explains why optimizing every health protocol ca
#1247
Monday · 46 min
The Robots Already Working in American Factories | Tutor Intelligence
What does it take to build robots that can actually work in factories and warehouses? Tutor Intelligence CEO Josh Gruenstein argues robotics is a systems problem spanning AI, hardware, manufacturing, and the work itself. Josh joins a16z General Partners Martin Casado and Raghu Raghuram to explain Tutor’s approach: deploy robots into real businesses, use human “tutors” when needed, and turn that work into training data that makes the robots more capable. They discuss Tutor’s 100-robot data factor
#1246
Sunday · 44 min
How Bending Spoons Built a $20 Billion Compounder | Luca Ferrari
Can relentless optimization create as much value as breakthrough invention? Bending Spoons CEO Luca Ferrari argues that radical innovation can produce extraordinary outcomes, but systematic improvement can be more dependable, especially when paired with a model designed to compound over decades. Speaking with a16z General Partner Anish Acharya at Wave by Vento, Luca explains how Bending Spoons acquires technology companies, integrates them onto a shared platform, improves their economics, and re
#1245
Saturday · 25 min
Can AI Fix Professional Networking? | Inside Cosign
What if finding your next job, co-founder, or collaborator depended less on a resume and more on who is willing to vouch for you? Cosign is building a professional network around those signals, with the longer-term goal of giving AI agents access to the relationship and reputation data that traditional networks keep locked away. a16z New Media’s David Booth and Dhruv Gupta join MTS to introduce the Cosign Awards, which recognize standout operators, companies, and products based on nominations fr
#1244
Friday · 53 min
Why AI Could Turn Small Law Firms Into Billion-Dollar Businesses
What happens when AI makes legal work cheap enough to take cases lawyers couldn't afford to touch before? Eve CEO Jay Madheswaran argues that AI won't just cut costs for law firms. It could expand access to legal representation by making an entirely new class of cases economically viable. Jay joins a16z General Partner Alex Rampell to explain how Eve is automating plaintiff law from the first client call through settlement, and why some firms are already using it to increase the number of client
#1243
October 29 · 50 min
The Startups Rebuilding American Industry | The AD50
America’s defense, energy, manufacturing, and robotics booms are increasingly becoming one story: the rebuilding of the country’s industrial base. This year’s AD50 highlights the companies building across that stack, from critical materials and factories to the systems they ultimately power. a16z’s Erin Price-Wright and Connor Love join Elena Burger to unpack what has changed. They discuss how defense demand can help finance manufacturing capacity that ultimately serves much larger commercial ma
#1242
October 28 · 1 hr 1 min
Mark Cuban on Why AI Could Turn Solo Founders Into Trillionaires
Mark Cuban thinks AI could transform healthcare, but it won’t fix opaque prices and broken incentives on its own. His starting point for employers: run every benefits contract through AI and ask where you’re getting ripped off. Mark joins a16z General Partner Julie Yoo and Erik Torenberg to discuss what he’s learned building Cost Plus Drugs, why trust is its core product, and how greater transparency could put pressure on healthcare costs. They also explore where AI can help, what personalized m
#1241
October 27 · 56 min
Reinventing School for the AI Era | Joe Liemandt, Gagan Biyani & Erik Torenberg
What should school look like if AI can help students learn dramatically faster? Alpha School founder Joe Liemandt argues the answer isn’t to fill the extra time with more academics, but to redesign school around the skills traditional classrooms struggle to teach: agency, teamwork, entrepreneurship, communication, and doing hard things. Joe joins Erik Torenberg and Horowitz and Andreessen Academy co-founder Gagan Biyani to discuss Alpha’s model, where students spend two hours a day on core acade
#1240
October 26 · 45 min
OpenAI: When AI Agents Use Computers Faster Than You
AI agents are approaching a point where they can use computers faster than expert humans, turning the user interface itself into a universal way for AI to interact with software. OpenAI’s Ari Weinstein and James Sun argue that computer use is now entering its scaling moment, as better models, faster execution, and stronger safety controls make agents practical for more consumer and enterprise work. Ari and James join a16z’s Seema Amble and Fabrizio Serafini to explain how computer-using agents a
#1239
October 25 · 34 min
The New Startup Playbook | Box CEO Aaron Levie
Can a 10-person startup outperform a company with hundreds of employees? Box CEO Aaron Levie argues AI agents are giving small teams a level of leverage that simply wasn't economically possible before, creating a window for startups to outrun incumbents. In this episode of Speedrun Office Hours, Aaron explains why founders are shifting from doing the work themselves to orchestrating agents, and why that puts a new premium on strategy, taste, and knowing exactly what to build. He makes the case t
#1238
October 24 · 41 min
What It Takes to Win as a Founder | Ben Horowitz
What does it take to build a company when AI is changing the rules this quickly? Ben Horowitz argues that technology may make companies easier to start, but the hardest parts of entrepreneurship, making decisions under uncertainty, building momentum, and managing your own doubts, aren't going away. Speedrun's Andrew Chen sits down with Ben to discuss why AI feels different from previous technology shifts, whether billion-dollar companies can be built with tiny teams, and why Ben thinks the appli
#1236
October 23 · 1 hr 1 min
Amazon CEO Andy Jassy on the $220 Billion AI Buildout
Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help make AWS a $1 trillion annual run-rate business. Andy joins a16z co-founder Ben Horowitz and Erik Torenberg to discuss why AI demand is growing so quickly, how Amazon decides how much infrastructure to build, and why lower inference costs could unlock broader enterprise adoption. They also discuss
#1237
October 22 · 1 hr 1 min
The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon
a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to explain why founders should increasingly ask not “is this too ambitious?” but “is this ambitious enough?” — and how AI could pull decades of technological progress forward across hardware, robotics, entertainment, science, and entirely new forms of media. They also explore the coming internet of AI a
#1235
October 21 · 38 min
The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham
AI agents can reason over enormous amounts of information, but much of the world’s actual work is still trapped in PDFs, spreadsheets, scans, and other formats that models struggle to reliably understand. Reducto co-founder and CEO Adit Abraham argues that solving this document layer is essential if agents are going to take on consequential work in healthcare, legal, finance, and insurance. Adit joins a16z General Partner Jennifer Li to explain why traditional OCR breaks down on messy real-world
#1234
October 20 · 55 min
What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal
More than 300 million people use ChatGPT for health and wellness questions each week. OpenAI’s Karan Singhal thinks that’s only the beginning: the longer-term goal is AI that can help people navigate their health proactively, while making trustworthy medical intelligence dramatically more accessible. Karan joins a16z Partner Jay Rughani to explain why OpenAI trains healthcare expertise directly into its general-purpose frontier models, how it works with hundreds of medical experts to evaluate sa
#1233
October 19 · 1 hr 2 min
What Happens When Al Agents Can Spend Your Money?
Why hasn't AI transformed everyday work as quickly as coding? Town CEO Jean-Denis Greze argues the bottleneck isn't intelligence, but making AI useful to people who don't have the time or technical skills to build their own automations. Jean-Denis joins a16z General Partner Alex Rampell to share why he pivoted Town from tax software to a personal AI assistant built around email, calendars, and the workflows that run businesses. They discuss why consumer-grade experiences may win in enterprise AI
#1232
October 18 · 24 min
Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone
What changes when an AI mistake doesn’t just hurt a benchmark score, but affects someone’s housing or healthcare? EliseAI Head of Applied Research Mario Martone argues that deploying AI in essential industries requires a very different standard of reliability. Mario joins MTS to explain how EliseAI handles roughly 5 million phone calls a month, why LLMs aren’t the right solution for every problem, and how the team combines language models, traditional machine learning, neural networks, and inter
#1231
October 17 · 34 min
Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz
Why is booking a doctor's appointment still so difficult, and can AI finally change that? Zocdoc CEO Oliver Kharraz argues that the real problem isn't finding doctors, but connecting patients to accurate availability and making appointments bookable wherever they start their search. Oliver joins a16z General Partner Julie Yoo to discuss how Zocdoc spent nearly 20 years building the infrastructure behind online scheduling, and why it's now opening that technology to AI agents, insurers, and other

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