
Clinical Pathology with Dr. Nicole Weinstein
An abnormal CBC or a belly full of fluid can leave you with a lot of questions—and sometimes the best place to start is a slide. In this episode of 2 AM Consult, Dr. Deer is joined by Dr. Nicole Weinstein, a board-certified veterinary clinical pathologist and founder of Birdbrain.vet, to talk about practical clinical pathology for general practice and emergency clinicians. Together, they walk through how to approach effusions and blood smears, and how the patient’s history and presentation can help put those findings into context. Dr. Weinstein shares tips for preparing and evaluating effusion slides, recognizing inflammatory cells and bacteria, and interpreting those tricky mesothelial cells. They also discuss blood smear “deal breakers,” including anemias that can mimic IMHA, confirming a low platelet count, estimating white blood cells, and recognizing when an in-house analyzer result deserves a closer look. Whether you love looking at slides or feel a little intimidated by your microscope, this episode is packed with practical ways to build confidence and make the most of the information in front of you. In this episode, we discuss: Approaching effusions based on the patient, fluid appearance, and cytology Slide preparation and microscope tips Recognizing inflammation and looking for bacteria Chylous effusions and reactive mesothelial cells Blood smear findings in anemia and potential mimics of IMHA Platelet clumping, platelet estimates, and thrombocytopenia Estimating white blood cells and understanding the limitations of in-house analyzers Ways to practice and improve your blood smear skills Resources from Dr. Weinstein: Birdbrain.vet — clinical pathology education and resources Free resource for 2 AM Consult listeners Focus Vet Path — Dr. Weinstein’s diagnostic laboratory
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