Talk Python To Me

Michael Kennedy

Talk Python to Me is a weekly podcast for Python developers, data scientists, and AI builders, hosted by developer and entrepreneur Michael Kennedy. We dive deep into the packages, tools, and people shaping Python, from web development and data science to AI and LLMs. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from its leaders. And if you've been Pythoning for years, you'll hear about your favorite packages and the hot new ones coming out of open source.

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#567
October 27 · 1 hr 6 min
#567: Personal AI Agents for Pythonistas
The most popular Python project you've probably never heard of has 252,000 GitHub stars and merged over 1,800 pull requests in a single week. It's Hermes, a self-hosted AI agent you program just by talking to it. And it never clocks out. It runs 24/7 on a box in your house, wakes up every 15 minutes, keeps your YouTube channel in sync, and has your morning briefing ready before you're up. Mine started as a few config files. A few months later, it's 16,000 files of skills, memories, and tools it built for itself, all while I wasn't watching. Jeff Triplett joins me to explore this honestly weird but kind of amazing world. And yes, Hermes has a few words for you, too. Episode sponsors Talk Python Membership Talk Python Membership Talk Python Courses Links from the show Talk Python Tech Talks: talkpython.fm/meetups Hermes: github.com Ollama cloud models: ollama.com https\://hermes-agent.nousresearch.com: hermes-agent.nousresearch.com Hermes Web UI: get-hermes.ai built my own UI: blobs.talkpython.fm the Hermes Dashboard: blobs.talkpython.fm the audio from the chat example: blobs.talkpython.fm the CLI: blobs.talkpython.fm Tailscale: tailscale.com Hindsight: hindsight.vectorize.io trmnl display: trmnl.com JEV: typesafe.ai Home Assistant Green: www.home-assistant.io QMD - Query Markup Documents: github.com OrangePi: www.orangepi.org Watch this episode on YouTube: youtube.com Episode #567 deep-dive: talkpython.fm/567 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
- Transcript
#566
October 17 · 1 hr 5 min
#566: State of the art in Python 2026
Which of your Python tools would you still pick if you started fresh today? For a long time, the answer was easy. The stack felt settled. AI has reopened almost every one of those choices. Some tools got faster. Others got replaced outright. On this episode, a panel takes stock of the state of the art in Python for 2026. Calvin Hendryx-Parker is CTO and co-founder of Six Feet Up. Pat Decker works in DevOps at Hibu. Reuven Lerner has trained Python developers for 15 years. Sydney Runkle does product management for open source at LangChain. One of them barely opens an editor anymore. Listen in to hear the surprising replacement. Episode sponsors Talk Python Membership Talk Python Membership Talk Python Courses Links from the show Guests Pat Decker Reuven Lerner: github.com Calvin Hendryx-Parker: linkedin.com Sydney Runkle: github.com Talk Python Membership: talkpython.fm/community This Reddit post: www.reddit.com PSF+Jetbrains survey: blog.jetbrains.com vscode: code.visualstudio.com pycharm: www.jetbrains.com cmux: cmux.com warp.dev: www.warp.dev herdr: herdr.dev Royal TS: apps.microsoft.com Tailscale: tailscale.com uv: docs.astral.sh FastAPI: fastapi.tiangolo.com Litestar: litestar.dev Django: www.djangoproject.com httpx2: github.com ty: github.com pyrefly: pyrefly.org postgres: www.postgresql.org sqlite: www.sqlite.org duckdb: duckdb.org Hetzner: www.hetzner.com DigitalOcean: www.digitalocean.com AWS: aws.amazon.com Great Docs: posit-dev.github.io Zensical: zensical.org Vue.js: Vue.js AgentsView: www.agentsview.io LangChain Blog: www.langchain.com Umami Example of Great Docs: mkennedy.codes Mintlify: www.mintlify.com DuckLake: ducklake.select Robyn Web Framework: robyn.tech Django Ninja: django-ninja.dev Talk Python CLI: talkpython.fm KEdit: www.kedit.com Kitty: sw.kovidgoyal.net Watch this episode on YouTube: youtube.com Episode #566 deep-dive: talkpython.fm/566 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
- Transcript
#565
October 2 · 1 hr 27 min
#565: Tachyon, Python 3.15's Built-in Sampling Profiler
Do you know what's actually slow in your Python app? Or are you guessing? Until now, profiling Python meant a tracing profiler that made your code 2 to 3 times slower. Or a third-party tool that broke with every new release. Python 3.15 fixes that. It ships Tachyon, a sampling profiler built into the standard library. It attaches to live production apps with almost zero overhead. My guests are Pablo Galindo Salgado, CPython core developer and Steering Council member, and László Kiss Kollár from Bloomberg's Python infrastructure team. Their first prototype ran at two samples a second. Now it does over a million hz. And it lands in Python 3.15 this October. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show Guests László Kiss Kollár: linkedin.com Pablo Galindo Salgado 3.11: talkpython.fm Memray: talkpython.fm PyStack: talkpython.fm profile and cProfile: docs.python.org py-spy: github.com Austin: github.com PEP 799: peps.python.org PEP 768: peps.python.org PyCon US 2026 talk: us.pycon.org The docs: docs.python.org Backport to 3.14: github.com Watch this episode on YouTube: youtube.com Episode #565 deep-dive: talkpython.fm/565 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#564
September 22 · 1 hr 7 min
#564: EVE Online Departs for Python 3
Every ship in EVE Online eventually undocks and leaves the station. This time, it's the whole game. EVE has run on Python 2 since it launched in 2003, all 2.4 million lines of it, on a custom Stackless interpreter that stopped at 3.8 and was archived last year. Destination: Python 3.12. The route runs through 6,500 lines of division that decide who wins a fight, and 100 gigabytes of pickled Python objects that have to survive the jump intact. Kristinn Sigurbergsson was on this show ten years ago. He's back, with Jamie Bannister, who is flying the EVE Online migration right now, and Thomas Dähling, who took EVE Frontier through first. In EVE, a destroyed ship is gone for good. There are no do-overs, and the universe has to stay online the whole way. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show Guests Jamie Bannister: linkedin.com Thomas Dähling: linkedin.com Kristinn Sigurbergsson: linkedin.com EVE Online: www.eveonline.com EVE Frontier: evefrontier.com 2.4 million lines of Python: www.eveonline.com Example of graphics, ships walk-through: www.youtube.com Stackless: www.stackless.com futurize: python-future.org blue: github.com Dev blog on the Frontier upgrade: evefrontier.com Upgrading CARBON to Python 3: www.youtube.com carbon-scheduler: github.com Scheduling in Carbon: Leaving Stackless Python Behind: www.youtube.com All of Carbon is on GitHub now: github.com did a whole course: training.talkpython.fm Trade Wars BBS (Wikipedia): en.wikipedia.org TW 3002 - TradeWars 2002, reimagined as a modern browser game: www.reddit.com Watch this episode on YouTube: youtube.com Episode #564 deep-dive: talkpython.fm/564 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#563
September 16 · 1 hr 10 min
#563: Getting Started with Rust as Python Devs
Lint the entire CPython code base from scratch. It takes 0.3 seconds. Three blinks of an eye. That is ruff, and it is written in Rust. So are Pydantic, Polars, uv, and Granian. Rust shows up in Python three ways: tools that happen to be Rust, libraries Python imports, and servers that run Python inside Rust. This is Rust for Python developers, not Rust experts. Christopher Trudeau is back on Talk Python to discuss Rust and his latest course Up and Running with Rust. The core rule is that only one thing can own a value at a time. Pass it around freely in Python and the garbage collector cleans up. Do that in Rust and it will not compile. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show Up and Running with Rust course: training.talkpython.fm Rust: rust-lang.org pydantic: pydantic.dev ruff: docs.astral.sh granian: github.com By example: doc.rust-lang.org rust-lang.org: rust-lang.org rustup.rs: rustup.rs crates.io: crates.io main.rs: main.rs PyO3: github.com https://github.com/ritwiktiwari/awesome-python-rs: github.com ty: docs.astral.sh pyrefly: pyrefly.org uv: github.com polars: pola.rs Watch this episode on YouTube: youtube.com Episode #563 deep-dive: talkpython.fm/563 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#562
September 10 · 1 hr 11 min
#562: DuckLake: The Lakehouse That's Just SQL and Parquet
How many files does your query read before it reads any data? On some data lakes, you go through JSON and metadata files first, just to learn which Parquet files matter. DuckLake asks one SQL question instead. The metadata lives in a real database. The data stays in plain Parquet. That's the entire format. Pedro Holanda joined DuckDB in 2018, when it was still a research prototype at CWI. He's the lead DuckLake developer. Guillermo Sanchez Dionis works on DuckLake and the new Quack protocol. With Quack as the catalog, DuckLake handles 200 transactions a second under heavy contention. No other open table format comes close. Episode sponsors Six Feet Up Talk Python Courses Links from the show Guests Pedro Holanda: pedroholanda.org Guillermo Sanchez: linkedin.com PhD on progressive indexes: ir.cwi.nl SQLite: www.sqlite.org Litestream: litestream.io boring hardware: talkpython.fm DuckDB: duckdb.org episode 491: talkpython.fm Iceberg: iceberg.apache.org manifesto: ducklake.select DuckLake: ducklake.select spec: ducklake.select this diagram: blobs.talkpython.fm Data inlining: ducklake.select ducklake-dataframe: github.com Polars course: training.talkpython.fm CSV parser: duckdb.org Zero-copy Arrow: duckdb.org ART index: duckdb.org async I/O: duckdb.org v1.0: ducklake.select Git-like branching: ducklake.select Watch this episode on YouTube: youtube.com Episode #562 deep-dive: talkpython.fm/562 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#561
September 4 · 1 hr 15 min
#561: TonIO, a Multi-threaded Async Runtime for Python
How many cores does your machine have, 10, 18? Your async Python code uses just one of them. That isn't a bug in asyncio. That's the design, and optimizing event loops to be faster by 20% doesn't change it. So Giovanni Barillari started over. Joe is the creator of Granian, the Rust-based server that powers Talk Python. His new project is TonIO, an async runtime written from scratch for free-threaded Python. Real threads, a handful of primitives instead of asyncio's pile of them, and it flat out refuses to start if the GIL is on. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show Guest Giovanni Barillari: github.com Granian: github.com Hyper: github.com Free threaded Python: docs.python.org Sort of: labs.quansight.org did a whole course: training.talkpython.fm uvloop: github.com rloop: github.com TonIO: github.com your EuroPython 2026 talk: www.youtube.com Michael's Cutting Python Web App Memory Over 31% Article: mkennedy.codes Watch this episode on YouTube: youtube.com Episode #561 deep-dive: talkpython.fm/561 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#560
August 26 · 1 hr 2 min
#560: Building a Research OS: From Django to 30,000 Samples
In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years from three cities and a dozen hospitals. He asked around about how researchers keep track of that. The answer was Microsoft Excel. Shaun Chuah had written some HTML by hand in Notepad back in high school and that was about the whole of his programming experience, so he opened the Django tutorial and started reading. Six years later that app is Foundry120, holding 10 terabytes of clinical and genomics data with an agentic AI running on top of it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Talk Python Courses Links from the show Guest Shaun Chuah: github.com Up and Running with Rust Course: talkpython.fm Foundry120: www.foundry120.com Designing Data Intensive Applications: www.oreilly.com Microsoft Foundry: ai.azure.com ChatIBD: www.chatibd.com Blog: shaunchuah.github.io @drshaunchuah: x.com github.com/shaunchuah: github.com Watch this episode on YouTube: youtube.com Episode #560 deep-dive: talkpython.fm/560 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#559
August 19 · 1 hr 7 min
#559: 12 Things You Should (and Shouldn't) Do in AWS
Your site is down. It's 3am. Is it a bug, a bill, or a breach? You can't tell yet, and everyone is watching you find out. Matt Lea has spent fifteen years being the person companies call when an outage is costing them real money per hour, and his whole argument is that everything you'd want in that moment gets decided months earlier, on ordinary afternoons, when someone chose the convenient thing. We walk his top twelve dos and don'ts in AWS - infrastructure as code, IAM roles instead of access keys, private subnets, no wildcards, no public buckets - and I push on which of them actually matter if you're one person on a small VPS. Then we get to Cloud War Games, where Matt breaks things on purpose so your team's first real incident isn't their first incident. Let's get into it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Talk Python Courses Links from the show Guest Matt Lea: linkedin.com Talk Python Certificates: training.talkpython.fm/certificates Schematical: schematical.com CloudWarGames.com: cloudwargames.com Zero to Hero on AWS Security: www.oreilly.com Repo: github.com Custom Wheel Offset: customwheeloffset.com 2012 TechCrunch Disrupt Hackathon: techcrunch.com tech comics: schematical.com shhgit: github.com Zero Trust in 200ms: Implementing Identity-Per-Transaction: us.pycon.org Coolify: coolify.io returned to full GA Nov 2025: aws.amazon.com Signed URLs/cookies: docs.aws.amazon.com Cloudflare: www.cloudflare.com Bunny Shield: bunny.net Cloud War Games One: www.youtube.com Cloud War Games Two: www.youtube.com LinkedIn: linkedin.com YouTube: youtube.com KnocKnoc: knocknoc.io Watch this episode on YouTube: youtube.com Episode #559 deep-dive: talkpython.fm/559 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#558
August 10 · 1 hr 2 min
#558: Hyper-Personal Software with Python
Every company has one. The little internal tool that Jane built back in 2021, and then Jane left. Nobody understands it, nobody will touch it. There are two unwritten rules around it: don't change it, it's working. And if you break it, you bought it. That's dark-matter enterprise software. For every app you can actually see, there are ten of these sitting in the shadows, frozen. Michael Booth thinks that just changed. He read my article on hyper-personal software and ran with it, writing about hyper-team software: small teams inside big companies finally building the tools that were never going to get built. We cover where this works, where it quietly goes wrong, and the guardrails that keep it from turning into a mess. Let's get into it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show Guest Michael Booth: github.com Talk Python AI Integrations: talkpython.fm/blog From Hyper-Personal to Hyper-Team Software: Small Team-Built, AI-Assisted Tools Inside the Enterprise: www.databooth.com.au What hyper-personal software looks like (MK's article): mkennedy.codes Databooth Site: www.databooth.com.au Wall Street just lost $285 billion because of 13 markdown files: martinalderson.com SaaSpocalypse is real but everyone is panicking about the wrong thing: www.reddit.com Warp Terminal: www.warp.dev Watch this episode on YouTube: youtube.com Episode #558 deep-dive: talkpython.fm/558 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#557
August 2 · 1 hr 8 min
#557: Security of everything at PyCon 2026
Security has always been the vegetables of software. Everyone agrees it matters, and somehow it never quite makes it onto the plate. At PyCon US this year, that changed. For the first time ever, security got its own dedicated, day-long track, one of just two at the whole conference, sitting right next to AI. And the room was packed to the back wall. On this episode, I'm joined by the three people at the center of it. Seth Larson, Security Developer in Residence at the Python Software Foundation and, very recently, a CPython core developer. Juanita Gomez, a PhD researcher at UC Santa Cruz in open source security, who co-chaired the track. And Mike Fiedler, PyPI's Safety and Security Engineer, one of the very few people paid full-time to keep the packages you install safe. We use the arc of the track's talks to take the temperature of Python security right now: supply chain attacks, dependency cooldowns, zero trust, SBOMs, and the push to bring Rust into CPython. And why not one of us thinks security is anywhere close to solved. Turns out that's the good news. It's why the room was full. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show Guests Juanita Gomez: linkedin.com Mike Fiedler: miketheman.dev Seth Michael Larson: sethmlarson.dev Trailblazing Python Security: us.pycon.org Everything Security at PyCon US 2026 (PSF blog): pyfound.blogspot.com Dependency Cooldowns: cooldowns.dev Anatomy of a Phishing Campaign (Mike Fiedler) Recording: www.youtube.com FedRAMP: www.gsa.gov Zero Trust in 200ms: Implementing Identity-Per-Transaction with Python & Serverless-Tristan McKinnon: www.youtube.com Rust for CPython project: blog.python.org pre-PEP: discuss.python.org Rust for CPython: Making Python Safer and More Robust for Everyone - Emma Smith: www.youtube.com SBOMit: github.com Asleep at the Wheel: Getting your SBOMs to pay attention... - Sanchit Sahay, Abhishek Reddypalle: www.youtube.com Volatility: volatilityfoundation.org Post Incident Runtime SBOM Generation from Python Memory - Hala Ali: www.youtube.com zizmor: docs.zizmor.sh GitHub Actions security in Python packages (Andrew Nesbitt write-up): nesbitt.io andrew/pycon: data & analysis for the GitHub Actions security talk: github.com GitHub Actions Security in Python Packages - Andrew Nesbitt: www.youtube.com gh-profiler: examine a GitHub user's profile to gauge their contributions: github.com PyCon US YouTube channel: www.youtube.com SBOMit: adding verification to SBOMs (OpenSSF): openssf.org Ecosystems: ecosyste.ms Watch this episode on YouTube: youtube.com Episode #557 deep-dive: talkpython.fm/557 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#556
July 26 · 1 hr 4 min
#556: Updates on Django's Async Story
For years, "Django and async" came with an asterisk. The docs themselves warned you off it. Scary performance notes, a story that felt half-finished. Well, that story just got rewritten, literally, and the person who rewrote it is here to tell you why the old framing was wrong. Carlton Gibson is a former Django Fellow, sat on the security team for eight years, and he's on the steering council. On this episode we get into the async topic doc rewrite, what actually remains versus what was just fear, the new Tasks framework in 6.0, DB-level cascades and fetch modes landing in 6.1, and why free-threading is the bet that's about to pay off big for Django. If you've been told Django's async story isn't ready, this is the episode that puts that myth to bed. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show DjangoCon Europe: djangocon.eu PyCon Italia: pycon.it Django on the Med: djangomed.eu Django Mantle: noumenal.es PyPI: pypi.org release notes: docs.djangoproject.com on_delete: docs.djangoproject.com Fetch modes: docs.djangoproject.com HttpRequest.multipart_parser_class: docs.djangoproject.com async topic doc: docs.djangoproject.com docs: docs.djangoproject.com DEP 14: github.com django-tasks: github.com django-tasks-local: github.com Celery: docs.celeryq.dev PEP 703: peps.python.org free-threading HOWTO: docs.python.org PEP 779: peps.python.org ASGI: docs.djangoproject.com PGBouncer: www.pgbouncer.org Channels: channels.readthedocs.io sync_to_async / async_to_sync: docs.djangoproject.com noumenal.es: noumenal.es Django Chat: djangochat.com @carlton@fosstodon.org: fosstodon.org Article: Cutting Python Web App Memory Over 31%: mkennedy.codes Watch this episode on YouTube: youtube.com Episode #556 deep-dive: talkpython.fm/556 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
- Transcript
#555
July 13 · 1 hr 4 min
#555: Marimo Pair - A Canvas for Agent + Developers Collaboration
Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on disk. But that is not how data work feels. You load something, you look at it, you run a cell, you watch how it responds, and you decide the next move from whatever is sitting in memory. And until now, your agent couldn't see any of that. It only saw the files. Never the live state. This episode, that wall comes down. marimo pair drops a coding agent right inside a running notebook, with full access to every variable Python is holding in memory. The notebook becomes a shared canvas. You point, it runs the code. You tell it to zoom in on the Picasso paintings, and the chart just updates. No MCP tools to wire up, no schema to describe. Just Python, and an agent that can finally see what you see. Trevor Manz is back to walk us through it. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show marimo pair: marimo.io/pair Course transcripts announcement: talkpython.fm/blog anywidget: Jupyter Widgets made easy: talkpython.fm marimo: marimo.io blog: marimo.io GitHub: github.com given this: martinalderson.com llms.txt: talkpython.fm mcp: talkpython.fm cli: talkpython.fm open issues: github.com Discord: marimo.io Marimo Pair: marimo.io OpenCode: opencode.ai AI Tooling for Software Engineers in 2026: newsletter.pragmaticengineer.com Watch this episode on YouTube: youtube.com Episode #555 deep-dive: talkpython.fm/555 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
- Transcript
#554
July 10 · 1 hr
#554: Trustworthy AI in Healthcare and Longevity
You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what if the question is medical, and there's a real patient on the other end? In that world, a hallucination isn't a bug, it's a patient-safety event. Sumit Gundawar is a London-based software engineer who builds the clinical platform for a UK longevity and aesthetic-medicine clinic, and his whole argument is that in high-stakes AI, the model is the easy part. Earning trust is the real engineering. We dig into grounding, refusal logic, human-in-the-loop design, and the messy frontier of longevity and biohacking, plus a live demo of an assistant that refuses to answer when it can't back up the claim. Let's get into it. Episode sponsors Six Feet Up Talk Python Courses Links from the show Guest Sumit Gundawar: linkedin.com Course transcripts announcement: talkpython.fm/blog Sumit Gundawar - JAX London Speaker: jaxlondon.com Anthropic: anthropic.com OpenAI Platform: platform.openai.com Anthropic: anthropic.com LangChain: langchain.com OWASP: owasp.org Pydantic: pydantic.dev EU AI Act - Regulatory Framework: digital-strategy.ec.europa.eu HIPAA - HHS: www.hhs.gov NHS: www.nhs.uk Llama: llama.com Qwen - QwenLM on GitHub: github.com OpenAI Platform: platform.openai.com Hugging Face: huggingface.co Llama: llama.com Granola: www.granola.ai HIPAA - HHS: www.hhs.gov CodeRabbit: www.coderabbit.ai Cursor Origin: cursor.com GitHub Status: www.githubstatus.com Midjourney Medical: www.midjourney.com Neko Health: www.nekohealth.com CERN: home.cern ATLAS Experiment: atlas.cern Watch this episode on YouTube: youtube.com Episode #554 deep-dive: talkpython.fm/554 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
- Transcript
#553
June 26 · 55 min
#553: All of our tools
This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken has moved on and Calvin Hendryx-Parker has joined the show as the new co-host. To kick off this new era, we decided to do a longer and more personal episode called "All Our Tools". The idea is both of us talk about some of our most useful day-to-day developer and business owner tools that we think you all would find useful. It was so well received, that I'm bringing it to you all as a crossover episode. Enjoy and we hope you find something new and awesome to help you with your software and data science day to day. Episode sponsors Sentry Error Monitoring, Code talkpython26 Python in Production Talk Python Courses Links from the show Guest Calvin Hendryx-Parker: linkedin.com @calvinhp@sixfeetup.social: sixfeetup.social @calvinhp.com: bsky.app calvinhp.com: calvinhp.com Original airing on Python Bytes: pythonbytes.fm pi: pi.dev superpowers: github.com Warp.dev: Warp.dev OhMyZSH: ohmyz.sh Commandbookapp.com: Commandbookapp.com Blink: blink.sh kitty: sw.kovidgoyal.net mosh: mosh.org tmux: github.com Claude code: www.anthropic.com Claude.md: Claude.md MacWhisper: goodsnooze.gumroad.com Handy: handy.computer Tailscale: tailscale.com Talk Python episode with Alex: talkpython.fm Telescopo: www.telescopo.app Typora markdown: typora.io formal documentation for many of my open source packages: mkennedy.codes Great Docs: posit-dev.github.io Statement on the US government directive to suspend access to Fable 5 and Mythos 5: www.anthropic.com No second date: x.com Watch this episode on YouTube: youtube.com Episode #553 deep-dive: talkpython.fm/553 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#552
June 17 · 1 hr 5 min
#552: Astral joins OpenAI
OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But here's the twist Charlie Marsh shared with me: he thinks they may ship more open source at OpenAI than they ever did at Astral. On this episode, we get into the acquisition, the mixed feelings, the future of your favorite Python tools, and what it's like to build right at the center of the AI universe. Episode sponsors Sentry Error Monitoring, Code talkpython26 Talk Python Courses Links from the show Guest Charlie Marsh: github.com The announcement: astral.sh OpenAI: openai.com uv: github.com ty: github.com Ruff: github.com pyx: astral.sh Codex team: openai.com Anthropic did something similar by acquiring Bun: www.anthropic.com Daily Stars Explorer: emanuelef.github.io Agentic AI Programming for Python: training.talkpython.fm Python Web Security: OWASP Top 10 with Agentic AI: training.talkpython.fm Episode #552 deep-dive: talkpython.fm/552 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#551
June 11 · 1 hr 48 min
#551: Stroll Down Startup Lane - 2026
If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companies built on Python show off what they're creating. But only attendees get to walk that lane, so let's bring it to everyone. In this episode, we stroll down Startup Row together. We kick things off with the organizers, Jason and Shay, who share the program's origin story going back to Paul Graham and the PSF, plus some surprising stats, including two unicorns among the alumni. Then we meet five startups: Tetrix, bringing AI to institutional investing in private markets. Arcjet, security that lives inside your app as an SDK. Phemeral.dev, serverless hosting built for Python web apps. CapiscIO, an identity and authority layer for AI agents. And Pixeltable, a multimodal database from Marcel Kornacker, co-creator of Apache Parquet. See if you can spot the theme running through them all. Let's go for a walk. Episode sponsors AgentField AI Talk Python Courses Links from the show Guests Naunidh Bhalla: linkedin.com Grant Gittes: linkedin.com Marcel Kornacker: linkedin.com Beon de Nood: linkedin.com Chinmaya Joshi: linkedin.com David Mytton: linkedin.com Shea Tate-Di Donna: linkedin.com Jason Rowley: linkedin.com Azul Garza: github.com Renée Rosillo: linkedin.com Tetrix: tetrix.co Tetrix Jobs: tetrix.co Arcjet: arcjet.com Pixeltable: pixeltable.com Phemeral.dev: phemeral.dev CapiscIO: capisc.io Episode #551 deep-dive: talkpython.fm/551 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#550
May 30 · 1 hr 2 min
#550: AI Contributions and Maintainer Load in Open Source
You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added. No issue filed first. No discussion. Just "here, please review this for me." Over the past year, GitHub activity has spiked roughly twelve times in a few short months, and a huge chunk of that signal is landing on the same small group of maintainers who were already stretched thin. The curl bug bounty got buried under AI-generated noise. Jazzband, the home of Django classics like pip-tools and the Django debug toolbar, hit what its maintainer called an "apocalypse" and started sunsetting. Even CPython just shipped fresh guidelines on AI-assisted contributions this week. So what does all of this actually look like from the receiving end of the pull request? On this episode, Paolo Melchiorre joins us to tell that story from inside the maintainer's chair. Paolo is a director of the Django Software Foundation, an organizer of PyCon Italy, a Django Girls coach, and he has spent the past year carefully collecting examples of how AI is reshaping open source contributions. The good, the bad, and the extra fingers. We dig into his PyCon US talk on AI-assisted contributions and maintainer load, why AI is best understood as an amplifier rather than a new kind of contributor, the wildly different policies across 86 open source foundations, whether projects banning AI today are reacting to last year's models. Episode sponsors AgentField AI Talk Python Courses Links from the show Guest Paolo Melchiorre: github.com DSF: www.djangoproject.com djangonaut-space: djangonaut.space PyCon Italia: 2026.pycon.it uDjango: github.com My PyCon US 2026 post: www.paulox.net AI-Assisted Contributions and Maintainer Load: www.paulox.net Senior Engineer Tries Vibe Coding: www.youtube.com Code Rabbit AI PR Reviews: www.coderabbit.ai GitHub Usage Graphs: github.blog Update on CPython's AI Policies: fosstodon.org High-Quality Chaos from Curl: daniel.haxx.se The Generative AI Policy Landscape in Open Source: redmonk.com Watch this episode on YouTube: youtube.com Episode #550 deep-dive: talkpython.fm/550 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#549
May 25 · 1 hr 7 min
#549: Great Docs
Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannone and Michael Chow from Posit are back on Talk Python with a brand new Python documentation tool called Great Docs that takes both seriously. Rich is the creator of Great Tables, and before that the R package GT, the man has a serious eye for design, and he's pointed that energy at the Python docs ecosystem. We'll talk about how Great Docs spins up a polished site in three commands, why every page ships as Markdown for your favorite LLM, how it leans on Quarto for executable code blocks and tabbed install sections, and where it lands against Sphinx, MkDocs, and Zensical. Plus, you'll meet Tablin. Here we go. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guests Michael Chow: github.com Rich lannone: github.com Python Web Security with OWASP Top 10 and Agentic AI Course: talkpython.fm Great Docs: posit-dev.github.io/great-docs Great Tables: posit-dev.github.io GT Episode: talkpython.fm Sphinx: www.sphinx-doc.org mkdocs: www.mkdocs.org Zensical: zensical.org Hugo: gohugo.io Ghost: ghost.org Rs pkgdown: pkgdown.r-lib.org Quarto: quarto.org quickstart: posit-dev.github.io llms.txt file: llmstxt.org llms.txt: talkpython.fm mcp: talkpython.fm cli: talkpython.fm Watch this episode on YouTube: youtube.com Episode #549 deep-dive: talkpython.fm/549 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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#548
May 11 · 1 hr 8 min
#548: Event Sourcing Design Pattern
What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row that quietly forgets its own history. That's event sourcing, and Chris May is back on Talk Python, fresh off our Datastar panel, to walk us through what it actually looks like in Python. We'll cover the core patterns, the libraries to reach for, when not to use it, and why event sourcing turns out to be a surprisingly good fit for AI-assisted coding. Episode sponsors Sentry Error Monitoring, Code talkpython26 Temporal Talk Python Courses Links from the show Guest Chris May: everydaysuperpowers.dev Intro to event sourcing e-book: everydaysuperpowers.gumroad.com Domain-Driven Design: The Power of CQRS and Event Sourcing: How CQRS/ES Redefine Building Scalable System: ricofritzsche.me DDD: www.amazon.com Understanding Eventsourcing (Martin Dilger): www.amazon.com Event Sourcing Explained using Football Video: www.youtube.com Why I finally embraced event sourcing and why you should too article: everydaysuperpowers.dev valkey: valkey.io diskcache: talkpython.fm eventsourcing package: github.com eventsourcing docs: eventsourcing.readthedocs.io John Bywater: github.com Datastar: data-star.dev Microconf: microconf.com Event Modeling & Event Sourcing Podcast: podcast.eventmodeling.org Python Package Guides for AI Agents: github.com Iodine tablets AI joke: x.com KurrentDb: www.kurrent.io Watch this episode on YouTube: youtube.com Episode #548 deep-dive: talkpython.fm/548 Episode transcripts: talkpython.fm Theme Song: Developer Rap 🥁 Served in a Flask 🎸: talkpython.fm/flasksong ---== Don't be a stranger ==--- YouTube: youtube.com/@talkpython Bluesky: @talkpython.fm Mastodon: @talkpython@fosstodon.org X.com: @talkpython Michael on Bluesky: @mkennedy.codes Michael on Mastodon: @mkennedy@fosstodon.org Michael on X.com: @mkennedy
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