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Sabrina Halper Show

Sabrina Halper

The mind, the machine, and the meaning of it all.

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  • 20 episodes
  • Avg 55 min
  • English

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  • August 5 · 54 min

    Reed Jobs’ Fight Against Cancer

    I sat down with Reed Jobs to discuss one of medicine’s hardest problems: why we’ve spent hundreds of billions of dollars fighting cancer, yet still don’t have a cure. Reed explains why there may never be a cure for cancer and why that’s actually the wrong goal. Instead, the future is making cancer a disease that no one dies from. He gives an inside look at Yosemite, the venture firm he founded to rethink how to bring breakthrough therapies to patients. We go deep on how AI is reshaping biology, why Yosemite combines grants with venture capital to fund ambitious science, how to de-risk breakthrough research, and the extraordinary biology that makes our bodies work. TIMESTAMPS: 00:00 Intro 00:36 Early Cancer Mission 03:41 Working at a Cancer Lab as a Teen 05:16 Immunotherapy Breakthrough 07:05 Emerson Collective 09:20 Founding Yosemite 10:17 Making Cancer Nonlethal12:28 Using Grants to De-Risk Biotech Investing 15:33 Academic vs. CEO Role 19:11 Biology Is a Miracle22:52 Next-Decade Tooling 25:22 His Dream of In Vivo CAR-T Cell Therapy 28:51 Cracking Solid Tumors 29:27 Same-Day Cell Editing 33:46 The AI Era of Biology 37:00 Cutting Clinical Trial Costs 41:43 Highest-ROI Philanthropy 45:10 Taylor Francis 47:28 Yosemite’s Long-Term Impact 50:29 San Francisco Today#CancerResearch #Biotech #AI #Medicine #ReedJobs

  • July 10 · 1 hr 23 min

    How He’s Leading the Race to Reverse Aging - New Limit's Cofounder Jacob Kimmel

    The secret to staying young may already be inside your cells. We just need to figure out how to unlock it. NewLimit is one of the world's leading longevity companies, co-founded by Coinbase founder Brian Armstrong, investor Blake Byers, and stem cell biologist Jacob Kimmel. NewLimit has already shown it can take old human liver and immune cells and restore them to a younger, healthier-working state and it's now preparing its first medicine for human trials.The company has raised over $600M - including a $435M round in 2026 that valued it at $3.1B - from investors like Founders Fund, Kleiner Perkins, Thrive Capital, and Khosla Ventures. We hear the word "longevity" all the time. But what's actually real? And how do we meaningfully extend lifespan for our generation, our kids, and our grandkids? Jacob Kimmel shares his world-leading expertise as we discuss everything from evolutionary tradeoffs to epigenetic reprogramming to AI biorisk. TIMESTAMPS: 00:00 Aging as Entropy 01:25 Why Evolution Limits Lifespan 03:13 Evolution Tradeoffs Explained 07:44 Why Women Live Longer 10:15 Lessons from Long Lived Species 16:20 Peak Intelligence and Aging 23:26 What Aging Really Is 26:23 Epigenetics and Reprogramming 27:59 Yamanaka Factors 101 32:18 New Limit's Approach 33:56 AI for Factor Discovery 37:28 Organ by Organ Longevity 40:28 Is Immortality Possible? 42:04 Lifespan Progress Curve 45:44 Testing Longevity Drugs 49:30 Placebo Mind Body Link 53:56 What longevity hacks are actually work? 57:25 Peptides And Stem Cells 01:00:34 Germline Gene Editing 01:05:10 Personalized Medicine Abundance 01:08:48 Longer Lifespans and Power Turnover 01:14:57 Living Off Earth 01:16:55 AI And Biosecurity Risks #longevity #antiaging #biotech

  • May 20 · 39 min

    Engineering Biology With AI: The Future of Medicine

    Jack Dent, co-founder of Chai Discovery, gives us a look at how AI could change the way we discover drugs, understand biology, and treat disease. Jack went from cold-emailing Stripe and joining as a teenager to co-founding Chai Discovery, the AI drug design company Sam Altman asked him and Josh to start years before they did. Chai has since raised $225M from investors including OpenAI and Thrive Capital, and built a model that hit a drug-design breakthrough far faster than expected, with roughly 200x better antibody success rates.We talk about whether people could one day help cure their own diseases with AI, whether each of us might have a personalized biology model, and whether medicine shifts from treating sickness to preventing it before it starts. Jack also gets into whether frontier AI labs will build these biology models themselves, what AI can and can’t fix in our current healthcare system, why clinical trials are still such a bottleneck, and how much of science may become less random when AI can generate and test better hypotheses. TIMESTAMPS: 00:00 Intro 02:28 Inside Stripe When It Was Only 100 People 08:45 How Sam Altman Sparked Chai’s Origin Story 10:52 Why Chai Discovery Exists 16:20 The Chai-2 Antibody Breakthrough 19:24 Approaching Biology as Engineering 24:45 Using AI to treat ourselves26:52 Robotics in labs 27:22 Why Pharma Is Finally Moving on AI 29:49 Can AI Fix Clinical Trials? 32:53 Personalized biology models 36:24 Longevity, Peptides, and Trillion-Dollar Drugs 39:02 Does it matter that the government cuts exploratory science grants? 41:00 What Next-Gen Chai Models Will Do 42:08 Will Frontier AI Labs Build Biology Models? 43:26 Biology is hard

  • April 16 · 56 min

    How She Became One of Wall Street’s Most Successful Investors

    Keri Findley, founder of Thiel-Backed fund Tacora Capital, shares a rare glimpse into her life and career: her path to Wall Street, eventually becoming one of the youngest partners at hedge fund Third Point while building its structured credit business from scratch, founding Tacora Capital with Peter Thiel anchoring the first fund as his biggest check ever. Along with wild success comes a target on your back and Keri reflects on difficult moments of litigation, divorce, and betrayal that ultimately informed her outlook on life. She pulls back the curtain on Wall Street: big wins, pressure, risk, and competition. We discuss venture credit, what contrarian investing actually looks like, the AI boom, today's tumultuous private credit markets, and what it means to be a high-ethics person in business. TIMESTAMPS: 00:00 – From Columbia grad to Third Point partner: building a trading desk at 25 03:30 – Discovering Wall Street by accident and landing at Morgan Stanley 06:00 – The 2008 financial crisis and making her first high-stakes trades 10:00 – Hedge fund life: massive trades, pressure, and doubling money in mortgage bonds 14:00 – Wall Street rivalries and the fallout with Morgan Stanley 18:00 – The Bloomberg article 22:00 – Calling Alex Spiro and discovering the investigation might not exist 24:00 – Peter Thiel offering to fund the entire first fund and founding Tacora Capital 36:00 – Silicon Valley venture capital, AI hype, and herd mentality in investing 46:00 – The dark side of startups: unethical founder behavior and financial fraud 55:00 – Carrie’s advice to her 21-year-old self: resilience, integrity, and ignoring titles

  • February 19 · 59 min

    AI Has Taste Now. The Radical Disruption Coming for Hollywood | Edward Saatchi, Fable Studios

    Edward Saatchi (Saatchi & Saatchi family, former Head of Oculus Story Studio, Founder of Fable Studios) joins us to make the case that Hollywood is sleepwalking into the most radical disruption in the history of storytelling."Creativity is at a deep blue and Kasparov moment" "AI isn't just a tool in the toolbox for filmmakers. It's a competitor" We talk about: ★ Whether AI can be truly creative - Edward says yes ★ Silicon Valley's quiet takeover of Hollywood ★ Tech companies becoming media companies ★ The rise of the one-person film ★ Why AI will bring an aesthetic shift to cinema Then we go deeper into what this actually means for authorship, storytelling, and who gets to have a creative voice, when the cost of making a film collapses to near zero. TIMESTAMPS: 00:00 Finding the New Medium of AI Art 00:57 From Obama Campaign Tech to VR Storytelling at Oculus 03:02 Why VR Didn’t Pan Out 04:03 Fable Studios’ Vision 04:20 Why “Cheaper VFX” Misses the Point of AI in Hollywood 07:09 The Playable Star Wars Thought Experiment (and Studio Pushback) 09:08 AI Media: Interactive, Remixable, Personal 12:48 Simulation-First Story Worlds 14:51 AI Will Be Creative 16:43 World-Building vs. Prompt Engineering 20:03 Hollywood’s Shifting Attitude 24:37 One-Person Films, YouTube Discovery, and AI-Generated Feeds 29:21 Can AI Art Have a Point of View? 31:10 From Creativity to Consciousness: Why Simulations Matter 32:13 ‘Exit Valley’: Using AI Satire Against Tech Power 36:50 Silicon Valley vs. Hollywood 40:52 Video Models, Robotics, and the ‘War on Cliché’ 44:45 Generated Media’s Role in Globalizing Content 50:51 ‘AI Aesthetic’ in Film 56:06 Saatchi & Saatchi: Edward’s Family Roots

  • February 6 · 1 hr 13 min

    Moxie Marlinspike, Founder of Signal

    Moxie Marlinspike founded Signal, the nonprofit privacy messenger used by millions. He’s now building Confer, a fully private, end-to-end encrypted AI chat. This conversation covers everything.TIMESTAMPS:00:00 Intro 01:09 Building Physical World Projects Centered on Experiences07:43 Tales from Hitchhiking15:04 The Birth of Signal22:23 Privacy in the Digital Age31:21 Introducing Confer: Private AI Chat37:17 Generative AI and Developer Responsibility38:21 Encryption and Cryptography: A Historical Perspective39:15 Skepticism Towards Crypto41:24 The Impact of Self-Publishing and Cancel Culture44:01 Imagining MoxieLand49:41 Why Do Conspiracy Theories Exist58:00 Signal Gate1:02:30 Limits of Solo Ambitions1:05:09 Solving Aging1:09:00 Moxie’s Next Physical World Project FOLLOW:Follow MoxieSign up for ConferFollow SabrinaPlease support this show by subscribing!

  • January 8 · 1 hr 4 min

    When AI Becomes Conscious, How Will We Even Know? — Ken Liu

    Ken Liu: Renowned sci-fi author of The Paper Menagerie, The Hidden Girl and Other Stories, and his new book All That We See or Seem; producer of Pantheon; futurist who works with world governments to prepare for what’s ahead. TIMESTAMPS: (0:00) Introduction (1:41) Mechanism vs meaning: what science explains vs what stories explain (5:47) What is consciousness, really? (6:42) Psychedelics and the mystery of the mind (7:55) Can intelligence exist without consciousness? (12:10) How mind-uploading might actually work (and the Singularity) (19:15 — Falling in love with AI - why “imaginary companions” aren’t new (23:40) Modern day myths around romantic love (27:15) Preservation vs. transformation of humanity (32:37) When technical skill disappears: what is craft? (40:00) When using AI actually makes us feel more human (41:05) Writing, imagination, and “All That We See or Seem” (47:35) Dreams, reality, and how we know what’s real (54:45) Privacy in an age of digital selves (58:03) Data, the commons, and how knowledge should be shared Follow Ken: https://x.com/kyliu99 Buy his new book All That We See or Seem : https://www.amazon.com/All-That-Seem-Julia-Novel/dp/1668083175 When will AI become conscious and how would we even know if it did? We talk about the decoupling of intelligence and consciousness in today's LLMs, and the ethical questions in regulating models. Ken walks me through a thought experiment to understand the singularity: what uploading our minds might actually look like, a theme explored in his Netflix series Pantheon. If we replace our minds piece by piece with silicon, at what point do “we” disappear? In the age of AI, when many technical skills are made obsolete, who are the experts of craft? We explore why falling in love with AI may be grounded in our religious history, and is an act of falling in love with our own reflection. We discuss how phones have killed daydreaming and access to the collective unconscious, and the mysteries of psychedelics, natural intelligence, and the universe at large. “We are willing to die for the sake of a story. In fact, it’s the only thing humans have ever willingly died for.” Most of human life, Ken argues, has two levels of explanation: 1.Evolution & 2.Stories — the way we make sense of the world and find meaning in it.

  • Nov 27, 2025 · 1 hr 10 min

    Isabelle Boemeke - The Real Story of Nuclear: Fear, Politics, and the Grid We Need for AI

    Isabelle Boemeke went from Brazilian model to the internet’s most creative nuclear advocate who led the largest pro nuclear rally in US history. In this episode, we talk about nuclear energy's wild history, political drama, and what America’s energy grid needs to look like to keep up with the future demands. Shownotes: 0:00 : Introduction 1:37 : Growing up in rural Brazil 3:44 : Getting to the United States 5:15 : Reading Richard Dawkins, getting involved in the climate movement, learning about nuclear 12:05 : A historical deep dive: What went wrong with nuclear energy? 24:32 : What really happened at Three Mile Island and Chernobyl - separating fear from facts. 30:43 : Deaths from Nuclear Vs. Fossil Fuels 37:15 : Nuclear Proliferation Risk 42:17 : Gaps in the US supply chain & AI’s need for more energy 49:40 : Promise vs. reality of SMRs (Small modular reactors) 54:54 : Designing energy grid for the US 59:10 : Why are Germany, Taiwan, and Australia shutting down nuclear energy programs? 1:02:10 : Saving California’s last nuclear plant Diablo Canyon 1:08:24 : Today’s nuclear renaissance

  • Nov 14, 2025 · 31 min

    OpenAI’s Isa Fulford on Building Deep Research, ChatGPT’s Agent, and the Future of the Internet

    Isa Fulford is only a few years out of school and is already the mind behind Deep Research and ChatGPT Agent - two of the most important and ambitious projects at OpenAI. She’s a close friend from our Stanford days, someone I adore, and someone the world is going to hear a lot more about in coming years. We talk about how her upbringing and violin training shaped the discipline behind her professional work. Isa breaks down how these systems were built, how they think, and where AI is heading, from agents talking to agents to a future where humans guide the work instead of doing it.SHOWNOTES: 0:00 Introduction 1:50 Early life, math, music, and discipline 4:40 Stanford, Journey into AI, & joining OpenAI 7:15 Deep Research, building datasets, & early indications 11:35 Building ChatGPT Agent 13:47 What comes next from OpenAI? 15:58 Personal Use of AI 16:40 Future of Internet + Agent Communication 19:03 Personal AI agents 20:06 Safety Risks 22:44 AGI 24:03 Agents for personal growth 25:00 How AI is changing the way we work 27:43 Talent war and poaching 28:30 Lessons from Sam Altman: raise ambition level 30:18 Rapid questions EPISODE LINKS: YouTube: https://www.youtube.com/@SabrinaHalper Apple Podcasts: https://podcasts.apple.com/us/podcast/sabrina-halper-show/id1627753991

  • S2 · E1
    Nov 6, 2025 · 46 min

    Life After AGI — Richard Ngo (Philosopher & Researcher, ex-OpenAI / DeepMind)

    Richard Ngo is a leading AI philosopher and researcher, formerly at OpenAI and DeepMind. We discuss what life looks like once we have AGI and how every aspect of the human experience could change. TIMESTAMPS 00:00 – Introduction 01:44 – Technology as an Inequality Engine 03:52 – AI as a Personal Tutor vs. Distraction Machine 06:11 – Therapy, Coaching, and Emotional Mediation 09:16 – The Future of Work and the Socio-Political Economy 13:15 – Relationships, Intimacy, and AI Companions 19:03 – Marriage Decline and the Birth Rate Crisis 22:15 – Speed of Change and Political Control 23:55 – Human Augmentation and Speciation 30:52 – Comparing Artificial Intelligence to Natural Intelligence 35:57 – Religion, Continuity, and Identity in the Future 37:26 – China vs. the U.S. in AI Governance 39:39 – Why Richard Left OpenAI 43:43 – Drones, Simulation, Power, and More

  • Dec 21, 2023 · 1 hr 2 min

    The AI Revolution in Music: A Conversation with DAOuda Leonard, Manager of Grimes and Founder of CreateSafe

    In this episode, Sabrina Halper sits down with DAOuda Leonard, Grimes' manager and founder of music tech studio CreateSafe, which just launched its generative AI-powered platform Triniti. Triniti enables artists to create an AI voice clone, generate text-to-audio samples, ask a chatbot music industry-related questions, monetize creations and manage music IP. Subscribe to stay up to date on all the best clips and upcoming episodes! Socials👇 *Follow DAOuda on Twitter and check out CreateSafe. *Connect with Sabrina on Twitter *Engage with HOF on Twitter or read our March to Utopia.

  • Nov 29, 2023 · 1 hr 8 min

    Eric Jang on Humanoid Robots, Why AI is Good For You, and a Future of Abundance.

    In this episode, Sabrina Halper sits down with Eric Jang. Eric is the VP of AI at 1X Technologies, a humanoid robot company built to benefit society, with investment led by OpenAI. He also published AI is Good for You, a book about the last 10 Years and the next 10 Years of Artificial Intelligence (link to buy attached below). Previously, Eric was a senior research scientist at Google on their robotics team. Timestamps: (0:00) - Highlights (2:53) - Intro (3:32) - The outdated political system & AI's applications for campaigns7:55 - Debating ideas with AI "champions" (9:20) - How Meta's VR Quest headset could be a humanoid robot, data engines for AI (13:20) - Building genuine AI companionship (18:26) - AI chatbots as sparring partners and improving peoples' social capabilities (20:45) - Can we achieve AGI through online, text-only data? Or do we need a data engine such as VR, robots, or cars? (24:20) - How to acquire and label "truth" for LLMs?30:00 - How far are we from AGI? How do you define AGI? (32:20) - Should we be modeling AI systems after biology and replicating nature-inspired architectures?36:00 - Confronting workforce disruption of humanoid robots, 1X's approach39:00 - Lump of labor fallacy, 10X-ing workforces (40:10) - Security risks of humanoid robots, high leverage technology = risk (42:35) - Engineering hardware to mimic the human body, lack of robotics parts (46:04) - Why is now the right time to invest and build in general purpose robots? (48:25) - Visualizing a post-AGI future of abundance & utopia situation (52:27) - What will our relationship to robots look like and which hierarchies will exist? How to engineer an equality dynamic (55:50) - The academia vs start-up landscape in AI and why some researches are going back to academia (59:54) - Criticisms of the effective altruist and AI safety communities (1:04:20) - Good policies and models for regulation, issues with regulation today Please subscribe to stay up to date on all the best clips and upcoming episodes! Follow Eric on Twitter Purchase Eric's book here. Connect with Sabrina on Twitter Engage with HOF on Twitter or learn more and visit HOF's website.

  • Oct 9, 2023 · 1 hr 1 min

    Martin Varsavsky on fertility and birth rate decline, gene editing, modern evolution, and why humanity needs more babies.

    In this episode, Sabrina Halper sits down with renowned entrepreneur Martin Varsavsky. Martin has founded five unicorn companies across industries. He discusses his cutting edge work in the fertility space and how technology will revolutionize our biology. Timestamps: (0:00) - Intro (1:30) - Catalyst for building in fertility (3:00) - Reasons for increased infertility in society (7:00) - Climate change and overpopulation narrative (10:00) - Reasons for declining birth rates & how to design a society that combats this (16:40) - Europe vs America on abortion, surrogacy, and the anti-science movements (22:00) - How to decrease the cost of fertility treatments by an order of magnitude (27:15) - Embryo selection vs CRISPR (32:34) - Mapping out IQ to a gene, editing for intelligence (34:00) - How regulation of CRISPR will vary between China and the west (36:00) - The potential disparity between humans, and the context of AI (37:20) - Why evolution doesn't work anymore (39:40) - Why humans may speciate and evolve into multiple species (41:59) - Is CRISPR happening today? 45:30 - In-vitro gametogenesis (IVG) (47:00) - What having a baby will look like in the future (49:05) - Male birth control, longevity, gene therapy (52:00) - Martin's philosophy around company building (54:15) - Having clear views around where the future is going (58:00) - Fast-paced popcorn questions: space, Einstein, quantum physics (1:00:30) - Outro Follow Tomorrow Talk to stay up to date on all the best clips and upcoming episodes! Follow Martin on Twitter Connect with Sabrina on Twitter Engage with HOF on Twitter or visit our website

  • Aug 30, 2023 · 1 hr

    Delian on Varda's space drugs, Founders Fund, and Silicon Valley's history of mentorship.

    Delian Asparouhov is the co-founder of Varda Space, the startup that is manufacturing products in space to benefit life on Earth. He is also a partner at Founders Fund. The first 30 minutes of this episode cover all things space: Varda, investing and building in Space, Elon's role in pushing the industry forward, working in highly-regulated industries, inception of ideas. The second 30 minutes go deep into Delian's personal path into venture, lessons from his first company, what personal characteristics define the best founders, lessons he learned from his mentors, which investment sectors he sees as being the next wave, and some fun fast facts. Follow https://twitter.com/TomorrowTalk_ to stay up to date on all the best clips and upcoming episodes! Follow Delian on Twitter: https://twitter.com/zebulgar. Connect with Sabrina on Twitter: https://twitter.com/SabrinaHalper. Engage with HOF on Twitter: https://twitter.com/HOFCapital or visit https://hofcapital.com/. Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer.

  • Aug 7, 2023 · 46 min

    Living Carbon's Maddie Hall on bioengineering super trees to help fight climate change, synthetic bio's potential, carbon credits, lessons from Sam Altman & using LLMs to understand animals.

    Maddie Hall is the co-founder and CEO of Living Carbon, a plant bio-tech company growing genetically modified poplars and pines capable of absorbing much more carbon dioxide from the atmosphere than regular trees. Previously, she worked on special projects at Y Combinator and OpenAI. Follow https://twitter.com/TomorrowTalk_ to stay up to date on all the best clips and upcoming episodes! Follow Maddie on Twitter: https://twitter.com/maddiehalla?s=20 Connect with Sabrina on Twitter: https://twitter.com/SabrinaHalper. Engage with HOF on Twitter: https://twitter.com/HOFCapital or visit https://hofcapital.com/. Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer.

  • Jul 11, 2023 · 42 min

    Tye Sheridan and Nikola Todorovic on harnessing AI to revolutionize special effects, founding Wonder Dynamics, the future of content, and Hollywood’s tech roots.

    Tye Sheridan, the lead actor in films such as Ready Player One, X-Men, and Mud, and Nikola Todorovic, award-winning filmmaker and visual effects supervisor, met on a set in 2016. They quickly became best friends, and eventually cofounders of Wonder Dynamics, a company building AI software that makes VFX special effects affordable and accessible on a browser, ultimately empowering a whole new generation of people to create new types of content that were previously reserved for big-budget studios. Today, they are about to launch to the public after compiling hundreds of thousands of users on their waitlist, and an advisory board that includes the likes of Steven Spielberg. We discuss how AI will empower filmmakers, Hollywood’s history with innovation, how content will change, their personal journey's, and much more. ---------------------------------------- Subscribe on YouTube: https://www.youtube.com/channel/UCRFhoFf-rNAHZLvPa7TbJrA Follow Tomorrow Talk on Twitter: https://twitter.com/TomorrowTalk_ Follow Sabrina Halper on Twitter: https://twitter.com/SabrinaHalper Follow Wonder Dynamics on Twitter: https://twitter.com/WonderDynamics Follow HOF Capital on Twitter: https://twitter.com/HOFCapital Visit our Website: https://hofcapital.com/ ------------------------------------------ Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer. HOF Capital is a global multistage VC firm with $1 billion in AUM that partners with ambitious entrepreneurs from idea to IPO.

  • Jun 12, 2023 · 44 min

    Bryan Johnson on reducing his biological age, longevity, human alignment, & negotiating with pain.

    Bryan Johnson sits down with HOF investor Sabrina Halper for an in-depth conversation that spans philosophy, biology, and technology. Bryan Johnson is the world's most measured human. He is investing millions to slow and reverse his aging. In 2021, he set a world record by reducing his epigenetic age by 5.1 years in 7 months. In this conversation, Bryan confronts many of the criticisms around his pursuit and presents his vision for the future of humanity. Previously, Johnson sold his company Braintree Venmo to PayPal for $800M in 2013. Johnson is also the founder of Kernel, creator of the world's first non-invasive neuroimaging system, and OS fund, where he invested $100M in the predictable engineering of atoms, molecules, and organisms into companies now collectively valued over $6B. Follow Bryan on Twitter: https://twitter.com/bryan_johnson or Instagram: https://www.instagram.com/bryanjohnson_/?hl=en. Connect with Sabrina on Twitter: https://twitter.com/SabrinaHalper. Engage with HOF on Twitter: https://twitter.com/HOFCapital or visit https://hofcapital.com/. Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer.

  • May 23, 2023 · 50 min

    Elad Gil on the power of peer groups, investing in 40+ unicorns, today's AI ecosystem, and staying dynamic.

    In this episode, Elad sits down with Sabrina Halper for a candid conversation about all things technology. You'll hear his thoughts on: 1.How to develop a long-term career in technology: -The power of peer groups and cohorts -Which jobs to pursue -Re-inventing yourself -Living in the physical hubs 2.Advice for founders of startups and growth-stage companies: -Why large companies stagnate and how to avoid it as you scale -How to think about startup moats and defensibility -The power of picking the right market -What led to Twitter's lack of iteration pre-Elon 3.Artificial Intelligence: -How to pick the winners -How things might shake up between OpenAI, Google, and Meta/ opensource -Amazon's play -Incentives around regulation -The need for thoughtful cost-benefit analysis -The best and worst case scenarios of AGI 4.Personal advice on: -Being a dynamic individual -Resilience -Time management Who is Elad Gil? Elad Gil is a serial entrepreneur, operating executive, and investor or advisor to companies such as AirBnB, Airtable, Brex, Coinbase, Deel, Figma, Gusto, Instacart, Notion, Pinterest, Rippling, Square, Stripe and others. Elad has invested in 40+ companies worth $1B or more, 30+ of them at the seed or series A. Elad was early to the AI space, running AI-centric products at Twitter (search), Google (ads targeting) and has invested in generative AI companies like Perplexity, Harvey.AI, Character. Elad is a Co-Founder of Color Health, a digital population healthcare delivery company. Elad also founded Mixer Labs, which was acquired by Twitter, and was VP of Corporate Strategy at Twitter. Elad received a Ph.D. from MIT and BS and BA in Math from UCSD. He is the author of the bestselling book High Growth Handbook. Follow Elad on Twitter or check out his website. Engage with HOF on Twitter & read our March to Utopia. Connect with Sabrina on Twitter.

  • Apr 24, 2023 · 1 hr 8 min

    Sahil Lavingia on growing Gumroad to $100M, today's AI ecosystem, finding a business idea, an Isaac Asimov future, his 300k Twitter audience + more

    In this episode, Sabrina Halper sits down with Sahil Lavingia for an in-depth conversation that goes far and wide. They discuss: -his journey dropping out of USC to join Pinterest as the 2nd employee -founding and scaling Gumroad to $100M -his advice for others looking to build profitable products and companies -the current AI wave: which companies excite him, what he's been building, how the competitive ecosystem might play out -AGI and what our future society may look like -Balaji's Bitcoin bet -whether TikTok should be banned Please like & subscribe! Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer. Follow Sahil on Twitter or check out his website. Engage with HOF on Twitter or read our March to Utopia. Connect with Sabrina on Twitter. Please follow this show and download episodes to stay up to date on Tomorrow Talk's latest! We have an exciting month ahead.

  • Mar 19, 2023 · 34 min

    Ben Lamm, Colossal Founder & CEO: De-Extinction, Artificial Wombs & the Future of Genetics

    In this episode, Sabrina sits down with Ben Lamm, CEO & Founder of the biotechnology and genetic engineering company Colossal. Ben is a serial entrepreneur who has started several moonshot companies, including AI company Hypergiant. Ben co-founded Colossal alongside renowned geneticist George Church. Together they are working to genetically resurrect key species, such as the wooly mammoth, the Tasmanian tiger, and the dodo to mitigate climate change and protect against the loss of biodiversity. Colossal has raised over $225M in funding. They're currently building cutting-edge technologies such as artificial wombs, multiplex editing, and in vitro gametogenesis. You’ll learn about how genetic engineering may allow us to protect our coral reefs, bring back extinct animals, and potentially create radiation-resistant humans. You’ll also get Ben’s advice on fundraising, attracting the best talent, and his framework on moonshot thinking. Please like & subscribe! Reach out to Shalper@hofcapital.com with any feedback, requests for guests, or if you're building something to bring the future closer. Follow Ben’s work on Twitter and Instagram Engage with HOF on Twitter and read our March to Utopia Connect with Sabrina on Twitter

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