
Supplements Not Working? Absorption Is the Missing Step | Dr. Mandell
transcript
show notes
Most people assume supplements fail because they chose the wrong brand or the wrong dose. In reality, supplements often fail because the body cannot absorb or utilize them properly. In this video, I explain why absorption matters more than dosage, how digestion controls whether supplements work at all, and why taking pills without food, fat, minerals, or proper gut function often leads to wasted money and poor results. I also share a simple Absorption Test you can use every time you take a supplement to determine whether your body can actually use it. Real food provides the biological signals, enzymes, cofactors, and minerals your body evolved to recognize. Supplements are designed to fill gaps, not replace nutrition. When taken correctly and supported by healthy digestion, they can be powerful tools. When taken without that foundation, they often pass right through the body. This video is about using supplements intelligently, not taking more of them.
PUBMED REFERENCES
Heaney RP. Factors influencing the measurement of bioavailability, taking calcium as a model. Journal of Nutrition. 2001;131(4 Suppl):1344S–1348S. PMID: 11285356
Rein MJ, Renouf M, Cruz-Hernandez C, Actis-Goretta L, Thakkar SK, da Silva Pinto M. Bioavailability of bioactive food compounds. European Journal of Clinical Nutrition. 2013;67(1):2–9. PMID: 23149637
Russell RM. Factors in aging that effect the bioavailability of nutrients. Journal of Nutrition. 2001;131(4 Suppl):1359S–1361S. PMID: 11285360
Camilleri M. Gastrointestinal motility disorders in neurologic disease. Journal of Clinical Investigation. 2021;131(4):e143771. PMID: 33539405
Lombardo M, Bellia C, Padua E, et al. The key role of gut microbiota in nutritional absorption and metabolism. Nutrients. 2020;12(2):349. PMID: 32050656
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