Less of You: Life on Semaglutide & Tirzepatide

Eva Sheie & Kami Gamlem

Eva + Kami are two old-ish moms confronting our reasons for being obese while losing weight on semaglutide and tirzepatide, and roasting our past selves. Sarcasm is our happy place. Follow us on Instagram @lessofyoupodcast.

After a friend (who is a plastic surgeon) talked Eva into starting semaglutide in February of 2023, she lost 70 pounds in 14 months, alternating between long stretches of being stalled at the same weight and consistent but slow weight loss. Chasing a lifelong dream to being considered just overweight and not obese by the BMI calculator, after 14 months Eva switched to tirzepatide to try and reach a goal that still seems just out of reach.

A prolific eater of her feelings, Kami was tired of being uncomfortable and when she heard through a mutual friend how semaglutide had changed Eva’s life, she found a trusted medical weight loss provider and took the first step.

As Kami starts her life on semaglutide, Eva adjusts to a world with less food noise and figures out how to let go of the crippling negative self-talk.

On each episode, we connect on how our lives are changing in real time as semaglutide and tirzepatide help us be smaller people, and try to answer the bigger question for ourselves:

When there’s less of you, what is left?

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21 episodes
Updated Friday
Explicit

Episodes21

Newest first

Friday · 30 min
I Did Halo Laser Resurfacing On My Way to a Dance Recital
After Eva went in for Halo laser resurfacing with a friend (who happens to be one of the best in the world), she walked out looking horrifying (according to the 8 year old) then drove straight to a dance recital tearing a cooling mask in half and...
July 31 · 45 min
We're Back, and We Found a Cheaper Way to Get Your Meds
After an accidental three-and-a-half-month hiatus, we are back with updates and committing to every week. We catch up on kids, summer camps, GLP-1 dosing and pricing, HRT and perimenopause, peptides, and one genuinely scary night at the tennis court....
March 27 · 31 min
Why you shouldn’t go off meds
Kami goes off her GLP-1, stops her thyroid meds, and gains back 25 lbs. After 3 months of Eva being angry for no reason, it turns out she just needs hormones. Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese...
January 9 · 29 min
The Dryer Shrunk My Jeans
Kami runs out of weight loss meds during the holidays, gains 10 pounds, and blames the dryer for shrinking her clothes. Eva overschedules everything, battles inconsistent clothing sizes at fancy events, and gets unsolicited body size comments at work....
Nov 14, 2025 · 37 min
I took a 4 week break from semaglutide and here’s what happened
Eva gets ghosted in the middle of an important situation and spirals for a day. Kami stops her meds and finds out what it feels like to be hungry again after two years. Check out https://a.co/d/aOqG8Jd Shop https://shapermint.com/ Eva + Kami are...
Oct 3, 2025 · 30 min
You Want Fries With That?
After sewing a quilt on the floor, Kami’s back goes out. After kicking a dumbbell, her foot goes out too. New compounded meds including glycine and B12 make a noticeable dent in Eva’s persistent body aches. A 3-week pause in medication to get a tooth...
Sep 5, 2025 · 17 min
Replacing one addiction with another?
While working on a project about addiction, Eva realizes she went from drinking and smoking to a food addiction. But she’s not even sure what her “thing” is now, which is… a little terrifying. Meanwhile, Kami loses some weight—not exactly from a...
Aug 15, 2025 · 47 min
How to hide that you’re on a GLP-1
If you want to keep your meds a secret from someone you live with, here’s how we would keep it secret. Kami’s cat, Leonardo Von Flouffe, makes his debut. Eva remembers why she was rejected from the United States Marine Corps (really). Eva + Kami...
Aug 8, 2025 · 36 min
Have we replaced food noise with mom guilt?
How does being hungry seem to interfere with every activity? One child can’t stop eating sugar, the other starts yelling about being hungry while sitting in the 4th row at Mary Poppins, and some mom guilt creeps in over kolaches, portion sizes, and...
Jul 18, 2025 · 1 hr
Do GLP-1s Help With Binge Eating?
Ashley tried everything. She tried all the diets: Weight Watchers, Nutrisystem, SlimFast, Houston Methodist Medical Weight Management program. Even after a gastric sleeve, her weight climbed back up to 320 lbs. Going to therapy for binge eating was...
Jun 20, 2025 · 29 min
Not-So Texas Roadhouses
Kami forgets to track her calories and take her meds. Eva sends her daughter to camp and Kami remembers getting left behind at camp at age 12, back when there were no cell phones. Eva + Kami are two old-ish moms with little kids confronting our...
May 23, 2025 · 35 min
Muffin Top, Sleep Apnea, Payment Plans
Eva gained a few pounds back and got a muffin top. Kami vs. insurance: It should not be this hard to get sleep apnea treatment. Yep, you can get a payment plan for weight loss meds. Because results shouldn’t depend on your wallet crying. Learn more...
Apr 25, 2025 · 20 min
No I Don’t Feel Totally Different Now
Kami broke her foot, and can’t move. Eva ate 4 dark chocolate mini eggs and got sick (4 eggs, not 4 bags of eggs). We beat the question “Don’t you feel totally different now?” to death. Kami SW 250, CW 198, GW 150? Eva SW 280, CW 184, GW 170 Eva +...
Mar 14, 2025 · 24 min
Teetering on the Edge of One-derland
Kami finally busted through the plateau, now hovering at 200 at officially down 50 lbs. Eva’s creeping toward 100 lbs lost, and had to try on size 8 jeans for the first time since 5th grade. For the record, yes, we’ve lost weight, but we’re still...
Mar 7, 2025 · 46 min
The GLP-1 and addiction connection no one’s talking about with Dr. Jason Giles
In this special bonus episode, an excerpt from a conversation with Los Angeles Addictionologist Dr. Jason Giles about the potential for GLP-1s as a treatment for substance abuse, explaining their impact on cravings and brain chemistry. Dr. Giles...
Feb 14, 2025 · 17 min
Debra’s 6 month progress update & tips for those with only 15 lbs to lose
The Debra returns with a progress update and fills in for Kami, who’s out with the flu. She started at 168, now at 154, aiming for 150. It took almost two months before the scale even moved, but she stuck with it. Hear Debra’s thoughtful tips if...
Jan 31, 2025 · 27 min
Possibly The Worst Before Photo Ever
Kami stalls at 203 and wonders if it’s time for a higher dose to make it to one-derland. Eva shares a jaw-dropping “before” pic from August 2021 after eating at Paula Deen’s while in Nashville. Meet Eva’s doctor,...
Jan 3, 2025 · 34 min
Tips for Newbies: Getting Started on Semaglutide and Tirzepatide
New to semaglutide or tirzepatide? Here are our tips for what to expect when you are just getting started. We survived the mountains of Christmas food and Eva let a wardrobe stylist give her closet a full makeover. Kami SW 250, CW 205, GW 150?...
Dec 13, 2024 · 29 min
Even More Rear End Problems
Thanksgiving chaos update, questionable ingredients brought by in-laws, a recurrence of rear-end issues, and how Eva got peer-pressured into tucking in a shirt. Eva + Kami are two old-ish moms with little kids confronting our reasons for being obese...
Nov 29, 2024 · 24 min
If your weight loss progress is stalled on a GLP-1, here’s my advice
Eva has lost 90 lbs, the equivalent of 9 gallons of paint according to the Lose It! app. It’s Kami’s birthday and she makes big plans for the night. An old friend reaches out at the end of her 2nd month of semaglutide injections with questions about...