EP Edge Journal Watch Issue 13 (March 2026): Ultrashort AF, ILR Accuracy, Semaglutide + Ablation, PADIT, PCOS, LBBAP and Next-Gen nanosecond PFA (SCENA-AF)
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EP Edge Journal Watch — Issue 13 (March 2026) explores a core 2026 EP problem: signal detection (wearables, patches, ILRs) and energy delivery (next-gen PFA) are advancing faster than the clinical rules we use to interpret risk and outcomes.
In this episode, Dr. Niraj Sharma breaks down what’s clinically actionable, what’s methodologically fragile, and what should change practice now versus what needs better evidence.
Topics covered (high-level):
- Ultrashort atrial arrhythmias (<30 seconds) and what they may imply on continuous monitoring
- Implantable loop recorder (ILR) “AF alerts” and why vendor performance is not interchangeable
- Semaglutide (GLP-1) and AF ablation in obesity: metabolic modulation as an EP strategy, not an afterthought
- Nanosecond pulsed field ablation (nsPFA) for paroxysmal AF (SCENA-AF) and what it means for workflow (including anesthesia strategy)
- A high-stakes coronary spasm signal in a population-enriched cohort
- LBBAP perforation detection: interpreting iEGMs as phenotype, not just amplitude
- PADIT score validation by infection subtype—toward phenotype-aware prevention
- PCOS and long-term arrhythmia risk: a women’s cardiovascular EP domain hiding in plain sight
Read the full newsletter (graphics + references): epedge.substack.com
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