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Weekly Pep Talk · May 19 · 43 min

GLP-1 FASTING MYTH-Are you doing it WRONG?

Does Retatrutide completely change how fasting works? And are most people using GLP-1 peptides the wrong way? In Episode 8 of Pep-Talk, Max Plasencia and Mike Sheffer dive deep into the science behind GLP-1 peptides, fasting, longevity, and anti-aging optimization — including powerful compounds like Tesamorelin, Epitalon, FOXO4-DRI, SS31, and MOTS-C. We break down why so many people fail with GLP-1 protocols, how Retatrutide impacts fasting and metabolism, and how to build smarter peptide stacks for long-term fat loss, performance, and longevity. 💡 What You’ll Learn: Does Retatrutide break a fast? The truth about Tesamorelin + fasting Why insulin resistance shuts down GH signaling How GLP-1 peptides improve insulin sensitivity The biggest GLP-1 mistakes people make Epitalon benefits for anti-aging & longevity FOXO4-DRI and “zombie cell” research explained The best peptide stacking strategy for longevity How SS31 + MOTS-C support mitochondrial health & energy 🎙️ About Pep-Talk: Hosted by Max Plasencia & Mike Sheffer, Pep-Talk is a weekly podcast focused on peptides, longevity, fat loss, biohacking, and performance optimization. ⏱️ CHAPTERS: 00:00 Intro 01:00 GLP-1 + Fasting Discussion 05:00 Retatrutide & Tesamorelin Explained 12:00 What Actually Counts as “Fasting”? 18:00 Insulin Resistance & GH Signaling 24:00 Why People Misuse GLP-1 31:00 Muscle Loss & GLP-1 Myths 40:00 Epitalon Benefits Explained 48:00 FOXO4-DRI & Zombie Cells 56:00 Anti-Aging Peptide Stack 01:04:00 SS31 + MOTS-C Synergy 01:12:00 Longevity Protocol Discussion 01:18:00 Final Thoughts Buy Peptides online at Prime Longevity Peptides: Enter code:welcome20 for 20% off your first order:⁠⁠https://primelongevitypeptides.com⁠⁠ Join Our Community Group: GLP& Peptide Warriors: Science-Backed & Supported Instagram @mikesheffer_ Instagram ⁠prime_longevity_protocol⁠ Email - info@primelongevityprotocol.com

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show notes

Does Retatrutide completely change how fasting works? And are most people using GLP-1 peptides the wrong way?

In Episode 8 of Pep-Talk, Max Plasencia and Mike Sheffer dive deep into the science behind GLP-1 peptides, fasting, longevity, and anti-aging optimization — including powerful compounds like Tesamorelin, Epitalon, FOXO4-DRI, SS31, and MOTS-C.

We break down why so many people fail with GLP-1 protocols, how Retatrutide impacts fasting and metabolism, and how to build smarter peptide stacks for long-term fat loss, performance, and longevity.

💡 What You’ll Learn:

  • Does Retatrutide break a fast?

  • The truth about Tesamorelin + fasting

  • Why insulin resistance shuts down GH signaling

  • How GLP-1 peptides improve insulin sensitivity

  • The biggest GLP-1 mistakes people make

  • Epitalon benefits for anti-aging & longevity

  • FOXO4-DRI and “zombie cell” research explained

  • The best peptide stacking strategy for longevity

  • How SS31 + MOTS-C support mitochondrial health & energy

🎙️ About Pep-Talk:
Hosted by Max Plasencia & Mike Sheffer, Pep-Talk is a weekly podcast focused on peptides, longevity, fat loss, biohacking, and performance optimization.

⏱️ CHAPTERS:
00:00 Intro
01:00 GLP-1 + Fasting Discussion
05:00 Retatrutide & Tesamorelin Explained
12:00 What Actually Counts as “Fasting”?
18:00 Insulin Resistance & GH Signaling
24:00 Why People Misuse GLP-1
31:00 Muscle Loss & GLP-1 Myths
40:00 Epitalon Benefits Explained
48:00 FOXO4-DRI & Zombie Cells
56:00 Anti-Aging Peptide Stack
01:04:00 SS31 + MOTS-C Synergy
01:12:00 Longevity Protocol Discussion
01:18:00 Final Thoughts


Buy Peptides online at Prime Longevity Peptides: Enter code:welcome20 for 20% off your first order:⁠⁠https://primelongevitypeptides.com⁠⁠

Join Our Community Group: GLP& Peptide Warriors: Science-Backed & Supported

Instagram @mikesheffer_

Instagram ⁠prime_longevity_protocol⁠

Email - info@primelongevityprotocol.com

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