TWiV 1275: An amazing sequence and a gutsy therapy

TWiV explains the Nobel Prize-winning discovery of pre-mRNA splicing, and engineering bacteriophage to deliver proteins to the human intestine.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Support science education at MicrobeTV
• Immune 100 live at the Incubator
• Spliced segments of adenovirus mRNA (PNAS)
• An amazing sequence in adenovirus mRNA (Cell)
• Nobel Prize for mRNA splicing (Nobel)
• A predominant undecanucleotide in adenovirus late mRNAs (Cell)
• Splicing RNA with Phillip A. Sharp (ASM)
• Protein production in the gut by engineered phage (Nat Biotech)
• Engineered phage T4 (Curr Op Virol)
• Timestamps by Jolene Ramsey. Thanks!

Weekly Picks

Brianne – Can You Identify These Lines from Classic SciFi Novels? Kathy – Saturday Morning Physics, Photograph 51 and JCE article Rich – Wikipedia:Wiki Science Competition 2025 in the United States Jolene – Data visualization workshop Vincent – Transformer: The Deep Chemistry of Life and Death by Nick Lane

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.