Theoretical Neuroscience Podcast
On whole-cell modeling of bacteria - with Markus Covert - #28
May 24, 2025 · 2 hr 4 min · Season 1 · Episode 28 · 179.1 MB
0:00-2:04:23
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A future computational neuroscience project could be to model not only the signal processing properties of neurons, but also all processes that keep a neuron alive for, say, a 100-year life span.
In 2012 the group of the guest published the first such whole-cell model for a very simple bacterium (M. genitalia). In 2020 a model of the larger E. coli bacterium comprising 10.000 equations and 19.000 model parameters was presented.
How are such models built, and what can they do?
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