Ep. 211: “Quantitative Stem Cell Dynamics” Featuring Dr. Alejo Rodriguez-Fraticelli

Guest:

Dr. Alejo Rodriguez-Fraticelli is a Group Leader at the Institute for Research in Biomedicine in Barcelona, where his team studies stem cell memory and epigenetics in hematopoiesis, immunity, and leukemia. He talks about setting up a new lab as a “playground for scientists,” how cancer is the “evil twin” of regeneration, and advanced methods for lineage tracing.

Featured Products and Resources:

• Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions.
• The StemSpan™ Leukemic Cell Culture Kit is optimized for in vitro culture and drug screening of human leukemic cells.

The Stem Cell Science Round Up

Curing Cancer with CAR T Therapy – Ten years after treatment, two leukemia patients remained in remission and had long-persisting CD4⁺ CAR T cells.

Retinal Organoids with Active Cones – Researchers generated retinal organoids with cone photoreceptors that respond to light.

Lineage Fate in the Mouse Embryo – Scientists identified a new type of mitotic spindle that is assembled exclusively at the eight-cell stage of development.

Switching Differentiation Paths – Knocking out Brm allows mesoderm cells to transform directly into ectoderm cells.

Photo Reference: Courtesy of Dr. Alejo Rodriguez-Fraticelli

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