Exposomics & 5P medicine | Gary Miller

Gary Miller, PhD is Professor of Environmental Health Sciences (in Molecular Pharmacology and Therapeutics) and Vice Dean for Research Strategy and Innovation at Mailman School of Public Health, Columbia University, USA Favorite metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) A toxic intermediate in the metabolism of dopamine linked to the damage to dopamine neurons in Parkinson’s disease. Paper discussed in the episode Zhao et al. Neurology 2024 | Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort Learn more about the outcomes of the Banbury conference on exposome in the Science paper, including the newly unified definition of the exposome. Read the Washington Declaration established and signed at the Exposome Moonshot forum in May 2025, a few days after recording the episode. Follow the progress of the Exposome Moonshot. Sign up for The Metabolomist mailing list to be the first to hear about the latest episodes and news around metabolomics at https://themetabolomist.com Finally available – Alice’s book on metabolomics data interpretation The STORY principle – A guide to the biological interpretation of metabolomics