Peptide of the Week: Retatrutide (GLP-3) – Fat Loss, Brain Boost & Total Control

Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas return with the first full drop of 2026 and it's a fan-favorite: Retatrutide. Also known as GLP-3, this triple agonist is quickly becoming the most powerful fat loss compound in the peptide world.

Whether you're just getting started or you're a seasoned gym rat trying to chisel that last layer of fat, this episode explains exactly why Retatrutide is dominating and how to use it strategically.

We cover:

🔥 Retatrutide (GLP-3) Breakdown

– Triple action: GLP-1, GIP, and Glucagon receptor agonist

– Suppresses appetite, increases insulin sensitivity, and boosts metabolic rate

– Torches visceral fat, especially in the midsection

– Major brain and focus benefits no more “hanger,” no mental fog

– Minimal to no nausea compared to semaglutide or tirzepatide

– Adaptable for both weight loss and lean bulking it’s all about dosage

⚙️ Real Dosing Strategies for Different Goals

– JD’s experience: 0.5mg 3x/week got him ultra-lean in just 2 weeks

– Beginners: Start at 1mg 3x/week and assess after 2 weeks

– Fat loss protocols: ramp up slowly to 5–6mg/week max

– Lean bulk protocol: pair with MK-677 or CJC/Ipamorelin for nutrient partitioning

💊 Stacking for Results

For Fat Loss:

– Retatrutide + Tesamorelin (for visceral fat)

– + 5-Amino 1MQ (fat cell breakdown)

– + L-Carnitine (fuel fat over sugar)

– + Sloof (exercise mimetic)

For Lean Bulking:

– Retatrutide + MK-677 (hunger + growth hormone boost)

– + IGF-1 LR3 (nutrient partitioning and local muscle growth)

– + Testosterone (non-negotiable for serious gains)

⚖️ Why Retatrutide Works for Nearly Everyone

– Gym rats = get chiseled without extreme dieting

– High-fat dieters = see double the burn from keto-style eating

– Busy parents & business pros = regain control of food, energy, and cravings

– Women should use extreme caution — not recommended for low-BMI users

🧠 Mindset Matters

– Retatrutide isn’t a shortcut it’s a tool to help retrain habits

– Discipline is a muscle: cutting sugar, eating clean, and saying NO becomes easier

– From JD’s carnivore hacks to Will’s own transformation this peptide builds more than bodies

📌 Final Recap:

– Retatrutide is a scientific breakthrough for fat loss, metabolism, and clarity

– It burns fat like butter, kills cravings without killing your appetite, and protects your muscle

– Get your blood work, understand your dose, and build the stack that fits your goals

💬 Got questions? Drop them in the comments stacks, doses, use cases, we’ll answer them all in the next Q&A.

📺 Subscribe now — Q&A episode drops Thursday and we’re just getting started for 2026.